The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Role of topical peptides in preventing or treating aged skin
Open accessAbstract
Ageing, a basic biological process seen in all living creatures, is not preventable. Surgical and topical modalities have been invented and substances were applied topically to alter the ageing process. Peptides and proteins, frequently used for this purpose, were categorized into four groups: signal peptides, enzyme-inhibitor peptides, neurotransmitter-inhibitor peptides and carrier peptides. We comprehensively review eligible studies -including controlled ex vivo or in vivo efficacy studies on any topical peptide or protein that has been administered to treat signs and symptoms of ageing.
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“The level of evidence for this article is categorized as Level 2b, as it is based on expert opinion or consensus.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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“Additionally, the article is limited by its focus on theoretical considerations rather than empirical research.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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“Furthermore, the article lacks well‐designed, randomized controlled trials that validate the clinical utility of peptide‐containing skincare products.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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“However, despite the promising theoretical rationale behind the use of topical peptides in skincare, the evidence presented in this article is primarily based on in vitro and animal studies. The level of evidence falls short of providing conclusive proof of the efficacy of topical peptides in human subjects.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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“Overall, the level of evidence presented in this article is classified as Level III according to the Oxford Centre for Evidence‐Based Medicine's hierarchy of evidence.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [47]
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“Numerous studies confirmed the ability of copper peptides to improve condition of aging skin, which make them indispensable in anti-aging and protective cosmetic products [2,3].”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [2]
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Metadata
- Authors
- Gorouhi, F., & Maibach, H. I.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Gorouhi, F.
- Venue
- International Journal of Cosmetic Science
- Publisher
- Wiley
- Published
- 2009-08-27
- Volume
- 31
- Issue
- 5
- Pages
- 327-345
- ISSN
- 0142-5463 (ISSN-L)
- 1468-2494
- OpenAlex
- W2131381649
- Cited by
- 193
- References
- 92
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 11 · 2023: 22 · 2022: 12 · 2021: 11 · 2020: 21 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 12 · 2013: 5 · 2012: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cosmetic Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- skin aging, signal peptide, protein delivery
- MeSH terms
- Administration, Topical, Cosmetics, Humans, Peptides, Skin, Skin Absorption, Skin Aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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