Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions

De Leonibus, Elvira; Verheij, Michel M. M.; Mele, Andrea; Cools, Alexander

doi:10.1111/j.1460-9568.2006.04658.x

Cited by 57Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeural and Behavioral Psychology Studies

Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions

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De Leonibus, Elvira, Verheij, Michel M. M., Mele, Andrea, Cools, Alexander·2006·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2006.04658.x

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Abstract

Behaviourally relevant novel stimuli are known to activate the mesocorticolimbic dopaminergic (DAergic) system. In this study we tested the reactivity of this system in response to distinct kinds of novelty processing. Using the in vivo microdialysis technique, we measured extracellular amounts of dopamine (DA) in different DAergic terminal regions during a social learning task in rats. In the first session (40 min) rats were exposed to two never previously encountered juveniles (i.e. unconditional novelty). Afterwards, the animals were divided into three groups: Control group was not exposed to any other stimulus; Discrimination group was exposed to one familiar and one new juvenile (i.e. novel stimulus discrimination); and Recognition group was re-exposed to the two familiar juveniles (i.e. familiarity recognition). In both the medial prefrontal cortex and the nucleus accumbens shell DA increased in response to the first presentation of the juveniles, showing that both structures are involved in processing unconditional social novelty. During the novel stimulus discrimination, we found no change in the prefrontal cortex, although DA increased in the accumbal shell in comparison with the group exposed to two familiar juveniles, showing that the shell is also involved in processing novel social stimulus discrimination. None of the stimuli presented affected DA in the accumbal core. This study provided the original evidence that DA in the various terminal regions is differentially coupled to distinct aspects of novelty processing.

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Various types of novelty produce dopamine release in the rat striatum, including social novelty, novel tastes, and novel environments.
“Microdialysis [90, 91] and fast scan cyclic voltammetry [92] show that various types of novelty produce dopamine release in the rat striatum. These include social novelty [90], novel tastes [91], and novel environments [92].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [90]

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Recognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,555 · see citing works
The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Importance of unpredictability for reward responses in primate dopamine neurons
Mirenowicz, J., & Schultz, W. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.1024 · Cited by 544 · see citing works
Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study
Tidey, J. W., & Miczek, K. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00159-x · Cited by 496 · see citing works
Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats
Ito, R., Dalley, J. W., Howes, S. R., Robbins, T. W., & Everitt, B. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07489.2000 · Cited by 441 · see citing works
Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments.
Bassareo, V., & Chiara, G. D. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00583-1 · Cited by 433 · see citing works
Differential involvement of NMDA, AMPA/kainate and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior
Di Ciano, P., Cardinal, R. N., Cowell, R. A., Little, S. J., & Everitt, B. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09471.2001 · Cited by 354 · see citing works
Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex
Bassareo, V., De Luca, M. A., & Di Chiara, G. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04709.2002 · Cited by 339 · see citing works
Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: further evidence for limbic cortical–ventral striatopallidal systems
Parkinson, J. A., Willoughby, P. J., Robbins, T. W., & Everitt, B. J. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.42 · Cited by 314 · see citing works
Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: Further evidence for limbic cortical-ventral striatopallidal systems.
Parkinson, J. A., Willoughby, P. J., Robbins, T. W., & Everitt, B. J. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.1.42 · Cited by 309 · see citing works
Exposing Rats to a Predator Blocks Primed Burst Potentiation in the HippocampusIn Vitro
Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0004.1999 · Cited by 276 · see citing works
Social discrimination procedure: An alternative method to investigate juvenile recognition abilities in rats
Engelmann, M., Wotjak, C. T., & Landgraf, R. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00053-l · Cited by 274 · see citing works
Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty
Rebec, G. V., Christensen, J. R. C., Guerra, C., & Bardo, M. T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01004-4 · Cited by 235 · see citing works
Dynamic changes in nucleus accumbens dopamine efflux during the Coolidge effect in male rats
Fiorino, D. F., Coury, A., & Phillips, A. G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04849.1997 · Cited by 226 · see citing works
Aberrant responses in social interaction of dopamine transporter knockout mice
Rodriguiz, R. M., Chu, R., Caron, M. G., & Wetsel, W. C. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00187-6 · Cited by 221 · see citing works
Restraint increases dopaminergic burst firing in awake rats
Anstrom, K. K., & Woodward, D. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300730 · Cited by 181 · see citing works
A neurochemical and behavioral investigation of the involvement of nucleus accumbens dopamine in instrumental avoidance
McCullough, L. D., Sokolowski, J. D., & Salamone, J. D. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90538-q · Cited by 180 · see citing works
Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty
Feenstra, M. G. P., & Botterblom, M. H. A. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00945-6 · Cited by 169 · see citing works
Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat
Ahn, S., & Phillips, A. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-j0003.1999 · Cited by 160 · see citing works
A functional neuroanatomical investigation of the role of the medial preoptic area in neural circuits regulating maternal behavior
Stack, E. C., Balakrishnan, R., Numan, M. J., & Numan, M. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00370-9 · Cited by 151 · see citing works
Dopamine and noradrenaline efflux in the prefrontal cortex in the light and dark period: effects of novelty and handling and comparison to the nucleus accumbens
Feenstra, M. G. P., Botterblom, M. H. A., & Mastenbroek, S. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00319-5 · Cited by 138 · see citing works
RECOGNITION MEMORY IN RATS—I.CONCEPTS AND CLASSIFICATION
Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A., & Aggleton, J. P. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00060-9 · Cited by 126 · see citing works
Prefrontocortical Dopamine Loss in Rats Delays Long-Term Extinction of Contextual Conditioned Fear, and Reduces Social Interaction Without Affecting Short-Term Social Interaction Memory
Fernández‐Espejo, E. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300066 · Cited by 96 · see citing works
High and low responders to novelty: effects of a catecholamine synthesis inhibitor on novelty-induced changes in behaviour and release of accumbal dopamine
Saigusa, T., Tuinstra, T., Koshikawa, N., & Cools, A. R. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00275-9 · Cited by 87 · see citing works
Self-citation
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BLUMBERG, M. S., & Lucas, D. E. (1996) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199601)29:1 · Cited by 81 · see citing works
NMDA and AMPA Antagonist Infusions into the Ventral Striatum Impair Different Steps of Spatial Information Processing in a Nonassociative Task in Mice
Roullet, P., Sargolini, F., Oliverio, A., & Mele, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02143.2001 · Cited by 78 · see citing works
Self-citation
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Petrulis, A., Alvarez, P., & Eichenbaum, H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.001 · Cited by 75 · see citing works
Selective cytotoxic lesions of the retrohippocampal region produce a mild deficit in social recognition memory
Bannerman, D. M., Lemaire, M., Yee, B. K., Iversen, S. D., Oswald, C., Good, M. A., & Rawlins, J. N. P. (2002) · Experimental Brain Research · doi:10.1007/s00221-001-0938-z · Cited by 57 · see citing works
Dopamine and noradrenaline release in the prefrontal cortex of rats during classical aversive and appetitive conditioning to a contextual stimulus: interference by novelty effects
Feenstra, M. G. P., Teske, G. J. D., Botterblom, M. H. A., & de Bruin, J. P. C. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00601-1 · Cited by 52 · see citing works
Stimulus‐specific plasticity of prefrontal cortex dopamine neurotransmission
Jackson, M., & Moghaddam, B. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02205.x · Cited by 49 · see citing works
Role of the nucleus accumbens in social memory in rats
Ploeger, G. E., Willemen, A., & Cools, A. R. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90187-o · Cited by 46 · see citing works
Self-citation
Psychological stress selectively increases extracellular dopamine in the ‘shell’, but not in the ‘core’ of the rat nucleus accumbens: a novel dual-needle probe simultaneous microdialysis study
Wu, Y., Yoshida, M., Emoto, H., & Tanaka, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00747-8 · Cited by 46 · see citing works
Short-term social memory in the laboratory rat: its susceptibility to disturbance
Burman, O. H. P., & Mendl, M. (2000) · Applied Animal Behaviour Science · doi:10.1016/s0168-1591(99)00120-3 · Cited by 42 · see citing works
Opposite genotype-dependent mesocorticolimbic dopamine response to stress
Ventura, R., Cabib, S., & Puglisi‐Allegra, S. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00160-9 · Cited by 41 · see citing works
Effects of Single and Repeated Footshock on Dopamine Release and Metabolism in the Brains of Fischer Rats
Chrapusta, S. J., Wyatt, R. J., & Masserano, J. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052024.x · Cited by 41 · see citing works
Behavioral and mesocorticolimbic dopamine responses to non aggressive social interactions depend on previous social experiences and on the opponent’s sex
Cabib, S., D'Amato, F. R., Puglisi‐Allegra, S., & Dario Maestripieri, A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00157-1 · Cited by 39 · see citing works
A single exposure to novelty differentially affects the accumbal dopaminergic system of apomorphine-susceptible and apomorphine-unsusceptible rats
van der Elst, M. C. J., Verheij, M. M. M., Roubos, E. W., Ellenbroek, B. A., Veening, J. G., & Cools, A. R. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.10.023 · Cited by 23 · see citing works
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Alcaro, A., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.03.002 · Cited by 240 · see citing works
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O’Tuathaigh, C. M. P., Babovic, D., O’Sullivan, G. J., Clifford, J. J., Tighe, O., Croke, D. T., Harvey, R. P., & Waddington, J. L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.051 · Cited by 230 · see citing works
Good Vibrations: Cross-frequency Coupling in the Human Nucleus Accumbens during Reward Processing
Cohen, M. X., Axmacher, N., Lenartz, D., Elger, C. E., Sturm, V., & Schlaepfer, T. E. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21062 · Cited by 197 · see citing works
Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer’s disease
Guzmán-Ramos, K., Moreno-Castilla, P., Castro-Cruz, M., McGaugh, J. L., Martínez-Coria, H., LaFerla, F. M., & Bermúdez-Rattoni, F. (2012) · Learning & Memory · doi:10.1101/lm.026070.112 · Cited by 127 · see citing works
Spatial deficits in a mouse model of Parkinson disease
Leonibus, E. D., Pascucci, T., Lopez, S., Oliverio, A., Amalric, M., & Mele, A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0862-4 · Cited by 85 · see citing works
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Holly, E. N., DeBold, J. F., & Miczek, K. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4082-z · Cited by 83 · see citing works
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Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics
Yoder, K. K., Albrecht, D., Džemidžić, M., Normandin, M. D., Federici, L. M., Graves, T., Herring, C. M., Hile, K. L., Walters, J. W., Liang, T., et al. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.01.001 · Cited by 73 · see citing works
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Yang, K., Broussard, J. I., Levine, A. T., Jenson, D., Arenkiel, B. R., & Dani, J. A. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13406 · Cited by 58 · see citing works
“Using in vivo microdialysis, previous studies reported that novel stimulation increases DA efflux in the medial prefrontal cortex (Feenstra & Botterblom, 1996), the nucleus accumbus shell (De Leonibus et al., 2006), and the insular cortex (Guzman-Ramos et al., 2012), suggesting broad DA influence.”
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Managò, F., Castellano, C., Oliverio, A., Mele, A., & Leonibus, E. D. (2008) · Learning & Memory · doi:10.1101/lm.1177509 · Cited by 57 · see citing works
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Slow phasic changes in nucleus accumbens dopamine release during fixed ratio acquisition: a microdialysis study
Segovia, K. N., Correa, M., & Salamone, J. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.078 · Cited by 44 · see citing works
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Segovia, K. N., Correa, M., Lennington, J. B., Conover, J. C., & Salamone, J. D. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08036.x · Cited by 40 · see citing works
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Rinaldi, A., Romeo, S., Agustín‐Pavón, C., Oliverio, A., & Mele, A. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.08.004 · Cited by 41 · see citing works
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P19 A TRIPLE DISSOCIATION IN THE PATTERN OF DOPAMINE RELEASE IN THE MEDIAL PREFRONTAL CORTEX, CORE AND SHELL SUBREGIONS OF NUCLEUS ACCUMBENS, DURING DIFFERENT KINDS OF NOVELTY PROCESSING
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Rebec, G. V., Grabner, C. P., Johnson, M., Pierce, R. C., & Bardo, M. T. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00382-x · Cited by 184 · see citing works

Authors: De Leonibus, E., Verheij, M. M. M., Mele, A., & Cools, A.
Affiliations: Radboud University Nijmegen (NL)
Sapienza University of Rome (IT)
ORCID: Verheij, Michel M. M.
Mele, Andrea
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2006-03
Volume: 23
Issue: 5
Pages: 1332-1340
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2006.04658.x
OpenAlex: W2102622213
Cited by: 57
References: 38
Citations by year: 2025: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2012: 4
FWCI: 1.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Rotary Foundation
Ministero dell’Istruzione, dell’Università e della Ricerca
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: novelty processing, extracellular dopamine, social novelty, medial prefrontal cortex, nucleus accumbens shell, nucleus accumbens core, social learning, rats
MeSH terms: Animals, Behavior, Animal, Brain, Dopamine, Male, Sensation, Social Behavior, Rats, Wistar, Microdialysis, Rats

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Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions

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