Cited by 601Physical Activity and HealthCardiovascular and exercise physiologyNeurogenesis and neuroplasticity mechanisms

Exercise, brain, and cognition across the life span.

Open access
Voss, Michelle W., Nagamatsu, Lindsay S., Liu-Ambrose, Teresa, Kramer, Arthur F.·2011·Journal of Applied Physiology

Abstract

This is a brief review of current evidence for the relationships between physical activity and exercise and the brain and cognition throughout the life span in non-pathological populations. We focus on the effects of both aerobic and resistance training and provide a brief overview of potential neurobiological mechanisms derived from non-human animal models. Whereas research has focused primarily on the benefits of aerobic exercise in youth and young adult populations, there is growing evidence that both aerobic and resistance training are important for maintaining cognitive and brain health in old age. Finally, in these contexts, we point out gaps in the literature and future directions that will help advance the field of exercise neuroscience, including more studies that explicitly examine the effect of exercise type and intensity on cognition, the brain, and clinically significant outcomes. There is also a need for human neuroimaging studies to adopt a more unified multi-modal framework and for greater interaction between human and animal models of exercise effects on brain and cognition across the life span.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.00210.2011

Cites

113 of 113 references verified0 citation errors · 0 not checkable

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  • Physical activity decreases the rate of cognitive decline in healthy people and in people with neurodegenerative disorders across the life span.

    “In general, it is found that physical activity decreases the rate of cognitive decline in healthy people and in people with neurodegenerative disorders across the life span (73).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [73]

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Authors
Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T., & Kramer, A. F.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • University of British Columbia (CA)
Corresponding author
Kramer, Arthur F.
Venue
Journal of Applied Physiology
Published
2011-11
Volume
111
Issue
5
Pages
1505-1513
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W2158250395
Cited by
601
References
113
Citations by year
2026: 57 · 2025: 42 · 2024: 45 · 2023: 35 · 2022: 41 · 2021: 31 · 2020: 43 · 2019: 51 · 2018: 35 · 2017: 30 · 2016: 32 · 2015: 56 · 2014: 34 · 2013: 36 · 2012: 25
FWCI
3.46
Type
journal article
Language
en
Open access
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research (99130)
  • National Institute on Aging (R01AG025032, 05-R370-AG025667)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
physical activity, brain health, cognitive function, aerobic exercise, resistance training, aging, neurobiological mechanisms, exercise intensity, multimodal neuroimaging, lifespan
MeSH terms
Animals, Brain, Cognition, Humans, Motor Activity, Exercise

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