Cited by 124Bipolar Disorder and TreatmentPersonality Disorders and PsychopathologySchizophrenia research and treatment

An International Society of Bipolar Disorders task force report: Precursors and prodromes of bipolar disorder

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Faedda, Gianni L., Baldessarini, Ross J., Marangoni, Ciro, Bechdolf, Andreas, Berk, Michael, Birmaher, Boris, Conus, Philippe, DelBello, Melissa P. +14 more·2019·Bipolar Disorders

Abstract

Objectives: To clarify the clinical features preceding the onset of bipolar disorder (BD) has become a public health priority for the prevention of high morbidity and mortality. BD remains frequently under‐ or misdiagnosed, and under‐ or mistreated, often for years. Methods: We assessed the predictive value of precursors and prodromes of BD. We assessed precursors of first‐lifetime manic or hypomanic episodes with/without mixed features in retrospective and prospective studies. The task force evaluated and summarized separately assessments of familial risk, premorbid personality traits, retrospective, and prospective studies. Results: Cyclothymic features, a family history of BD, retrospectively reported attenuated manic symptoms, prospectively identified subthreshold symptoms of hypomania, recurrence of depression, panic anxiety and psychotic features, have been identified as clinical precursors of BD. The prodromal symptoms like [hypo]mania often appears to be long enough to encourage early identification and timely intervention. Conclusions: The predictive value of any risk factor identified remains largely unknown. Prospective controlled studies are urgently needed for prevention and effective treatment.

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  • Indicated prevention in bipolar disorder was developed only fifteen years ago and is rapidly emerging, but its supporting evidence lags behind that for CHR-P.

    “Indicated prevention in bipolar disorder was developed, following the CHR-P template, only fifteen years ago 96,97 , and is rapidly emerging 98-101 . The supporting evidence lags behind that for CHR-P 99,102 .”

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  1. Faedda, G. L., Baldessarini, R. J., Marangoni, C., Bechdolf, A., Berk, M., Birmaher, B., Conus, P., DelBello, M. P., Duffy, A. C., Hillegers, M. H. J., Pfennig, A., Post, R. M., Preisig, M., Ratheesh, A., Salvatore, P., Tohen, M., Vazquez, G. H., Vieta, E., Yatham, L. N. ,... Correll, C. U. (2019). An International Society of Bipolar Disorders task force report: Precursors and prodromes of bipolar disorder. BIPOLAR DISORDERS, 21 (8), pp.720-740. https:// doi.org/10.1111/bdi.12831. Persistent Link: http://hdl.handle.net/11343/286430

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Authors
Faedda, G. L., Baldessarini, R. J., Marangoni, C., Bechdolf, A., Berk, M., Birmaher, B., Conus, P., DelBello, M. P., Duffy, A. C., Hillegers, M. H. J., Pfennig, A., Post, R. M., Preisig, M., Ratheesh, A., Salvatore, P., Tohen, M., Vázquez, G. H., Vieta, E., Yatham, L. N., Youngstrom, E. A., Van Meter, A., & Correll, C. U.
Affiliations
  • McLean Hospital (US)
  • Harvard University (US)
  • Azienda ULSS 9 Scaligera (IT)
  • University of Cologne (DE)
  • Barwon Health (AU)
  • University of Pittsburgh (US)
  • Centre Hospitalier Universitaire Vaudois (CH)
  • University of Cincinnati (US)
  • Queen's University (CA)
  • Erasmus MC (NL)
  • University Hospital Carl Gustav Carus (DE)
  • George Washington University (US)
  • University of Parma (IT)
  • University of New Mexico (US)
  • Centro de Investigación Biomédica en Red de Salud Mental (ES)
  • University of British Columbia (CA)
  • University of North Carolina at Chapel Hill (US)
  • Department of Psychiatry and Molecular Medicine Hofstra Northwell School of Medicine Hempstead NY USA
  • Northwell Health (US)
Corresponding author
Faedda, Gianni L.
Venue
Bipolar Disorders
Publisher
Wiley
Published
2019-09-18
Volume
21
Issue
8
Pages
720-740
ISSN
  • 1398-5647 (ISSN-L)
  • 1399-5618
OpenAlex
W2971478001
Cited by
124
References
144
Citations by year
2026: 14 · 2025: 24 · 2024: 18 · 2023: 18 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 1
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Bipolar Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • IRIS (submittedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
National Health and Medical Research Council (GNT1059660, 1156072)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
bipolar disorder, prodromal symptoms, hypomania, family history (medicine), familial risk, premorbid personality traits, mixed features, depression recurrence, early detection, prevention
MeSH terms
Adult, Anxiety, Anxiety Disorders, Bipolar Disorder, Cyclothymic Disorder, Depression, Female, Humans, Male, Prospective Studies, Retrospective Studies, Risk Factors, Risk Assessment, Advisory Committees, Prodromal Symptoms

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