A Randomized Multicenter Study to Compare Two Treatment Regimens of Topical Methyl Aminolevulinate (Metvix ® )‐PDT in Actinic Keratosis of the Face and Scalp
Open accessAbstract
Photodynamic therapy (PDT) with topical methyl aminolevulinate (MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL (regimen I; n=105) or two treatments 1 week apart (regimen II; n=106). Each treatment involved surface debridement, application of Metvix cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system (peak wavelength 634+/-3 nm, light dose 37 J/cm2). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI=87-97%), which was similar to 89% (82-96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% (60-78%) vs 84% (77-91%)), but improved after repeated treatment (88% (82-94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions; however, repeated treatment is recommended for thicker or non-responding lesions.
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Compared with cryotherapy for actinic keratosis MAL-PDT was found to have a better or similar effectiveness (complete response rate 68%-75% after single treatment).
“Compared with cryotherapy for actinic keratosis MAL-PDT was found to have a better or similar effectiveness (complete response rate 68%–75% after single treatment) [129,130].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [129]
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- Authors
- Tarstedt, M., Rosdahl, I., Berne, B., Svanberg, K., & Wennberg, A.
- Affiliations
- Karlstad Central Hospital (SE)
- ORCID
- Svanberg, Katarina
- Venue
- Acta Dermato-Venereologica
- Published
- 2005-09-01
- Volume
- 85
- Issue
- 5
- Pages
- 424-428
- ISSN
- 0001-5555 (ISSN-L)
- OpenAlex
- W2151481608
- Cited by
- 196
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 6 · 2015: 23 · 2014: 11 · 2013: 8 · 2012: 11
- FWCI
- 10.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Acta Dermato Venereologica (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- actinic keratosis, methyl aminolevulinate, photodynamic therapy, treatment regimen comparison, lesion thickness, complete response rate, treatment safety
- MeSH terms
- Administration, Topical, Aged, Aminolevulinic Acid, Facial Dermatoses, Female, Humans, Keratosis, Male, Photochemotherapy, Scalp Dermatoses, Ultraviolet Rays, Photosensitizing Agents
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