Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications

Rutella, Sergio; Lemoli, Roberto M

doi:10.1016/j.imlet.2004.04.015

Cited by 147T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation

Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications

Rutella, Sergio, Lemoli, Roberto M·2004·Immunology Letters

DOI 10.1016/j.imlet.2004.04.015

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Abstract

The induction of antigen (Ag)-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. Recently, attention has been focused on induction of active suppression by regulatory T cells (Treg cells). Also, a role for dendritic cells (DCs) in the promotion of peripheral tolerance has been demonstrated by several studies and is the subject of intensive investigation. It is currently believed that the maturation/activation state of DCs might be a control point for the induction of peripheral tolerance through modifications of the activation state of T cells. Several lines of experimental evidence suggest that unique DC subsets or discrete functional states of the DCs might be devoted to the promotion of Treg cell differentiation. The present review summarizes the emerging literature on the developmental origin and function of human Treg cells and tolerogenic/regulatory DCs. Furthermore, clinical implications of these studies for cellular therapy of immune-mediated pathologies are discussed.

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Glucocorticoids can convert dendritic cells to tolerogenic cells that promote regulatory T cell production, and this effect relies on glucocorticoid-mediated expression of GILZ.
“GCs can also convert DCs to tolerogenic cells, which promote the production of regulatory T cells (38, 39). This immunosuppressive effect critically relies on the GC-mediated expression of glucocorticoid-induce leucine zipper (GILZ), since this transcription factor appears as both necessary and sufficient for the induction of a tolerogenic state (40, 41).”
From The HPA â€“ Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [39]

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Authors: Rutella, S., & Lemoli, R. M.
Affiliations: Università Cattolica del Sacro Cuore (IT)
University of Bologna (IT)
Corresponding author: Rutella, Sergio
ORCID: Rutella, Sergio
Lemoli, Roberto M
Venue: Immunology Letters
Publisher: Elsevier BV
Published: 2004-06
Volume: 94
Issue: 1-2
Pages: 11-26
ISSN: 0165-2478 (ISSN-L)
DOI: 10.1016/j.imlet.2004.04.015
OpenAlex: W2005981263
Cited by: 147
References: 127
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 1 · 2013: 8 · 2012: 3
FWCI: 1.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Immunology Letters (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: regulatory T cells, tolerogenic dendritic cells, peripheral tolerance, antigen-specific tolerance, autoimmunity, immune homeostasis, dendritic cell maturation, Treg differentiation, dendritic cell subsets, cell therapy, immune-mediated diseases
MeSH terms: Autoimmune Diseases, Dendritic Cells, Humans, Immune Tolerance, Antigen Presentation, T-Lymphocytes, Regulatory

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Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications

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