Dictyostelium as host model for pathogenesis

A kingdom-level phylogeny of eukaryotes based on combined protein data.

Baldauf, S., Roger, A., Wenk-Siefert, I., & Doolittle, W. (2000) · Science · doi:10.1126/science.290.5493.972 · Cited by 1,243

Microorganisms Resistant to Free-Living Amoebae

Greub, G., & Raoult, D. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.413-433.2004 · Cited by 1,066

Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis

Tan, M., Mahajan‐Miklos, S., & Ausubel, F. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.715 · Cited by 1,008

Macromolecular Architecture in Eukaryotic Cells Visualized by Cryoelectron Tomography

Medalia, O., Weber, I. T., Frangakis, A. S., Nicastro, D., Gerisch, G., & Baumeister, W. P. (2002) · Science · doi:10.1126/science.1076184 · Cited by 841

Legionella PneumophilaPathogenesis: A Fateful Journey from Amoebae to Macrophages

Swanson, M. S., & Hammer, B. K. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.567 · Cited by 402

How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions.

Tzou, P., Gregorio, E. D., & Lemaître, B. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00294-1 · Cited by 399

Differentiate to thrive: lessons from the Legionella pneumophila life cycle

Molofsky, A. B., & Swanson, M. S. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04129.x · Cited by 338

Legionella Effectors That Promote Nonlytic Release from Protozoa

Chen, J. Y.-S., de Felipe, K. S., Clarke, M., Lu, H. X., Anderson, O. R., Segal, G., & Shuman, H. A. (2004) · Science · doi:10.1126/science.1094226 · Cited by 294

Legionella pneumophila: an aquatic microbe goes astray

Steinert, M., Hentschel, U., & Hacker, J. H. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00607.x · Cited by 292

The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum

Pukatzki, S., Kessin, R. H., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052704399 · Cited by 289

Microbial Interactions — Underexplored Links Between Public Health Relevant Bacteria and Protozoa in Coastal Environments

Eriksson, K. I. A., Thelaus, J., Andersson, A., & Ahlinder, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.877483 · Cited by 8

Small molecule communication of Legionella : the ins and outs of autoinducer and nitric oxide signaling

Michaelis, S., Gómez-Valero, L., Chen, T., Schmid, C., Buchrieser, C., & Hilbi, H. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00097-23 · Cited by 7

Animal Models to Understand Host–Pathogen Interactions

Anju, V. T., Busi, S., & Dyavaiah, M. (2020) · Springer eBooks · doi:10.1007/978-981-15-1695-5_20 · Cited by 7

Two potential evolutionary origins of the fruiting bodies of the dictyostelid slime moulds

Hehmeyer, J. (2019) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12516 · Cited by 7

Discovery of anti-infective compounds against Mycobacterium marinum after biotransformation of simple natural stilbenes by a fungal secretome

Nitschke, J., Huber, R., Vossio, S., Moreau, D., Marcourt, L., Gindro, K., Queiroz, E. F., Soldati, T., & Hanna, N. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1439814 · Cited by 6

Symbiotic bacteria, immune-like sentinel cells, and the response to pathogens in a social amoeba

Scott, T. J., Larsen, T. J., Brock, D. A., Uhm, S. Y. S., Queller, D. C., & Strassmann, J. E. (2023) · Royal Society Open Science · doi:10.1098/rsos.230727 · Cited by 5

A Rapid Image-based Bacterial Virulence Assay Using Amoeba

Perinbam, K., & Siryaporn, A. (2018) · Journal of Visualized Experiments · doi:10.3791/57844 · Cited by 4

Surfing Through a Sea of Sharks: Report on the British Society for Cell Biology Meeting on ‘Signaling and Cytoskeletal Dynamics During Infection’, October 2–5, 2005, Edinburgh, Scotland

Lehmann, M. J., & Frischknecht, F. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00402.x · Cited by 4

Symbiotic T6SS affects horizontal transmission of Paraburkholderia bonniea among Dictyostelium discoideum amoeba hosts

Chen, A., Covitz, R., Folsom, A. A., Mu, X., Peck, R. F., & Noh, S. (2025) · ISME Communications · doi:10.1093/ismeco/ycaf005 · Cited by 3

Rapid Icm/Dot T4SS Inactivation Prevents Resuscitation of Heat‐Induced VBNC Legionella pneumophila by Amoebae

Schmid, C., & Hilbi, H. (2025) · Environmental Microbiology · doi:10.1111/1462-2920.70035 · Cited by 3

Caenorhabditis elegans : modèle d'étude in vivo de la virulence bactérienne

Lavigne, J., Blanc‐Potard, A., Bourg, G., O’Callaghan, D., & Sotto, A. (2006) · Pathologie Biologie · doi:10.1016/j.patbio.2006.07.011 · Cited by 3

Interactions of Pseudomonads with Mushrooms and Other Eukaryotic Hosts

Burlinson, P., Knaggs, J., Hodgkin, J., Pears, C. J., & Preston, G. M. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6901-7_31 · Cited by 3

Mycobacteria as evolutionary drivers of host innate immunity: insights from comparing experimental host models

Cortacans, M., & Cardona, P.-J. (2025) · Frontiers in Tuberculosis · doi:10.3389/ftubr.2025.1735950 · Cited by 2

Heavy Metals and Bacteria; Example of P. aeruginosa

Kahraman, H. (2020) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2020.29.004801 · Cited by 2

Assaying Rho GTPase-Dependent Processes in Dictyostelium discoideum

Xiong, H., & Rivero, F. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-442-1_25 · Cited by 2

Abnormalities of Endocytosis, Phagocytosis, and Development Process in Dictyostelium Cells That Over-Express Acanthamoeba castellanii Metacaspase Protein.

Saheb, E. J., Trzyna, W., Maringer, K. V., & Bush, J. (2015) · PubMed Central · Cited by 2

Pathogenicity ofCryptococcus neoformans: an Evolutionary Perspective

Zaragoza, Ó., Frasés, S., & Casadevall, A. (2014) · ASM Press eBooks · doi:10.1128/9781555815639.ch48 · Cited by 2

Pseudomonas aeruginosa in Tasmania

Bradbury, R. S. (2009) · UTAS Research Repository · doi:10.25959/23210834 · Cited by 2

Effects of Vibrio cholerae protease and pigment production on environmental survival and host interaction

Vaitkevicius, K. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 2

Unlocking CRISPR-Cas9 editing for widely diverse Dictyostelid species

Garriga-Canut, M., Cannon, N., Benton, M. A., Zanon, A., Horsfield, S., Scheurich, J., Remans, K., Lees, J. A., Paix, A., & van Gestel, J. (2026) · Molecular Systems Biology · doi:10.1038/s44320-025-00180-8 · Cited by 1

Tracking tripartite interaction dynamics: isolation, integration, and influence of bacteriophages in the Paraburkholderia-Dictyostelium discoideum symbiosis system

DiSalvo, S., Maness, N., Braun, A., Tran, M., & Hofferkamp, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1537073 · Cited by 1

Chemical Ecology of Dictyostelium discoideum

Herbst, R., Günther, M., & Stallforth, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14719-5 · Cited by 1

Ancient roles of non-coding RNAs in eukaryotic evolution

Avesson, L. (2011) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 1

Análise de interações da subunidade catalítica da fosfatase do tipo 1 (PP1c) de Dictyostelium discoideum identificadas através do sistema de duplo-híbrido em leveduras

Raposo, R. A. (2010) · doi:10.11606/d.46.2010.tde-14052013-102905 · Cited by 1

The Amoeba Dictyostelium discoideum Contributes to Legionella Infection

Steinert, M., Wagner, C., Fajardo, M., Shevchuk, O., Ünal, C., Galka, F., Heuner, K., Eichinger, L., & Bozzaro, S. (2014) · ASM Press eBooks · doi:10.1128/9781555815660.ch91 · Cited by 1

Regulação da expressão da fímbria CupD por sistemas de dois componentes de Pseudomonas aeruginosa Pa14 e ensaios de virulência no hospedeiro-modelo Dictyostelium discoideum

Borges, A. L. B. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2008.tde-27112008-092658 · Cited by 1

4 Evolution of Signalling and Morphogenesis in the Dictyostelids

Schaap, P. (2011) · Springer eBooks · doi:10.1007/978-3-642-19974-5_4

Animal Models Commonly Used to Study Quorum-Sensing Inhibitors

Balaban, N., Givskov, M., Rasmussen, T. B., Giacometti, A., & Cirioni, O. (2007) · Springer series on biofilms · doi:10.1007/7142_2007_011

Dictyostelium discoideum, UNA AMEBA PECULIAR

Galardi‐Castilla, M., & Sastre, L. (2011) · RACO (Revistes Catalanes amb Accés Obert) (Consorci de Serveis Universitaris de Catalunya) · doi:10.2436/20.1501.02.104

Flagellin is critical for Legionella motility and macrophage recognition

Whitfield, N. N. (2009) · Deep Blue (University of Michigan)

Cellular Model Systems Used to Study Phagosome Biogenesis

Steinert, M. (2009) · Wiley eBooks · doi:10.1002/9783527629176.ch4

Etudes structure-fonction de lectines (DiscI et DiscII) de Dictyostelium discoideum

Aragão, K. S. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)

Characterization of CDK5RAP2 as a novel regulator in the Hippo signaling pathway

Sukumaran, S. K. (2014) · Kölner Universitäts PublikationsServer (Universität zu Köln)

Heterophilic Cell Adhesion Molecule TgrC1 and its Binding Partners during Dictyostelium discoideum Development

Chen, G. (2014) · TSpace (University of Toronto)

Infectivity of Novel Intracellular Bacteria for Eukaryotic Cells

Swehla, A. (2017)

Allorecognition and Innate Immunity in the Dictyostelid Social Amoebae

Kuspa, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-76768-0_2

Prokaryote-Eukaryote Symbiosis to Produce RNA-Based Therapeutics

Tahayori, B. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.583464

Dictyostelium Discoideum: Live Cell Imaging in Changing Perspective

(2020) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789811439315120010016

Free-living amoebae act as transient permissive hosts for Leptospira sppPreprint

Luga, A., Inizan, C., Meunier, E., Albon, A., Sarramégna, V., Picardeau, M., Goarant, C., & Thibeaux, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.16.712017

Analyse structurale et fonctionnelle des glycolipides pariétaux de Mycobacterium marinum : une mycobactérie modèle dans l’étude de la tuberculose

Rombouts, Y. (2010) · theses.fr (ABES) · doi:10.70675/94dc6fa4z13afz4a52za303z6fdce9cb1d36

A novel TaqMan probe-based qPCR method for rapid detection of the bacteria-associated amoeba Heterostelium pallidum

Sun, D., Ge, J., Jin, J., Xie, X., Long, Y., Li, Y., Li, Z., Stephenson, S. L., Li, Y., & Liu, P. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.01311-25

Exploring Foundations of Animal Host-microbe Interactions in a Freshwater Sponge

Pawley, J. S. (2026) · doi:10.56902/etdcrp.2026.183

Pathogen–host interactions in Dictyostelium, Legionella, Mycobacterium and other pathogens

Steinert, M. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.11.003 · Cited by 94

Screening of Virulence Traits in Legionella pneumophila and Analysis of the Host Susceptibility to Infection by Using the Dictyostelium Host Model System

Shevchuk, O., & Steinert, M. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-204-5_4 · Cited by 11

Dictyostelium discoideum as a Model to Study Host–Pathogen Interactions

Ünal, C., & Steinert, M. (2006) · Humana Press eBooks · doi:10.1385/1-59745-144-4:507 · Cited by 18

Dictyostelium Host Response to Legionella Infection: Strategies and Assays

Bozzaro, S., Peracino, B., & Eichinger, L. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-161-5_26 · Cited by 11

Legionella

Bozzaro, S., Peracino, B., & Eichinger, L. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-161-5 · Cited by 14