The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Pyroptosis and host cell death responses during Salmonella infection
Abstract
Salmonella enterica are facultatively intracellular pathogens causing diseases with markedly visible signs of inflammation. During infection, Salmonella interacts with various host cell types, often resulting in death of those cells. Salmonella induces intestinal epithelial cell death via apoptosis, a cell death programme with a notably non-inflammatory outcome. In contrast, macrophage infection triggers caspase-1-dependent proinflammatory programmed cell death, a recently recognized process termed pyroptosis, which is distinguished from other forms of cellular demise by its unique mechanism, features and inflammatory outcome. Rapid macrophage pyroptosis depends on the Salmonella pathogenicity island-1 type III secretion system (T3SS) and flagella. Salmonella dynamically modulates induction of macrophage pyroptosis, and regulation of T3SS systems permits bacterial replication in specialized intracellular niches within macrophages. However, these infected macrophages later undergo a delayed form of caspase-1-dependent pyroptosis. Caspase-1-deficient mice are more susceptible to a number of bacterial infections, including salmonellosis, and pyroptosis is therefore considered a generalized protective host response to infection. Thus, Salmonella-induced pyroptosis serves as a model to understand a broadly important pathway of proinflammatory programmed host cell death: examining this system affords insight into mechanisms of both beneficial and pathological cell death and strategies employed by pathogens to modulate host responses.
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Cites
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Background
Cited by
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Sborgi, L., Rühl, S., Mulvihill, E., Pipercevic, J., Heilig, R., Stahlberg, H., Farady, C. J., Müller, D. J., Broz, P., & Hiller, S. (2016) · The EMBO Journal · doi:10.15252/embj.201694696 · Cited by 1,152
Sensing and reacting to microbes through the inflammasomes
Franchi, L., Muñoz-Planillo, R., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2231 · Cited by 1,012
Function of Nod‐like receptors in microbial recognition and host defense
Franchi, L., Warner, N., Viani, K., & Nuñez, G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00734.x · Cited by 903
Metadata
- Authors
- Fink, S. L., & Cookson, B. T.
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2007-11
- Volume
- 9
- Issue
- 11
- Pages
- 2562-2570
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2050819949
- Cited by
- 383
- References
- 58
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- closed
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