Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory

Savalli, Giorgia; Bashir, Zafar I.; Warburton, E. Clea

doi:10.1101/lm.036921.114

PreprintCited by 19Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorMemory Processes and Influences

Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory

Open access

Savalli, Giorgia, Bashir, Zafar I., Warburton, E. Clea·2015·Learning & Memory

DOI 10.1101/lm.036921.114PMC PMC4341361

Open this paper in CoChat — free account Open PDF

Abstract

Object-in-place (OiP) memory is critical for remembering the location in which an object was last encountered and depends conjointly on the medial prefrontal cortex, perirhinal cortex, and hippocampus. Here we examined the role of dopamine D1/D5 receptor neurotransmission within these brain regions for OiP memory. Bilateral infusion of D1/D5 receptor antagonists SCH23390 or SKF83566 into the medial prefrontal cortex, prior to memory acquisition, impaired OiP performance following a 5 min or 1 h delay. Retrieval was unaffected. Intraperirhinal or intrahippocampal infusions of SCH23390 had no effect. These results reveal a selective role for D1/D5 receptors in the mPFC during OiP memory encoding.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/lm.036921.114

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The mPFC has an integrative role in object, place and time information.
“The mPFC has an integrative role in object, place and time information [114, 115] as well as reward-regulated mechanisms of spatial learning [116, 117].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [115]
The passage labeled Abstract (page unavailable) says the mPFC integrates object and location information for object-in-place memory. It does not say that the mPFC integrates temporal information; the task delays described elsewhere in the paper do not establish that part of the claim. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Processing of OiP memory requires participation of the mPFC.
“The processing of OiP memory requires the participation of the mPFC, as evidenced by studies of lesions or blocking of glutamate-, acetylcholine (ACh)- or dopamine (DA)-R (Barker et al., 2007; Barker and Warburton, 2008, 2009, 2015; Savalli et al., 2015).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Savalli et al., 2015
Pre-sample prefrontal microinjections of SCH23390 do not impair NOP memory tested 1 hour later.
“Pre-sample prefrontal microinjections of SCH23390 did not impair the NOP memory tested 1 hour later (Savalli et al., 2015), although contrary results have also been reported (Clausen et al., 2011).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Savalli et al., 2015
Pre-test infusions of SCH23390 into the PFC have no effect in OiP (1 hour) memory.
“Pre-test infusions of SCH23390 into the PFC had no effect in the OiP (1 hour) memory (Savalli et al., 2015).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Savalli et al., 2015
In the OiP test, pre-sample infusions of SCH23390 or SKF83566 into the rat mPFC lead to impairment tested 5 and 1 hour later.
“In the OiP test, pre-sample infusions of SCH23390 or SKF83566, a DA D1-R antagonist, into the rat mPFC led to an impairment, tested 5 and 1 hour later.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Savalli et al., 2015

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
When Is the Hippocampus Involved in Recognition Memory?
Barker, G. R. I., & Warburton, E. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6413-10.2011 · Cited by 818 · see citing works
Self-citation
Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex
Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5289-06.2007 · Cited by 691 · see citing works
Self-citation
Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition
Dix, S. L., & Aggleton, J. P. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00079-5 · Cited by 598 · see citing works
Scene-Specific Memory for Objects: A Model of Episodic Memory Impairment in Monkeys with Fornix Transection
Gaffan, D. (1994) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1994.6.4.305 · Cited by 484 · see citing works
D1Receptor Modulation of Hippocampal–Prefrontal Cortical Circuits Integrating Spatial Memory with Executive Functions in the Rat
Seamans, J. K., Floresco, S., & Phillips, A. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01613.1998 · Cited by 472 · see citing works
Essential Role of D1 But Not D2 Receptors in the NMDA Receptor-Dependent Long-Term Potentiation at Hippocampal-Prefrontal Cortex SynapsesIn Vivo
Gurden, H., Takita, M., & Jay, T. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-j0003.2000 · Cited by 366 · see citing works
Dopamine D 1 /D 5 Receptors Gate the Acquisition of Novel Information through Hippocampal Long-Term Potentiation and Long-Term Depression
Lemon, N., & Manahan‐Vaughan, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1454-06.2006 · Cited by 345 · see citing works
Origin of dopaminergic innervation of the rat hippocampal formation
Scatton, B., Simon, H., Le Moal, M., & Bischoff, S. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90314-6 · Cited by 323 · see citing works
Histochemical confirmation for dopaminergic innervation of the rat cerebral cortex after destruction of the noradrenergic ascending pathways
Berger, B., Tassin, J., Blanc, G., Doyennette‐Moyne, M., & Thierry, A. M. (1974) · Brain Research · doi:10.1016/0006-8993(74)90948-2 · Cited by 278 · see citing works
Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memoryPreprint
O’Carroll, C., Martin, S. J., Sandin, J., Frenguelli, B. G., & Morris, R. G. M. (2006) · Learning & Memory · doi:10.1101/lm.321006 · Cited by 237 · see citing works
Interaction between Perirhinal and Medial Prefrontal Cortex Is Required for Temporal Order But Not Recognition Memory for Objects in Rats
Hannesson, D. K., Howland, J. G., & Phillips, A. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5517-03.2004 · Cited by 231 · see citing works
The medial frontal cortex and temporal memory: tests using spontaneous exploratory behaviour in the rat
Mitchell, J. B. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00032-1 · Cited by 212 · see citing works
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
Baldwin, A. E., Sadeghian, K., & Kelley, A. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01063.2002 · Cited by 191 · see citing works
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex
Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., et al. (2007) · Learning & Memory · doi:10.1101/lm.461407 · Cited by 184 · see citing works
Object-in-Place Associative Recognition Memory Depends on Glutamate Receptor Neurotransmission Within Two Defined Hippocampal-Cortical Circuits: A Critical Role for AMPA and NMDA Receptors in the Hippocampus, Perirhinal, and Prefrontal Cortices
Barker, G. R. I., & Warburton, E. C. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht245 · Cited by 159 · see citing works
Self-citation
D1 and D2 dopamine receptors in separate circuits cooperate to drive associative long-term potentiation in the prefrontal cortex
Xu, T., & Yao, W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004108107 · Cited by 149 · see citing works
Novelty-induced increase in dopamine release in the rat prefrontal cortex in vivo: inhibition by diazepam
Feenstra, M. G. P., Botterblom, M. H. A., & Uum, J. F. M. V. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11456-7 · Cited by 148 · see citing works
Memory for spatial location and object‐place associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex
Bachevalier, J., & Nemanic, S. (2007) · Hippocampus · doi:10.1002/hipo.20369 · Cited by 147 · see citing works
Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D1R Null,Drd1a−/−Mice and in Hippocampal siRNA SilencedDrd1aMice
Ortiz, O., Delgado-García, J. M., Espadas, I., Bahí, A., Trullas, R., Dreyer, J.-L., Gruart, A., & Moratalla, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2655-10.2010 · Cited by 143 · see citing works
Interaction of Perirhinal Cortex with the Fornix–Fimbria: Memory for Objects and “Object-in-Place” Memory
Gaffan, D., & Parker, A. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05864.1996 · Cited by 143 · see citing works
Glutamatergic and dopaminergic afferents to the prefrontal cortex regulate spatial working memory in rats
ROMANIDES, A., Duffy, P., & Kalivas, P. W. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00747-7 · Cited by 136 · see citing works
The "selective" dopamine D 1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin 2C receptors
Millan, M. J., Newman‐Tancredi, A., Quentric, Y., & Cussac, D. (2001) · Psychopharmacology · doi:10.1007/s002130100742 · Cited by 131 · see citing works
Altered object-in-place recognition memory, prepulse inhibition, and locomotor activity in the offspring of rats exposed to a viral mimetic during pregnancy
Howland, J. G., Cazakoff, B. N., & Zhang, Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.011 · Cited by 127 · see citing works
NMDA Receptor Plasticity in the Perirhinal and Prefrontal Cortices Is Crucial for the Acquisition of Long-Term Object-in-Place Associative Memory
Barker, G. R. I., & Warburton, E. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4447-07.2008 · Cited by 118 · see citing works
Self-citation
The medial dorsal thalamic nucleus and the medial prefrontal cortex of the rat function together to support associative recognition and recency but not item recognition
Cross, L., Brown, M. W., Aggleton, J. P., & Warburton, E. C. (2013) · Learning & Memory · doi:10.1101/lm.028266.112 · Cited by 106 · see citing works
Self-citation
Modulatory influence of dopamine receptors on consolidation of object recognition memory
de Lima, M. N. M., Presti-Torres, J., Dornelles, A. D. S., Scalco, F. S., Roesler, R., Garcia, V. A., & Schröder, N. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.12.007 · Cited by 102 · see citing works
Visuospatial memory and learning in first-episode schizophreniform psychosis and established schizophrenia: a functional correlate of hippocampal pathology?
Wood, S. J., Proffitt, T., Mahony, K. E., SMITH, D. J., Buchanan, J., Brewer, W. J., Stuart, G. W., Velakoulis, D., McGorry, P. D., & Pantelis, C. (2002) · Psychological Medicine · doi:10.1017/s0033291702005275 · Cited by 90 · see citing works
The role of prefrontal cortex in object‐in‐place learning in monkeys
Browning, P. G. F., Easton, A., Buckley, M. J., & Gaffan, D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04477.x · Cited by 73 · see citing works
D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs
Stramiello, M., & Wagner, J. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.053 · Cited by 71 · see citing works
Differential effects of three 5-HT receptor antagonists on the performance of rats in attentional and working memory tasks
Ruotsalainen, S., Sirviö, J., Jäkälä, P., Puumala, T., MacDonald, E., & Riekkinen, P. J. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00389-6 · Cited by 62 · see citing works
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions
De Leonibus, E., Verheij, M. M. M., Mele, A., & Cools, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04658.x · Cited by 57 · see citing works
SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors
Ohlstein, E. H., & Berkowitz, B. A. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90728-9 · Cited by 55 · see citing works
Dopamine in the prefrontal cortex regulates rats behavioral flexibility to changing reward value
Winter, S., Dieckmann, M., & Schwabe, K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.040 · Cited by 53 · see citing works
The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects
Nelson, A. J. D., Cooper, M. T., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2011) · Behavioral Neuroscience · doi:10.1037/a0023337 · Cited by 53 · see citing works
A link between role of two prefrontal areas in immediate memory and in long-term memory consolidation
Izquierdo, L. A., Barros, D. M., da Costa, J. C., Furini, C. R. G., Zinn, C. G., Cammarota, M., Bevilaqua, L. R., & Izquierdo, I. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.04.014 · Cited by 52 · see citing works
Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in learning
Meneses, A., & Hong, E. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02266-8 · Cited by 50 · see citing works
Different laminar distributions of dopamine D1 and D2 receptors in the rat hippocampal region
Köhler, C., Ericson, H., & Radesäter, A. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90530-7 · Cited by 49 · see citing works
Dopamine D1 receptor activity modulates object recognition memory consolidation in the perirhinal cortex but not in the hippocampus
Balderas, I., Moreno‐Castilla, P., & Bermudez‐Rattoni, F. (2013) · Hippocampus · doi:10.1002/hipo.22143 · Cited by 46 · see citing works
Recognition memory for object form and object location: An event-related potential study
Mecklinger, A., & Meinshausen, R. M. (1998) · Memory & Cognition · doi:10.3758/bf03201184 · Cited by 45 · see citing works
Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain
Laurier, L. G., O’Dowd, B. F., & George, S. R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90170-8 · Cited by 44 · see citing works
Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats
Clausen, B., Schachtman, T. R., Mark, L. T., Reinholdt, M., & Christoffersen, G. R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.069 · Cited by 41 · see citing works
Dopamine in the CNS I
(2002) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-56051-4 · Cited by 39 · see citing works
The interaction between the dopaminergic forebrain projections and the medial prefrontal cortex is critical for memory of objects: implications for Parkinson’s disease
Chao, O. Y.-H., Pum, M. E., & Huston, J. P. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.003 · Cited by 39 · see citing works
Modafinil restores methamphetamine induced object-in-place memory deficits in rats independent of glutamate N -methyl- d -aspartate receptor expression
Reichel, C. M., Gilstrap, M. J., Ramsey, L. A., & See, R. E. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.09.018 · Cited by 30 · see citing works
Extracellular dopamine in the rat prefrontal cortex during reward-, punishment- and novelty-associated behaviour. Effects of diazepam
Beaufour, C., Bihan, C. L., Hamon, M., & Thiébot, M.-H. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00492-0 · Cited by 30 · see citing works
Dopamine Induces a Slow Afterdepolarization in Lateral Amygdala Neurons
Yamamoto, R., Ueta, Y., & Kato, N. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00204.2007 · Cited by 30 · see citing works
Axonal branching of ventral tegmental and raphe projections to the frontal cortex in the rat
Sobel, E., & Corbett, D. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90006-5 · Cited by 24 · see citing works
The Effects of Diazepam
WEAVER, D. C. (1969) · Anesthesiology · doi:10.1097/00000542-196908000-00019 · Cited by 23 · see citing works
Perirhinal cortical inactivation impairs object-in-place memory and disrupts task-dependent firing in hippocampal CA1, but not in CA3
Lee, I., & Park, S. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00134 · Cited by 17 · see citing works
Serotonergic mechanisms of memory trace retrieval
Molodtsova, G. F. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.12.005 · Cited by 16 · see citing works
Dopamine in the CNS II
(2002) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-06765-9 · Cited by 3 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Fallon J, Laughlin S 1995 Substantia Nigra. In: The rat nervous system (ed. Paxinos G), pp. 215– 237 Academic Press, San Diego.

Sorted by citations

The extracellular matrix and perineuronal nets in memory
Fawcett, J. W., Fyhn, M., Jendelova, P., Kwok, J. C. F., Ruzicka, J., & Sorg, B. A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01634-3 · Cited by 169 · see citing works
The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Medial prefrontal cortex role in recognition memory in rodents
Morici, J. F., Bekinschtein, P., & Weisstaub, N. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.030 · Cited by 119 · see citing works
Brain networks activated to form object recognition memory
Tanimizu, T., Kono, K., & Kida, S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.05.017 · Cited by 81 · see citing works
Sex differences in animal models of schizophrenia shed light on the underlying pathophysiology
Hill, R. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.014 · Cited by 61 · see citing works
Distributed interactive brain circuits for object-in-place memory: A place for time?
Aggleton, J. P., & Nelson, A. J. D. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820933471 · Cited by 50 · see citing works
Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats
Westbrook, S. R., Dwyer, M. R., Cortes, L. R., & Gulley, J. M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112659 · Cited by 35 · see citing works
Dopamine D1 receptor in the medial prefrontal cortex mediates anxiety-like behaviors induced by blocking glutamatergic activity of the ventral hippocampus in rats
Liu, L., Zhang, L., Wang, T., & Chen, L. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.024 · Cited by 25 · see citing works
Probing the nature of episodic memory in rodents
Huston, J. P., & Chao, O. Y.-H. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104930 · Cited by 16 · see citing works
CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memoryPreprint
Barker, G. R., Wong, L. F., Uney, J. B., & Warburton, E. C. (2020) · Learning & Memory · doi:10.1101/lm.050021.119 · Cited by 14 · see citing works
Self-citation
Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake
Ramli, N. Z., Yahaya, M. F., Fahami, N. A. M., Hamezah, H. S., Bakar, Z. H. A., Arrozi, A. P., Yanagisawa, D., Tooyama, I., Singh, M., & Damanhuri, H. A. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112607 · Cited by 6 · see citing works
Dopamine D1/D5 Receptors in the Retrosplenial Cortex Are Necessary to Consolidate Object Recognition Memory
de Landeta, A. B., Medina, J. H., & Katche, C. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.922971 · Cited by 6 · see citing works
Functional and Regional Specificity of Noradrenergic Signaling for Encoding and Retrieval of Associative Recognition Memory in the Rat
Tran, S., Barker, G. R. I., Mathiasen, M. L., Aggleton, J. P., & Warburton, E. C. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.2408-24.2025 · Cited by 1 · see citing works
Self-citation
The contribution of dopamine to the functioning of the hippocampus during spatial learning (a hypothetical mechanism)
Silkis, I. G. (2016) · Neurochemical Journal · doi:10.1134/s181971241601013x · Cited by 2 · see citing works
The Neuropharmacology of What, Where, When
Cassaday, H. J., & Nelson, A. J. D. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-812012-5.00024-0 · Cited by 1 · see citing works
Dopamine is a double-edged sword: Enhancing memory retrieval performance at the expense of metacognitionPreprint
Clos, M., Bunzeck, N., & Sommer, T. (2018) · bioRxiv · doi:10.1101/274159 · Cited by 1 · see citing works
Intermediate CA1 is Required for Object-in-Place Recognition Memory in MicePreprint
Cruz-Sanchez, A., Inayat, M., Parikh, P., Appings, R., Violi, F., & Arruda-Carvalho, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.01.569628
Ventral and Intermediate Hippocampus Are Required for Object-in-Place Recognition Memory in Mice
Cruz-Sanchez, A., Inayat, M., Parikh, P., Appings, R., Violi, F., & Arruda-Carvalho, M. (2026) · eNeuro · doi:10.1523/eneuro.0105-26.2026 · Cited by 1 · see citing works
Task optimization and ontogenetic profile of the object-in-Place task in mice
Inayat, M., Cruz-Sanchez, A., LaDouceur, K. E., Parikh, P., & Arruda-Carvalho, M. (2026) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2026.108199

An investigation of the neural basis of associative recognition memory in the rat
Savalli, G. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
Self-citation
Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex
Pezze, M. A., Marshall, H. J., Fone, K. C. F., & Cassaday, H. J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.07.018 · Cited by 51 · see citing works
Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus
Rossato, J. I., Radiske, A., Kohler, C. A., Gonzalez, C., Bevilaqua, L. R., Medina, J. H., & Cammarota, M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.012 · Cited by 75 · see citing works
Dopamine D1 receptor activity modulates object recognition memory consolidation in the perirhinal cortex but not in the hippocampus
Balderas, I., Moreno‐Castilla, P., & Bermudez‐Rattoni, F. (2013) · Hippocampus · doi:10.1002/hipo.22143 · Cited by 46 · see citing works
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364 · see citing works

Authors: Savalli, G., Bashir, Z. I., & Warburton, E. C.
Affiliations: Medical University of Vienna (AT)
University of Bristol (GB)
Corresponding author: Warburton, E. Clea
ORCID: Bashir, Zafar I.
Warburton, E. Clea
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2015-01-15
Volume: 22
Issue: 2
Pages: 69-73
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.036921.114
PMC: PMC4341361
OpenAlex: W2005585617
Cited by: 19
References: 53
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2020: 4 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2
Type: posted content
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Learning & Memory (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Bristol Research (University of Bristol) (publishedVersion, cc-by)
Explore Bristol Research (publishedVersion, cc-by)
Funders: Biotechnology and Biological Sciences Research
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: dopamine D1/D5 receptors, medial prefrontal cortex, dopamine signaling, associative recognition memory, memory encoding, perirhinal cortex, hippocampus, SCH 23390, receptor antagonists
MeSH terms: Animals, Association Learning, Benzazepines, Male, Synaptic Transmission, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Prefrontal Cortex, Receptors, Dopamine D1, Dopamine Antagonists, Recognition, Psychology, Receptors, Dopamine D5, Rats, Spatial Memory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks