Cited by 171Phytochemicals and Medicinal PlantsMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Withanoside IV and its active metabolite, sominone, attenuate Aβ(25–35)‐induced neurodegeneration

Kuboyama, Tomoharu, Tohda, Chihiro, Komatsu, Katsuko·2006·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2006.04664.x

Open this paper in CoChat — free account

Abstract

At the present, medication of dementia is limited to symptomatic treatments such as the use of cholinesterase inhibitors. To cure dementia completely, that is regaining neuronal function, reconstruction of neuronal networks is necessary. Therefore, we have been exploring antidementia drugs based on reconstructing neuronal networks in the damaged brain and found that withanoside IV (a constituent of Ashwagandha; the root of Withania somnifera) induced neurite outgrowth in cultured rat cortical neurons. Oral administration of withanoside IV (10 micromol/kg/day) significantly improved memory deficits in Abeta(25-35)-injected (25 nmol, i.c.v.) mice and prevented loss of axons, dendrites, and synapses. Sominone, an aglycone of withanoside IV, was identified as the main metabolite after oral administration of withanoside IV. Sominone (1 microM) induced axonal and dendritic regeneration and synaptic reconstruction significantly in cultured rat cortical neurons damaged by 10 microM Abeta(25-35). These data suggest that orally administrated withanoside IV may ameliorate neuronal dysfunction in Alzheimer's disease and that the active principle after metabolism is sominone.

Integrity signals

Registry

Crossref · 10.1111/j.1460-9568.2006.04664.x

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975
Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity
Pike, C. J., Walencewicz‐Wasserman, A. J., Kosmoski, J., Cribbs, D. H., Glabe, C. G., & Cotman, C. W. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64010253.x · Cited by 699
Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction
Maurice, T., Lockhart, B. P., & Privat, A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01032-7 · Cited by 530
Reversible memory loss in a mouse transgenic model of Alzheimer’s disease
Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., Younkin, S., & Ashe, K. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06331.2002 · Cited by 420
Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.
Simmons, L. K., May, P. C., Tomaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Lieberburg, I. M., Becker, G. W., & Brems, D. N. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10007-2 · Cited by 371

Show all 34 references

Research works printed but not linked: 3

10.1016/S0024-3205(02)01949-5 · DOI
10.3987/COM-91-5791 · DOI
Tohda C., 2005, Scientific basis for anti‐dementia drugs of constituents from Ashwagandha (Withania somnifera), J. Trad. Med., 22, 176

Sorted by citations

An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda
Singh, N., Bhalla, M., De Jager, P., & Gilca, M. (2011) · African Journal of Traditional, Complementary and Alternative Medicines · doi:10.4314/ajtcam.v8i5s.9 · Cited by 544
Withania somnifera: an Indian ginseng
Kulkarni, S. K., & Dhir, A. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.011 · Cited by 416
Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
Sehgal, N., Gupta, A., Valli, R. K., Joshi, S. D., Mills, J. T., Hamel, E., Khanna, P., Jain, S. C., Thakur, S. S., & Ravindranath, V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112209109 · Cited by 390
Pharmacologic overview of Withania somnifera, the Indian Ginseng
Dar, N. J., Hamid, A., & Ahmad, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2012-1 · Cited by 391
Review on Alzheimer’s Disease: Inhibition of Amyloid Beta and Tau Tangle Formation
Ashrafian, H., Zadeh, E. H., & Khan, R. H. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.11.192 · Cited by 368
Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041057 · Cited by 387
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306
Neuroprotective effect of natural products against Alzheimer’s disease
Essa, M. M., Vijayan, R. K., Castellano-Gonzalez, G., Memon, M. A., Braidy, N., & Guillemin, G. J. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0799-9 · Cited by 278
Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
Sairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 260
Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia
Speers, A. B., Cabey, K., Soumyanath, A., & Wright, K. M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210712151556 · Cited by 255
The Role of Phytochemicals in the Treatment and Prevention of Dementia
Howes, M. R., & Perry, E. K. (2011) · Drugs & Aging · doi:10.2165/11591310-000000000-00000 · Cited by 187
Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics
Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160
Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects
Mandlik, D. S., & Namdeo, A. G. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1741484 · Cited by 149
Natural Withanolides in the Treatment of Chronic Diseases
White, P. T., Subramanian, C., Motiwala, H. F., & Cohen, M. S. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_14 · Cited by 139
Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor
Tripathi, M. K., Singh, P., Sharma, S., Singh, T. P., Ethayathulla, A. S., & Kaur, P. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1790425 · Cited by 132
Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases
Kuboyama, T., Tohda, C., & Komatsu, K. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00022 · Cited by 127
Self-citation
Neurodegenerative diseases and Withania somnifera (L.): An update
Dar, N. J., & Ahmad, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112769 · Cited by 123
Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus
Tohda, C., Tamura, T., Matsuyama, S., & Komatsu, K. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706865 · Cited by 116
Self-citation
Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A
Grover, A., Shandilya, A., Punetha, A., Bisaria, V. S., & Sundar, D. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-s4-s25 · Cited by 113
Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology
Uddin, M. S., Mamun, A. A., Kabir, M. T., Jakaria, M., Mathew, B., Barreto, G. E., & Ashraf, G. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1420-2 · Cited by 110
Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: Combinational approach for enhanced differentiation
Shah, N., Kataria, H., Kaul, S. C., Ishii, T., Kaur, G., & Wadhwa, R. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01236.x · Cited by 109
Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108
“Sominone (1 microM) a metabolite of Withanoside IV, induced axonal and dendritic regeneration and synaptic reconstruction in cultures of rat cortical neurons damaged by the amyloid peptide, Aβ(25–35) [44].”
Background
Antiamnesic and Neuroprotective Effects of the Aminotetrahydrofuran Derivative ANAVEX1-41 Against Amyloid β25–35-Induced Toxicity in Mice
Villard, V., Espallergues, J., Keller, E., Alkam, T., Nitta, A., Yamada, K., Nabeshima, T., Vamvakides, A., & Maurice, T. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.212 · Cited by 107
A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway Engineering
Dhar, N., Razdan, S., Rana, S., Bhat, W. W., Vishwakarma, R. A., & Lattoo, S. K. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.01031 · Cited by 105
Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β‐induced neurite atrophy
Urano, T., & Tohda, C. (2010) · Phytotherapy Research · doi:10.1002/ptr.3183 · Cited by 103
Self-citation
Withanolides and Related Steroids
Misico, R. I., Nicotra, V. E., Oberti, J. C., Barboza, G. E., Gil, R. R., & Burton, G. (2011) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-7091-0748-5_3 · Cited by 99
Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs
Thakral, S., Yadav, A., Singh, V., Kumar, M., Kumar, P., Narang, R., Sudhakar, K., Verma, A., Khalilullah, H., Jaremko, M., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101960 · Cited by 103
Selective killing of cancer cells by leaf extract of Ashwagandha: Components, activity and pathway analyses
Widodo, N., Takagi, Y., Shrestha, B. G., Ishii, T., Kaul, S. C., & Wadhwa, R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2007.11.037 · Cited by 96
Ashwagandha (Withania somnifera): Role in Safeguarding Health, Immunomodulatory Effects, Combating Infections and Therapeutic Applications: A Review
Tiwari, R., Chakrabort, S., Saminathan, M., Dhama, K., & Singh, S. V. (2014) · Journal of Biological Sciences · doi:10.3923/jbs.2014.77.94 · Cited by 93
Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A
Grover, A., Shandilya, A., Agrawal, V., Pratik, P., Bhasme, D., Bisaria, V. S., & Sundar, D. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-s1-s30 · Cited by 85
In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β‐amyloid(1–42)‐induced cytotoxicity in differentiated PC12 cells
Kumar, S., Seal, C. J., Howes, M. R., Kite, G. C., & Okello, E. J. (2010) · Phytotherapy Research · doi:10.1002/ptr.3261 · Cited by 84
Desert Plants
Ramawat, K. G. (2009) · Springer eBooks · doi:10.1007/978-3-642-02550-1 · Cited by 122
Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors
Candelario, M., Cuellar, E., Reyes‐Ruiz, J. M., Darabedian, N., Zhou, F., Miledi, R., Russo‐Neustadt, A. A., & Limón, A. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.05.058 · Cited by 82
A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction
Ng, Q. X., Loke, W., Foo, N. X., Tan, W. J., Chan, H. W., Lim, D. Y., & Yeo, W. S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6552 · Cited by 77
Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET
Tohda, C., & Joyashiki, E. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00313.x · Cited by 62
Self-citation
An Aqueous Extract of Withania somnifera Root Inhibits Amyloid β Fibril Formation In Vitro
Kumar, S., Harris, R. J., Seal, C. J., & Okello, E. J. (2012) · Phytotherapy Research · doi:10.1002/ptr.3512 · Cited by 62
Characterization of Anti-neurodegenerative Effects of Polygala tenuifolia in A.BETA.(25-35)-Treated Cortical Neurons
Naito, R., & Tohda, C. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1892 · Cited by 61
Self-citation
Biology‐Oriented Synthesis of a Withanolide‐Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling
Švenda, J., Sheremet, M., Kremer, L., Maier, L., Bauer, J. O., Carsten Strohmann, B., Ziegler, S., Kumar, K., & Waldmann, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500112 · Cited by 62
Traditional Herbal Medicines Against CNS Disorders from Bangladesh
Uddin, M. J., & Zidorn, C. (2020) · Natural Products and Bioprospecting · doi:10.1007/s13659-020-00269-7 · Cited by 66
Bioactive Compound Collections: From Design to Target Identification
Laraia, L., Robke, L., & Waldmann, H. (2018) · Chem · doi:10.1016/j.chempr.2018.01.012 · Cited by 61
A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte‐secreted vimentin
Teshigawara, K., Kuboyama, T., Shigyo, M., Nagata, A., Sugimoto, K., Matsuya, Y., & Tohda, C. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02211.x · Cited by 59
Self-citation
Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25–35)-induced neuritic atrophy in cultured rat cortical neurons
Bai, Y., Tohda, C., Zhu, S., Hattori, M., & Komatsu, K. (2011) · Journal of Natural Medicines · doi:10.1007/s11418-011-0509-y · Cited by 58
Self-citation
Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review
Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024) · Plants · doi:10.3390/plants13060771 · Cited by 66
Ashwagandha
Bharti, V. K., Malik, J. K., & Gupta, R. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00052-8 · Cited by 53
Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation
Gupta, M., & Kaur, G. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2635-0 · Cited by 49
Inhibitory Effects of Eleutherococcus senticosus Extracts on Amyloid β(25-35)–Induced Neuritic Atrophy and Synaptic Loss
Tohda, C., Ichimura, M., Bai, Y., Tanaka, K., Zhu, S., & Komatsu, K. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08046fp · Cited by 48
Self-citation
Withania somnifera Prevents Morphine Withdrawal-Induced Decrease in Spine Density in Nucleus Accumbens Shell of Rats: A Confocal Laser Scanning Microscopy Study
Kasture, S. B., Vinci, S., Ibba, F., Puddu, A., Marongiu, M., Balasubramanian, M., Pisanu, A., Lecca, D., Zernig, G., & Acquas, E. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9069-2 · Cited by 44
Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts
Wadhwa, R., Konar, A., & Kaul, S. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.001 · Cited by 43
Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia
Alzobaidi, N., Quasimi, H., Emad, N. A., Alhalmi, A., & Naqvi, M. (2021) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s299589 · Cited by 48
Efficacy of Natural Compounds in Neurodegenerative Disorders
Srivastava, P., & Yadav, R. S. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_7 · Cited by 43
Curcumin Derivatives Inhibit or Modulate Beta-Amyloid Precursor Protein Metabolism
Narlawar, R., Baumann, K., Schubenel, R., & Schmidt, B. (2007) · Neurodegenerative Diseases · doi:10.1159/000101832 · Cited by 39
Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy
Singh, M., Jayant, K., Singh, D., Bhutani, S., Poddar, N. K., Chaudhary, A. A., Khan, S.-U.-D., Adnan, M., Siddiqui, A. J., Hassan, M. I., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.933824 · Cited by 41
Synthesis of Sominone and Its Derivatives Based on an RCM Strategy: Discovery of A Novel Anti-Alzheimer’s Disease Medicine Candidate “Denosomin”
Matsuya, Y., Yamakawa, Y.-I., Tohda, C., Teshigawara, K., Yamada, M., & Nemoto, H. (2009) · Organic Letters · doi:10.1021/ol901553w · Cited by 38
Self-citation
Aqueous Leaf Extract of Withania somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: a Mechanistic Study
Manchanda, S., Mishra, R., Singh, R., Kaur, T., & Kaur, G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9883-5 · Cited by 38
In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera
Singh, M., & Ramassamy, C. (2017) · Journal of Nutritional Science · doi:10.1017/jns.2017.48 · Cited by 37
Sominone Improves Memory Impairments and Increases Axonal Density in Alzheimer's Disease Model Mice, 5XFAD
Joyashiki, E., Matsuya, Y., & Tohda, C. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2010.541571 · Cited by 39
Self-citation
Role of nutraceuticals in cognition during aging and related disorders
Singh, P., Sivanandam, T. M., Konar, A., & Thakur, M. K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104928 · Cited by 37
Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer’s disease agent
Sugimoto, K., Tamura, K., Ohta, N., Tohda, C., Toyooka, N., Nemoto, H., & Matsuya, Y. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.10.127 · Cited by 35
Self-citation
Withanolide A: synthesis and structural requirements for neurite outgrowth
Liffert, R., Hoecker, J., Jana, C. K., Woods, T. M., Burch, P., Jessen, H. J., Neuburger, M. A., & Gademann, K. (2013) · Chemical Science · doi:10.1039/c3sc50653c · Cited by 34
Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ 25–35 -Induced Axonal Atrophy
Yang, Z., Kuboyama, T., Kazuma, K., Konno, K., & Tohda, C. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00290 · Cited by 33
Self-citation
Ameliorative Effects of Nutraceuticals in Neurological Disorders
Chauhan, N. B., & Mehla, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411462-3.00027-8 · Cited by 32
Withania somnifera prevents acquisition and expression of morphine-elicited conditioned place preference
Ruiu, S., Longoni, R., Spina, L., Orrù, A., Cottiglia, F., Collu, M., Kasture, S. B., & Acquas, E. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32835f3d15 · Cited by 31
Indian Herbs for the Treatment of Neurodegenerative Disease
Mannangatti, P., & Naidu, K. N. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_17 · Cited by 30
Identification of AChE targeted therapeutic compounds for Alzheimer’s disease: an in-silico study with DFT integration
Rawat, K., Tewari, D., Bisht, A., Chandra, S., Tiruneh, Y. K., Hassan, H. M., Al‐Emam, A., Sindi, E. R., & Al-Dies, A.-A. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-81285-2 · Cited by 35
Neuropharmacological Properties of Withania somnifera - Indian Ginseng: An Overview on Experimental Evidence with Emphasis on Clinical Trials and Patents
Yenisetti, S. C., Manjunath, M. J., & ., M. (2016) · Recent Patents on CNS Drug Discovery · doi:10.2174/1574889810666160615014106 · Cited by 29
Withania somnifera: a pre-clinical study on neuroregenerative therapy for stroke
Shah, Z., & Raghavan, A. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.152362 · Cited by 25
Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage
Kuboyama, T., Lee, Y., Nishiko, H., & Tohda, C. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.005 · Cited by 27
Self-citation
Biodiversity, Biology and Conservation of Medicinal Plants of the Thar Desert
Arora, J., Goyal, S., & Ramawat, K. G. (2009) · Springer eBooks · doi:10.1007/978-3-642-02550-1_1 · Cited by 25
Learning Deficits and Agenesis of Synapses and Myelinated Axons in Phosphoinositide-3 Kinase-Deficient Mice
Tohda, C., Nakanishi, R., & Kadowaki, M. (2006) · Neurosignals · doi:10.1159/000108936 · Cited by 24
Self-citation
Epimedium koreanumExtract and Its Constituent Icariin Improve Motor Dysfunction in Spinal Cord Injury
Tohda, C., & Nagata, A. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/731208 · Cited by 23
Self-citation
Withania somnifera
Ahmad, M., & Dar, N. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805413-0.00008-9 · Cited by 23
A blend of Withania somnifera (L.) Dunal root and Abelmoschus esculentus (L.) Moench fruit extracts relieves constipation and improves bowel function: A proof-of-concept clinical investigation
Punukollu, R. S., Chadalawada, A. K., Siddabattuni, K., & Gogineni, N. T. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116997 · Cited by 21
Traditional Medicine for Memory Enhancement
Howes, M. R., & Houghton, P. J. (2008) · Springer eBooks · doi:10.1007/978-3-540-79116-4_15 · Cited by 22
Withania somnifera Extract Protects Model Neurons from In Vitro Traumatic Injury
Saykally, J. N., Hatic, H., Keeley, K. L., Jain, S. C., Ravindranath, V., & Citron, B. A. (2017) · Cell Transplantation · doi:10.1177/0963689717714320 · Cited by 24
A comparative study of goji berry and ashwagandha extracts effects on promoting neural stem cell proliferation and reducing neuronal cell death
Zhang, Y.-M., & Wang, G. (2024) · Food & medicine homology. · doi:10.26599/fmh.2025.9420039 · Cited by 20
Literature-Related Discovery (LRD)
Kostoff, R. N., Block, J. A., Solka, J. L., Briggs, M. B., Rushenberg, R. L., Stump, J. A., Johnson, D., Lyons, T. J., & Wyatt, J. R. (2007) · Defense Technical Information Center (DTIC) · doi:10.21236/ada473438 · Cited by 19
Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study
Ijasul Haque, M., Mishra, A., Kalra, B. S., & Chawla, S. (2021) · Brain Sciences · doi:10.3390/brainsci11070919 · Cited by 20
Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease
Afewerky, H. K., Li, H., Zhang, T., Li, X., Mahaman, Y. A. R., Duan, L., Qin, P., Zheng, J., Pei, L., & Lu, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-05568-2 · Cited by 18
Plants, phytochemicals, and natural practices in complementary and alternative system of medicine for treatment of central nervous system disorders
Awuchi, C. G. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2205039 · Cited by 19
Ashwagandha: multiple health benefits
Bharti, V. K., Malik, J. K., & Gupta, R. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00050-1 · Cited by 20
Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides
Holvoet, H., Long, D. M., Law, A. D., McClure, C., Choi, J., Yang, L., Marney, L. C., Poeck, B., Strauß, R., Stevens, J. F., et al. (2022) · Nutrients · doi:10.3390/nu14193923 · Cited by 20
Overcoming Several Neurodegenerative Diseases by Traditional Medicines
Tohda, C. (2008) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.128.1159 · Cited by 18
Self-citation
A Novel Ashwagandha (Withania somnifera) Formulation Mitigates Sleep Deprivation-Induced Cognitive Impairment and Oxidative Stress in a Rat Model
Er, B., Ozmen, B., Şahin, E., Orhan, C., Şahin, N., Morde, A. A., Padigaru, M., & Şahin, K. (2025) · Biomolecules · doi:10.3390/biom15050710 · Cited by 18
Signalling Pathways Involved in Microglial Activation in Alzheimer’s Disease and Potential Neuroprotective Role of Phytoconstituents
Ali, M. U., Anwar, L., Ali, M. H., Iqubal, M. K., Iqubal, A., Baboota, S., & Ali, J. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666221223091529 · Cited by 17
Extracting β-amyloid from Alzheimer's disease
Dries, D. R., Yu, G., & Herz, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121560109 · Cited by 17
Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions
Sandhir, R., & Sood, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_18 · Cited by 18
Withania somnifera
Rathi, V. K., Dhingra, A. K., & Chopra, B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00034-7 · Cited by 17
Biology‐Oriented Synthesis of a Withanolide‐Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling
Švenda, J., Sheremet, M., Kremer, L., Maier, L., Bauer, J. O., Carsten Strohmann, B., Ziegler, S., Kumar, K., & Waldmann, H. (2015) · Angewandte Chemie · doi:10.1002/ange.201500112 · Cited by 16
New Age Therapy for Alzheimer’s Disease by Neuronal Network Reconstruction
Tohda, C. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00438 · Cited by 14
Self-citation
Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury
Nakayama, N., & Tohda, C. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.02.014 · Cited by 14
Self-citation
Effects of root extract of withania somnifera in 3- nitropropionic acid-induced cognitive dysfunction and oxidative damage in rats
Kumar, P., & Kumar, A. (2010) · International Journal of Health Research · doi:10.4314/ijhr.v1i3.55359 · Cited by 14
Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer’s Disease
Tancreda, G., Ravera, S., & Panfoli, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115403 · Cited by 13
Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models
Liu, Y., Lawless, M. S., Li, M., Fairman, K., Embry, M. R., & Mitchell, C. A. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4617 · Cited by 13
Phytotherapeutics against Alzheimer’s Disease: Mechanism, Molecular Targets and Challenges for Drug Development
S, G. S., Raghu, C. H., & Fayaz, S. M. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210920120612 · Cited by 13
Current Naturopathy to Combat Alzheimer’s Disease
Chakrovorty, A., Bhattacharjee, B., Saxena, A., Samadder, A., & Nandi, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220927121022 · Cited by 13
Plant Adaptogens: Natural Medicaments for 21 st Century?
Özdemir, Z., Bildziukevich, U., Wimmerová, M., Macůrková, A., Lovecká, P., & Wimmer, Z. (2018) · ChemistrySelect · doi:10.1002/slct.201702682 · Cited by 17
Integrated System Pharmacology and In Silico Analysis Elucidating Neuropharmacological Actions of Withania somnifera in the Treatment of Alzheimer’s Disease
Hannan, M. A., Dash, R., Haque, M. N., Choi, S. M., & Moon, I. S. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319999200730214807 · Cited by 12
Withania somnifera Dunal (Indian ginseng) impairs acquisition and expression of ethanol-elicited conditioned place preference and conditioned place aversion
Spina, L., Longoni, R., Rosas, M., Collu, M., Peana, A. T., Espa, E., Kasture, S. B., Cotti, E., & Acquas, E. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115600132 · Cited by 12
Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods
Speers, A. B., Lozano-Ortiz, A., & Soumyanath, A. (2024) · Nutrients · doi:10.3390/nu16223836 · Cited by 14
Anti-amnesic effects of withaferin A, a steroidal lactone isolated from Withania adpressa, on scopolamine-induced memory impairment in mice
Bakrim, W. B., Bouzidi, L. E., Manouze, H., Hafsa, J., Sobeh, M., Ba-M’hamed, S., Bekkouche, K., & Kouisni, L. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103529 · Cited by 12

Authors: Kuboyama, T., Tohda, C., & Komatsu, K.
Affiliations: University of Toyama (JP)
Corresponding author: Tohda, Chihiro
ORCID: Kuboyama, Tomoharu
Tohda, Chihiro
Komatsu, Katsuko
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2006-03
Volume: 23
Issue: 6
Pages: 1417-1426
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2006.04664.x
OpenAlex: W1841364166
Cited by: 171
References: 34
Citations by year: 2026: 9 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 12 · 2021: 13 · 2020: 15 · 2019: 6 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 5 · 2013: 3 · 2012: 5
FWCI: 15.77
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 15 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: withanoside IV, amyloid beta 25-35, Alzheimer's disease, neurodegeneration, anti-dementia drugs, neurite outgrowth, axon regeneration, memory impairment, Withania somnifera, oral administration, cortical neurons
MeSH terms: Animals, Cerebral Cortex, Chromatography, High Pressure Liquid, Ergosterol, Immunohistochemistry, Male, Memory, Nerve Degeneration, Nerve Regeneration, Neurons, Peptide Fragments, Plant Extracts, Mass Spectrometry, Synapses, Amyloid beta-Peptides, Neurites, Rats, Sprague-Dawley, Maze Learning, Withania, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Withanoside IV and its active metabolite, sominone, attenuate Aβ(25–35)‐induced neurodegeneration

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks