Glycaemic control throughout pregnancy and risk of pre-eclampsia in women with type I diabetes
Abstract
The aim of this study was to examine the influence of pre-pregnancy care and its effect on early glycaemic control and also the effect of glycaemic control in later pregnancy on risk of pre-eclampsia in women with type I diabetes. A prospective cohort study of 290 consecutive nonselected pregnancies in women with type I diabetes was performed from 1991 to 2002. We examined the relationship of monthly glycosylated haemoglobin (HbA1c) level, pre-pregnancy care, parity, diabetes duration, microvascular complications, maternal age, weight and smoking with risk of pre-eclampsia. Pre-eclampsia developed in 31/243 singleton births (12.8%). HbA1c level at 24 weeks was significantly increased in women with pre-eclampsia compared with women without pre-eclampsia (6.0 versus 5.6%, P= 0.017) and was, after nulliparity, the strongest independent predictor of increased risk (OR 1.65 for each 1% increase in HbA1c; P= 0.01). In contrast, there was no relationship between pre-pregnancy care or HbA1c level at booking and risk of pre-eclampsia.
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In the second and third trimesters, A1C <6% has the lowest risk of large-for-gestational-age infants, preterm delivery, and preeclampsia.
“In the second and third trimesters, A1C <6% (<42 mmol/mol) has the lowest risk of large-for-gestational-age infants (40,43,44), preterm delivery (45), and preeclampsia (1,46).”
From 15. Management of Diabetes in Pregnancy: <i>Standards of Care in Diabetes—2024</i> (2024) · cites this paper as [46]
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15. Management of Diabetes in Pregnancy: <i>Standards of Medical Care in Diabetes—2022</i>
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s015 · Cited by 504 · see citing works
15. Management of Diabetes in Pregnancy: <i>Standards of Care in Diabetes—2024</i>
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- Authors
- Temple, R., Aldridge, V, Stanley, K., & Murphy, H.
- Affiliations
- Norfolk and Norwich University Hospital (GB)
- Corresponding author
- Temple, RC
- ORCID
- Stanley, K
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 2006-09-27
- Volume
- 113
- Issue
- 11
- Pages
- 1329-1332
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2009498127
- Cited by
- 63
- References
- 12
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 3 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- preeclampsia, type 1 diabetes, glycemic control, glycosylated haemoglobin, HbA1c, pregnancy, preconception care, nulliparity, diabetes duration, microvascular complications, risk factors
- MeSH terms
- Adult, Analysis of Variance, Blood Glucose, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Pre-Eclampsia, Pregnancy, Pregnancy in Diabetics, Prospective Studies, Risk Factors, Cohort Studies, Preconception Care
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