Cited by 34Antifungal resistance and susceptibilityBacterial Identification and Susceptibility TestingFungal Plant Pathogen Control

EUCAST technical note on posaconazole

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Arendrup, M.C., Cuenca-Estrella, M., Donnelly, J.P., Hope, W., Lass-Flörl, C., Rodriguez-Tudela, J.-L.·2011·Clinical Microbiology and Infection

Abstract

The European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing (EUCAST-AFST) has determined breakpoints for posaconazole for Candida spp. This Technical Note is based on the EUCAST posaconazole rationale document (available on the EUCAST website: http://www.eucast.org). Species-specific breakpoints for C. albicans, C. parapsilosis and C. tropicalis are S: MIC ≤0.06 mg/L, R: MIC >0.06 mg/L. There are insufficient data to set breakpoints for C. glabrata and C. krusei as well as non-species-related breakpoints. The breakpoints are based upon pharmacokinetic data, epidemiological cut-off values and clinical experience. Breakpoints will be reviewed regularly.

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Crossref · 10.1111/j.1469-0691.2011.03646.x

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Authors
Arendrup, M. C., Cuenca-Estrella, M., Donnelly, J. P., Hope, W., Lass-Flörl, C., & Rodriguez-Tudela, J.-L.
Affiliations
  • Statens Serum Institut (DK)
  • Radboud University Nijmegen (NL)
  • Manchester Academic Health Science Centre (GB)
  • Instituto de Salud Carlos III (ES)
Corresponding author
Arendrup, M.C.
Venue
Clinical Microbiology and Infection
Publisher
Elsevier BV
Published
2011-11
Volume
17
Issue
11
Pages
E16-E17
ISSN
1198-743X (ISSN-L)
OpenAlex
W2104305938
Cited by
34
References
6
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 5
FWCI
2.82
Type
journal article
Language
en
Open access
Locations
  • Clinical Microbiology and Infection (publishedVersion)
  • PubMed (publishedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords
posaconazole, antifungal susceptibility testing, antimicrobial susceptibility breakpoints, Candida species, Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata, Candida krusei, epidemiological cut-off values, MIC
MeSH terms
Antifungal Agents, Candida, Humans, Microbial Sensitivity Tests, Triazoles

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