Photodynamic therapy using topical 5-aminolaevulinic acid vs. surgery for basal cell carcinoma
Abstract
BACKGROUND: Photodynamic therapy (PDT) is an attractive modality for the treatment of BCC, based on its generally favorable efficacy, adverse effect profile and its excellent cosmetic outcome. OBJECTIVES: The purpose of the study is to compare the efficacy and cosmetic outcome of photodynamic therapy with topical 5-aminolaevulinic acid (ALA-PDT) vs. simple excision surgery for superficial and nodular basal cell carcinoma (BCC). METHODS: A total of 72 patients, 32 with 48 lesions, were treated with ALA- PDT, and 40 with 46 lesions treated by excision were included in this prospective, comparative, controlled, clinical study. The patients have been followed for 16-37 months (mean 25 months). The PDT was performed in combination with 5-aminolaevulinic acid twice, one month apart. Surgical excision was performed under local anesthesia with a 3-mm margin, followed by histological examination. The cosmetic outcome was evaluated by the physician according to a 4-point scale. RESULTS: Overall 94 BCC were treated. Complete healing rates did not differ significantly between groups, P = 0.64 (46/48 [95.83%] lesions treated with PDT vs. 44/46 [95.65%] lesions with surgery). In the first 12 months of follow-up, 4 lesions had recurred, 2 of which were in the PDT group while 2 lesions after surgery. The mean follow-up was 25 months. The recurrence rate in the ALA-PDT group was 4.16% vs. 4.34% in the surgery group, p = 0.64. The cosmetic outcome was superior for ALA-PDT at all time points. At 12 months, 100% lesions treated with ALA-PDT had an excellent or good cosmetic outcome, according to the investigator, compared with 88.86% with surgery, P = 0.01. CONCLUSION: ALA-PDT offers a similarly high efficacy, and a better cosmetic outcome than simple excision surgery in the treatment of BCC.
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Several studies have shown that PDT results in superior cosmetic outcomes compared to surgical treatment.
“Several studies have shown that PDT results in superior cosmetic outcomes compared to surgical treatment.”
From Photodynamic Therapy for Non-Melanoma Skin Cancers (2016) · cites this paper as [47]
Compared to surgical excision, PDT appears to result in higher BCC recurrence rates.
“Compared to surgical excision, PDT appears to result in higher BCC recurrence rates [42,47,51,52,54].”
From Photodynamic Therapy for Non-Melanoma Skin Cancers (2016) · cites this paper as [47]
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- Authors
- Cosgarea, R., Susan, M., Crisan, M., & Senila, S.
- Affiliations
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- ORCID
- Cosgarea, R.
- Venue
- Journal of the European Academy of Dermatology and Venereology
- Publisher
- Wiley
- Published
- 2012-06-28
- Volume
- 27
- Issue
- 8
- Pages
- 980-984
- ISSN
- 0926-9959 (ISSN-L)
- 1468-3083
- OpenAlex
- W1611326883
- Cited by
- 70
- References
- 19
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 8 · 2018: 11 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 8
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the European Academy of Dermatology and Venereology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- photodynamic therapy, 5-aminolevulinic acid, basal cell carcinoma, surgical excision, cosmetic outcome, recurrence, superficial basal cell carcinoma, nodular basal cell carcinoma, treatment efficacy
- MeSH terms
- Administration, Topical, Aged, Aged, 80 and over, Aminolevulinic Acid, Basal Cell Carcinoma, Female, Humans, Male, Middle Aged, Photochemotherapy, Skin Neoplasms, Photosensitizing Agents
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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