‘Blood On The Tracks’ from corpora lutea to endometriomas*
Abstract
Objective To detect a direct transition from a haemorrhagic corpus luteum to an endometriotic cyst by serial transvaginal ultrasonographic scans. Design Prospective observational study. Setting An academic tertiary care and referral centre for women with endometriosis. Population One hundred and nine women younger than 40 years, with regular menstrual cycles, undergoing first‐line surgery for endometriomas, and not wanting postoperative oral contraception. Methods Three‐monthly transvaginal ultrasonography during the luteal phase for 2 years after surgery. Main outcome measure Sonographic identification of progression from a haemorrhagic corpus luteum to a recurrent endometriotic cyst. Results A haemorrhagic corpus luteum was identified in 13 women. Serial ultrasonographic scans demonstrated transition to an endometriotic cyst in 11 (85%) instances and resorption in two. A unilateral endometriotic cyst without previous detection of a cystic corpus luteum was observed in 14 women. Conclusions Bleeding from a corpus luteum appears to be a critical event in the development of endometriomas.
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Ovulation is usually not inhibited by the LNG-IUS.
“The LNG-IUS induces profound effects on the eutopic endometrium, which became atrophic and inactive, whereas ovulation is usually not inhibited [74].”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [86]
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- Authors
- Vercellini, P., Somigliana, E., Vigano, P., Abbiati, A., Barbara, G., & Fedele, L.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Vercellini, P
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 2009-01-21
- Volume
- 116
- Issue
- 3
- Pages
- 366-371
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2017172690
- Cited by
- 114
- References
- 29
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 12 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 14 · 2012: 6
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometrioma, corpus luteum, endometriosis, endometriotic cysts, cyst progression, transvaginal ultrasound, luteal phase, endometrioma recurrence
- MeSH terms
- Adult, Corpus Luteum, Endometriosis, Female, Humans, Luteal Phase, Ovarian Cysts, Laparoscopy, Prospective Studies, Recurrence, Ultrasonography, Uterine Hemorrhage, Young Adult
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