Idiopathic polyneuropathy and impaired glucose metabolism in a Norwegian patient series
Abstract
Background and purpose: North American studies have indicated a high prevalence of impaired glucose tolerance (IGT) in patients with sensory polyneuropathy. We searched for the occurrence of IGT in a Norwegian patient material with polyneuropathy. Methods: Seventy patients with symptoms and signs of sensory polyneuropathy were included. Cases with known causes of neuropathy were excluded. All patients underwent a 2 h oral glucose tolerance test (OGTT). Nerve conduction studies (NCS), quantitative sensory testing (QST) and skin biopsy with assessment of intra‐epidermal nerve fibre (IENF) density were performed. Results: Sixteen patients (23%) had impaired glucose metabolism (IGM): 2 (3%) were found to have diabetes, 9 (13%) had IGT, 3 (4%) had impaired fasting glucose (IFG) and 2 (3%) both IFG and IGT. About 62% of the patients with IGM and polyneuropathy and 50% of those with chronic idiopathic axonal polyneuropathy (CIAP) had abnormalities on NCS. Reduction of IENF occurred in 37% of the patients with IGM and 43% of those with CIAP. Conclusions: Patients with polyneuropathy and IGM had essentially the same degree of involvement of small and large nerve fibres as patients with CIAP. IGT seems less frequent in Norwegian patients with polyneuropathy than reported in North American populations.
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Evidence is accumulating on increased prevalence of idiopathic polyneuropathy among prediabetic individuals, with IGT being more strongly related to painful than non-painful neuropathy.
“Finally, evidence is accumulating on increased prevalence of idiopathic polyneuropathy (eg, idiopathic sensory/painful neuropathy,73–78 and sensory/small fibre only neuropathy)73,75,78 among prediabetic individuals with IGT being more strongly related to painful than non-painful neuropathy.73,75,78”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [76]
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Prediabetes: a high-risk state for diabetes development
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- Authors
- Nebuchennykh, M., Løseth, S., Jorde, R., & Mellgren, S. I.
- Affiliations
- University Hospital of North Norway (NO)
- Corresponding author
- Nebuchennykh, M.
- ORCID
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2008-07-09
- Volume
- 15
- Issue
- 8
- Pages
- 810-816
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W1967513212
- Cited by
- 49
- References
- 34
- Citations by year
- 2024: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Keywords
- idiopathic polyneuropathy, impaired glucose tolerance, impaired glucose metabolism, impaired fasting glucose, chronic idiopathic axonal polyneuropathy, sensory polyneuropathy, small fiber neuropathy, oral glucose tolerance test, nerve conduction abnormalities, Norwegian patients
- MeSH terms
- Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Female, Glucose, Glucose Tolerance Test, Humans, Male, Middle Aged, Nerve Fibers, Neural Conduction, Norway, Polyneuropathies, Skin, Prevalence, Glucose Intolerance
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