Dynamic changes in nucleus accumbens dopamine efflux during the Coolidge effect in male rats
Open accessAbstract
The Coolidge effect describes the reinitiation of sexual behavior in a "sexually satiated" animal in response to a novel receptive mate. Given the role of the mesolimbic dopamine (DA) system in the initiation and maintenance of motivated behavior, microdialysis was used to monitor nucleus accumbens (NAC) DA transmission during copulation, sexual satiety, and the reinitiation of sexual behavior. In agreement with earlier reports, the presentation of an estrous female behind a screen and copulation were associated with significant increases in NAC DA efflux. Return of NAC DA concentrations to baseline values coincided with a period of sexual satiety, although concentrations of the DA metabolites, dihydroxyphenylacetic acid and homovanillic acid, remained elevated. The presentation of a novel receptive female behind a screen resulted in a slight increase in NAC DA, which was augmented significantly during renewed copulation with the novel female. The present data suggest that the stimulus properties of a novel receptive female may serve to increase NAC DA transmission in a sexually satiated male rat, and this, in turn, may be related to the reinitiation of sexual behavior.
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Sexual novelty boosts dopaminergic neurotransmission at the nucleus accumbens.
“Sexual novelty boosts dopaminergic neurotransmission at the nucleus accumbens (Fiorino et al., 1997).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Fiorino et al., 1997
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- Authors
- Fiorino, D. F., Coury, A., & Phillips, A. G.
- Affiliations
- University of British Columbia (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-06-15
- Volume
- 17
- Issue
- 12
- Pages
- 4849-4855
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6573325
- OpenAlex
- W2098949098
- Cited by
- 226
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 1 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 11 · 2014: 10 · 2013: 9 · 2012: 13
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council Canada
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- nucleus accumbens, dopamine efflux, sexual behavior, mesolimbic dopamine system, dihydroxyphenylacetic acid, homovanillic acid, copulation, male rats
- MeSH terms
- Animals, Brain Mapping, Copulation, Dopamine, Ejaculation, Female, Homovanillic Acid, Male, Motivation, Nucleus Accumbens, Ovariectomy, Sexual Behavior, Animal, 3,4-Dihydroxyphenylacetic Acid, Rats, Sprague-Dawley, Microdialysis, Rats
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