Cited by 471Nerve injury and regenerationMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

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Learning deficit in BDNF mutant mice.

Linnarsson, Sten, Björklund, Anders, Ernfors, Patrik·1997·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.1997.tb01687.x

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Abstract

Brain-derived neurotrophic factor (BDNF) has been implicated in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, processes that are also thought to be involved in the learning of spatial tasks such as the Morris water maze. In order to determine whether BDNF is required for normal spatial learning, mice carrying a deletion in one copy of the BDNF gene were subjected to the Morris water maze task. Young adult BDNF mutant mice were significantly impaired compared with wild-type mice, requiring twice the number of days to reach full performance. Aged wild-type mice performed significantly worse than young wild-type mice and the effect was even more pronounced in the BDNF mutant mice, which did not learn at all. Although there was no difference in mean swimming speed between BDNF mutant and wild-type mice, we cannot exclude the possibility that developmental or peripheral deficits also contribute to the learning deficits in these mice. In situ hybridization and RNase protection analysis revealed that BDNF mRNA expression was indeed decreased in BDNF mutant mice. Furthermore, a pronounced effect of age on BDNF mRNA expression was seen, displayed as both a reduced level of mRNA expression and a reduced or entirely absent layer-specific expression pattern in the cerebral cortex of aged animals. Thus, our data suggest that BDNF expression may be linked to learning.

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Authors: Linnarsson, S., Björklund, A., & Ernfors, P.
Affiliations: Karolinska Institutet (SE)
Lund University (SE)
Corresponding author: Linnarsson, Sten
ORCID: Linnarsson, Sten
Björklund, Anders
Ernfors, Patrik
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 1997-12
Volume: 9
Issue: 12
Pages: 2581-2587
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.1997.tb01687.x
OpenAlex: W2136761139
Cited by: 471
References: 44
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 12 · 2018: 9 · 2017: 16 · 2016: 20 · 2015: 25 · 2014: 25 · 2013: 29 · 2012: 30
FWCI: 3.15
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3049 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Cancerfonden
Vetenskapsrådet
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: brain-derived neurotrophic factor, BDNF knockout mice, spatial learning, Morris water maze, hippocampus, long-term potentiation, synaptic transmission, BDNF mRNA expression, age-related decline, cerebral cortex, learning deficits
MeSH terms: Age Factors, Animals, Mice, Inbred BALB C, Mice, Neurologic Mutants, Retention, Psychology, RNA, Messenger, Spatial Behavior, Long-Term Potentiation, Gene Expression Regulation, Developmental, Maze Learning, Brain-Derived Neurotrophic Factor, Mice

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Learning deficit in BDNF mutant mice.

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