Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats

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Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Segatto, M., Fittipaldi, R., Pin, F., Sartori, R., Dae Ko, K., Zare, H., Fenizia, C., Zanchettin, G., Pierobon, E. S., Hatakeyama, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01645-7 · Cited by 101 · see citing works

Cholesterol Metabolism Is Altered in Rett Syndrome: A Study on Plasma and Primary Cultured Fibroblasts Derived from Patients

Segatto, M., Trapani, L., Di Tunno, I., Sticozzi, C., Valacchi, G., Hayek, J., & Pallottini, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104834 · Cited by 80 · see citing works

Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?

Cartocci, V., Servadio, M., Trezza, V., & Pallottini, V. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25488 · Cited by 77 · see citing works

Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats

Manduca, A., Morena, M., Campolongo, P., Servadio, M., Palmery, M., Trabace, L., Hill, M. N., Vanderschuren, L. J. M. J., Cuomo, V., & Trezza, V. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.005 · Cited by 67 · see citing works

Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats

Manduca, A., Servadio, M., Campolongo, P., Palmery, M., Trabace, L., Vanderschuren, L. J. M. J., Cuomo, V., & Trezza, V. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.05.009 · Cited by 66 · see citing works

An updated animal model capturing both the cognitive and emotional features of post-traumatic stress disorder (PTSD)

Berardi, A., Trezza, V., Palmery, M., Trabace, L., Cuomo, V., & Campolongo, P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00142 · Cited by 60 · see citing works

BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

Segatto, M., Szokoll, R., Fittipaldi, R., Bottino, C., Nevi, L., Mamchaoui, K., Filippakopoulos, P., & Caretti, G. (2020) · Nature Communications · doi:10.1038/s41467-020-19839-x · Cited by 56 · see citing works

Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference

Hsu, T. M., Noble, E. E., Reiner, D. J., Liu, C. M., Suarez, A. N., Konanur, V., Hayes, M. R., & Kanoski, S. E. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.039 · Cited by 54 · see citing works

Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome

Segatto, M., Tonini, C., Pfrieger, F. W., Trezza, V., & Pallottini, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133317 · Cited by 51 · see citing works

Statins and the brain: New perspective for old drugs

Ling, Q., & Tejada-Simon, M. V. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.013 · Cited by 38 · see citing works

Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis

Tonini, C., Colardo, M., Colella, B., Bartolomeo, S. D., Berardinelli, F., Caretti, G., Pallottini, V., & Segatto, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041297 · Cited by 38 · see citing works

Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer’s disease

Tong, X., Royea, J., & Hamel, É. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04784-y · Cited by 35 · see citing works

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5 gene from Malus domestica enhances oxidative stress tolerance in Arabidopsis thaliana

Zhang, M., Liu, H., Wang, Q., Liu, S., & Zhang, Y. (2019) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2019.11.031 · Cited by 28 · see citing works

Modulation of the Isoprenoid/Cholesterol Biosynthetic Pathway During Neuronal Differentiation In Vitro

Cartocci, V., Segatto, M., Di Tunno, I., Leone, S., Pfrieger, F. W., & Pallottini, V. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25500 · Cited by 28 · see citing works

Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling

Wong, M. J., Kantores, C., Ivanovska, J., Jain, A., & Jankov, R. P. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00345.2016 · Cited by 27 · see citing works

The pharmacological bases for repurposing statins in depression: a review of mechanistic studies

Giorgi, R. D., Pesci, N. R., Rosso, G., Maina, G., Cowen, P. J., & Harmer, C. J. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02533-z · Cited by 29 · see citing works

The mevalonate pathway in breast cancer biology

Göbel, A., Riffel, R. M., Hofbauer, L. C., & Rachner, T. D. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215761 · Cited by 25 · see citing works

Statins Reduce the Risks of Relapse to Addiction in Rats

Chauvet, C., Nicolas, C., Lafay‐Chebassier, C., Jaber, M., Thiriet, N., & Solinas, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.317 · Cited by 25 · see citing works

Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses

Tonini, C., Segatto, M., Gagliardi, S., Bertoli, S., Leone, A., Barberio, L., Mandalà, M., & Pallottini, V. (2020) · Nutrients · doi:10.3390/nu12051448 · Cited by 25 · see citing works

Evaluation of IL 8 pathway on the ocular surface: new insights in patients with ocular mucous membrane pemphigoid

Bruscolini, A., Lambìase, A., Segatto, M., Cava, M. L., Nebbioso, M., & Sacchetti, M. (2019) · Acta Ophthalmologica · doi:10.1111/aos.14240 · Cited by 22 · see citing works

Characterization and function of the 3-hydroxy-3-methylglutaryl-CoA reductase gene in Alisma orientale (Sam.) Juz. and its relationship with protostane triterpene production

Gu, W., Geng, C., Xue, W., Wu, Q., Chao, J., Xu, F., Sun, H., Jiang, L., Han, Y., & Zhang, S. (2015) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.10.031 · Cited by 21 · see citing works

VEGF inhibition alters neurotrophin signalling pathways and induces caspase‐3 activation and autophagy in rabbit retina

Segatto, M., Fico, E., Gharbiya, M., Rosso, P., Carito, V., Tirassa, P., Plateroti, R., & Lambìase, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28462 · Cited by 21 · see citing works

Pharmacodynamic and pharmacokinetic interactions between simvastatin and diazepam in rats

Słupski, W., Trocha, M., & Rutkowska, M. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.03.012 · Cited by 19 · see citing works

Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats

Schiavi, S., Manduca, A., Segatto, M., Campolongo, P., Pallottini, V., Vanderschuren, L. J. M. J., & Trezza, V. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05226-y · Cited by 15 · see citing works

ProNGF/p75NTR Axis Drives Fiber Type Specification by Inducing the Fast-Glycolytic Phenotype in Mouse Skeletal Muscle Cells

Pallottini, V., Colardo, M., Tonini, C., Martella, N., Strimpakos, G., Colella, B., Tirassa, P., Bartolomeo, S. D., & Segatto, M. (2020) · Cells · doi:10.3390/cells9102232 · Cited by 15 · see citing works

Hippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats

Rea, J. J., Liu, C. M., Hayes, A., Bashaw, A. G., Schwartz, G. M., Ohan, R., Décarie-Spain, L., Kao, A. E., Klug, M. E., Phung, K. J., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.07.014 · Cited by 13 · see citing works

Long-lasting impact of perinatal dietary supplementation of omega 3 fatty acids on mevalonate pathway: potential role on neuron trophism in male offspring hippocampal formation

Tonini, C., Schiavi, S., Macca, F., Segatto, M., Trezza, V., & Pallottini, V. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1724452 · Cited by 13 · see citing works

Effects of RhoA on Depression-Like Behavior in Prenatally Stressed Offspring Rats

Zhou, J., Ma, Y., Chen, J., Yao, D., Feng, C., Dong, Y., Ren, Y., Ma, H., Wang, Z., Li, G., et al. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113973 · Cited by 12 · see citing works

High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin

Okudan, N., & Belviranlı, M. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.09.019 · Cited by 14 · see citing works

Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome

Parente, M., Tonini, C., Buzzelli, V., Carbone, E., Trezza, V., & Pallottini, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063408 · Cited by 11 · see citing works

Cholesterol Homeostasis Imbalance and Brain Functioning: Neurological Disorders and Behavioral Consequences

Lecis, C., & Segatto, M. (2014) · Journal of Neurology and Neurological Disorders · doi:10.15744/2454-4981.1.101 · Cited by 9 · see citing works

Cognitive function in dyslipidemia patients: exploring the impact of statins

Wang, W., & Li, X. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1436010 · Cited by 9 · see citing works

Glial contribution to cyclodextrin-mediated reversal of cholesterol accumulation in murine NPC1-deficient neurons in vivo

Barthelemy, A., Demais, V., Stancu, I., Vasile, E., Houben, T., Reber, M., Pallottini, V., Perraut, M., Reibel, S., & Pfrieger, F. W. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105469 · Cited by 9 · see citing works

Statins in depression: a repurposed medical treatment can provide novel insights in mental health

Giorgi, R. D., Cowen, P. J., & Harmer, C. J. (2022) · International Review of Psychiatry · doi:10.1080/09540261.2022.2113369 · Cited by 9 · see citing works

Comprehensive genome-wide analysis of the HMGR gene family of Asparagus taliensis and functional validation of AtaHMGR10 under different abiotic stresses

Zeng, L., Brown, S. E., Wu, H., Dongchen, W., Li, Y., Lin, C., Liu, Z., & Mao, Z. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1455592 · Cited by 7 · see citing works

Effects of Late-Life Caloric Restriction on Age-Related Alterations in the Rat Cortex and Hippocampus

Tonini, C., Segatto, M., Martino, F., Cigliano, L., Nazzaro, M., Barberio, L., Mandalà, M., & Pallottini, V. (2021) · Nutrients · doi:10.3390/nu13010232 · Cited by 6 · see citing works

Regulation of cholesterol metabolism: New players for an old physiological process

Parente, M., Tonini, C., Segatto, M., & Pallottini, V. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30477 · Cited by 7 · see citing works

Preliminary Study on Clusterin Protein (sCLU) Expression in PC-12 Cells Overexpressing Wild-Type and Mutated (Swedish) AβPP genes Affected by Non-Steroid Isoprenoids and Water-Soluble Cholesterol

Pająk, B., Kania, E., Gołaszewska, A., & Orzechowski, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061481 · Cited by 5 · see citing works

Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice

Nchodu, M., Efuntayo, A., du Preez, R., Ali, H., & Olateju, O. I. (2024) · Cardiovascular Toxicology · doi:10.1007/s12012-023-09821-6 · Cited by 4 · see citing works

3-Hydroxy-3-methylglutaryl-coenzyme A reductase modulator: toward age- and sex-personalized medicine

Pallottini, V. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2015.1061996 · Cited by 4 · see citing works

Advancing Biological Research: New Automated Analysis of Immunofluorescence Signals

Salzano, F., Martella, N., Pareschi, R., & Segatto, M. (2024) · Applied Sciences · doi:10.3390/app14072809 · Cited by 3 · see citing works

Preclinical evidence for statin modulation of analgesic tolerance and substance use disorders: a narrative review

Ranaiy, M. S., Tamijani, S. M. S., Ghazvini, H., Alaedini, K., & Rafaiee, R. (2026) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2025.2610464 · Cited by 1 · see citing works

Adult neurogenesis in avian auditory cortex, caudomedial nidopallium (NCM): Lateralization and effects of statins

Tsoi, S. C. (2016) · CUNY Academic Works (City University of New York)

The Effect of High-Dose Simvastatin Therapy on Patients with Acute Cerebral Infarction

Liu, X., Liang, H., Li, K., Li, J., Li, L., & Zhang, L. (2017) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.1000527

Cholesterol synthesis requirements in oligodendrocyte development and myelination

Mathews, E. S. (2016) · doi:10.25677/fqza-rd07

Degeneration of pyramidal cells of CA1, CA2, and CA3 are of the hippocampus in male rats under the influence of simvastatinPreprint

Ranaiy, M. S., Farokhi, F., & Babaei-Balderlou, F. (2021) · Research Square · doi:10.21203/rs.3.rs-882972/v1

Degeneration of pyramidal cells of CA1, CA2, and CA3 area of the hippocampus in male rats under the influence of SimvastatinPreprint

Ranaiy, M. S., Farokhi, F., & Babaei-Balderlou, F. (2021) · Research Square · doi:10.21203/rs.3.rs-898243/v1

Molecular mechanisms for simvastatin-mediated enhancement of synaptic plasticity

Mans, R. A., McMahon, L. L., & Li, L. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-s1-o4 · Cited by 6 · see citing works

The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet

Can, Ö. D., Ulupınar, E., Özkay, Ü. D., Yeğin, B., & Öztürk, Y. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328356c3f2 · Cited by 78 · see citing works

Simvastatin Treatment Enhances NMDAR-Mediated Synaptic Transmission by Upregulating the Surface Distribution of the GluN2B Subunit

Parent, M.-A. L. T., Hottman, D. A., Cheng, S., Zhang, W., McMahon, L. L., Yuan, L., & Li, L. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0051-z · Cited by 39 · see citing works

Simvastatin Effects On Brain and Behavior in Animal Model

Vevera, J., Fiar, Z., Nekovářová, T., & Vale, K. (2015) · European Psychiatry · doi:10.1016/s0924-9338(15)30645-3

The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model

Vevera, J., Valeš, K., Fišar, Z., Hroudová, J., Singh, N., Stuchlı́k, A., Kačer, P., & Nekovářová, T. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.029 · Cited by 24 · see citing works