EUCAST technical note on posaconazole
Open accessAbstract
The European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing (EUCAST-AFST) has determined breakpoints for posaconazole for Candida spp. This Technical Note is based on the EUCAST posaconazole rationale document (available on the EUCAST website: http://www.eucast.org). Species-specific breakpoints for C. albicans, C. parapsilosis and C. tropicalis are S: MIC ≤0.06 mg/L, R: MIC >0.06 mg/L. There are insufficient data to set breakpoints for C. glabrata and C. krusei as well as non-species-related breakpoints. The breakpoints are based upon pharmacokinetic data, epidemiological cut-off values and clinical experience. Breakpoints will be reviewed regularly.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
POS0.5 is an order of magnitude above the defined epidemiological cut-off value for MIC.
“and is an order of magnitude above the defined epidemiological cut-off value for MIC (Arendrup et al. 2011; CLSI 2020).”
From Acquisition of cross-azole tolerance and aneuploidy in <i>Candida albicans</i> strains evolved to posaconazole (2022) · cites this paper as Arendrup et al. 2011
Cites
Krishna, G., Moton, A., Ma, L., Medlock, M. M., & McLeod, J. F. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01034-08 · Cited by 348 · see citing works
Vázquez, J. A., Skiest, D. J., Nieto, L., Northland, R., Sanne, I., Gogate, J. P., Greaves, W. L., & ISAACS, R. E. (2006) · Clinical Infectious Diseases · doi:10.1086/501457 · Cited by 171 · see citing works
Skiest, D. J., Vazquez, J. A., Anstead, G. M., Graybill, J. R., Reynes, J., Ward, D., Hare, R., Boparai, N., & Isaacs, R. (2007) · Clinical Infectious Diseases · doi:10.1086/511039 · Cited by 162 · see citing works
Posaconazole Plasma Concentrations in Juvenile Patients with Invasive Fungal Infection
Krishna, G., Sansone‐Parsons, A., Martinho, M., Kantesaria, B. S., & Pedicone, L. D. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00454-06 · Cited by 155 · see citing works
Vázquez, J. A., Skiest, D. J., Tissot‐Dupont, H., Lennox, J. L., Boparai, N., & Isaacs, R. (2007) · HIV Clinical Trials · doi:10.1310/hct0802-86 · Cited by 66 · see citing works
Krishna, G., Ma, L., Vickery, D., Yu, X. Y., Wu, I., Power, E., Beresford, E., & Komjathy, S. F. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00889-09 · Cited by 55 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Antifungal Susceptibility Testing: Current Approaches
Berkow, E. L., Lockhart, S. R., & Ostrosky‐Zeichner, L. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00069-19 · Cited by 394 · see citing works
ESCMID guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures.
Cuenca-Estrella, M., Verweij, P. E., Arendrup, M. C., Arikan-Akdagli, S., Bille, J., Donnelly, J. P., Jensen, H. E., Lass-Flörl, C., Richardson, M. D., Akova, M., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12038 · Cited by 386 · see citing works
Self-citationCendejas‐Bueno, E., Kolecka, A., Alastruey‐Izquierdo, A., Theelen, B., Groenewald, M., Kostrzewa, M., Cuenca‐Estrella, M., Gómez‐López, A., & Boekhout, T. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.02248-12 · Cited by 234 · see citing works
Self-citationNational Surveillance of Fungemia in Denmark (2004 to 2009)
Arendrup, M. C., Bruun, B., Christensen, J. J., Fuursted, K., Johansen, H. K., Kjældgaard, P., Knudsen, J. D., Kristensen, L., Møller, J., Nielsen, L., et al. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01811-10 · Cited by 223 · see citing works
Self-citationArendrup, M. C., Dzajic, E., Jensen, R. H., Johansen, H. K., Kjaldgaard, P., Knudsen, J. D., Kristensen, L., Leitz, C., Lemming, L. E., Nielsen, L., et al. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12212 · Cited by 206 · see citing works
Self-citationEspinel-Ingroff, A., Pfaller, M. A., Bustamante, B., Canton, E., Fothergill, A., Fuller, J., Gonzalez, G. M., Lass-Flörl, C., Lockhart, S. R., Martin-Mazuelos, E., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02615-13 · Cited by 105 · see citing works
Self-citationEnfermedades Infecciosas y Microbiología Clínica
Viasus, D., Antón, A., Pumarola, T., & Carratalà, J. (2016) · Cited by 90 · see citing works
Recent Perspectives in the Management of Fungal Keratitis
Raj, N., Vanathi, M., Ahmed, N. H., Gupta, N., Lomi, N., & Tandon, R. (2021) · Journal of Fungi · doi:10.3390/jof7110907 · Cited by 89 · see citing works
Arendrup, M. C., Billé, J., Dannaoui, É., Ruhnke, M., Heussel, C. P., & Kibbler, C. C. (2012) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.246 · Cited by 88 · see citing works
Self-citationCendejas‐Bueno, E., Gómez‐López, A., Mellado, E., Rodrı́guez-Tudela, J. L., & Cuenca‐Estrella, M. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.00336-10 · Cited by 67 · see citing works
Self-citationSchmalreck, A., Willinger, B., Haase, G., Blum, G., Lass‐Flörl, C., Fegeler, W., Becker, K., & for the Antifungal Susceptibility Testing (AFST) Study Group (2012) · Mycoses · doi:10.1111/j.1439-0507.2011.02165.x · Cited by 57 · see citing works
Self-citationIngham, C. J., Boonstra, S., Levels, S., de Lange, M., Meis, J. F. G. M., & Schneeberger, P. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033818 · Cited by 51 · see citing works
Susceptibility Test Methods: Yeasts and Filamentous Fungi
Johnson, E. M., & Arendrup, M. C. (2015) · ASM Press eBooks · doi:10.1128/9781555817381.ch131 · Cited by 45 · see citing works
Self-citationDurgun, M. E., Kahraman, E., Hacıoğlu, M., Güngör, S., & Özsoy, Y. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00974-x · Cited by 42 · see citing works
Kukurudz, R. J., Chapel, M., Wonitowy, Q., Adamu Bukari, A.-R., Sidney, B., Sierhuis, R., & Gerstein, A. C. (2022) · G3 · doi:10.1093/g3journal/jkac156 · Cited by 35 · see citing works
Ramla, S., Sharma, V., & Patel, M. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-3035-8 · Cited by 35 · see citing works
Interactions of Yeasts, Moulds, and Antifungal Agents
Hall, G. S. (2011) · Humana Press eBooks · doi:10.1007/978-1-59745-134-5 · Cited by 33 · see citing works
EUCAST and CLSI: Working Together Towards a Harmonized Method for Antifungal Susceptibility Testing
Espinel‐Ingroff, A., Cuenca‐Estrella, M., & Cantón, E. (2013) · Current Fungal Infection Reports · doi:10.1007/s12281-012-0125-7 · Cited by 32 · see citing works
Self-citationOdds, F. C. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00577.x · Cited by 32 · see citing works
Cheng, Y., Roma, J. S., Shen, M., Fernandes, C. M., Tsang, P. S., Forbes, H. J., Boshoff, H. I., Lazzarini, C., Poeta, M. D., Zheng, W., et al. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01305-20 · Cited by 29 · see citing works
Molecular identification and susceptibility profile in vitro of the emerging pathogen Candida kefyr
Gómez‐López, A., Pan, D., Cuesta, I., Alastruey‐Izquierdo, A., Rodrı́guez-Tudela, J. L., & Cuenca‐Estrella, M. (2009) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2009.06.007 · Cited by 24 · see citing works
Self-citationKnabl, L., & Lass‐Flörl, C. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1760841 · Cited by 16 · see citing works
Self-citationIn vitro antifungal susceptibility pattern and ergosterol content in clinical yeast strains
Gómez‐López, A., Buitrago, M. J., Rodrı́guez-Tudela, J. L., & Cuenca‐Estrella, M. (2011) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2010.12.003 · Cited by 12 · see citing works
Self-citationBeredaki, M.-I., Arendrup, M. C., Andes, D. R., Mouton, J. W., & Meletiadis, J. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01292-20 · Cited by 10 · see citing works
Self-citationUtility of Antifungal Susceptibility Testing and Clinical Correlations
Diekema, D. J., & Pfaller, M. A. (2011) · Humana Press eBooks · doi:10.1007/978-1-59745-134-5_8 · Cited by 9 · see citing works
Ibe, C., Otu, A. A., & Pohl, C. H. (2025) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2024.2448844 · Cited by 6 · see citing works
Emerging Resistance to Azoles and Echinocandins: Clinical Relevance and Laboratory Detection
Espinel‐Ingroff, A., Pfaller, M. A., Cantón, E., & Pemán, J. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0026-6 · Cited by 5 · see citing works
miruka, H. N., Eric, O. O., Musyoki, S., & Awuor, S. O. (2022) · doi:10.1099/acmi.0.000620.v1 · Cited by 4 · see citing works
Mareș, M., Năstasă, V., Ramona, F. M., Doroftei, B., & Ştefanache, A. (2011) · Mycopathologia · doi:10.1007/s11046-011-9455-1 · Cited by 2 · see citing works
Susceptibility Test Methods: Yeasts and Filamentous Fungi
Johnson, E. M., & Arendrup, M. C. (2023) · ClinMicroNow · doi:10.1002/9781683674849.mcm0135 · Cited by 1 · see citing works
Self-citationSusceptibility Test Methods: Yeasts and Filamentous Fungi
Johnson, E. M., & Arendrup, M. C. (2023) · ClinMicroNow · doi:10.1002/9781683670438.mcm0135 · Cited by 1 · see citing works
Self-citationOwotade, F. J. (2014) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Uzel, E., Durgun, M. E., Aydilek, N., Hacıoğlu, M., Güngör, S., & Özsoy, Y. (2026) · Molecules · doi:10.3390/molecules31081235
Fungal Keratitis: Epidemiology, Diagnosis and Therapy
Rodríguez-García, A., & Amescua, G. (2026) · Springer eBooks · doi:10.1007/978-3-032-19923-2_7
- Authors
- Arendrup, M. C., Cuenca-Estrella, M., Donnelly, J. P., Hope, W., Lass-Flörl, C., & Rodriguez-Tudela, J.-L.
- Affiliations
- Statens Serum Institut (DK)
- Radboud University Nijmegen (NL)
- Manchester Academic Health Science Centre (GB)
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Arendrup, M.C.
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 17
- Issue
- 11
- Pages
- E16-E17
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W2104305938
- Cited by
- 34
- References
- 6
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Microbiology and Infection (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- posaconazole, antifungal susceptibility testing, antimicrobial susceptibility breakpoints, Candida species, Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata, Candida krusei, epidemiological cut-off values, MIC
- MeSH terms
- Antifungal Agents, Candida, Humans, Microbial Sensitivity Tests, Triazoles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review