The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Doublecortin expression levels in adult brain reflect neurogenesis
Abstract
Progress in the field of neurogenesis is currently limited by the lack of tools enabling fast and quantitative analysis of neurogenesis in the adult brain. Doublecortin (DCX) has recently been used as a marker for neurogenesis. However, it was not clear whether DCX could be used to assess modulations occurring in the rate of neurogenesis in the adult mammalian central nervous system following lesioning or stimulatory factors. Using two paradigms increasing neurogenesis levels (physical activity and epileptic seizures), we demonstrate that quantification of DCX‐expressing cells allows for an accurate measurement of modulations in the rate of adult neurogenesis. Importantly, we excluded induction of DCX expression during physiological or reactive gliogenesis and excluded also DCX re‐expression during regenerative axonal growth. Our data validate DCX as a reliable and specific marker that reflects levels of adult neurogenesis and its modulation. We demonstrate that DCX is a valuable alternative to techniques currently used to measure the levels of neurogenesis. Importantly, in contrast to conventional techniques, analysis of neurogenesis through the detection of DCX does not require in vivo labelling of proliferating cells, thereby opening new avenues for the study of human neurogenesis under normal and pathological conditions.
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Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
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Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
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Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
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“AD, Alzheimer’s disease; BrdU, bromodeoxyuridine; CNS, central nervous system; DCX, doublecortin; DRG, dorsal root ganglion; EGFP, enhanced green fluorescent protein; GFP, green fluorescent protein; SVZ, subventricular zone; TBS, Tris-buffered saline.”
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Cited by
Neurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072
A Neurovascular Niche for Neurogenesis after Stroke
Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
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CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
Rogers, J. T., Morganti, J. M., Bachstetter, A. D., Hudson, C. E., Peters, M. M., Grimmig, B. A., Weeber, E. J., Bickford, P. C., & Gemma, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3667-11.2011 · Cited by 624
Wang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550
Metadata
- Authors
- Couillard‐Despres, S., Winner, B., Schaubeck, S., Aigner, R., Vroemen, M., Weidner, N., Bogdahn, U., Winkler, J., Kuhn, H., & Aigner, L.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2005-01
- Volume
- 21
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1986346910
- Cited by
- 975
- References
- 10
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Couillard‐Despres, S., Winner, B., Schaubeck, S., Aigner, R., Vroemen, M., Weidner, N., Bogdahn, U., Winkler, J., Kuhn, H., & Aigner, L. (2005). Doublecortin expression levels in adult brain reflect neurogenesis. European Journal of Neuroscience. https://doi.org/10.1111/j.1460-9568.2004.03813.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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