Innate immunity to mycobacteria: vitamin D and autophagy
Open accessAbstract
Autophagy is an ancient mechanism of protein degradation and a novel antimicrobial strategy. With respect to host defences against mycobacteria, autophagy plays a crucial role in antimycobacterial resistance, and contributes to immune surveillance of intracellular pathogens and vaccine efficacy. Vitamin D3 contributes to host immune responses against Mycobacterium tuberculosis through LL-37/hCAP-18, which is the only cathelicidin identified to date in humans. In this review, we discuss recent advances in our understanding of host immune strategies against mycobacteria, including vitamin D-mediated innate immunity and autophagy activation. This review also addresses our current understanding regarding the autophagy connection to principal innate machinery, such as ubiquitin- or inflammasome-involved pathways. Integrated dialog between autophagy and innate immunity may contribute to adequate host immune defences against mycobacterial infection.
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Part of the anti-mycobacterial activity of cathelicidin is traced to induction of autophagy.
“as well as to induction of autophagy (4, 85).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [85]
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Macrophage defense mechanisms against intracellular bacteria
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- Authors
- Jo, E.-K.
- Affiliations
- Chungnam National University (KR)
- Corresponding author
- Jo, Eun-Kyeong
- ORCID
- Jo, Eun-Kyeong
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2010-06-14
- Volume
- 12
- Issue
- 8
- Pages
- 1026-1035
- ISSN
- 1462-5814 (ISSN-L)
- OpenAlex
- W1513303790
- Cited by
- 98
- References
- 77
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 11 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 14
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chungnam National University
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- innate immunity, mycobacteria, Mycobacterium tuberculosis, autophagy, vitamin D3, LL-37, cathelicidin, intracellular pathogens, vaccine efficacy, ubiquitin pathway, inflammasome, host-pathogen interaction
- MeSH terms
- Animals, Autophagy, Humans, Immunity, Innate, Models, Biological, Mycobacterium tuberculosis, Tuberculosis, Vitamin D, Vitamins
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