The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.
Bariatric surgery, bone loss, obesity and possible mechanisms
Abstract
Summary: Bariatric surgery remains the most effective treatment for severely obese patients. However, the potential long‐term effects of bariatric surgical procedures on health, including bone health, are only partially understood. The goal of this review was to present data on the impact of bariatric surgery on bone metabolism and to analyse possible reasons for the loss of bone mass that frequently occurs after bariatric surgery. Such factors include nutritional deficiencies, rapid weight loss per se, effects of fat‐derived adipokines and gut‐derived appetite‐regulatory hormones. However, the relative roles of these factors in skeletal regulation and the mechanisms by which they work are not yet fully defined. Our review was focussed on the complex relationship between body weight, fat mass and bone mass, as well as peripheral and central mediators potentially involved in the dual regulation of both energy and bone homeostasis. We also review the data on the inverse relationship between central obesity, bone marrow fat and osteoporosis. As the number of bariatric operations increases, it is imperative to recognize mechanisms responsible for bariatric surgery‐induced bone loss, with careful monitoring of bone health including long‐term fracture incidence in patients undergoing these procedures.
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“Sleeve gastrectomy is becoming increasingly common, with weight loss falling between the purely restrictive and malabsorptive procedures (1 to 2 year weight loss: 20-30%; excess BMI loss: 45-80%).36, 46-50.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [50]
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BackgroundInfluential
Metadata
- Authors
- Brzozowska, M. M., Sainsbury, A., Eisman, J. A., Baldock, P. A., & Center, J. R.
- Affiliations
- Garvan Institute of Medical Research (AU)
- The University of Sydney (AU)
- Osteoporosis and Bone Biology Division Garvan Institute of Medical Research Sydney Australia
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2012-10-25
- Volume
- 14
- Issue
- 1
- Pages
- 52-67
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W1909242889
- Cited by
- 128
- References
- 206
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 14 · 2015: 13 · 2014: 20 · 2013: 12
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- bariatric surgery, bone loss, obesity, bone metabolism, nutritional deficiency, rapid weight loss, adipokines, gastrointestinal hormones, appetite regulation, energy homeostasis, bone homeostasis, abdominal obesity, bone marrow fat, osteoporosis, fracture risk
- MeSH terms
- Avitaminosis, Bone and Bones, Bone Resorption, Gastrointestinal Hormones, Humans, Nutritional Requirements, Nutritional Status, Obesity, Morbid, Osteoporosis, Weight Loss, Bariatric Surgery
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