Cited by 300Child and Adolescent Psychosocial and Emotional DevelopmentPersonality Disorders and PsychopathologyMental Health Research Topics

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index; none of the 13 sources its claims cite is checked for support yet.

Subthreshold conditions as precursors for full syndrome disorders: a 15‐year longitudinal study of multiple diagnostic classes

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Abstract

Background: There has been increasing interest in the distinction between subthreshold and full syndrome disorders and specifically whether subthreshold conditions escalate or predict the onset of full syndrome disorders over time. Most of these studies, however, examined whether a single subthreshold condition escalates into the full syndrome form of that disorder. Equally important, though, is whether subthreshold conditions are likely to develop other full syndrome disorders and whether these associations are maintained after adjusting for comorbidity. Methods: A 15‐year longitudinal study of subthreshold psychiatric conditions was conducted with 1,505 community‐drawn young adults. We examined whether 1) subthreshold major depression, bipolar, anxiety disorders, alcohol use, substance use, conduct disorder and/or ADHD were precursors for the corresponding (homotypic) full syndrome disorder; 2) subthreshold conditions were precursors for other (heterotypic) full syndrome disorders; and 3) these homotypic and heterotypic precursors persisted after adjusting for comorbidity. Results: Subthreshold major depression, anxiety, alcohol use, substance use, and conduct all escalated into their corresponding full syndrome and nearly all homotypic developments were maintained after adjusting for comorbid subthreshold and full syndrome conditions. Many heterotypic associations were also observed and most remained after controlling for comorbidity, particularly among externalizing disorders (e.g., alcohol, substance, conduct/antisocial personality disorder). Conclusions: Many subthreshold conditions have predictive validity as they may represent precursors for full syndrome disorders. Alternatively, dimensional conceptualizations of psychopathology which include these more minor conditions may yield greater validity. Subthreshold conditions may represent good targets for preventive interventions.

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Crossref · 10.1111/j.1469-7610.2009.02117.x

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  1. First M.B., 1996, Structured Clinical Interview for DSM‐IV Axis I Disorders‐Non‐Patient Edition

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Metadata

Authors
Shankman, S. A., Lewinsohn, P. M., Klein, D. N., Small, J. W., Seeley, J. R., & Altman, S. E.
Affiliations
  • University of Illinois Chicago (US)
  • Oregon Research Institute (US)
Corresponding author
Shankman, Stewart A.
Venue
Journal of Child Psychology and Psychiatry
Publisher
Wiley
Published
2009-11-05
Volume
50
Issue
12
Pages
1485-1494
ISSN
  • 0021-9630 (ISSN-L)
  • 1469-7610
OpenAlex
W1974681461
Cited by
300
References
44
Citations by year
2026: 9 · 2025: 11 · 2024: 14 · 2023: 18 · 2022: 23 · 2021: 23 · 2020: 25 · 2019: 23 · 2018: 14 · 2017: 11 · 2016: 20 · 2015: 19 · 2014: 20 · 2013: 20 · 2012: 18
FWCI
16.78
Type
journal article
Language
en
Open access
Locations
  • Journal of Child Psychology and Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH 50522, R01MH066023, R01MH050522)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
alcohol consumption, substance use, conduct disorder, attention deficit hyperactivity disorder, antisocial personality disorder, comorbidities, dimensional models of psychopathology, young adults, predictive validity, preventive interventions
MeSH terms
Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Major Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Severity of Illness Index, Syndrome, Comorbidity, Conduct Disorder, Substance-Related Disorders, Diagnostic and Statistical Manual of Mental Disorders, Young Adult

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