Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty

Feenstra, Matthijs G.P; Botterblom, Margriet H.A

doi:10.1016/s0006-8993(96)00945-6

Cited by 169Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty

Feenstra, Matthijs G.P, Botterblom, Margriet H.A·1996·Brain Research

DOI 10.1016/s0006-8993(96)00945-6

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Abstract

We report the effects of physiological stimuli on extracellular dopamine (DA) in the medial prefrontal cortex (PFC) of the rat determined on-line in dialysates obtained every 5.5 min. The detection limit for DA was 0.03-0.1 pg/5 microl injection using a conventional HPLC set-up. Basal levels in PFC were at the detection limit, therefore 3 microM nomifensine was included in the Ringer perfusion fluid, producing readily detectable DA levels of 0.9 pg/injection. Perfusion with 3 microM TTX for 30 min decreased DA within 11 min to 10% of control. The routine use of rapid sampling of extracellular DA was applied to study cortical DA release in relation to behaviour. Exposure to a novel environment for 5.5 min led to an increase to 135%. Presentation of a food pellet to food-deprived rats resulted in a rapid increase to 150% within 5.5 min, which lasted 30-40 min, which is 10-20 min more than the time spent eating. Handling the rat for 5.5 min increased DA in PFC within 5.5 min to 160% and in 11 min to 190% of control followed by a 25-min period of a 50% increase, probably reflecting increased arousal. The results suggest that emotional arousal is a common denominator of increased cortical DA release and that responses are graded depending on the intensity of the stimulus.

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Authors: Feenstra, M. G. P., & Botterblom, M. H. A.
Corresponding author: Feenstra, Matthijs G.P
Venue: Brain Research
Publisher: Elsevier BV
Published: 1996-12
Volume: 742
Issue: 1-2
Pages: 17-24
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(96)00945-6
OpenAlex: W1981768163
Cited by: 169
References: 36
Citations by year: 2026: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 6 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 4 · 2012: 10
FWCI: 2.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: extracellular dopamine, medial prefrontal cortex, high-speed sampling, dopamine release, novelty exposure, dietary intake, food deprivation, handling, emotional arousal, tetrodotoxin, nomifensine
MeSH terms: Animals, Arousal, Dopamine, Eating, Male, Rats, Wistar, Prefrontal Cortex, Microdialysis, Rats

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Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty

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