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Time in range in pregnancy: is there a role?

Open access
Wyckoff, Jennifer A., Brown, Florence M.·2021·Diabetes Spectrum

Abstract

Continuous glucose monitoring (CGM) is being used with increasing frequency as an adjunct to self-monitoring of blood glucose in pregnancy, and novel targets based on CGM data are becoming standardized. This adoption of CGM is the result of its improving accuracy, patient preference, and evolving data demonstrating associations of novel targets such as time in range (TIR) with pregnancy and neonatal outcomes. A greater understanding of the relationship of various CGM metrics to outcomes in pregnancy complicated by diabetes is needed. It is clear that TIR parameters need to be uniquely lower for pregnant women than for nonpregnant individuals. CGM technology is also an integral part of hybrid closed-loop insulin delivery systems. These insulin delivery systems will be a significant advance in the management of diabetes during pregnancy if they can achieve the pre- and postprandial targets required for pregnancy and optimize TIR.

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Crossref · 10.2337/ds20-0103

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  • There are insufficient data to support the use of CGM in all people with type 2 diabetes or GDM.

    “There are insufficient data to support the use of CGM in all people with type 2 diabetes or GDM (53,54).”

    From 15. Management of Diabetes in Pregnancy: <i>Standards of Care in Diabetes—2024</i> (2024) · cites this paper as [54]

    The section on trials in type 2 diabetes or GDM says that CGM outcomes data are far less robust, with no RCTs specifically studying type 2 diabetes in pregnancy and limited data for GDM. That supports caution about universal CGM use during pregnancy, but the source does not address all people with type 2 diabetes outside pregnancy, as the citing sentence could imply. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • At this time, data are insufficient to recommend CGM for all pregnant people with type 2 diabetes or gestational diabetes mellitus.

    “At this time, data are insufficient to recommend the use of CGM in all pregnant people with type 2 diabetes or GDM (109,110).”

    From 7. Diabetes Technology: Standards of Care in Diabetes—2025 (2025) · cites this paper as [110]

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Authors
Wyckoff, J. A., & Brown, F. M.
Affiliations
  • University of Michigan (US)
  • Joslin Diabetes Center (US)
Corresponding author
Wyckoff, Jennifer A.
Venue
Diabetes Spectrum
Published
2021-05-01
Volume
34
Issue
2
Pages
119-132
ISSN
  • 1040-9165 (ISSN-L)
  • 1944-7353
OpenAlex
W3165330610
Cited by
39
References
83
Citations by year
2026: 4 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 6
FWCI
5.90
Type
journal article
Language
en
Open access
Locations
  • Diabetes Spectrum (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords
time in range, continuous glucose monitoring, pregnancy, gestational diabetes mellitus, glycemic targets, hybrid closed-loop insulin delivery, neonatal outcomes, self-monitoring of blood glucose, insulin therapy

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