Cited by 128Bariatric Surgery and OutcomesBone health and osteoporosis researchBone Metabolism and Diseases

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Bariatric surgery, bone loss, obesity and possible mechanisms

Brzozowska, M. M., Sainsbury, A., Eisman, J. A., Baldock, P. A., Center, J. R.·2013·Obesity Reviews

DOI 10.1111/j.1467-789x.2012.01050.x

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Abstract

Summary: Bariatric surgery remains the most effective treatment for severely obese patients. However, the potential long‐term effects of bariatric surgical procedures on health, including bone health, are only partially understood. The goal of this review was to present data on the impact of bariatric surgery on bone metabolism and to analyse possible reasons for the loss of bone mass that frequently occurs after bariatric surgery. Such factors include nutritional deficiencies, rapid weight loss per se, effects of fat‐derived adipokines and gut‐derived appetite‐regulatory hormones. However, the relative roles of these factors in skeletal regulation and the mechanisms by which they work are not yet fully defined. Our review was focussed on the complex relationship between body weight, fat mass and bone mass, as well as peripheral and central mediators potentially involved in the dual regulation of both energy and bone homeostasis. We also review the data on the inverse relationship between central obesity, bone marrow fat and osteoporosis. As the number of bariatric operations increases, it is imperative to recognize mechanisms responsible for bariatric surgery‐induced bone loss, with careful monitoring of bone health including long‐term fracture incidence in patients undergoing these procedures.

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Bariatric Surgery: A Systematic Review and Meta-analysis
Buchwald, H., Avidor, Y., Braunwald, E., Jensen, M. D., Pories, W., Fahrbach, K., & Schoelles, K. (2004) · JAMA · doi:10.1001/jama.292.14.1724 · Cited by 6,800
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Prospective Studies Collaboration (2009) · The Lancet · doi:10.1016/s0140-6736(09)60318-4 · Cited by 4,807
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · cited 1×
“The circulating concentrations of ghrelin increase under pre-prandial and fasting (157) conditions, and this change likely contributes to the drive to eat after periods without food (157).”
Background
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
Seeman, E., & Delmas, P. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmra053077 · Cited by 2,157
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604
Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
Buse, J. B., Henry, R. R., Han, J., Kim, D. D., Fineman, M. S., Baron, A. D., & for the Exenatide-113 Clinical Study Group (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2628 · Cited by 1,346
Leptin regulation of bone resorption by the sympathetic nervous system and CART
Elefteriou, F., Ahn, J. D., Takeda, S., Starbuck, M., Yang, X., Liu, X., Kondo, H., Richards, W. G., Bannon, T. W., Noda, M., et al. (2005) · Nature · doi:10.1038/nature03398 · Cited by 1,311
Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.
Riggs, B. L., Wahner, H. W., Dunn, W. L., Mazess, R. B., Offord, K. P., & Melton, L. J. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110039 · Cited by 1,194
Adiponectin and development of type 2 diabetes in the Pima Indian population
Lindsay, R. S., Funahashi, T., Hanson, R. L., Matsuzawa, Y., Tanaka, S., Tataranni, P. A., Knowler, W. C., & Krakoff, J. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09335-2 · Cited by 1,094
Clinical Implications of the Osteoprotegerin/RANKL/RANK System for Bone and Vascular Diseases
Hofbauer, L. C. (2004) · JAMA · doi:10.1001/jama.292.4.490 · Cited by 990
Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters
Roux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985
Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
Ferron, M., Hinoi, E., Karsenty, G., & Ducy, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711119105 · Cited by 900
Growth Hormone and Bone
Ohlsson, C., Bengtsson, B., Isaksson, O. G. P., Andreassen, T. T., & Slootweg, M. C. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.1.0324 · Cited by 863
Osteopontin--a possible anchor of osteoclasts to bone.
Reinholt, F. P., Hultenby, K. R., Oldberg, Å., & Heinegård, D. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4473 · Cited by 831
Weight Loss, Appetite Suppression, and Changes in Fasting and Postprandial Ghrelin and Peptide-YY Levels After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy
Karamanakos, S. N., Vagenas, K., Kalfarentzos, F. E., & Alexandrides, T. K. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e318156f012 · Cited by 831
Changes in Bone Mineral Density of the Proximal Femur and Spine with Aging
Riggs, B. L., Wahner, H. W., Seeman, E., Offord, K. P., Dunn, W. L., Mazess, R. B., Johnson, K. A., & Melton, L. J. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110667 · Cited by 816
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
Sun, Y., Wang, P., Zheng, H., & Smith, R. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305930101 · Cited by 756
Deletion of Ghrelin Impairs neither Growth nor Appetite
Sun, Y., Ahmed, S., & Smith, R. G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7973-7981.2003 · Cited by 651
Osteopontin
Scatena, M., Liaw, L., & Giachelli, C. M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.144824 · Cited by 643
SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
Bradshaw, A. D., & Sage, E. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12939 · Cited by 638
The Early Effect of the Roux-en-Y Gastric Bypass on Hormones Involved in Body Weight Regulation and Glucose Metabolism
Rubino, F., Gagner, M., Gentileschi, P., Kini, S. U., Fukuyama, S., Feng, J. J., & Diamond, E. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133117.12646.48 · Cited by 638
Relationship of Obesity with Osteoporosis
Zhao, L.-J., Liu, Y., Liu, P.-Y., Hamilton, J., Recker, R. R., & Deng, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0572 · Cited by 626
Relationships among body mass, its components, and bone11Published simultaneously at BoneKEy-Osteovision (http://www.bonekey-ibms.org), a Web site sponsored by the International Bone and Mineral Society.
Reid, I. R. (2002) · Bone · doi:10.1016/s8756-3282(02)00864-5 · Cited by 625
Skeletal disease in primary hyperparathyroidism
Silverberg, S. J., Shane, E. J., de la Cruz, L., Dempster, D. W., Feldman, F., Seldin, D. W., Jacobs, T. P., Siris, E. S., Cafferty, M. S., Parisien, M. V., et al. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040302 · Cited by 621
Glucagon-Like Peptide-1-(7–36)Amide Is Transformed to Glucagon-Like Peptide-1-(9–36)Amide by Dipeptidyl Peptidase IV in the Capillaries Supplying the L Cells of the Porcine Intestine1
Hansen, L., Deacon, C. F., Ørskov, C., & Holst, J. J. (1999) · Endocrinology · doi:10.1210/endo.140.11.7143 · Cited by 595
Glucagon-like peptide-1: a potent regulator of food intake in humans
Gutzwiller, J.-P., Göke, B., Drewe, J., Hildebrand, P., Ketterer, S., Handschin, D., Winterhalder, R., Conen, D., & Beglinger, C. (1999) · Gut · doi:10.1136/gut.44.1.81 · Cited by 577
Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity
Vendrell, J. J., Broch, M., Vilarrasa, N., Molina, A., Gómez, J. M., Gutiérrez, C., Simón, I., Soler, J., & Richart, C. (2004) · Obesity Research · doi:10.1038/oby.2004.118 · Cited by 558
Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
Hsu, Y.-H., Venners, S. A., Terwedow, H. A., Feng, Y., Niu, T., Li, Z., Laird, N., Brain, J. D., Cummings, S. R., Bouxsein, M. L., et al. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.1.146 · Cited by 537
Leptin is a potent stimulator of bone growth in ob/ob mice
Steppan, C. M., Crawford, D. T., Chidsey-Frink, K. L., Ke, H., & Swick, A. G. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00152-x · Cited by 512
Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause.
Riggs, B. L., Wahner, H. W., Melton, L. J., Richelson, L. S., Judd, H. L., & Offord, K. P. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112462 · Cited by 511
Adiponectin and its receptors are expressed in bone-forming cells
Berner, H. S., Lyngstadaas, S. P., Spahr, A., Monjo, M., Thommesen, L., Drevon, C. A., Syversen, U., & Reseland, J. E. (2004) · Bone · doi:10.1016/j.bone.2004.06.008 · Cited by 507
Molecular Basis and Clinical Application of Biological Markers of Bone Turnover*
Calvo, M. S., Eyre, D. R., & Gundberg, C. M. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-4-333 · Cited by 506
Sleeve Gastrectomy as Sole and Definitive Bariatric Procedure: 5-Year Results for Weight Loss and Ghrelin
Bohdjalian, A., Langer, F. B., Shakeri-Leidenmühler, S., Gfrerer, L., Ludvik, B., Zacherl, J., & Prager, G. (2010) · Obesity Surgery · doi:10.1007/s11695-009-0066-6 · Cited by 503
Plasma Acylation-Stimulating Protein, Adiponectin, Leptin, and Ghrelin before and after Weight Loss Induced by Gastric Bypass Surgery in Morbidly Obese Subjects
Faraj, M., Havel, P. J., Phélis, S., Blank, D. W., Sniderman, A. D., & Cianflone, K. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021309 · Cited by 500
Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.
Näslund, E., Barkeling, B., King, N., Gutniak, M., Blundell, J., Holst, J., Rössner, S., & Hellström, P. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800818 · Cited by 468
Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
Inui, A., Asakawa, A., Bowers, C. Y., Mantovani, G., Laylano, A., Meguid, M. M., & Fujimiya, M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0641rev · Cited by 438
Hypothalamic Y2 receptors regulate bone formation
Baldock, P. A. J., Sainsbury, A., Couzens, M., Enriquez, R. F., Thomas, G. P., Gardiner, E. M., & Herzog, H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14588 · Cited by 434
Self-citation
Determinants of total body and regional bone mineral density in normal postmenopausal women--a key role for fat mass
Reid, I. R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.1.45 · Cited by 433
Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass
Coates, P. S., Fernstrom, J. D., Fernstrom, M. H., Schauer, P. R., & Greenspan, S. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031756 · Cited by 423 · cited 4×
“These changes have been noted as early as 3 months post surgery (45,50,51), and occurred in spite of patients taking routinely recommended calcium and vitamin D supplements (45–47,49,54,55,57).”
BackgroundInfluential
Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast
Oshima, K., Nampei, A., Matsuda, M., Iwaki, M., Fukuhara, A., Hashimoto, J., Yoshikawa, H., & Shimomura, I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.210 · Cited by 403
Relation between body size and bone mineral density in elderly men and women.
Edelstein, S. L., & Barrett-Connor, E. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116842 · Cited by 400
Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects
Morínigo, R., Moizé, V., Musri, M., Lacy, A. M., Navarro, S., Marín, J. L., Delgado, S., Casamitjana, R., & Vidal, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0904 · Cited by 397
Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner
Wang, Y., Lam, K. S. L., Xu, J. Y., Lü, G., Xu, L. Y., Cooper, G. J. S., & Xu, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501149200 · Cited by 386
Adiponectin Stimulates RANKL and Inhibits OPG Expression in Human Osteoblasts Through the MAPK Signaling Pathway
Luo, X., Guo, L., Xie, H., Yuan, L., Wu, X., Zhou, H., & Liao, E.-Y. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060707 · Cited by 376
Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
Idris, A. I., van 't Hof, R. J., Greig, I. R., Ridge, S. A., Baker, D., Ross, R. A., & Ralston, S. H. (2005) · Nature Medicine · doi:10.1038/nm1255 · Cited by 356
Reciprocal relations of subcutaneous and visceral fat to bone structure and strength
Gilsanz, V., Chalfant, J., Mo, A. O., Lee, D. C., Dorey, F. J., & Mittelman, S. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2422 · Cited by 351
Vertebral Bone Marrow Fat Is Positively Associated With Visceral Fat and Inversely Associated With IGF‐1 in Obese Women
Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Rosen, C. J., Klibanski, A., & Miller, K. K. (2010) · Obesity · doi:10.1038/oby.2010.106 · Cited by 346
Growth Hormone and Bone
Ohlsson, C. (1998) · Endocrine Reviews · doi:10.1210/er.19.1.55 · Cited by 346
The Gut Hormone Peptide YY Regulates Appetite
Batterham, R. L., & Bloom, S. R. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03176.x · Cited by 345
Body Composition, Dietary Intake, and Energy Expenditure After Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Vertical Banded Gastroplasty: A Randomized Clinical Trial
Olbers, T., Bj??rkman, S., Lindroos, A., Maleckas, A., L??nn, L., Sj??str??m, L., & L??nroth, H. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000218085.25902.f8 · Cited by 340
Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass
Korner, J., Inabnet, W., Febres, G., Conwell, I. M., McMahon, D. J., Salas, R., Taveras, C., Schrope, B., & Bessler, M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.79 · Cited by 338
Osteopenia and decreased bone formation in osteonectin-deficient mice
Delany, A. M., Amling, M., Priemel, M., Howe, C. C., Baron, R., & CANALIS, E. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7039 · Cited by 331
Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety
Borg, C.-M., le Roux, C. W., Ghatei, M. A., Bloom, S. R., Patel, A. G., & Aylwin, S. J. B. (2006) · British journal of surgery · doi:10.1002/bjs.5227 · Cited by 325
Ghrelin Directly Regulates Bone Formation
Fukushima, N., Hanada, R., Teranishi, H., Fukue, Y., Tachibana, T., Ishikawa, H., Takeda, S., Takeuchi, Y., Fukumoto, S., Kangawa, K., et al. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041237 · Cited by 325
Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans
Holdstock, C., Engström, B. E., Öhrvall, M., Lind, L., Sundbom, M., & Karlsson, F. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021734 · Cited by 318
The Murine Glucagon-Like Peptide-1 Receptor Is Essential for Control of Bone Resorption
Yamada, C., Yamada, Y., Tsukiyama, K., Yamada, K., Udagawa, N., Takahashi, N., Tanaka, K., Drucker, D. J., Seino, Y., & Inagaki, N. (2008) · Endocrinology · doi:10.1210/en.2007-1292 · Cited by 318
Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus
Yatagai, T., Nagasaka, S., Taniguchi, A., Fukushima, M., Nakamura, T., Kuroe, A., Nakai, Y., & Ishibashi, S. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00195-1 · Cited by 315
Leptin Reduces Ovariectomy-Induced Bone Loss in Rats
Burguera, B. G., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L., & Turner, R. T. (2001) · Endocrinology · doi:10.1210/endo.142.8.8346 · Cited by 313
Nutritional Deficiencies in Obesity and After Bariatric Surgery
Xanthakos, S. A. (2009) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2009.07.002 · Cited by 311
Adiponectin as a novel determinant of bone mineral density and visceral fat
Lenchik, L., Register, T. C., Hsu, F.-C., Lohman, K., Nicklas, B. J., Freedman, B. I., Langefeld, C. D., Carr, J. J., & Bowden, D. W. (2003) · Bone · doi:10.1016/s8756-3282(03)00237-0 · Cited by 305
Obesity and fractures in postmenopausal women
Premaor, M. O., Pilbrow, L., Tonkin, C., Parker, R. A., & Compston, J. E. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.091004 · Cited by 304
Feeding and drinking elicited by central injection of neuropeptide Y: Evidence for a hypothalamic site(s) of action
Stanley, B. G., Chin, A. S., & LEIBOWITZ, S. F. (1985) · Brain Research Bulletin · doi:10.1016/0361-9230(85)90100-5 · Cited by 285
Obesity as a protective factor for postmenopausal osteoporosis.
Cecilia Albala, B., Yáñez, M., Enzo Devoto, C., Sostin, C., Zeballos, L., & Santos, J. L. (1996) · PubMed · Cited by 282
The decline in hip bone density after gastric bypass surgery is associated with extent of weight loss
Fleischer, J., Stein, E. M., Bessler, M., Badia, M. D., Restuccia, N., Olivero-Rivera, L., McMahon, D. J., & Silverberg, S. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0481 · Cited by 278
Effect of peptide YY on gastric, pancreatic, and biliary function in humans
Adrian, T. E., Savage, A. P., Sagor, G. R., Allen, J. M., Bacarese-Hamilton, A. J., Tatemoto, K., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90442-1 · Cited by 276
Bone and Body Composition of Children and Adolescents With Repeated Forearm Fractures
Goulding, A., Grant, A. M., & Williams, S. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050820 · Cited by 276
DXA in vivo BMD methodology: An erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodelling
Bolotin, H. H. (2007) · Bone · doi:10.1016/j.bone.2007.02.022 · Cited by 274
Leptin Treatment Induces Loss of Bone Marrow Adipocytes and Increases Bone Formation in Leptin-Deficient ob/ob Mice
Hamrick, M. W., Della-Fera, M. A., Choi, Y.-H., Pennington, C., Hartzell, D., & Baile, C. A. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050103 · Cited by 268 · cited 1×
“Given the greater contribution of cortical bone mass to total BMD and content than trabecular bone (104), this differential effect of leptin on trabecular and cortical bone probably accounts for the observation of decreased weightcorrected BMC and BMD in ob/ob mice (102), as well as independent reports of overall decr…”
Background
Leptin receptor action and mechanisms of leptin resistance
Münzberg, H., Björnholm, M., Bates, S. H., & Myers, M. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4432-1 · Cited by 267
Visfatin: the missing link between intra-abdominal obesity and diabetes?
Sethi, J. K., & Vidal‐Puig, A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.06.010 · Cited by 267
Effect of an energy-restrictive diet, with or without exercise, on lean tissue mass, resting metabolic rate, cardiovascular risk factors, and bone in overweight postmenopausal women
Svendsen, O. L., Hassager, C., & Christiansen, C. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90253-l · Cited by 257
Evidence for the necessity to systematically assess micronutrient status prior to bariatric surgery
Ernst, B., Thurnheer, M., Schmid, S. M., & Schultes, B. (2009) · Obesity Surgery · doi:10.1007/s11695-008-9545-4 · Cited by 255 · cited 2×
“While reductions in weight bearing (26) and delivery of vital nutrients such as vitamin D and calcium (27,28) are likely important contributors to bariatric surgery-induced bone loss, in this review, we focus on novel potential mechanisms emanating from the adipose tissue–gut–brain axis.”
Background
Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study
von Mühlen, D. G., Safii, S. H., Jassal, S. K., Svartberg, J. B., & Barrett-Connor, E. L. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0385-1 · Cited by 254
Effects of PYY1–36and PYY3–36on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects
Sloth, B., Holst, J. J., Flint, A., Gregersen, N. T., & Astrup, A. V. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00450.2006 · Cited by 250
Elevated Peptide YY Levels in Adolescent Girls with Anorexia Nervosa
Misra, M., Miller, K. K., Tsai, P., Gallagher, K. M., Lin, A., Lee, N., Herzog, D. B., & Klibanski, A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1878 · Cited by 248
Differential Effects of Gastric Bypass and Banding on Circulating Gut Hormone and Leptin Levels
Korner, J., Inabnet, W., Conwell, I. M., Taveras, C., Daud, A., Olivero‐Rivera, L., Restuccia, N. L., & Bessler, M. (2006) · Obesity · doi:10.1038/oby.2006.179 · Cited by 240 · cited 3×
“However, most studies demonstrate a decrease in fasting and/or postprandial circulating ghrelin levels in RYGB patients compared with control patients and to baseline readings, with this change possibly contributing to the greater weight loss associated with this procedure than with less invasive procedures such as ga…”
Background
Bone, Fat, and Body Composition: Evolving Concepts in the Pathogenesis of Osteoporosis
Rosen, C. J., & Klibanski, A. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.11.027 · Cited by 236
Bone and gastric bypass surgery: effects of dietary calcium and vitamin D
Goode, L. R., Brolin, R. E., Chowdhury, H. A., & Shapses, S. A. (2004) · Obesity Research · doi:10.1038/oby.2004.7 · Cited by 233
Bariatric Surgery in Adolescents
Tsai, W. S., Inge, T. H., & Burd, R. S. (2007) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.161.3.217 · Cited by 231
Regulation of bone remodeling by the central and peripheral nervous system
Elefteriou, F. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.016 · Cited by 229
Vitamin and Trace Mineral Levels after Laparoscopic Gastric Bypass
Madan, A. K., Orth, W. S., Tichansky, D. S., & Ternovits, C. A. (2006) · Obesity Surgery · doi:10.1381/096089206776945057 · Cited by 216
Serum Adiponectin and Bone Mineral Density in Women
Richards, J. B., Valdes, A. M., Burling, K., Perks, U., & Spector, T. D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2097 · Cited by 214
Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism
Thommesen, L., Stunes, A. K., Monjo, M., Grøsvik, K., Tamburstuen, M. V., Kjøbli, E., Lyngstadaas, S. P., Reseland, J. E., & Syversen, U. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20915 · Cited by 209
Central control of bone remodeling by neuromedin U
Sato, S., Hanada, R., Kimura, A., Abe, T., Μatsumoto, T., Iwasaki, M., Inose, H., Ida, T., Mieda, M., Takeuchi, Y., et al. (2007) · Nature Medicine · doi:10.1038/nm1640 · Cited by 208
Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells
Kim, S. W., Her, S. J., Park, S. J., Kim, D., Park, K. S., Lee, H. K., Han, B. H., Kim, M., Shin, C. S., & Kim, S. Y. (2005) · Bone · doi:10.1016/j.bone.2005.04.020 · Cited by 205
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
Tam, J., Trembovler, V., Marzo, V. D., Petrosino, S., Leo, G., Alexandrovich, A., Regev, E., Casap, N., Shteyer, A., Ledent, C. A., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7957com · Cited by 203
Is Leptin the Link Between Fat and Bone Mass?
Thomas, T., & Burguera, B. G. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.9.1563 · Cited by 203
Bone Mineral Changes in Obese Women During a Moderate Weight Loss With and Without Calcium Supplementation
Jensen, L. B., Kollerup, G., QUAADE, F., & Sørensen, O. H. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.1.141 · Cited by 201
Novel Role of Y1 Receptors in the Coordinated Regulation of Bone and Energy Homeostasis
Baldock, P. A. J., Allison, S. J., Lundberg, P., Lee, N. J., Slack, K., Lin, E.-J. D., Enriquez, R. F., McDonald, M. M., Zhang, L., During, M. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700644200 · Cited by 200
Self-citation
The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle‐aged men
Oh, K. W., Lee, W., Rhee, E., Baek, K. H., Yoon, K., Kang, M. I., Yun, E. J., Park, C., Ihm, S. H., Choi, M. G., et al. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02312.x · Cited by 200
Ghrelin: a Gut-Brain Hormone: Effect of Gastric Bypass Surgery
Geloneze, B., Tambascia, M. A., Pilla, V. F., Geloneze, S. R., Repetto, E., & Pareja, J. C. (2003) · Obesity Surgery · doi:10.1381/096089203321136539 · Cited by 198
On the Mechanism of Cancellous Bone Preservation in Postmenopausal Women with Mild Primary Hyperparathyroidism1
Dempster, D. W., Parisien, M. V., Silverberg, S. J., Liang, X. G., Schnitzer, M., Shen, V., Shane, E. J., Kimmel, D. B., Recker, R. R., Lindsay, R., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5652 · Cited by 195
Effect of Human Body Weight Changes on Circulating Levels of Peptide YY and Peptide YY3–36
Pfluger, P. T., Kampe, J., Castañeda, T. R., Vahl, T. P., D’Alessio, D. A., Kruthaupt, T., Benoit, S. C., Cuntz, U., Rochlitz, H., Moehlig, M., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1425 · Cited by 193
Changes of Body Weight and Plasma Ghrelin Levels after Gastric Banding and Gastric Bypass
Stoeckli, R., Chanda, R., Langer, I., & Keller, U. B. (2004) · Obesity Research · doi:10.1038/oby.2004.43 · Cited by 192
Effect of GLP-1 Treatment on Bone Turnover in Normal, Type 2 Diabetic, and Insulin-Resistant States
Nuche‐Berenguer, B., Moreno, P., Esbrit, P., Dapía, S., Caeiro, J. R., Cancelas, J., Haro‐Mora, J. J., & Villanueva‐Peñacarrillo, M. L. (2009) · Calcified Tissue International · doi:10.1007/s00223-009-9220-3 · Cited by 192
Ghrelin regulates proliferation and differentiation of osteoblastic cells
Maccarinelli, G., Sibilia, V., Torsello, A., Raimondo, F., Pitto, M., Giustina, A., Netti, C., & Cocchi, D. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05837 · Cited by 189
Relationships between Serum Adipokines, Insulin Levels, and Bone Density in Girls with Anorexia Nervosa
Misra, M., Miller, K. K., Cord, J., Prabhakaran, R., Herzog, D. B., Goldstein, M. A., Katzman, D. K., & Klibanski, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2855 · Cited by 186
The Long-term Effects of Gastric Bypass on Vitamin D Metabolism
Johnson, J. M., Maher, J. W., DeMaria, E. J., Downs, R. W., Wolfe, L. G., & Kellum, J. M. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000216773.47825.c1 · Cited by 184
Potential value of vertebral proton MR spectroscopy in determining bone weakness.
Schellinger, D., Lin, C. S., Hatipoğlu, H. G., & Fertikh, D. (2001) · PubMed Central · Cited by 181
Effects of Gastric Bypass Procedures on Bone Mineral Density, Calcium, Parathyroid Hormone, and Vitamin D
Johnson, J. M., Maher, J. W., Samuel, I., Heitshusen, D. S., Doherty, C., & Downs, R. W. (2005) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2005.07.012 · Cited by 179
Effect of diet-induced weight loss on total body bone mass
Compston, J. E., Laskey, M. A., Croucher, P. I., Coxon, A. Y., & Kreitzman, S. N. (1992) · Clinical Science · doi:10.1042/cs0820429 · Cited by 173
Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study
Lalmohamed, A., de Vries, F., Bazelier, M. T., Cooper, A., van Staa, T.-P., Cooper, C., & Harvey, N. C. (2012) · BMJ · doi:10.1136/bmj.e5085 · Cited by 173
Changes in bone mineral density, body composition and adiponectin levels in morbidly obese patients after bariatric surgery
Carrasco, F., Ruz, M., Rojas, P., Csendes, A., Rebolledo, A., Codoceo, J., Inostroza, J., Basfi-fer, K., Papapietro, K., Rojas, J., et al. (2009) · Obesity Surgery · doi:10.1007/s11695-008-9638-0 · Cited by 169
Different Plasma Ghrelin Levels after Laparoscopic Gastric Bypass and Adjustable Gastric Banding in Morbid Obese Subjects
Leonetti, F., Silecchia, G., Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Tiberti, C., Iannucci, C. V., Perrotta, N., Bacci, V., Basso, M. S., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030133 · Cited by 167
Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
Delhanty, P. J. D., van der Eerden, B. C. J., van der Velde, M., Gauna, C., Pols, H. A. P., Jahr, H., Chiba, H., van der Lely, A. J., & van Leeuwen, J. P. T. M. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06404 · Cited by 167
Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight
Baldock, P. A., Lee, N. J., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E.-J. D., Zhang, L., Enriquez, R. F., Wong, I. P. L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008415 · Cited by 164
Self-citation
Changes in bone mineral content after surgical treatment of morbid obesity
von Mach, M.-A., Stoeckli, R., Bilz, S., Kraenzlin, M., Langer, I., & Keller, U. (2004) · Metabolism · doi:10.1016/j.metabol.2004.01.015 · Cited by 164
Effect of Bariatric Surgery on Cardiovascular Risk Profile†Drs. Heneghan and Meron-Eldar contributed equally to this article.
Heneghan, H., Eldar, S. M., Brethauer, S. A., Schauer, P. R., & Young, J. B. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.06.076 · Cited by 161
Metabolic Bone Disease after Gastric Bypass Surgery for Obesity
Prisco, C. D., & Levine, S. N. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200502000-00001 · Cited by 161
Calcium Supplementation Suppresses Bone Turnover During Weight Reduction in Postmenopausal Women
Ricci, T. A., Chowdhury, H., Heymsfield, S., Stahl, T. J., Pierson, R. N., & Shapses, S. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.6.1045 · Cited by 155
On the Mechanism of Cancellous Bone Preservation in Postmenopausal Women with Mild Primary Hyperparathyroidism
Dempster, D. W. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.5.1562 · Cited by 155
Hypothalamic Control of Bone Formation: Distinct Actions of Leptin and Y2 Receptor Pathways
Baldock, P. A. J., Sainsbury, A., Allison, S. J., Lin, E.-J. D., Couzens, M., Boey, D., Enriquez, R. F., During, M. J., Herzog, H., & Gardiner, E. M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050523 · Cited by 150
Self-citation
Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus
Olszewski, P. K., Li, D., Grace, M. K., Billington, C. J., Kotz, C. M., & Levine, A. S. (2003) · Peptides · doi:10.1016/s0196-9781(03)00105-0 · Cited by 148
Effect of a lifestyle intervention on bone mineral density in premenopausal women: a randomized trial
Salamone, L. M., Cauley, J. A., Black, D. M., Simkin‐Silverman, L. R., Lang, W., Gregg, E. W., Palermo, L., Epstein, R. S., Kuller, L. H., & Wing, R. R. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.1.97 · Cited by 143
Leptin Decreases Food Intake Induced by Melanin-Concentrating Hormone (MCH), Galanin (GAL) and Neuropeptide Y (NPY) in the Rat
Sahu, A. (1998) · Endocrinology · doi:10.1210/endo.139.11.6432 · Cited by 137
Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women.
Garnero, P., & Delmas, P. D. (2004) · PubMed · Cited by 136
Relationships between serum adiponectin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in Chinese men
Peng, X.-D., Xie, H., Zhao, Q., Wu, X., Sun, Z., & Liao, E.-Y. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.08.012 · Cited by 136
Bone Marrow Fat and Bone Mineral Density on Proton MR Spectroscopy and Dual-Energy X-Ray Absorptiometry:Their Ratio as a New Indicator of Bone Weakening
Schellinger, D., Lin, C. S., Lim, J., Hatipoglu, H. G., Pezzullo, J. C., & Singer, A. J. (2004) · American Journal of Roentgenology · doi:10.2214/ajr.183.6.01831761 · Cited by 132
Primary structures of PYY, [Pro34]PYY, and PYY-(3–36) confer different conformations and receptor selectivity
Keire, D. A., Mannon, P., Kobayashi, M., Walsh, J. H., Solomon, T. E., & Reeve, J. R. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.1.g126 · Cited by 126
Characterization of neuropeptide Y binding sites in rat brain membrane preparations using [125I][Leu31,Pro34]peptide YY and [125I]peptide YY3-36 as selective Y1 and Y2 radioligands.
Dumont, Y., Fournier, A., St-Pierre, S. A., & Quirion, R. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24459-7 · Cited by 125
The Role of CNS Fuel Sensing in Energy and Glucose Regulation
Cota, D., Proulx, K., & Seeley, R. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.049 · Cited by 122
Ghrelin and Bone Metabolism in Adolescent Girls with Anorexia Nervosa and Healthy Adolescents
Misra, M., Miller, K. K., Stewart, V., Hunter, E., Kuo, K., Herzog, D. B., & Klibanski, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0512 · Cited by 122
Serum markers of bone turnover are increased at six and 18 months after Roux-en-Y bariatric surgery: correlation with the reduction in leptin
Bruno, C., Fulford, A. D., Potts, J. R., McClintock, R., Jones, R., Cacucci, B. M., Gupta, C. E., Peacock, M., & Considine, R. V. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0265 · Cited by 121
Bone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal women
Pugnale, N., Giusti, V, Suter, M., Zysset, E., Héraïef, E., Gaillard, R. C., & Burckhardt, P. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802177 · Cited by 121
Bone Mineral Density During Reduction, Maintenance and Regain of Body Weight in Premenopausal, Obese Women
Fogelholm, M., nen, H. S., Kukkonen-Harjula, T. K., & Pasanen, M. E. (2001) · Osteoporosis International · doi:10.1007/s001980170130 · Cited by 121
Effect of weight loss on bone mineral content and bone mineral density in obese women
Loan, M. V., Johnson, H., & Barbieri, T. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.4.734 · Cited by 119
Aerobic exercise maintains regional bone mineral density during weight loss in postmenopausal women
Ryan, A. S., Nicklas, B. J., & Dennis, K. E. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.4.1305 · Cited by 118
Surgical Management of Morbid Obesity
Schneider, B. E., & Mun, E. C. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.475 · Cited by 118
Hypothalamic Regulation of Cortical Bone Mass: Opposing Activity of Y2 Receptor and Leptin Pathways
Baldock, P. A. J., Allison, S. J., McDonald, M. M., Sainsbury, A., Enriquez, R. F., Little, D. G., Eisman, J. A., Gardiner, E. M., & Herzog, H. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060705 · Cited by 117
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Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit
Sainsbury, A., & Zhang, L. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.025 · Cited by 113
Self-citation
Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity
Lee, N. J., Doyle, K. L., Sainsbury, A., Enriquez, R. F., Hort, Y., Riepler, S. J., Baldock, P. A. J., & Herzog, H. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.61 · Cited by 113
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Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa
Utz, A. L., Lawson, E. A., Misra, M., Mickley, D. W., Gleysteen, S., Herzog, D. B., Klibanski, A., & Miller, K. K. (2008) · Bone · doi:10.1016/j.bone.2008.03.007 · Cited by 111
Anomalies in the Measurement of Changes in Total-Body Bone Mineral by Dual-Energy X-Ray Absorptiometry During Weight Change
Tothill, P., Hannan, W. J., Cowen, S. J., & Freeman, C. P. L. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1908 · Cited by 109
Short‐Term Effects of Gastric Bypass Surgery on Circulating Ghrelin Levels
Morínigo, R., Casamitjana, R., Moizé, V., Lacy, A. M., Delgado, S., Gomis, R., & Vidal, J. (2004) · Obesity Research · doi:10.1038/oby.2004.139 · Cited by 108
Bone Remodeling, Energy Metabolism, and the Molecular Clock
Rosen, C. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.004 · Cited by 107
Hormonal evaluation following laparoscopic treatment of type 2 diabetes mellitus patients with BMI 20–34
DePaula, A. L., Macedo, A. L. V., Schraibman, V., Mota, B., & Vencio, S. A. C. (2008) · Surgical Endoscopy · doi:10.1007/s00464-008-0168-6 · Cited by 104
From observation to experimentation: leptin action in the mediobasal hypothalamus
Williams, K. W., Scott, M. M., & Elmquist, J. K. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788d · Cited by 104
Regulation of Bone Mass and Bone Turnover by Neuronal Nitric Oxide Synthase
Hof, R. V., MacPhee, J., Libouban, H., Helfrich, M., & Ralston, S. H. (2004) · Endocrinology · doi:10.1210/en.2004-0205 · Cited by 104
Central control of bone formation
Takeda, S., & Karsenty, G. (2001) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740170042 · Cited by 103
Examining the Link Between Bariatric Surgery, Bone Loss, and Osteoporosis: a Review of Bone Density Studies
Scibora, L. M., Ikramuddin, S., Buchwald, H., & Petit, M. A. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0596-1 · Cited by 101
PYY transgenic mice are protected against diet-induced and genetic obesity
Boey, D., Lin, S., Enriquez, R. F., Lee, N. J., Slack, K., Couzens, M., Baldock, P. A. J., Herzog, H., & Sainsbury, A. (2008) · Neuropeptides · doi:10.1016/j.npep.2007.11.003 · Cited by 99
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A High Dairy Protein, High-Calcium Diet Minimizes Bone Turnover in Overweight Adults during Weight Loss
Bowen, J., Noakes, M., & Clifton, P. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.568 · Cited by 97
Leptin Is a Negative Independent Predictor of Areal BMD and Cortical Bone Size in Young Adult Swedish Men
Lorentzon, M., Landin‐Wilhelmsen, K., Mellström, D., & Ohlsson, C. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060814 · Cited by 97
Anomalies in dual energy X-ray absorptiometry measurements of total-body bone mineral during weight change using Lunar, Hologic and Norland instruments.
Tothill, P., Laskey, M. A., Orphanidou, C., & van Wijk, M. (1999) · British Journal of Radiology · doi:10.1259/bjr.72.859.10624323 · Cited by 96
Osteoblast specific Y1 receptor deletion enhances bone mass
Lee, N. J., Nguyen, A., Enriquez, R. F., Doyle, K. L., Sainsbury, A., Baldock, P. A. J., & Herzog, H. (2010) · Bone · doi:10.1016/j.bone.2010.10.174 · Cited by 96
Self-citation
Ghrelin, Leptin and Insulin Levels after Restrictive Surgery: a 2-Year Follow-up Study
Nijhuis, J., van Dielen, F. M. H., Buurman, W. A., & Greve, J. W. M. (2004) · Obesity Surgery · doi:10.1381/0960892041590980 · Cited by 96
Biochemical evidence of metabolic bone disease in women following Roux-Y gastric bypass for morbid obesity
Ott, M. T., Fanti, P., Malluche, H. H., Ryo, U. Y., Whaley, F. S., Strodel, W. E., & Colacchio, T. A. (1992) · Obesity Surgery · doi:10.1381/096089292765559936 · Cited by 96
Medical and Surgical Treatments for Obesity Have Opposite Effects on Peptide YY and Appetite: A Prospective Study Controlled for Weight Loss
Valderas, J. P., Verónica Irribarra, P., Boza, C., de la Cruz, R., Yéssica Liberona, Z., Acosta, A. M., Yolito, M., & Alberto Maiz, G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0983 · Cited by 92
Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss
Vilarrasa, N., Gómez, J. M., Elio, I., Gómez-Vaquero, C., Masdevall, C., Pujol, J., Virgili, N., Burgos, R., Sánchez-Santos, R., de Gordejuela, A. G. R., et al. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9843-5 · Cited by 91
Gastric banding induces negative bone remodelling in the absence of secondary hyperparathyroidism: potential role of serum C telopeptides for follow-up
Giusti, V, Gasteyger, C., Suter, M., Heraief, E., Gaillard, R. C., & Burckhardt, P. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803040 · Cited by 91
Increase of Bone Resorption and the Parathyroid Hormone in Postmenopausal Women in the Long-term after Roux-en-Y Gastric Bypass
Valderas, J. P., Velasco, S., Solari, S., Yéssica Liberona, Z., Paola Viviani, G., Alberto Maiz, G., Escalona, A., & González, G., V (2009) · Obesity Surgery · doi:10.1007/s11695-009-9890-y · Cited by 90
Cart Overexpression Is the Only Identifiable Cause of High Bone Mass in Melanocortin 4 Receptor Deficiency
Ahn, J. D., Dubern, B., Lubrano-Berthelier, C., Clément, K., & Karsenty, G. (2006) · Endocrinology · doi:10.1210/en.2006-0281 · Cited by 90
Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women
Papakitsou, E., Margioris, A. N., Dretakis, K., Trovas, G., Zoras, U., Lyritis, G. P., Dretakis, E. K., & Stergiopoulos, K. (2003) · Maturitas · doi:10.1016/s0378-5122(03)00282-2 · Cited by 89
The New Field of Neuroskeletal Biology
Patel, M. S., & Elefteriou, F. (2007) · Calcified Tissue International · doi:10.1007/s00223-007-9015-3 · Cited by 89
Role of the hypothalamus in the neuroendocrine regulation of body weight and composition during energy deficit
Sainsbury, A., & Zhang, L. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00948.x · Cited by 88
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Peptide YY Regulates Bone Remodeling in Mice: A Link between Gut and Skeletal Biology
Wong, I. P. L., Drießler, F., Khor, E. C., Shi, Y., Hörmer, B. A., Nguyen, A., Enriquez, R. F., Eisman, J. A., Sainsbury, A., Herzog, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040038 · Cited by 87
Self-citation
Effect of Roux-en Y Gastric Bypass on Bone Metabolism in Patients with Morbid Obesity: Mansoura Experiences
Mahdy, T., Attia, S. M., Farid, M., & Adulatif, A. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9653-1 · Cited by 86
Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls
Russell, M., Stark, J., Nayak, S., Miller, K. K., Herzog, D. B., Klibanski, A., & Misra, M. (2009) · Bone · doi:10.1016/j.bone.2009.03.668 · Cited by 83
Changes in Body Composition with Weight Loss: Obese Subjects Randomized to Surgical and Medical Programs
Dixon, J. B., Strauss, B. J., Laurie, C., & O’Brien, P. E. (2007) · Obesity · doi:10.1038/oby.2007.639 · Cited by 83
Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women
Jürimäe, J., & Jürimäe, T. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0365-5 · Cited by 83
The Effect of Laparoscopic Gastric Banding Surgery on Plasma Levels of Appetite-Control, Insulinotropic, and Digestive Hormones
Shak, J. R., Roper, J., Perez-Perez, G. I., Tseng, C., François, F., Gamagaris, Z., Patterson, C., Weinshel, E. H., Fielding, G., Ren, C. J., et al. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9454-6 · Cited by 83
Novel generation of hormone receptor specificity by amino terminal processing of peptide YY
Grandt, D., Teyssen, S., Schimiczek, M., Reeve, J. R., Feth, F., Rascher, W., Hirche, H., Singer, M. V., Layer, P., Goebell, H., et al. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81547-5 · Cited by 82
Peptide YY Regulates Bone Turnover in Rodents
Wortley, K. E., García, K., Okamoto, H., Thabet, K., Anderson, K. D., Shen, V., Herman, J. P., Valenzuela, D. M., Yancopoulos, G. D., Tschöp, M. H., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.024 · Cited by 82
Changes in bone mineral content in obese dieting women.
Andersen, R., Wadden, T., & Herzog, R. (1997) · Metabolism: Clinical and Experimental · doi:10.1016/s0026-0495(97)90070-6 · Cited by 82
Bone mass loss after sleeve gastrectomy: A prospective comparative study with gastric bypass
Nogués, X., Goday, A., Peña, M. J., Benaiges, D., Ramón, M., Crous, X., Vial, M., Pera, M., Grande, L., Díez‐Pérez, A., et al. (2010) · Cirugía Española (English Edition) · doi:10.1016/s2173-5077(10)70015-6 · Cited by 80
Pérdida de masa ósea tras gastrectomía tubular: estudio prospectivo comparativo con el bypass gástrico
Nogués, X., Goday, A., Peña, M. J., Benaiges, D., de Ramón, M., Crous, X., Vial, M., Pera, M., Grande, L., Díez-Pérez, A., et al. (2010) · Cirugía Española · doi:10.1016/j.ciresp.2010.04.008 · Cited by 79
Bone Loss in Adolescents After Bariatric Surgery
Kaulfers, A.-M. D., Bean, J. A., Inge, T. H., Dolan, L. M., & Kalkwarf, H. J. (2011) · PEDIATRICS · doi:10.1542/peds.2010-0785 · Cited by 77
Surgical approaches to the treatment of obesity
Dixon, J. B., Straznicky, N. E., Lambert, É., Schlaich, M. P., & Lambert, G. W. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.112 · Cited by 76
Can BMD Assessed by DXA at Age 8 Predict Fracture Risk in Boys and Girls During Puberty?: An Eight-Year Prospective Study
Flynn, J. A., Foley, S., & Jones, G. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070509 · Cited by 71
Dual-Energy X-Ray Absorptiometry Measurements of Total-Body Bone Mineral During Weight Change
Tothill, P. (2005) · Journal of Clinical Densitometry · doi:10.1385/jcd:8:1:031 · Cited by 69
NPY revealed as a critical modulator of osteoblast function in vitro: New insights into the role of Y1 and Y2 receptors
Teixeira, L., Sousa, D. M., Nunes, A. F., Sousa, M. M., Herzog, H., & Lamghari, M. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22194 · Cited by 69
Ghrelin: A Novel Player in the Gut-Brain Regulation of Growth Hormone and Energy Balance
St-Pierre, D. H., Wang, L., & Taché, Y. (2003) · Physiology · doi:10.1152/nips.01460.2003 · Cited by 63
Validation of a dual energy X-ray absorptiometer: measurement of bone mass and soft tissue composition
Madsen, O. R., Jensen, J.-E. B., & S�rensen, O. H. (1997) · European Journal of Applied Physiology · doi:10.1007/s004210050204 · Cited by 60
Influence of Body Mass Index on the Age-related Slope of Total and Regional Bone Mineral Content
Revilla, M., Villa, L. F., Sanchez-Atrio, A. I., Hernández, E. R., & Rico, H. (1997) · Calcified Tissue International · doi:10.1007/s002239900310 · Cited by 58
Left-Shifted Relation between Calcium and Parathyroid Hormone in Obesity
Hultin, H., Edfeldt, K., Sundbom, M., & Hellman, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2822 · Cited by 50
Downregulation of leptin and resistin expression in blood following bariatric surgery
Edwards, C., Hindle, A. K., Fu, S. W., & Brody, F. J. (2010) · Surgical Endoscopy · doi:10.1007/s00464-010-1494-z · Cited by 48
Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women
Scheid, J. L., Toombs, R. J., Ducher, G., Gibbs, J. C., Williams, N. I., & Souza, M. J. D. (2011) · Bone · doi:10.1016/j.bone.2011.04.011 · Cited by 47
Pancreatic polypeptide, pancreatic glucagon and enteroglucagon in morbid obesity and following gastric bypass operation.
Meryn, S., Stein, D., & Straus, E. W. (1986) · PubMed · Cited by 47
Ghrelin and Bone: Is There an Association in Older Adults?: The Rancho Bernardo Study
Weiss, L. A., Langenberg, C., & Barrett-Connor, E. L. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060209 · Cited by 46
Regulation of Secreted Protein Acidic and Rich in Cysteine during Adipose Conversion and Adipose Tissue Hyperplasia
Carine Chavey, A., Boucher, J., Monthouel, M.-N., Sage, E. H., Castan‐Laurell, I., Valet, P., Tartare‐Deckert, S., & OBBERGHEN, E. V. (2006) · Obesity · doi:10.1038/oby.2006.220 · Cited by 45
Simulated Change in Body Fatness Affects Hologic QDR 4500A Whole Body and Central DXA Bone Measures
Evans, E. M., Mojtahedi, M. C., Kessinger, R. B., & Misic, M. M. (2006) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2006.04.117 · Cited by 42
Solutions in weight control: lessons from gastric surgery
Blackburn, G. L. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.248s · Cited by 41
Leptin and the skeleton
Whipple, T., Sharkey, N. A., Demers, L. M., & Williams, N. I. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01630.x · Cited by 40
Trabecular bone structure in patients with primary hyperparathyroidism
Vogel, M., Hahn, M., & Delling, G. (1995) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00192633 · Cited by 39
Serum peptide YY in response to short-term overfeeding in young men
Cahill, F., Shea, J. L., Randell, E. W., Vasdev, S., & Sun, G. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.003624 · Cited by 37
Evidence for the Involvement of Resistin in Inflammation and Cardiovascular Disease
Gómez‐Ambrosi, J., & Frühbeck, G. (2005) · Current Diabetes Reviews · doi:10.2174/157339905774574392 · Cited by 36
Impact of Gastric Banding on Plasma Ghrelin, Growth Hormone, Cortisol, DHEA and DHEA-S Levels
Ram, E., Vishne, T. H., Diker, D., Gal-Ad, I., Maayan, R., Lerner, I., Dreznik, Z., Seror, D., Vardi, P., & Weizman, A. (2005) · Obesity Surgery · doi:10.1381/0960892055002329 · Cited by 36
Circulating neuropeptide Y (NPY) and catecholamines in rat under resting and stress conditions. Arguments for extra-adrenal origin of NPY, adrenal and extra-adrenal sources of catecholamines
Bernet, F., Dedieu, J. F., Laborie, C., Montel, V., & Dupouy, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00454-6 · Cited by 32
Central regulation of bone mass
Wong, I. P. L., Zengin, A., Herzog, H., & Baldock, P. A. J. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.08.001 · Cited by 30
Self-citation
Changes in NPY and POMC, but not serotonin transporter, following a restricted feeding/repletion protocol in rats
Lauzurica, N., García‐García, L., Pinto, S., Fuentes, J. A., & Delgado, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.075 · Cited by 29
Osteopenia in genetically diabetic db/db mice and effects of 1α-hydroxyvitamin D3 on the osteopenia
Takeshita, N., Mutoh, S., & Yamaguchi, I. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00046-9 · Cited by 26
Expression of ghrelin in fundus is increased after gastric banding in morbidly obese patients
Uzzan, B., Catheline, J.-M., Lagorce, C., Airinei, G., Bon, C., Cohen, R., Perret, G. Y., Aparicio, T., & Benamouzig, R. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9197-9 · Cited by 24
The Relationship between BMI, Plasma Leptin, Insulin and Proinsulin Before and After Laparoscopic Adjustable Gastric Banding
Ram, E., Vishne, T. H., Maayan, R., Lerner, I., Weizman, A., Dreznik, Z., Bloch, K. O., Seror, D., & Vardi, P. (2005) · Obesity Surgery · doi:10.1381/096089205774859146 · Cited by 24

Research works printed but not linked: 2

Hall S, 2007, Basic Biomechanics, 88
10.1172/JCI0214588 · DOI

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Review article: the nutritional and pharmacological consequences of obesity surgery
Stein, J. M., Stier, C. K., Raab, H., & Weiner, R. A. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12872 · Cited by 257
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See all 128

Authors: Brzozowska, M. M., Sainsbury, A., Eisman, J. A., Baldock, P. A., & Center, J. R.
Affiliations: Garvan Institute of Medical Research (AU)
The University of Sydney (AU)
Osteoporosis and Bone Biology Division Garvan Institute of Medical Research Sydney Australia
ORCID: Brzozowska, M. M.
Sainsbury, A.
Eisman, J. A.
Venue: Obesity Reviews
Publisher: Wiley
Published: 2012-10-25
Volume: 14
Issue: 1
Pages: 52-67
ISSN: 1467-7881 (ISSN-L)
1467-789X
DOI: 10.1111/j.1467-789x.2012.01050.x
OpenAlex: W1909242889
Cited by: 128
References: 206
Citations by year: 2026: 3 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 14 · 2015: 13 · 2014: 20 · 2013: 12
FWCI: 2.69
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Obesity Reviews (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: bariatric surgery, bone loss, obesity, bone metabolism, nutritional deficiency, rapid weight loss, adipokines, gastrointestinal hormones, appetite regulation, energy homeostasis, bone homeostasis, abdominal obesity, bone marrow fat, osteoporosis, fracture risk
MeSH terms: Avitaminosis, Bone and Bones, Bone Resorption, Gastrointestinal Hormones, Humans, Nutritional Requirements, Nutritional Status, Obesity, Morbid, Osteoporosis, Weight Loss, Bariatric Surgery

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Bariatric surgery, bone loss, obesity and possible mechanisms

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