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Cited by 62Amyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment ResearchTreatment of Major Depression

Prevalence of depression in amyotrophic lateral sclerosis and other motor disorders

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Taylor, L., Wicks, P., Leigh, P. N., Goldstein, L. H.·2010·European Journal of Neurology
DOI 10.1111/j.1468-1331.2010.02960.x
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Abstract

Background: Research suggests the prevalence of severe depression in ALS is <20%. In contrast, studies have reported that severe depression affects 40–50% of patients with other neurodegenerative motor conditions (e.g. multiple sclerosis, Parkinson’s disease and Huntington’s disease). The comparison with such disorders has generated a clinical impression that patients with ALS have surprisingly low rates of depression. However, comparisons with such disorders do not take into account the markedly different pathological, physical and behavioural profiles associated with these disorders. To assess further the extent to which ALS is associated with a low prevalence of depression, we compared the prevalence of depression in patients with ALS to that in patients with neuromuscular disorders with more comparable disease profiles. Methods: The Beck Depression Inventory‐II (BDI‐II), the Major Depression Inventory (MDI), the Hospital Anxiety and Depression Scale (HADS) and the ALS Functional Rating Scale‐Revised were sent to 212 patients from a tertiary referral Motor Nerve Clinic in London, UK. Results: Data were obtained from 51 people with ALS and 39 with other neuromuscular disorders. The non‐ALS group included patients diagnosed with disorders that are characterized by motor neurone dysfunction and/or a decline in everyday function. Analyses revealed no between‐group differences on severity and prevalence rates of depression according to the BDI‐II, HADS Depression Subscale and MDI. Conclusions: Our findings do not support the impression that patients with ALS have lower rates of depression than patients with other varied neuromuscular disorders.

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Authors
Taylor, L., Wicks, P., Leigh, P. N., & Goldstein, L. H.
Affiliations
King's College London (GB)
Corresponding author
Goldstein, L. H.
ORCID
Venue
European Journal of Neurology
Publisher
Wiley
Published
2010-07-13
Volume
17
Issue
8
Pages
1047-1053
ISSN
  • 1351-5101 (ISSN-L)
  • 1468-1331
DOI
10.1111/j.1468-1331.2010.02960.x
OpenAlex
W1939100005
Cited by
62
References
34
Citations by year
2025: 1 · 2024: 2 · 2023: 10 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 8
FWCI
4.18
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
amyotrophic lateral sclerosis, depression prevalence, neuromuscular disorders, motor neuron disease, multiple sclerosis, Parkinson's disease, Huntington's disease, depression severity, functional decline, neuropsychiatric symptoms
MeSH terms
Amyotrophic Lateral Sclerosis, Depressive Disorder, Female, Humans, Male, Psychiatric Status Rating Scales, Surveys and Questionnaires, Severity of Illness Index, Prevalence, Patient Selection, Neurodegenerative Diseases

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