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Cited by 130Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Colesevelam lowers glucose and lipid levels in type 2 diabetes: the clinical evidence

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Fonseca, Vivian A., Handelsman, Yehuda, Staels, Bart·2010·Diabetes, Obesity and Metabolism
DOI 10.1111/j.1463-1326.2009.01181.xPMC PMC2871173
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Abstract

Simultaneous control of blood glucose and other risk factors such as hypertension and dyslipidaemia is essential for reducing the risk of complications associated with type 2 diabetes mellitus (T2DM). As relatively few patients with T2DM have their risk factors managed to within the limits recommended by the American Diabetes Association, American College of Endocrinology or National Cholesterol Education Program Adult Treatment Panel III guidelines, treatment that can simultaneously control more than one risk factor is of therapeutic benefit. Clinical studies have shown that bile acid sequestrants have glucose‐lowering effects in addition to their low‐density lipoprotein cholesterol‐lowering effects in patients with T2DM. The bile acid sequestrant colesevelam hydrochloride is approved as an adjunct to antidiabetes therapy for improving glycaemic control in adults with T2DM. This review examines data from three phase III clinical trials that evaluated the glucose‐ and lipid‐lowering effects of colesevelam when added to the existing antidiabetes treatment regimen of patients with T2DM.

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Figures

Figure 1 Mean change from baseline to endpoint LOCF in (A) HbA1c and (B) FPG with addition of colesevelam hydrochloride compared with placebo to ongoing metformin, sulfonylurea or insulin antidiabetes therapies in patients with T2DM. Endpoint was 26 weeks in the metformin and sulfonylurea trials, and 16 weeks in the insulin trial. Numbers above the bracketed pairs of bars are the mean treatment difference from baseline ± s.e. N is the number of patients with values at both baseline and endpoint. For HbA1c conversion from % to mmol/mol (%HbA1c—2.15*10.929); for FPG conversion from mg/dl to mmol/l, multiply by 0.0555. FPG, fasting plasma glucose; HbA1c, glycosylated haemoglobin; HCl, hydrochloride; LOCF, last observation carried forward; T2DM, type 2 diabetes mellitus.
Figure 1 Mean change from baseline to endpoint LOCF in (A) HbA1c and (B) FPG with addition of colesevelam hydrochloride compared with placebo to ongoing metformin, sulfonylurea or insulin antidiabetes therapies in patients with T2DM. Endpoint was 26 weeks in the metformin and sulfonylurea trials, and 16 weeks in the insulin trial. Numbers above the bracketed pairs of bars are the mean treatment difference from baseline ± s.e. N is the number of patients with values at both baseline and endpoint. For HbA1c conversion from % to mmol/mol (%HbA1c—2.15*10.929); for FPG conversion from mg/dl to mmol/l, multiply by 0.0555. FPG, fasting plasma glucose; HbA1c, glycosylated haemoglobin; HCl, hydrochloride; LOCF, last observation carried forward; T2DM, type 2 diabetes mellitus.CC BY · PubMed Central
Figure 2 Mean change from baseline to endpoint in lipid parameters with addition of colesevelam HCl compared with placebo to ongoing metformin, sulfonylurea or insulin antidiabetes therapies in patients with T2DM. Mean values are reported unless otherwise indicated. Apo, apolipoprotein; HCl, hydrochloride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LOCF, last observation carried forward; LS, least-squares; TC, total cholesterol; T2DM, type 2 diabetes mellitus; TG, triglycerides.
Figure 2 Mean change from baseline to endpoint in lipid parameters with addition of colesevelam HCl compared with placebo to ongoing metformin, sulfonylurea or insulin antidiabetes therapies in patients with T2DM. Mean values are reported unless otherwise indicated. Apo, apolipoprotein; HCl, hydrochloride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LOCF, last observation carried forward; LS, least-squares; TC, total cholesterol; T2DM, type 2 diabetes mellitus; TG, triglycerides.CC BY · PubMed Central
Figure 3 Change from baseline to endpoint in median high-sensitivity C-reactive protein (hsCRP) levels with addition of colesevelam HCl compared with placebo, to ongoing metformin, sulfonylurea or insulin antidiabetes therapies in patients with T2DM. N is the number of patients with values at both baseline and endpoint. HCl, hydrochloride; LOCF, last observation carried forward; T2DM, type 2 diabetes mellitus.
Figure 3 Change from baseline to endpoint in median high-sensitivity C-reactive protein (hsCRP) levels with addition of colesevelam HCl compared with placebo, to ongoing metformin, sulfonylurea or insulin antidiabetes therapies in patients with T2DM. N is the number of patients with values at both baseline and endpoint. HCl, hydrochloride; LOCF, last observation carried forward; T2DM, type 2 diabetes mellitus.CC BY · PubMed Central

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Citations

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Show all 46 references

Research works printed but not linked: 5

  1. 2009, Diabetes Care, S13
  2. 2008, Diabetes Care, S12
  3. Braunlin W, 2000, In vitro comparison of bile acid binding to colesevelam HCl and other bile acid sequestrants, Polymer Preprints, 41, 708
  4. 2007, Welchol (Colesevelam Hydrochloride Tablets) Product Information
  5. Brunzell JD, 2008, Diabetes Care, 811

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Metadata

Authors
Fonseca, V. A., Handelsman, Y., & Staels, B.
Affiliations
  • Tulane University (US)
  • Inserm (FR)
Corresponding author
Fonseca, Vivian A.
ORCID
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2010-03-30
Volume
12
Issue
5
Pages
384-392
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
DOI
10.1111/j.1463-1326.2009.01181.x
PMC
PMC2871173
OpenAlex
W1963557257
Cited by
130
References
46
Citations by year
2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 5 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 12 · 2012: 16
FWCI
1.53
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetes Obesity and Metabolism (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Daiichi Sankyo Europe
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
colesevelam, type 2 diabetes, bile acid sequestrants, glucose-lowering effect, hypolipidemic effect, LDL cholesterol, glycemic control, dyslipidemia, risk factor control
MeSH terms
Colesevelam Hydrochloride, Adult, Allylamine, Anticholesteremic Agents, Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Glycated Hemoglobin, Humans, Lipids, Male

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