The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Brain‐derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
Open accessAbstract
Brain‐derived neurotrophic factor (BDNF) has been shown to mediate the effects of exercise on synaptic plasticity and cognitive function, in a process in which energy metabolism probably plays an important role. The purpose of the present study was to examine the influence of exercise on rat hippocampal expression of molecules involved in the regulation of energy management and cognitive function, and to determine the role of BDNF in these events. One week of voluntary exercise that enhanced learning and memory performance elevated the expression of molecular systems involved in the metabolism of energy [AMP‐activated protein kinase (AMPK), ubiquitous mitochondrial creatine kinase (uMtCK) and uncoupling protein 2] and molecules that work at the interface of energy and synaptic plasticity [BDNF, insulin‐like growth factor I (IGF‐I) and ghrelin]. The levels of BDNF mRNA were associated with the mRNA levels of AMPK, uMtCK, IGF‐I and ghrelin. Inhibiting the action of BDNF during exercise abolished an exercise‐mediated enhancement in spatial learning and increased the expression of all of the molecular systems studied. BDNF blocking also disrupted the association between learning speed and levels of AMPK, uMtCK, ghrelin and IGF‐I mRNAs. These findings suggest that the effects of exercise on synaptic plasticity and cognitive function involve elements of energy metabolism, and that BDNF seems to work at the interface between the two processes as a metabotrophin.
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Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030
Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885
Plasticity of brain networks in a randomized intervention trial of exercise training in older adults
Voss (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00032 · Cited by 841
Exercise, brain, and cognition across the life span.
Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T., & Kramer, A. F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00210.2011 · Cited by 601
Metadata
- Authors
- Gomez‐Pinilla, F., Vaynman, S., & Ying, Z.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-11-24
- Volume
- 28
- Issue
- 11
- Pages
- 2278-2287
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2163006694
- Cited by
- 378
- References
- 14
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- green
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