Candida albicans mannoprotein influences the biological function of dendritic cells
Open accessAbstract
Cell wall components of fungi involved in induction of host immune response are predominantly proteins and glycoproteins, the latter being mainly mannoproteins (MP). In this study we analyse the interaction of the MP from Candida albicans (MP65) with dendritic cells (DC) and demonstrate that MP65 stimulates DC and induces the release of TNF-alpha, IL-6 and the activation of IL-12 gene, with maximal value 6 h post treatment. MP65 induces DC maturation by increasing costimulatory molecules and decreasing CD14 and FcgammaR molecule expression. The latter effect is partly mediated by toll-like receptor 2 (TLR2) and TLR4, and the MyD88-dependent pathway is involved in the process. MP65 enables DC to activate T cell response, its protein core is essential for induction of T cell activation, while its glycosylated portion primarily promotes cytokine production. The mechanisms involved in induction of protective response against C. albicans could be mediated by the MP65 antigen, suggesting that MP65 may be a suitable candidate vaccine.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mannans from C. albicans cell wall induce dendritic cell maturation.
“Mannans from C. albicans cell wall have the ability to stimulate cytokine production126,127, and induce dendritic cell maturation128.”
From Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs (2012) · cites this paper as [128]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129 · see citing works
Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964 · see citing works
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
Kurt-Jones, E., Popova, L., Kwinn, L. A., Haynes, L., Jones, L. P., Tripp, R., Walsh, E., Freeman, M., Golenbock, D., Anderson, L., et al. (2000) · Nature Immunology · doi:10.1038/80833 · Cited by 1,842 · see citing works
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Rissoan, M., Soumelis, V., Kadowaki, N., Grouard, G., Brière, F., Malefyt, R. D. W., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.283.5405.1183 · Cited by 1,835 · see citing works
T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
Kaliński, P., Hilkens, C. M. U., Wierenga, E. A., & Kapsenberg, M. L. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01547-9 · Cited by 933 · see citing works
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells
Re, F., & Strominger, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105927200 · Cited by 691 · see citing works
East, L. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00319-7 · Cited by 623 · see citing works
A universal role for MyD88 in TLR/IL-1R-mediated signaling.
Janssens, S., & Beyaert, R. (2002) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/s0968-0004(02)02145-x · Cited by 419 · see citing works
Tan, M., Mommaas, A. M., Drijfhout, J. W., Jordens, R., Onderwater, J. J. M., Verwoerd, D., Mulder, A. A., van der Heiden, A. N., Scheidegger, D., Oomen, L. C. J. M., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270942 · Cited by 325 · see citing works
Biology of Toll receptors: lessons from insects and mammals
Imler, J., & Zheng, L.-B. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403160 · Cited by 179 · see citing works
Normal Host Defense during Systemic Candidiasis in Mannose Receptor-Deficient Mice
Lee, S. J., Zheng, N., Clavijo, M., & Nussenzweig, M. C. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.437-445.2003 · Cited by 178 · see citing works
Grossi, P., Farina, C., FIOCCHI, R., & Gasperina, D. D. (2000) · PubMed · Cited by 162 · see citing works
Toll-like receptors and innate antifungal responses
Roeder, A. (2003) · Trends in Microbiology · doi:10.1016/j.tim.2003.11.003 · Cited by 160 · see citing works
Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications
Rutella, S., & Lemoli, R. M. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.04.015 · Cited by 147 · see citing works
Newman, S. L., & Holly, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.11.6813-6822.2001 · Cited by 146 · see citing works
Kazemi, M. R., McDonald, C. M., Shigenaga, J. K., Grünfeld, C., & Feingold, K. R. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000159163.52632.1b · Cited by 145 · see citing works
Oral Candida in HIV Infection and AIDS: New Perspectives/New Approaches
Coleman, D. C., Bennett, D. E., Sullivan, D. J., et al. (1993) · Critical Reviews in Microbiology · doi:10.3109/10408419309113523 · Cited by 144 · see citing works
The role of cell-mediated immunity in candidiasis
Fidel, P. L., & Sobel, J. D. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90112-i · Cited by 99 · see citing works
Fausch, S. C., Fahey, L. M., Silva, D. M. D., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7172 · Cited by 83 · see citing works
Gomez, M. J., Torosantucci, A., Arancia, S., Maras, B., Parisi, L., & Cassone, A. (1996) · Infection and Immunity · doi:10.1128/iai.64.7.2577-2584.1996 · Cited by 78 · see citing works
Mencacci, A., Torosantucci, A., Spaccapelo, R., Romani, L. R., Bistoni, F., & Cassone, A. (1994) · Infection and Immunity · doi:10.1128/iai.62.12.5353-5360.1994 · Cited by 64 · see citing works
Torosantucci, A., Bromuro, C., Gomez, M. J., et al. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/168.2.427 · Cited by 63 · see citing works
Nisini, R., Romagnoli, G., Gomez, M. J., Valle, R. L., Torosantucci, A., Mariotti, S., Teloni, R., & Cassone, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.3728-3736.2001 · Cited by 49 · see citing works
Mannoprotein fromCryptococcus neoformansPromotes T-Helper Type 1 Anticandidal Responses in Mice
Pietrella, D., Mazzolla, R., Lupo, P., et al. (2002) · Infection and Immunity · doi:10.1128/iai.70.12.6621-6627.2002 · Cited by 36 · see citing works
Self-citationCandida albicans: pathogenesis, immunity and host defence
Ashman, R. B. (1998) · Research in Immunology · doi:10.1016/s0923-2494(98)80752-9 · Cited by 35 · see citing works
Gomez, M. J., Maras, B., Barca, A., Valle, R. L., Barra, D., & Cassone, A. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.694-701.2000 · Cited by 33 · see citing works
Surveillance and treatment of liver transplant recipients for candidiasis and aspergillosis
Viviani, M. A., Tortorano, A. M., Malaspina, C., et al. (1992) · European Journal of Epidemiology · doi:10.1007/bf00158579 · Cited by 27 · see citing works
Sala, A. L., Urbani, F., Torosantucci, A., et al. (1997) · PubMed · Cited by 20 · see citing works
Oral candidiasis in HIV-infected patients.
Dl, B., & Aj, H. (1995) · PubMed · Cited by 20 · see citing works
Hoppe, J. E., Klausner, M., Klingebiel, T., & NIETHAMMER, D. (1997) · Mycoses · doi:10.1111/j.1439-0507.1997.tb00170.x · Cited by 16 · see citing works
Cryptococcus neoformansandCandida albicansRegulate CD4 Expression on Human Monocytes
Pietrella, D., Monari, C., Retini, C., et al. (1998) · The Journal of Infectious Diseases · doi:10.1086/314458 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
An integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946 · see citing works
Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs
Leach, M. D., Klipp, E., Cowen, L. E., & Brown, A. J. P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2875 · Cited by 107 · see citing works
The role of the cell wall in fungal pathogenesis
Arana, D. M., Prieto, D., Román, E., Nombela, C., Alonso‐Monge, R., & Pla, J. (2009) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00070.x · Cited by 92 · see citing works
- Authors
- Pietrella, D., Bistoni, G., Corbucci, C., Perito, S., & Vecchiarelli, A.
- Affiliations
- University of Perugia (IT)
- Imperial College London (GB)
- Corresponding author
- Vecchiarelli, Anna
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2006-04
- Volume
- 8
- Issue
- 4
- Pages
- 602-612
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2153496184
- Cited by
- 75
- References
- 31
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida albicans, mannoproteins, dendritic cells, dendritic cell maturation, TLR2, TLR4, MyD88 signaling, cytokine production, IL-12, CD14, Fc gamma receptor, T cell activation, vaccine candidate, host immune response
- MeSH terms
- Candida albicans, Cell Differentiation, Cells, Cultured, Dendritic Cells, Humans, Lymphocyte Activation, Membrane Glycoproteins, T-Lymphocytes, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, IgG, Antigen Presentation, Interleukin-12, Lipopolysaccharide Receptors, Adaptor Proteins, Signal Transducing, Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Factor 88
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
