Cited by 398Diabetes Treatment and ManagementDiabetes Management and ResearchPharmacology and Obesity Treatment

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

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Tahrani, Abd A., Barnett, Anthony H., Bailey, Clifford J.·2016·Nature Reviews Endocrinology

Abstract

Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-care systems. Improving metabolic control to approach normal glycaemia (where practical) greatly benefits long-term prognoses and justifies early, effective, sustained and safety-conscious intervention. Improvements in the understanding of the complex pathogenesis of T2DM have underpinned the development of glucose-lowering therapies with complementary mechanisms of action, which have expanded treatment options and facilitated individualized management strategies. Over the past decade, several new classes of glucose-lowering agents have been licensed, including glucagon-like peptide 1 receptor (GLP-1R) agonists, dipeptidyl peptidase 4 (DPP-4) inhibitors and sodium/glucose cotransporter 2 (SGLT2) inhibitors. These agents can be used individually or in combination with well-established treatments such as biguanides, sulfonylureas and thiazolidinediones. Although novel agents have potential advantages including low risk of hypoglycaemia and help with weight control, long-term safety has yet to be established. In this Review, we assess the pharmacokinetics, pharmacodynamics and safety profiles, including cardiovascular safety, of currently available therapies for management of hyperglycaemia in patients with T2DM within the context of disease pathogenesis and natural history. In addition, we briefly describe treatment algorithms for patients with T2DM and lessons from present therapies to inform the development of future therapies.

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Crossref · 10.1038/nrendo.2016.86

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Authors
Tahrani, A. A., Barnett, A. H., & Bailey, C. J.
Affiliations
  • Heart of England NHS Foundation Trust (GB)
  • Aston University (GB)
Corresponding author
Tahrani, Abd A.
Venue
Nature Reviews Endocrinology
Published
2016-06-24
Volume
12
Issue
10
Pages
566-592
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W2475311184
Cited by
398
References
362
Citations by year
2026: 23 · 2025: 29 · 2024: 46 · 2023: 33 · 2022: 44 · 2021: 42 · 2020: 36 · 2019: 53 · 2018: 41 · 2017: 42 · 2016: 8
FWCI
7.03
Type
journal article
Language
en
Licence
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (publishedVersion, cc-by-nc-nd)
  • Aston Publications Explorer (Aston University) (acceptedVersion)
Funders
National Institute for Health and Care Research (RTF/01/094, CS-2013-13-029)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
type 2 diabetes, antidiabetic drugs, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT2 inhibitors, biguanides, sulfonylureas, thiazolidinediones, pharmacokinetics, pharmacodynamics, drug safety, cardiovascular safety, hypoglycemia, weight management, treatment algorithm, pathogenesis
MeSH terms
Sodium-Glucose Transporter 2 Inhibitors, Glucagon-Like Peptide-1 Receptor Agonists, Benzamides, Biguanides, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Humans, Hypoglycemic Agents, Insulin, Sulfonylurea Compounds, Thiazolidinediones, Dipeptidyl-Peptidase IV Inhibitors, Glycoside Hydrolase Inhibitors

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