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Medicinal Plants as Novel Promising Therapeutics for Neuroprotection and Neuroregeneration

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Effect of ashwagandha ( Withania somnifera ) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study

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Combined effects of vermicompost and vermicompost leachate on the early growth of Meloidogyne incognita stressed Withania somnifera (L.) Dunal

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Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease

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Phytochemical Compounds Loaded to Nanocarriers as Potential Therapeutic Substances for Alzheimer’s Disease-Could They be Effective?

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Phytonutrient Inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (Mpro) Autocleavage Enzyme Critical for COVID-19 Pathogenesis

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Triclosan-induced neuroinflammation develops caspase-independent and TNF-α signaling pathway associated necroptosis in Neuro-2a cells

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In silico evaluation of pharmacokinetics and acute toxicity of withanolides in Ashawagandha

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Nutraceuticals for Cognitive Dysfunction

Gupta, R. C., Doss, R. B., Srivastava, A., Lall, R., & Sinha, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_26 · Cited by 6

Implications of phytochemicals as disease-modifying agents against Huntington's disease (HD): Bioactivity, animal models and transgenics, synergism and structure–activity studies

Dey, A., Nanda, B., Nandy, S., Mukherjee, A., & Pandey, D. K. (2020) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819483-6.00002-3 · Cited by 6

Exploring the potential of traditional herbal medicine in the management of central nervous system disorders

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Phytoconstituents and their Possible Mechanistic Profile for Alzheimer’s Disease – A Literature Review

Basavan, D., Chalichem, N. S. S., & Mohankumar, S. K. (2018) · Current Drug Targets · doi:10.2174/1389450119666180813095637 · Cited by 5

Neuroactive herbal agents for cognitive dysfunction

Awathale, S. N., Dhoble, L. R., Itankar, P. R., Raut, N. A., & Kokare, D. M. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819489-8.00002-8 · Cited by 5

A Comprehensive Review on Medicinal Herb Withania somnifera (L.) Dunal in Women’s Health: a Rejuvenator From Siddha Medicine

Sulekha, S. M. P. (2022) · Current Pharmacology Reports · doi:10.1007/s40495-021-00274-5 · Cited by 5

Implications of Herbal Components in the Treatment of Neurological Disorders

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Bioactivity Guided Fractionation and Purification of Anti-Depressant Molecule from Ashwagandha (Withania somnifera)

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Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy

Malik, J., & Choudhary, S. (2021) · Springer eBooks · doi:10.1007/978-981-15-8127-4_50 · Cited by 5

Therapeutic Effects of Ashwagandha in Brain Aging and Clock Dysfunction

Jagota, A., & Kukkemane, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_21 · Cited by 5

Molecular and therapeutic insights into Withania somnifera (Ashwagandha) for cognition and neuroprotection

Shukla, S. D. (2025) · Academia Biology · doi:10.20935/acadbiol7925 · Cited by 4

Ashwagandha (Withania Somnifera): a comprehensive narrative review of its role in enhancing physical performance and health

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African Traditional Medicine and Potential Role for Mental Health

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Emerging nano-derived therapy for the treatment of dementia: a comprehensive review

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Assessing Digestive Transformations of Withania somnifera Extracts via LC–MS/MS Profiling with a Focus on Bioactive Compounds Withaferin A, Withanolide A, Withanoside IV, and Untargeted Metabolomics

Barr, S. A., Davis, L. J., Vidar, W. S., Williamson, R. T., & Strangman, W. K. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09897 · Cited by 4

Ashwagandha: botanic occurrence, conventional uses, and significance in heart, metabolic, renal and hepatic disorder

Jain, V., Chaturvedi, S., Jamil, S., Tyagi, R., Arya, S., & Madan, S. (2024) · Nutrition & Food Science · doi:10.1108/nfs-01-2024-0030 · Cited by 5

A feasible procedure to detect widespread wrong labeling of Ashwagandha root extracts in dietary supplements

Thalhamer, B., Himmelsbach, M., Schatzmann, B., Klampfl, C. W., & Buchberger, W. W. (2024) · Exploration of Foods and Foodomics · doi:10.37349/eff.2024.00046 · Cited by 4

Combinatory Approaches Targeting Cognitive Impairments and Memory Enhancement: A Review

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Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

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Withania somnifera L. Dunal A potential herb for the treatment of rheumatoid arthritis

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Phytochemical and Therapeutic Potential of Herbal Cognitive Enhancer

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Gulf war toxicant-induced effects on the hippocampal dendritic arbor are reversed by treatment with a Withania somnifera extract

Shaikh, A. L., Murray, K. E., Ravindranath, V., & Citron, B. A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1368667 · Cited by 3

Clinical applications of Ashwagandha plant in depression and anxiety

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Exploring Withanolides from Withania somnifera: A Promising Avenue for Alzheimer’s Disease Treatment

Pullaiah, C. P., Preethi Priyadharshini, S. P., Phareedha, S. K., Yamini, N., Birudala, G., Lahari, S., Vippamakula, S., Shakila, R., Ganjayi, M. S., & Raghavendra, M. (2025) · Current Pharmacology Reports · doi:10.1007/s40495-025-00394-2 · Cited by 4

Neuroprotective Potential of Withania Somnifera in Cerebral Ischemia

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Experimental evidence to the untapped potential of Ayurvedic herb, Ashwagandha: Bench-to-Bedside

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Potential Therapeutic Use of Withania somnifera for Treatment of Amyotrophic Lateral Sclerosis

Dutta, K., Swarup, V., & Julien, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_19 · Cited by 3

Apoptosis Induction, Disruption of Cytoskeleton Remodeling and EMT Inhibition as Major Mechanism(s) Underlying the Pleiotropic Action of Withania somnifera in Breast Cancer

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Insights into the neuroprotective strategies to alleviate neurodegenerative conditions: Role of Ayurvedic herbs and their bioactives

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Ashwagandha for Brain Health: Experimental Evidence for Its Neuroregenerative Activities

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Withania somnifera (Ashwagandha) a plant of many possibilities

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Terpenoids (Isoprenoids)

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Antioxidants in Alzheimer’s Therapy

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Phytochemicals in Alzheimer’s Disease Prevention and Management: Molecular Mechanisms, Therapeutic Potential, Translational Challenges, and Emerging Research Directions

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The Potential Utility of Ashwagandha for Improving Cognitive Dysfunction in Persons with Bipolar or Other Neurocognitive Disorders

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Neuromodulatory Role of Withania somnifera

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The Glial Perspective of Energy Homeostasis, Neuroinflammation, and Neuro-nutraceuticals

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Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease

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Studies of Natural Product Synthesis of Withania somnifera and Their Conservation Strategy Through In Vitro Method

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Using Human Neural Stem Cells as a Model to Understand the “Science of Ashwagandha”

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Cellular and Molecular Targets Underpinning Memory Enhancement by Ashwagandha

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Neuropharmacology of Withania somnifera Dunal.

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Development of New Therapies for Neurodegenerative Diseases via Axonal Growth

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Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?

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How to use the monographs

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NEUROPROTECTIVE ACTIVITY OF SOME MEDICINAL PLANTS

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African Traditional Medicine and Potential Role for Mental Health

Lobine, D., & Mahomoodally, M. F. (2021) · Springer eBooks · doi:10.1007/978-3-030-57296-9_124

Phytochemical Profiles and Biological Studies of Selected Botanical Dietary Supplements Used in the United States

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Ashwagandha

Javed, S., Nazir, A., Zahoor, A. F., & AL‐Huqail, A. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-35403-8_6

Herbal Medicines for Management of Alzheimer’s Disease

Malik, J., Mandal, S. C., Choudhary, S., Parihar, S., & Rahamathulla, M. (2023) · Springer eBooks · doi:10.1007/978-981-99-7703-1_12

A Study On Potential Drug Target For SARS-CoV-2-And Combinatorial Therapeutic Approach To Combat COVID-19

Datta, D., & Ghosh, S. (2024) · Journal Of Advanced Zoology · doi:10.53555/jaz.v45i1.4567

Mannich base derivatives in neurological disorders: A comprehensive review with SAR approach

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The Role of Phytochemicals as Nutraceuticals in the Therapy of Cognitive Impairment: A Comprehensive Review

Raghuvanshi, S., Mazumder, A., & Das, S. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/48646

Mouse neuronal dendritic complexity and resilience to stress-induced depression in Drosophila melanogaster are enhanced by Withania somnifera alkaloids

Dutta, R., Holvoet, H., Marney, L. C., Cabey, K., Neff, C. J., Brandes, M. S., Zweig, J. A., Martinez, J., Choi, J., McClure, C., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120905

Indian ginseng (N.Hexane and Chloroform extracts) offers ameliorating effects on muscle functions restoration in a mouse model of peripheral nerve injury

Faiqa Sajid, H. A. (2021) · International Journal of Biosciences (IJB) · doi:10.12692/ijb/18.5.231-240 · Cited by 1

Phytomedicinal Approaches to Mitigating Neurological Disorder

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Rhodiola rosea, Ginkgo biloba, and Ashwagandha as novel antidepressant supplements: converging monoaminergic, neurotrophic, anti-inflammatory, and brain health pathways in depressive disorders

Li, X., Li, X., Li, Y., Liu, Z., Cai, Y., Yao, Q., Zhao, S., & Yu, Q. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1762061 · Cited by 5

Natural anti-AChE compounds for Alzheimer's disease therapy

Kim, C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45844-6.00013-5

Withanolides Are Detected in Human Urine Following Oral Administration of a Withania somnifera Product

Speers, A. B., Limoico, E. D., Lozano-Ortiz, A., Marney, L. C., Choi, J., Barr, S. A., Williamson, R. T., Strangman, W. K., Maier, C. S., & Soumyanath, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125289

PERAN PENGASUHAN ORANG TUA DALAM MEMBENTUK KEMAMPUAN INTERAKSI SOSIAL ANAK DI SLB D YPAC BANDUNG

Akin, K. A. Y. (2026) · Universitas Pasundan institutional repositories & scientific journals (Universitas Pasundan)

Steered molecular dynamics and free-energy analysis of withanolide unbinding from tau kinases TTBK1 and GSK-3β

Kavitha, J., S., S. K., George, M., Francis, D., & Abi, T. G. (2026) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2026.2736169

Overcoming Several Neurodegenerative Diseases by Traditional Medicines

Tohda, C. (2008) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.128.1159 · Cited by 18

Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET

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Multifunctional neuroprotective effect of Withanone, a compound from Withania somnifera roots in alleviating cognitive dysfunction

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β-Amyloid1-42, HIV-1Ba-L (Clade B) Infection and Drugs of Abuse Induced Degeneration in Human Neuronal Cells and Protective Effects of Ashwagandha (Withania somnifera) and Its Constituent Withanolide A

Kurapati, K. R. V., Samikkannu, T., Atluri, V. S. R., Kaftanovskaya, E. M., Yndart, A., & Nair, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112818 · Cited by 37

Effects of glycowithanolides from Withania somnifera on an animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats

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