Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging

Exercise training increases size of hippocampus and improves memory

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Physical Activity and Public Health in Older Adults

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Running enhances neurogenesis, learning, and long-term potentiation in mice

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Aerobic Exercise Training Increases Brain Volume in Aging Humans

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Exercise enhances learning and hippocampal neurogenesis in aged mice

van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works

Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review) [RETIRED]: Report of the Quality Standards Subcommittee of the American Academy of Neurology

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Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

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Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials

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Cardiovascular fitness, cortical plasticity, and aging

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Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease: A Randomized Trial

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Physical activity and risk of cognitive impairment and dementia in elderly persons

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Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

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Transport of brain-derived neurotrophic factor across the blood–brain barrier

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An <i>in vivo</i> correlate of exercise-induced neurogenesis in the adult dentate gyrus

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The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

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Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial

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Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus

Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017 · see citing works

Aerobic fitness reduces brain tissue loss in aging humans.

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Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

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Aerobic fitness is associated with hippocampal volume in elderly humans

Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007 · see citing works

Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence

Hamer, M., & Chida, Y. (2009) · Psychological Medicine · doi:10.1017/s0033291708003681 · Cited by 988 · see citing works

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works

VEGF is necessary for exercise‐induced adult hippocampal neurogenesis

Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., Kuo, C. J., & Palmer, T. D. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03041.x · Cited by 861 · see citing works

The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function.

FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849 · see citing works

Plasticity of brain networks in a randomized intervention trial of exercise training in older adults

Voss (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00032 · Cited by 841 · see citing works

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo

Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836 · see citing works

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 806 · see citing works

Resistance Training and Executive Functions: A 12-Month Randomized Controlled Trial

Liu-Ambrose, T. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.494 · Cited by 775 · see citing works

The Impact of Resistance Exercise on the Cognitive Function of the Elderly

CASSILHAS, R. C., VIANA, V. A. R., GRASSMANN, V., SANTOS, R. T., SANTOS, R. F., TUFIK, S., & MELLO, M. T. (2007) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/mss.0b013e318060111f · Cited by 770 · see citing works

Exercise Plus Behavioral Management in Patients With Alzheimer Disease

Teri, L. L., Gibbons, L. E., McCurry, S. M., Logsdon, R. G., Büchner, D. M., Barlow, W. E., Kukull, W. A., LaCroix, A. Z., McCormick, W. C., & Larson, E. B. (2003) · JAMA · doi:10.1001/jama.290.15.2015 · Cited by 765 · see citing works

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

Carro, E., Nuñez, A., Busiguina, S., & Torres-Aleman, I. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02926.2000 · Cited by 762 · see citing works

Prevalence of mild cognitive impairment is higher in men

Petersen, R. C., Roberts, R. O., Knopman, D. S., Geda, Y. E., Cha, R. H., Pankratz, V. S., Boeve, B. F., Tangalos, E. G., Ivnik, R. J., & Rocca, W. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f11d85 · Cited by 738 · see citing works

Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer’s disease

Peng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03135.x · Cited by 691 · see citing works

Systematic Review: Factors Associated With Risk for and Possible Prevention of Cognitive Decline in Later Life

Plassman, B. L., Williams, J. W., Burke, J. R., Holsinger, T., & Benjamin, S. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-3-201008030-00258 · Cited by 681 · see citing works

Review: Mortality trends in the general population: the importance of cardiorespiratory fitness

Lee, D.-C., Artero, E. G., Sui, X., & Blair, S. N. (2010) · Journal of Psychopharmacology · doi:10.1177/1359786810382057 · Cited by 628 · see citing works

Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF

Poduslo, J. F., & Curran, G. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00250-v · Cited by 614 · see citing works

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

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Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function

Ding, Q., Vaynman, S., Akhavan, M., Ying, Z., & Gomez-Pinilla, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.084 · Cited by 555 · see citing works

Incidence and Prediction of Falls in Dementia: A Prospective Study in Older People

Allan, L. M., Ballard, C. G., Rowan, E., & Kenny, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005521 · Cited by 532 · see citing works

Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study

Erickson, K. I., Raji, C. A., Lopez, O. L., Becker, J. T., Rosano, C., Newman, A. B., Gach, H. M., Thompson, P. M., Ho, A. J., & Kuller, L. H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f88359 · Cited by 508 · see citing works

Endurance training enhances BDNF release from the human brain

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Physical activity and memory functions: An interventional study

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Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

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Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density

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The aging brain: morphomolecular senescence of cortical circuits

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Brain‐derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition

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Exercise and time-dependent benefits to learning and memory

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Physical Exercise, Aging, and Mild Cognitive Impairment: A Population-Based Study

Geda, Y. E., Roberts, R. O., Knopman, D. S., Christianson, T. J. H., Pankratz, V. S., Ivnik, R. J., Boeve, B. F., Tangalos, E. G., Petersen, R. C., & Rocca, W. A. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.297 · Cited by 371 · see citing works

Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.

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Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans

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BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study

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Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults

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Physical Activity Over the Life Course and Its Association with Cognitive Performance and Impairment in Old Age

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Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease

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Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men.

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Exercise exerts neuroprotective effects on Parkinson's disease model of rats

Tajiri, N., Yasuhara, T., Shingo, T., Kondo, A., Yuan, W., Kadota, T., Wang, F., Baba, T., Tayra, J. T., Morimoto, T., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2009.10.075 · Cited by 308 · see citing works

Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls

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Depressive Symptom Outcomes of Physical Activity Interventions: Meta-analysis Findings

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Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

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Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men

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Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging

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Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial

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BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls

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The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning

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Functional connectivity: A source of variance in the association between cardiorespiratory fitness and cognition?

Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Malkowski, E., Alves, H., Kim, J., Morris, K. S., White, S. M., Wójcicki, T. R., et al. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.01.005 · Cited by 261 · see citing works

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

Yuede, C. M., Zimmerman, S., Dong, H., Kling, M. J., Bero, A. W., Holtzman, D. M., Timson, B. F., & Csernansky, J. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.002 · Cited by 250 · see citing works

Exercise differentially regulates synaptic proteins associated to the function of BDNF

Vaynman, S. S., Ying, Z., Yin, D., & Gomez-Pinilla, F. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.062 · Cited by 248 · see citing works

Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects

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Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education

Gordon, B. A., Rykhlevskaia, E. I., Brumback, C. R., Lee, Y., Elavsky, S., Konopack, J. F., McAuley, E., Kramer, A. F., Colcombe, S. J., Gratton, G., et al. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00676.x · Cited by 245 · see citing works

Essentials of the Proper Diagnoses of Mild Cognitive Impairment, Dementia, and Major Subtypes of Dementia

Knopman, D. S., Boeve, B. F., & Petersen, R. C. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.10.1290 · Cited by 245 · see citing works

Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF

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Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

Morra, J. H., Tu, Z., Apostolova, L. G., Green, A. E., Avedissian, C., Madsen, S. K., Parikshak, N., Toga, A. W., Jack, C. R., Schuff, N. W., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.043 · Cited by 241 · see citing works

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

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Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus

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Effects of resistance training on insulin-like growth factor-I and IGF binding proteins

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Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF)

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Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease

Honea, R. A., Thomas, G., Harsha, A., Anderson, H. S., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819cb8a2 · Cited by 214 · see citing works

Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease

Um, H.-S., Kang, E., Koo, J., Kim, H.-T., Jin-Lee, Kim, E.-J., Yang, C., An, G.-Y., Cho, I., & Cho, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.10.004 · Cited by 212 · see citing works

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

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Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway

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Untitled work

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Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus

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Vascular Risk Factors: Imaging and Neuropathologic Correlates

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Sarcopenia

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Management of osteoporosis in the elderly

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