Cited by 137Immune Response and InflammationAutophagy in Disease and TherapyPhagocytosis and Immune Regulation

Toll-like receptor signaling in the lysosomal pathways

Sanjuan, Miguel A., Milasta, Sandra, Green, Douglas R.·2009·Immunological Reviews

Abstract

The lysosomal pathway digests material received by two main routes, phagocytosis and autophagy. Cells use phagocytosis to ingest extracellular particles by invaginations of the plasma membrane. In autophagy, a double membrane structure isolates portions of the cytoplasm to target it for degradation. During infection, phagocytes use both of these cellular functions to restrict microbial replication and at the same time to orchestrate an appropriate response against the invader. Toll-like receptor recognition of a pathogen initiates an innate immune response against the pathogen that includes production of inflammatory cytokines, upregulation of costimulatory molecules to prime an adaptive immune response, and activation of phagocytosis and autophagy. Signaling through this family of receptors also produces a hybrid response in which proteins that participate in autophagy are recruited to phagosomes, resulting in expedited microbial elimination. In this review, we discuss recent views on how Toll-like receptors direct microbes to final destruction by regulating the different pathways that lead to the lysosome.

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Crossref · 10.1111/j.1600-065x.2008.00732.x

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129 of 129 references verified0 citation errors · 0 not checkable

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  • POS phagocytosis promotes a non-canonical form of autophagy (LAP) that is dependent on LC3 and Atg5 but is not classical autophagy which requires Ulk1, Fip200, and Atg13.

    “This supports the idea that POS phagocytosis promotes a non-canonical form of autophagy (i.e. LAP) that is dependent on LC3 and Atg5 but is not classical autophagy which requires Ulk1, Fip200, and Atg13 (Martinez et al., 2011; Sanjuan et al., 2007; Sanjuan et al., 2009).”

    From Noncanonical autophagy promotes the visual cycle (2013) · cites this paper as Sanjuan et al., 2009

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Authors
Sanjuan, M. A., Milasta, S., & Green, D. R.
Affiliations
St. Jude Children's Research Hospital (US)
Corresponding author
Green, Douglas R.
Venue
Immunological Reviews
Publisher
Wiley
Published
2008-12-19
Volume
227
Issue
1
Pages
203-220
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W2074680075
Cited by
137
References
129
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 10 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 15 · 2013: 17 · 2012: 12
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords
Toll-like receptors, lysosomal degradation, phagocytosis, autophagy, phagosome, innate immunity, microbial clearance, inflammatory cytokines, costimulatory molecules, adaptive immune response, receptor signaling
MeSH terms
Autophagy-Related Protein 12, Animals, Autophagy, Homeostasis, Humans, Infections, Lysosomes, Membrane Fusion, Microtubule-Associated Proteins, Phagosomes, Protein Kinases, Signal Transduction, Antigen Presentation, Protein Transport, Small Ubiquitin-Related Modifier Proteins, Toll-Like Receptors, TOR Serine-Threonine Kinases

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