EUCAST Technical Note on Candida and micafungin, anidulafungin and fluconazole
Abstract
The European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility Testing has determined breakpoints for micafungin and revised breakpoints for anidulafungin and fluconazole for Candida spp. This Technical Note is based on the corresponding rationale documents (http://www.eucast.org). The micafungin breakpoints are based on PK data, animal PK/PD data, microbiological data and clinical experience. The anidulafungin breakpoints for C. parapsilosis and fluconazole breakpoints for C. glabrata have been modified to species-specific values that categorise the wild-type as intermediate to accommodate use of these compounds in some clinical situations.
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- Authors
- Cavling Arendrup, M., Cuenca‐Estrella, M., Lass‐Flörl, C., Hope, W. W., & The European Committee on Antimicrobial Susceptibility Testing – Subcommittee on Antifungal Susceptibility Testing (EUCAST‐AFST)
- Affiliations
- Unit of Mycology Department of Microbiology & Infection Control Statens Serum Institute Copenhagen Denmark
- Mycology National Center for Microbiology Madrid Spain
- Innsbruck Medical University (AT)
- University of Liverpool (GB)
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 2014-01-13
- Volume
- 57
- Issue
- 6
- Pages
- 377-379
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W1971164793
- Cited by
- 43
- References
- 20
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 2
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research (CS/08/08/10)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida, micafungin, anidulafungin, fluconazole, antifungal susceptibility breakpoints, Candida parapsilosis, Candida glabrata, intermediate susceptibility, antifungal agents
- MeSH terms
- Micafungin, Anidulafungin, Animals, Antifungal Agents, Candida, Europe, Humans, Microbial Sensitivity Tests, Fluconazole, Echinocandins, Lipopeptides
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