The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance
Open accessAbstract
Aims: Obesity is associated with insulin resistance, liver steatosis and low‐grade inflammation. The role of oestrogen in sex differences in the above co‐morbidities is not fully understood. Our aim was to assess the role oestrogen has in modulating adipocyte size, adipose tissue oxidative stress, inflammation, insulin resistance and liver steatosis. Methods: To determine the role oestrogen has in the above co‐morbidities related to obesity, we randomized C57BL/6J mice into four groups (15 mice per group): (i) male, (ii) non‐ovariectomized female (novx), (iii) ovariectomized female (ovx) and (iv) ovariectomized female mice supplemented with 17 β estradiol (ovx‐E). Mice received either a low‐fat (LF) or a high‐fat (HF) diet for 10 weeks. Outcomes measured were bodyweight, body fat, adipocyte diameter, adipose tissue lipolysis markers, adipose tissue oxidative stress, inflammation, insulin resistance and liver steatosis. Results: Male and ovx‐female mice consuming the HF diet had a higher propensity of gaining weight, specifically in the form of body fat. Oestrogen protected female mice from adipocyte hypertrophy and from developing adipose tissue oxidative stress and inflammation. Moreover, novx‐female and ovx‐female+E mice had higher phosphorylated levels of protein kinase A and hormone sensitive lipase, markers associated with lipolysis. Additionally, male and ovx female mice had a higher propensity of developing liver steatosis and insulin resistance. In contrast, oestrogen protected female mice from developing liver steatosis and from becoming insulin resistant. Conclusion: We show that oestrogen protects female mice from adipocyte hypertrophy and adipose tissue oxidative stress and inflammation. Furthermore, oestrogen prevented female mice from developing liver steatosis and from becoming insulin resistant.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, estrogen prevented female mice from developing liver steatosis and from becoming insulin resistant [72, 138].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [138]
In the citing paper
“Administration of estrogens to ovariectomized female mice reduces significantly the mRNA of IL6, TNFα, and CD68.”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Global Cancer Statistics, 2002
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.74 · Cited by 18,710
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., & Karin, M. (2007) · Science · doi:10.1126/science.1140485 · Cited by 1,955
The complex role of estrogens in inflammation
Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000380842.14048.7e · Cited by 1,600
Research works printed but not linked: 1
- NahantL.Quantifying western blots without expensive commercial quantification software. In: Nahant L ed. 2007. Available from URL:http://lukemiller.org/journal/2007/08/quantifying‐western‐blots‐without.html.
Cited by
Sorted by citations
2016 IMS Recommendations on women’s midlife health and menopause hormone therapy
Baber, R., Panay, N., & Fenton, A. J. (2016) · Climacteric · doi:10.3109/13697137.2015.1129166 · Cited by 968
Understanding weight gain at menopause
Davis, S. R., Castelo‐Branco, C., Chedraui, P. A., Lumsden, M. A., Nappi, R. E., Shah, D., Villaseca, P., & as the Writing Group of the International Menopause Society for World Menopause Day 2012 (2012) · Climacteric · doi:10.3109/13697137.2012.707385 · Cited by 646
Estrogen deficiency and the origin of obesity during menopause
Lizcano, F., & Guzmán, G. (2014) · BioMed Research International · doi:10.1155/2014/757461 · Cited by 586
The Role of Estrogen in Insulin Resistance
Paoli, M. D., Zakharia, A., & Werstuck, G. H. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.011 · Cited by 322
Rodriguez, J., Hiel, S., Neyrinck, A. M., Roy, T. L., Pötgens, S. A., Leyrolle, Q., Pachikian, B. D., Gianfrancesco, M. A., Cani, P. D., Paquot, N., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319726 · Cited by 257
Sharma, G., Hu, C., Brigman, J. L., Zhu, G., Hathaway, H. J., & Prossnitz, E. R. (2013) · Endocrinology · doi:10.1210/en.2013-1357 · Cited by 210
Mechanisms of Estrogen Influence on Skeletal Muscle: Mass, Regeneration, and Mitochondrial Function
Pellegrino, A., Tiidus, P. M., & Vandenboom, R. (2022) · Sports Medicine · doi:10.1007/s40279-022-01733-9 · Cited by 178
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143
Ke, J., Kliewer, K., Hamad, E. M., Cole, R. M., Powell, K. A., Andridge, R., Straka, S. R., Yee, L. D., & Belury, M. A. (2015) · Nutrition & Metabolism · doi:10.1186/1743-7075-12-1 · Cited by 142
Sex differences in risk factors for vascular contributions to cognitive impairment & dementia
Gannon, O. J., Robison, L. S., Custozzo, A. J., & Zuloaga, K. L. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.11.014 · Cited by 146
Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00688.2013 · Cited by 141
Roles of G protein-coupled estrogen receptor GPER in metabolic regulation
Sharma, G., Mauvais‐Jarvis, F., & Prossnitz, E. R. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.02.012 · Cited by 132
Age at natural menopause and risk of type 2 diabetes: a prospective cohort study
Muka, T., Asllanaj, E., Avazverdi, N., Jaspers, L., Stringa, N., Milić, J., Ligthart, S., Ikram, M. A., Laven, J. S. E., Kavousi, M., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4346-8 · Cited by 130
Sex-based differences in insulin resistance
Gado, M., Tsaousidou, E., Bornstein, S. R., & Perakakis, N. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0245 · Cited by 126
Abildgaard, J., Ploug, T., Al-Saoudi, E., Wagner, T., Thomsen, C., Ewertsen, C., Bzorek, M., Pedersen, B. K., Pedersen, A. T., & Lindegaard, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-94189-2 · Cited by 116
GPER–novel membrane oestrogen receptor
Zimmerman, M. A., Budish, R. A., Kashyap, S. N., & Lindsey, S. H. (2016) · Clinical Science · doi:10.1042/cs20160114 · Cited by 114
Khoudary, S. R. E., Shields, K. J., Janssen, İ., Hanley, C. L., Budoff, M. J., Barinas‐Mitchell, E., Everson‐Rose, S. A., Powell, L. H., & Matthews, K. A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2110 · Cited by 113
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications
Arterburn, J. B., & Prossnitz, E. R. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-031122-121944 · Cited by 114
Kim, J. H., Cho, H. T., & Kim, Y. J. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0262 · Cited by 111
Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits
Norheim, F., Hasin-Brumshtein, Y., Vergnes, L., Krishnan, K. C., Pan, C., Seldin, M. M., Hui, S. T. Y., Mehrabian, M., Zhou, Z., Gupta, S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.013 · Cited by 110
Steroids and insulin resistance in pregnancy
Vejražková, D., Včelák, J., Vaňková, M., Lukášová, P., Bradnová, O., Hálková, T., Kancheva, R. L., & Bendlová, B. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.11.007 · Cited by 102
Vieira Potter, V. J., Strissel, K. J., Xie, C., Chang, E., Bennett, G., Defuria, J., Obin, M. S., & Greenberg, A. S. (2012) · Endocrinology · doi:10.1210/en.2011-2006 · Cited by 99
Estrogens and the regulation of glucose metabolism
Alemany, M. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i10.1622 · Cited by 106
Kruse, M., Seki, Y., Vuguin, P. M., Du, X. Q., Fiallo, A., Glenn, A. S., Singer, S., Breuhahn, K., Katz, E. B., & Charron, M. J. (2013) · Endocrinology · doi:10.1210/en.2012-1877 · Cited by 93
Obesity and sex interact in the regulation of Alzheimer's disease
Moser, V. A., & Pike, C. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.021 · Cited by 91
Adipocyte Metabolism and Health after the Menopause: The Role of Exercise
Marsh, M. L., Oliveira, M. N., & Vieira‐Potter, V. J. (2023) · Nutrients · doi:10.3390/nu15020444 · Cited by 97
Weight, Shape, and Body Composition Changes at Menopause
Fenton, A. J. (2021) · Journal of Mid-life Health · doi:10.4103/jmh.jmh_123_21 · Cited by 104
Ding, Y., Li, J., Liu, S., Zhang, L., Xiao, H., Li, J., Chen, H., Petersen, R. B., Huang, K., & Zheng, L. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.98 · Cited by 76
Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines
Takei, R., Inoue, T., Sonoda, N., Kohjima, M., Okamoto, M., Sakamoto, R., Inoguchi, T., & Ogawa, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223302 · Cited by 75
Nteeba, J., Ortinau, L. C., Perfield, J. W., & Keating, A. F. (2013) · Molecular Reproduction and Development · doi:10.1002/mrd.22231 · Cited by 74
Naville, D., Pinteur, C., Véga, N., Menade, Y., Vigier, M., Bourdais, A. L., Labaronne, E., Debard, C., Luquain‐Costaz, C., Bégeot, M., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-231670 · Cited by 74
Shen, L., Song, L., Li, H., Liu, B., Zheng, X., Zhang, L., Yuan, J., Liang, Y., & Wang, Y. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.12.011 · Cited by 72
CD36 is important for adipocyte recruitment and affects lipolysis
Vroegrijk, I. O. C. M., van Klinken, J. B., van Diepen, J. A., van den Berg, S. A. A., Febbraio, M., Steinbusch, L. K. M., Glatz, J. F. C., Havekes, L. M., Voshol, P. J., Rensen, P. C. N., et al. (2013) · Obesity · doi:10.1002/oby.20354 · Cited by 74
Cardoso, R. C., Veiga‐Lopez, A., Moeller, J., Beckett, E. M., Pease, A. P., Keller, E., Madrigal, V., Chazenbalk, G. D., Dumesic, D. A., & Padmanabhan, V. (2015) · Endocrinology · doi:10.1210/en.2015-1565 · Cited by 67
Tsai, S.-Y., Rodriguez, A. A., Dastidar, S. G., Del Greco, E., Carr, K. L., Sitzmann, J. M., Academia, E. C., Viray, C. M., Martinez, L. L., Kaplowitz, B. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.029 · Cited by 63
Nickelson, K. J., Stromsdorfer, K. L., Pickering, R. T., Liu, T., Ortinau, L. C., Keating, A. F., & Perfield, J. W. (2012) · Experimental Diabetes Research · doi:10.1155/2012/859395 · Cited by 69
Han, C. Y., Kang, I., Harten, I. A., Gebe, J. A., Chan, C. K., Omer, M., Alonge, K. M., den Hartigh, L. J., Kjerulf, D. G., Goodspeed, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107818 · Cited by 64
Metabolic control and sex: A focus on inflammatory‐linked mediators
Henstridge, D. C., Abildgaard, J., Lindegaard, B., & Febbraio, M. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14642 · Cited by 65
The Role of Sex and Sex Hormones in Regulating Obesity-Induced Inflammation
Varghese, M., Griffin, C. A., & Singer, K. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_5 · Cited by 62
Bourgonje, A. R., Abdulle, A. E., Al-Rawas, A. M., Al‐Maqbali, M., Al-Saleh, M., Enriquez, M. B., Al‐Siyabi, S., Al-Hashmi, K., Al‐Lawati, I., Bulthuis, M. L. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010314 · Cited by 58
Akoum, S. E., Lamontagne, V., Cloutier, I., & Tanguay, J. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-34 · Cited by 57
Gajda, A. M., Zhou, Y. X., Agellon, L. B., Fried, S. K., Kodukula, S., Fortson, W., Patel, K., & Storch, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.501676 · Cited by 56
Gender and strain-specific differences in the development of steatosis in rats
Stöppeler, S., Palmes, D., Fehr, M., Hölzen, J. P., Zibert, A., Siaj, R., Schmidt, H., Hu, S., & Bahde, R. (2013) · Laboratory Animals · doi:10.1177/0023677212473717 · Cited by 56
Diamanti‐Kandarakis, E., Papalou, O., Kandaraki, E., & Kassi, G. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0616 · Cited by 55
Modulation of SHBG binding to testosterone and estradiol by sex and morbid obesity
Grasa, M., Gulfo, J., Camps, N., Alcalá, R., Monserrat, L., Moreno‐Navarrete, J. M., Ortega, F. J., Esteve, M., Remesar, X., Fernández–Löpez, J., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0834 · Cited by 52
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue
Kim, M., Neinast, M. D., Frank, A. P., Sun, K., Park, J., Zehr, J. A., Vishvanath, L., Morselli, E., Amelotte, M., Palmer, B. F., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.007 · Cited by 52
The role of polycarbonate monomer bisphenol-A in insulin resistance
Pjanic, M. (2017) · PeerJ · doi:10.7717/peerj.3809 · Cited by 52
Immunometabolic Links between Estrogen, Adipose Tissue and Female Reproductive Metabolism
Eaton, S. A., & Sethi, J. K. (2019) · Biology · doi:10.3390/biology8010008 · Cited by 53
The effects of 17 alpha-estradiol to inhibit inflammation in vitro
Santos, R. D. S., de Fátima, L. A., Frank, A. P., Carneiro, E. M., & Clegg, D. J. (2017) · Biology of Sex Differences · doi:10.1186/s13293-017-0151-9 · Cited by 51
Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology
Barrientos, R. M., Brunton, P. J., Lenz, K. M., Pyter, L. M., & Spencer, S. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.010 · Cited by 50
How Estrogens Prevent From Lipid-Induced Insulin Resistance
Jeleník, T., & Roden, M. (2013) · Endocrinology · doi:10.1210/en.2013-1112 · Cited by 48
Risk Factors for Diabetes Mellitus in Women with Primary Ovarian Insufficiency
Kulaksızoğlu, M., İpekçi, S. H., Kebapçılar, L., Kebapçılar, A. G., Korkmaz, H., Akyürek, F., Baldane, S., & Gönen, M. S. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9738-0 · Cited by 48
Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance
Zidon, T. M., Padilla, J., Fritsche, K. L., Welly, R. J., McCabe, L., Stricklin, O. E., Frank, A. P., Park, Y.-M., Clegg, D. J., Lubahn, D. B., et al. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0321 · Cited by 48
Litzenburger, T., Huber, E.-K., Dinger, K., Wilke, R., Vohlen, C., Selle, J., Kadah, M., ten Persigehl, T., Heneweer, C., Dötsch, J., et al. (2020) · Clinical Science · doi:10.1042/cs20191229 · Cited by 48
Delaney, K. Z., & Santosa, S. (2022) · Obesity Reviews · doi:10.1111/obr.13393 · Cited by 50
Sex differences in behavior, response to LPS, and glucose homeostasis in middle-aged mice
Dockman, R. L., Carpenter, J. M., Diaz, A. N., Benbow, R. A., & Filipov, N. M. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113628 · Cited by 48
Baek, Y., Lee, M. N., Wu, D., & Pae, M. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.06.002 · Cited by 45
Varlamov, O., Chu, M. P., McGee, W., Cameron, J., O'Rourke, R., Meyer, K. A., Bishop, C., Stouffer, R., & Roberts, C. (2013) · Endocrinology · doi:10.1210/en.2013-1428 · Cited by 43
Estrogen and Mitochondria Function in Cardiorenal Metabolic Syndrome
Jia, G., Aroor, A. R., & Sowers, J. R. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00009-x · Cited by 44
Monks, J., Orlicky, D. J., Stefanski, A. L., Libby, A. E., Bales, E. S., Rudolph, M. C., Johnson, G. C., Sherk, V. D., Jackman, M. R., Williamson, K. M., et al. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-018-0027-z · Cited by 44
Recent Update on the Molecular Mechanisms of Gonadal Steroids Action in Adipose Tissue
Wawrzkiewicz–Jałowiecka, A., Lalik, A., & Soveral, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105226 · Cited by 46
Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Delanoye, A., Verwaerde, C., Spriet, C., Saule, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040351 · Cited by 40
Estrogen protects against obesity-induced mammary gland inflammation in mice
Bhardwaj, P., Du, B., Zhou, X. K., Sue, E., Giri, D., Harbus, M. D., Falcone, D. J., Hudis, C. A., Subbaramaiah, K., & Dannenberg, A. J. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0082 · Cited by 36
Guerra, R. C., Zúñiga-Muñoz, A. M., Guarner‐Lans, V., Díaz‐Díaz, E., Betancourt, C. A. T., & Pérez-Torres, I. (2014) · International Journal of Endocrinology · doi:10.1155/2014/175080 · Cited by 36
Anti-inflammatory agents as modulators of the inflammation in adipose tissue: A systematic review
Nascimento, S. S. D. C., de Queiroz, J. L. C., de Medeiros, A. F., Nunes, A. C. D. F., Piuvezam, G., Maciel, B. L. L., Passos, T. S., & Morais, A. H. D. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273942 · Cited by 37
Zhu, R., & Chen, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1095432 · Cited by 38
Stanimirović, J., Obradovic, M. M., Jovanović, A., Sudar-Milovanovic, E. M., Zafirovic, S. S., Pitt, S. J., Stewart, A. J., & Isenović, E. R. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.02.007 · Cited by 35
Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
Sharma, G., & Prossnitz, E. R. (2021) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2021.100080 · Cited by 34
Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer?
Khan, S. I., Andrews, K. L., Jennings, G., Sampson, A. K., & Chin-Dusting, J. P. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122892 · Cited by 34
Kim, W.-K., Choi, E., Sul, O., Park, Y.-K., Kim, E.-S., Yu, R., Suh, J., & Choi, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072108 · Cited by 31
Pae, M., Baek, Y., Lee, S., & Wu, D. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.011 · Cited by 31
Santos-Marcos, J. A., Barroso, A., Rangel-Zúñiga, O. A., Perdices-López, C., Haro, C., Sanchez-Garrido, M. A., Molina‐Abril, H., Ohlsson, C., Pérez‐Martínez, P., POUTANEN, M. H., et al. (2020) · Aging · doi:10.18632/aging.104140 · Cited by 32
Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice
Sinderen, M. L. V., Steinberg, G. R., Jørgensen, S. B., Honeyman, J. E., Chow, J. D. Y., Herridge, K. A., Winship, A., Dimitriadis, E., Jones, M. E. E., Simpson, E. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136143 · Cited by 29
Garratt, M. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-190067 · Cited by 30
Wu, B., Chiang, H.-C., Sun, X., Yuan, B., Mitra, P., Hu, Y., Curiel, T. J., & Li, R. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000964 · Cited by 30
Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats
Obradovic, M. M., Sudar-Milovanovic, E. M., Zafirovic, S. S., Stanimirović, J., Labudović‐Borović, M., & Isenović, E. R. (2013) · Angiology · doi:10.1177/0003319713514477 · Cited by 28
Tóth, M. E., Dukay, B., Péter, M., Balogh, G. E., Szűcs, G., Zvara, Á., Szebeni, G. J., Hajdu, P., Sárközy, M., Puskás, L. G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084198 · Cited by 29
Simmen, F. A., Pabona, J. M. P., Al‐Dwairi, A., Alhallak, I., Montales, M. T. E., & Simmen, R. C. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076613 · Cited by 28
Characterization of adipose-derived stem cells of anatomical region from mice
Luna, A. C. D. L., Madeira, M. E., Conceição, T. D. O., Moreira, J. A., Laiso, R. A. N., & Maria, D. A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-552 · Cited by 28
Ko, B., Kim, D. S., Kang, S., Ryuk, J. A., & Park, S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/750986 · Cited by 28
In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart
Obradovic, M. M., Stewart, A. J., Pitt, S. J., Labudović‐Borović, M., Sudar-Milovanovic, E. M., Petrović, V., Zafirovic, S. S., Maravić-Stojkovic, V., Vasić, V., & Isenović, E. R. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.03.005 · Cited by 27
Serglycin Is Involved in Adipose Tissue Inflammation in Obesity
Doncheva, A. I., Norheim, F., Hjorth, M., Grujić, M., Paivandy, A., Dankel, S. N., Hertel, J. K., Valderhaug, T. G., Böttcher, Y., Fernø, J., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100231 · Cited by 28
Fat mass, weight and body shape changes at menopause – causes and consequences: a narrative review
Fenton, A. J., Smart, C., Goldschmidt, L., Price, V., & Scott, J. (2023) · Climacteric · doi:10.1080/13697137.2023.2178892 · Cited by 27
Shamshoum, H., Medak, K. D., & Wright, D. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113049 · Cited by 27
Visceral obesity and cardiometabolic risk: features of hormonal and immune regulation
Кологривова, И. В., Vinnitskaya, I. V., Анатольевна, К. О., & Суслова, Т. Е. (2017) · Obesity and metabolism · doi:10.14341/omet201733-10 · Cited by 27
Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice
Hur, H. J., Jeong, Y.-H., Lee, S. Y., & Sung, M. J. (2020) · Life · doi:10.3390/life10100243 · Cited by 25
Sathkumara, H. D., Eaton, J. L., Field, M. A., Govan, B., Ketheesan, N., & Kupz, A. (2021) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12159 · Cited by 22
Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy
Eid, S., & Feldman, E. L. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049337 · Cited by 26
Sivasinprasasn, S., Sa‐nguanmoo, P., Pongkan, W., Pratchayasakul, W., Chattipakorn, S. C., & Chattipakorn, N. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000640 · Cited by 24
Christensen, A., Liu, J., & Pike, C. J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00113 · Cited by 23
Piotrowska, K., Tarnowski, M., Zgutka, K., & Pawlik, A. (2016) · Nutrients · doi:10.3390/nu8030176 · Cited by 22
Mahmassani, Z. S., Reidy, P. T., McKenzie, A. I., Petrocelli, J. J., Matthews, O., de Hart, N. M. M. P., Ferrara, P. J., O’Connell, R. M., Funai, K., & Drummond, M. J. (2020) · Obesity · doi:10.1002/oby.22759 · Cited by 23
Anti-Hyperglycemic Effect of a Kudzu (Pueraria lobata) Vine Extract in Ovariectomized Mice
Tanaka, T., YOKOTA, Y., Hanjun, T. A. N. G., Zaima, N., Moriyama, T., & Kawamura, Y. (2016) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.62.341 · Cited by 22
Estrogen: the forgotten player in metaflammation
Zhu, B. T., Liao, Q.-Q., Tian, H., Yu, D., Xie, T., Sun, X., Zhou, X.-M., Han, Y., Zhao, Y., El‐Kassas, M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1478819 · Cited by 22
Pedroni, S. M. A., Turban, S., Kipari, T. M. J., Dunbar, D. R., McInnes, K. J., Saunders, P. T. K., Morton, N. M., & Norman, J. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094680 · Cited by 21
Sathkumara, H. D., Muruganandah, V., Cooper, M. M., Field, M. A., Alim, M. A., Brosch, R., Ketheesan, N., Govan, B., Rush, C. M., Henning, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003235117 · Cited by 21
Estrogen suppresses adipogenesis by inhibiting S100A16 expression
Zhang, R., Su, D., Zhu, W., Huang, Q., Liu, M., Xue, Y., Zhang, Y., li, D., Zhao, A. Z., & Liu, Y. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0273 · Cited by 20
Diabetes prevalence in NZO females depends on estrogen action on liver fat content
Lubura, M., Hesse, D., Kraemer, M., Hallahan, N., Schupp, M., von Löffelholz, C., Kriebel, J., Rudovich, N. N., Pfeiffer, A. F. H., John, C., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00338.2015 · Cited by 22
Rodrigues, M. F. C., Ferreira, F. C., Magosso, N. S. S., Barbosa, M. R., Souza, M. V. C., Domingos, M. M., Canevazzi, G. H. R., Stotzer, U. S., Peviani, S. M., Lira, F. S., et al. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0443 · Cited by 20
Adeyanju, O. A., Soetan, O. A., Soladoye, A. O., & Olatunji, L. A. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0630 · Cited by 20
Metadata
- Authors
- Stubbins, R. E., Najjar, K., Holcomb, V. B., Hong, J., & Núñez, N. P.
- Affiliations
- The University of Texas at Austin (US)
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2011-11-22
- Volume
- 14
- Issue
- 1
- Pages
- 58-66
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- PMC
- PMC3236284
- OpenAlex
- W2166652825
- Cited by
- 204
- References
- 41
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 7 · 2023: 15 · 2022: 8 · 2021: 18 · 2020: 19 · 2019: 16 · 2018: 10 · 2017: 14 · 2016: 16 · 2015: 18 · 2014: 17 · 2013: 19 · 2012: 9
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society
- Centre National d’Etudes Spatiales
- National Institutes of Health (5k22ca127519-03)
- National Cancer Institute (K22 CA127519, 1K22 CA127519-01A1)
- National Institute of Environmental Health Sciences (R01ES009145, ES09145, P30ES007784, ES 007784)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- estrogen, estradiol, adipocyte hypertrophy, adipose tissue inflammation, insulin resistance, hepatic steatosis, oxidative stress, lipolysis, hormone-sensitive lipase, protein kinase A, ovariectomy, sex differences, obesity, high-fat diet, adipocyte size
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Body Weight, Estrogens, Fatty Liver, Female, Hypertrophy, Inflammation, Insulin Resistance, Lipolysis, Male, Mice, Inbred C57BL, Obesity, Ovariectomy, Random Allocation, Triglycerides, Adipocytes, Diet, Fat-Restricted, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
