Prevalence of risk factors for cardiovascular disease in HIV-infected patients over time: the Swiss HIV Cohort Study
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Objective: Metabolic changes caused by antiretroviral therapy (ART) may increase the risk of coronary heart disease (CHD). We evaluated changes in the prevalence of cardiovascular risk factors (CVRFs) and 10‐year risk of CHD in a large cohort of HIV‐infected individuals. Methods: All individuals from the Swiss HIV Cohort Study (SHCS) who completed at least one CVRF questionnaire and for whom laboratory data were available for the period February 2000 to February 2006 were included in the analysis. The presence of a risk factor was determined using cut‐offs based on the guidelines of the National Cholesterol Education Program (NCEP ATP III), the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7), the American Diabetes Association, and the Swiss Society for Cardiology. Results: Overall, 8033 individuals completed at least one CVRF questionnaire. The most common CVRFs in the first completed questionnaire were smoking (57.0%), low high‐density lipoprotein (HDL) cholesterol (37.2%), high triglycerides (35.7%), and high blood pressure (26.1%). In total, 2.7 and 13.8% of patients were categorized as being at high (>20%) and moderate (10–20%) 10‐year risk for CHD, respectively. Over 6 years the percentage of smokers decreased from 61.4 to 47.6% and the percentage of individuals with total cholesterol >6.2 mmol/L decreased from 21.1 to 12.3%. The prevalence of CVRFs and CHD risk was higher in patients currently on ART than in either pretreated or ART‐naive patients. Conclusion: During the 6‐year observation period, the prevalence of CVRFs remains high in the SHCS. Time trends indicate a decrease in the percentage of smokers and individuals with high cholesterol.
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HAART increases LDL-C and triglycerides and causes predominance of small dense LDL particles, doubling CAD risk compared with HIV-negative subjects.
“Highly active antiretroviral treatment (HAART) causes an increase of LDL-C and TG, and predominance of small, dense LDL particles, thus doubling their CAD risk when compared with HIV-negative subjects.212”
From ESC/EAS Guidelines for the management of dyslipidaemias (2011) · cites this paper as [212]
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- Authors
- Glass, T., Ungsedhapand, C., Wolbers, M., Weber, R., Vernazza, P., Rickenbach, M., Furrer, H., Bernasconi, E., Cavassini, M., Hirschel, B., Battegay, M., Bucher, H., & Study, T. S. H. C.
- Affiliations
- University Hospital of Basel (CH)
- University Hospital Zurich (CH)
- Kantonsspital St. Gallen (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Bern (CH)
- Ospedale regionale di Lugano (CH)
- University Hospital of Geneva (CH)
- Venue
- HIV Medicine
- Publisher
- Wiley
- Published
- 2006-07-24
- Volume
- 7
- Issue
- 6
- Pages
- 404-410
- ISSN
- 1464-2662 (ISSN-L)
- 1468-1293
- OpenAlex
- W2068156414
- Cited by
- 156
- References
- 23
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 9 · 2018: 3 · 2017: 11 · 2016: 13 · 2015: 17 · 2014: 13 · 2013: 11 · 2012: 12
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- HIV Medicine (publishedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- American Diabetes Association
- Cardiovascular Research Foundation
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- cardiovascular risk factors, HIV infection, coronary artery disease, antiretroviral therapy, metabolic changes, smoking, hypercholesterolemia, HDL cholesterol, triglycerides, hypertension, 10-year cardiovascular risk, temporal trends, Swiss HIV Cohort Study
- MeSH terms
- Adult, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypertension, Middle Aged, Surveys and Questionnaires, Risk Factors, Switzerland, Time Factors, Cohort Studies, HIV Infections, Prevalence, Practice Guidelines as Topic, Risk Assessment, Antiretroviral Therapy, Highly Active, Dyslipidemias
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