The role of the cell wall in fungal pathogenesis

Arana, David M.; Prieto, Daniel; Román, Elvira; Nombela, César; Alonso‐Monge, Rebeca; Pla, Jesús

doi:10.1111/j.1751-7915.2008.00070.x

Cited by 92Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

The role of the cell wall in fungal pathogenesis

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Arana, David M., Prieto, Daniel, Román, Elvira, Nombela, César, Alonso‐Monge, Rebeca, Pla, Jesús·2009·Microbial Biotechnology

DOI 10.1111/j.1751-7915.2008.00070.xPMC PMC3815752

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Abstract

Summary: Fungal infections are a serious health problem. In recent years, basic research is focusing on the identification of fungal virulence factors as promising targets for the development of novel antifungals. The wall, as the most external cellular component, plays a crucial role in the interaction with host cells mediating processes such as adhesion or phagocytosis that are essential during infection. Specific components of the cell wall (called PAMPs) interact with specific receptors in the immune cell (called PRRs), triggering responses whose molecular mechanisms are being elucidated. We review here the main structural carbohydrate components of the fungal wall (glucan, mannan and chitin), how their biogenesis takes place in fungi and the specific receptors that they interact with. Different model fungal pathogens are chosen to illustrate the functional consequences of this interaction. Finally, the identification of the key components will have important consequences in the future and will allow better approaches to treat fungal infections.

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β-1,3-glucan binds to Dectin-1 on host immune cells and promotes phagocytosis and inflammatory responses.
“As the primary fungal pathogen-associated molecular pattern (PAMP), β-1,3-glucan binds to Dectin-1, a C-type lectin pattern recognition receptor (PRR) of the host’s immune cells [11]; and promotes phagocytosis and inflammatory responses [12].”
From High iron-mediated increased oral fungal burden, oral-to-gut transmission, and changes to pathogenicity of Candida albicans in oropharyngeal candidiasis (2022) · cites this paper as [11]

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Authors: Arana, D. M., Prieto, D., Román, E., Nombela, C., Alonso‐Monge, R., & Pla, J.
Affiliations: Universidad Complutense de Madrid (ES)
ORCID: Arana, David M.
Prieto, Daniel
Román, Elvira
Nombela, César
Alonso‐Monge, Rebeca
Venue: Microbial Biotechnology
Publisher: Wiley
Published: 2009-04-17
Volume: 2
Issue: 3
Pages: 308-320
ISSN: 1751-7915 (ISSN-L)
DOI: 10.1111/j.1751-7915.2008.00070.x
PMC: PMC3815752
OpenAlex: W2051035915
Cited by: 92
References: 131
Citations by year: 2026: 7 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 15 · 2021: 6 · 2020: 12 · 2019: 11 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI: 0.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Microbial Biotechnology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Comunidad de Madrid
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: fungal cell wall, fungal pathogenesis, fungal virulence factors, antifungal drug targets, pathogen-associated molecular patterns, pattern recognition receptors, host-pathogen interaction, adhesion, phagocytosis, glucan, mannan, chitin, cell wall biosynthesis, fungal infection
MeSH terms: Animals, Cell Wall, Fungi, Humans, Mycoses, Carbohydrate Metabolism

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The role of the cell wall in fungal pathogenesis

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