Cited by 144Circadian rhythm and melatoninLight effects on plantsSleep and Work-Related Fatigue

Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans

Cajochen, Christian, Jud, Corinne, Münch, Mirjam, Kobialka, Szymon, Wirz‐Justice, Anna, Albrecht, Urs·2006·European Journal of Neuroscience

Abstract

We developed a non‐invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant in comparison to a non‐light control condition only after light at 460 nm (blue) but not after light exposure at 550 nm (green). Our results indicate that the non‐image‐forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders.

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Crossref · 10.1111/j.1460-9568.2006.04613.x

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  • Exposure to short wavelength visible light (between 400 and 500 nm) has a stronger influence on circadian resetting than longer wavelength light.

    “Exposure to short wavelength visible light (between 400 and 500 nm, i.e. blue and blue-enriched light) has a stronger influence on the circadian resetting than longer wavelength light [63–66].”

    From Human thermal perception and time of day: A review (2021) · cites this paper as [66]

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Authors
Cajochen, C., Jud, C., Münch, M., Kobialka, S., Wirz‐Justice, A., & Albrecht, U.
Affiliations
  • University of Basel (CH)
  • University of Fribourg (CH)
Corresponding author
Cajochen, Christian
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2006-02
Volume
23
Issue
4
Pages
1082-1086
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2022759634
Cited by
144
References
31
Citations by year
2025: 4 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 13 · 2012: 11
FWCI
3.23
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • RERO DOC (Universität Bern) (submittedVersion)
Funders
  • Velux Stiftung
  • Office of Science
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
Per2, clock genes, blue light, evening light exposure, oral mucosa, circadian gene expression, circadian rhythm, green light
MeSH terms
Adult, Color, Darkness, Dose-Response Relationship, Radiation, Female, Humans, Light, Male, Melatonin, Mucous Membrane, Nuclear Proteins, Transcription Factors, Gene Expression, Period Circadian Proteins

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