P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Shiratori, Miho; Tozaki‐Saitoh, Hidetoshi; Yoshitake, Mai; Tsuda, Makoto; Inoue, Kazuhide

doi:10.1111/j.1471-4159.2010.06809.x

Cited by 155Adenosine and Purinergic SignalingNeuroinflammation and Neurodegeneration MechanismsPain Mechanisms and Treatments

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

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Shiratori, Miho, Tozaki‐Saitoh, Hidetoshi, Yoshitake, Mai, Tsuda, Makoto, Inoue, Kazuhide·2010·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2010.06809.x

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Abstract

J. Neurochem.(2010)114, 810–819. Microglia plays an important role in many neurodegenerative conditions. ATP leaked or released by damaged cells triggers microglial activation through P2 receptors, and stimulates the release of oxygen radicals, proinflammatory cytokines and chemokines from activated microglia. However, little is known about mechanisms underlying ATP‐induced chemokine release from microglia. In this study, we found that a high concentration of ATP induces the mRNA expression and release of CXCL2 from microglia. A similar effect was observed following treatment of microglia with a P2X7 receptor (P2X7R) agonist, 2′‐and 3′‐O‐(4‐benzoylbenzoyl) ATP, and this was inhibited by pre‐treatment with a P2X7R antagonist, Brilliant Blue G. ATP induced both activation of nuclear factor of activated T cells (NFAT) and MAPKs (p38, ERK, and JNK) through P2X7R. ATP‐induced mRNA expression of CXCL2 was inhibited by INCA‐6 (an NFAT inhibitor), SB203580 (a p38 inhibitor), U0126 (a MEK‐ERK inhibitor) and JNK inhibitor II (a JNK inhibitor). However, MAPK inhibitors did not inhibit activation of NFAT. In addition, protein kinase C inhibitors suppressed ATP‐induced ERK and JNK activation, and also inhibited ATP‐induced CXCL2 expression in microglia. These results suggest that ATP increased CXCL2 production via both NFAT and protein kinase C/MAPK signaling pathways through P2X7 receptor stimulation in microglia.

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P2X7 receptor activation also promotes the release of other inflammatory mediators such as IL-6, TNF-α, CCL2, CCL3, and CXCL2.
“Moreover, P2X7 receptor activation also promotes the release of other inflammatory mediators such as IL-6, TNF-α, CCL2, CCL3, and CXCL2 [77–80].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [80]

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AP-1 function and regulation
Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904 · see citing works
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,605 · see citing works
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567 · see citing works
Self-citation
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976
Martiny‐Baron, G., Kazanietz, M. G., Mischak, H., Blumberg, P. M., Kochs, G., Hug, H., Marmé, D., & Schächtele, C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98335-3 · Cited by 1,565 · see citing works
Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus
Blasi, E., Barluzzi, R., Bocchini, V., Mazzolla, R., & Bistoni, F. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90073-v · Cited by 1,053 · see citing works
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B. V., Jacobson, K. A., Kohsaka, S., & Inoue, K. (2007) · Nature · doi:10.1038/nature05704 · Cited by 802 · see citing works
Self-citation
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 790 · see citing works
Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
Pellegatti, P., Raffaghello, L., Bianchi, G., Piccardi, F., Pistoia, V., & Di Virgilio, F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002599 · Cited by 668 · see citing works
The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4
Ho, I., Hodge, M. R., Rooney, J. W., & Glimcher, L. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81299-4 · Cited by 667 · see citing works
Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes
Gschwendt, M., Dieterich, S., Rennecke, J., Kittstein, W., Mueller, H.-J., & Johannes, F.-J. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00785-5 · Cited by 644 · see citing works
Purinergic Signalling: ATP Release
Bodin, P., & Burnstock, G. (2001) · Neurochemical Research · doi:10.1023/a:1012388618693 · Cited by 521 · see citing works
NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes
Rao, A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90007-8 · Cited by 512 · see citing works
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
Yiangou, Y., Facer, P., Durrenberger, P., Chessell, I. P., Naylor, A., Bountra, C., Banati, R. R., & Anand, P. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-12 · Cited by 509 · see citing works
P2X7 receptor inhibition improves recovery after spinal cord injury
Wang, X., Arcuino, G., Takano, T., Lin, J. H.-C., Peng, W. G., Wan, P., Li, P., Xu, Q., Liu, Q. S., Goldman, S. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1082 · Cited by 495 · see citing works
P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease
Parvathenani, L. K., Tertyshnikova, S., Greco, C. R., Roberts, S. B., Robertson, B., & Posmantur, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209478200 · Cited by 488 · see citing works
Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin
Ferrari, D., Chiozzi, P., Falzoni, S., Hanau, S., & Virgilio, F. D. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.579 · Cited by 474 · see citing works
Extracellular ATP Triggers Tumor Necrosis Factor‐α Release from Rat Microglia
Hide, I., Tanaka, M., Inoue, A., Nakajima, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750965.x · Cited by 447 · see citing works
Self-citation
Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
Peng, W., Cotrina, M. L., Han, X., Yu, H., Bekar, L. K., Blum, L., Takano, T., Tian, G.-F., Goldman, S. A., & Nedergaard, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902531106 · Cited by 425 · see citing works
Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
Geraldes, P., Hiraoka‐Yamamoto, J., Matsumoto, M., Clermont, A. C., Leitges, M., Marette, A., Aiello, L. P., Kern, T. S., & King, G. L. (2009) · Nature Medicine · doi:10.1038/nm.2052 · Cited by 424 · see citing works
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 418 · see citing works
Negative regulation of Toll-like-receptor signaling by IRF-4
Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., & Honda, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508327102 · Cited by 403 · see citing works
ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.
Steinberg, T. H., Newman, A. S., Swanson, J. A., & Silverstein, S. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47497-2 · Cited by 397 · see citing works
Production and Release of Neuroprotective Tumor Necrosis Factor by P2X7Receptor-Activated Microglia
Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394 · see citing works
Self-citation
Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway
Chow, C.-W., Rincón, M., Cavanagh, J., Dickens, M., & Davis, R. J. (1997) · Science · doi:10.1126/science.278.5343.1638 · Cited by 357 · see citing works
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca 2+ signals across the inner ear
Anselmi, F., Hernández, V. H., Crispino, G., Seydel, A., Ortolano, S., Roper, S. D., Kessaris, N., Richardson, W. D., Rickheit, G., Filippov, M. A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800793105 · Cited by 342 · see citing works
Microglial activation by purines and pyrimidines
Inoue, K. (2002) · Glia · doi:10.1002/glia.10150 · Cited by 313 · see citing works
Self-citation
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation
Dean, J. L. E., Sully, G., Clark, A. R., & Saklatvala, J. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.04.006 · Cited by 308 · see citing works
A Novel Recombinant Plasma Membrane-targeted Luciferase Reveals a New Pathway for ATP Secretion
Pellegatti, P., Falzoni, S., Pinton, P., Rizzuto, R., & Virgilio, F. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-03-0222 · Cited by 296 · see citing works
Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase
Beigi, R. D., Kobatake, E., Aizawa, M., & Dubyak, G. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.1.c267 · Cited by 296 · see citing works
Activation of Microglia by Amyloid β Requires P2X7 Receptor Expression
Sanz, J. M., Chiozzi, P., Ferrari, D., Colaianna, M., Idzko, M., Falzoni, S., Fellin, R., Trabace, L., & Di Virgilio, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803612 · Cited by 293 · see citing works
Extracellular ATP Activates Transcription Factor NF-κB through the P2Z Purinoreceptor by Selectively Targeting NF-κB p65 (RelA)
Ferrari, D., Wesselborg, S., Bauer, M. K. A., & Schulze‐Osthoff, K. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1635 · Cited by 286 · see citing works
Upregulated Expression of Purinergic P2X 7 Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus
McLarnon, J. G., Ryu, J. K., Walker, D. G., & Choi, H. B. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240470.97295.d3 · Cited by 281 · see citing works
P2Y12Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury
Tozaki‐Saitoh, H., Tsuda, M., Miyata, H., Ueda, K., Kohsaka, S., & Inoue, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-08.2008 · Cited by 279 · see citing works
Self-citation
Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines
Widmer, U., Manogue, K. R., Cerami, A., & Sherry, B. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.11.4996 · Cited by 251 · see citing works
P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system
James, G., & Butt, A. M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01756-9 · Cited by 236 · see citing works
Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha
Tessier, P. A., Naccache, P. H., Clark‐Lewis, I., Gladue, R. P., Neote, K. S., & McColl, S. R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.7.3595 · Cited by 233 · see citing works
P2X7Receptor Expression after Ischemia in the Cerebral Cortex of Rats
Franke, H., Günther, A., Grosche, J., Schmidt, R., Roßner, S., Reinhardt, R., Faber‐Zuschratter, H., Schneider, D., & Illés, P. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.686 · Cited by 227 · see citing works
The role of cell cycle‐mediated events in Alzheimer's disease
Raina, A. K., Monteiro, M. J., McShea, A., & Smith, M. A. (1999) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1999.00106.x · Cited by 226 · see citing works
Integration of calcineurin and MEF2 signals by the coactivator p300 during T‐cell apoptosis
Youn, H., Chatila, T. A., & Liu, J. O. (2000) · The EMBO Journal · doi:10.1093/emboj/19.16.4323 · Cited by 223 · see citing works
Activation and Deactivation of Gene Expression by Ca2+/Calcineurin-NFAT-mediated Signaling
Im, S., & Rao, A. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13074-3 · Cited by 211 · see citing works
SAPK/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor
Humphreys, B. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002770200 · Cited by 199 · see citing works
Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.
Greenberg, S., Virgilio, F. D., Steinberg, T. H., & Silverstein, S. C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81521-1 · Cited by 192 · see citing works
Selective inhibition of calcineurin-NFAT signaling by blocking protein–protein interaction with small organic molecules
Roehrl, M. H. A., Kang, S., Aramburu, J., Wagner, G., Rao, A., & Hogan, P. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401835101 · Cited by 175 · see citing works
Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases
Yang, T. T. C., Xiong, Q., Enslen, H., Davis, R. J., & Chow, C.-W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3892-3904.2002 · Cited by 174 · see citing works
The AU-Rich Transcriptome: More Than Interferons and Cytokines, and Its Role in Disease
Khabar, K. S. A. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.1 · Cited by 174 · see citing works
Mechanisms underlying extracellular ATP‐evoked interleukin‐6 release in mouse microglial cell line, MG‐5
Shigemoto‐Mogami, Y., Koizumi, S., Tsuda, M., Ohsawa, K., Kohsaka, S., & Inoue, K. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00514.x · Cited by 173 · see citing works
Self-citation
μ and κ Opioid Receptors Activate ERK/MAPK via Different Protein Kinase C Isoforms and Secondary Messengers in Astrocytes
Belcheva, M. M., Clark, A. L., Haas, P. D., Serna, J. S., Hahn, J. W., Kiss, A., & Coscia, C. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502593200 · Cited by 173 · see citing works
Upregulation of the Enzyme Chain Hydrolyzing Extracellular ATP after Transient Forebrain Ischemia in the Rat
Braun, N., Zhu, Y. S., Krieglstein, J., Culmsee, C., & Zimmermann, H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04891.1998 · Cited by 172 · see citing works
Stress-activated Protein Kinase/JNK Activation and Apoptotic Induction by the Macrophage P2X7 Nucleotide Receptor
Humphreys, B. D., Rice, J., Kertesy, S. B., & Dubyak, G. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61445-6 · Cited by 170 · see citing works
Multiple p21ras effector pathways regulate nuclear factor of activated T cells.
Genot, E. M., Cleverley, S. C., Henning, S. W., & Cantrell, D. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00766.x · Cited by 163 · see citing works
P2X7/P2Z Purinoreceptor-mediated Activation of Transcription Factor NFAT in Microglial Cells
Ferrari, D., Stroh, C., & Schulze‐Osthoff, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13205 · Cited by 156 · see citing works
Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization
Porter, C. M., Havens, M. A., & Clipstone, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3543 · Cited by 151 · see citing works
Identification of Elastase as a Secretory Protease from Cultured Rat Microglia
Nakajima, K., Shimojo, M., Hamanoue, M., Ishiura, S., Sugita, H., & Kohsaka, S. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11356.x · Cited by 139 · see citing works
Neutralization of Macrophage Inflammatory Protein 2 (MIP-2) and MIP-1α Attenuates Neutrophil Recruitment in the Central Nervous System during Experimental Bacterial Meningitis
Diab, A., Abdalla, H., Li, H. L., Shi, F., Zhu, J., Höjberg, B., Lindquist, L., Wretlind, B., Bakhiet, M., & Link, H. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2590-2601.1999 · Cited by 138 · see citing works
Peripheral blood stem cell mobilization: The CXCR2 ligand GROβ rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties
Pelus, L. M., & Fukuda, S. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.04.004 · Cited by 127 · see citing works
Role of P2X 7 Receptors in Ischemic and Excitotoxic Brain Injury In Vivo
Feuvre, R. A. L., Brough, D., Touzani, O., & Rothwell, N. J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048519.34839.97 · Cited by 122 · see citing works
Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT
Kataoka, A., Tozaki‐Saitoh, H., Koga, Y., Tsuda, M., & Inoue, K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05744.x · Cited by 121 · see citing works
Self-citation
P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C
BRADFORD, M. D., & Soltoff, S. P. (2002) · Biochemical Journal · doi:10.1042/bj20020358 · Cited by 97 · see citing works
Characterization and possible function of adenosine 5′‐triphosphate receptors in activated rat microglia
Nörenberg, W., Langosch, J. M., Gebicke‐Haerter, P. J., & Illés, P. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14830.x · Cited by 96 · see citing works
Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis
Kerstetter, A. E., Padovani-Claudio, D. A., Bai, L., & Miller, R. H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.010 · Cited by 95 · see citing works
Differential regulation of the CXCR2 chemokine network in rat brain trauma: Implications for neuroimmune interactions and neuronal survival
Vallès, A., Grijpink-Ongering, L. G., de Bree, F. M., Tuinstra, T., & Ronken, E. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.015 · Cited by 95 · see citing works
c-Jun N-terminal Kinase (JNK) Positively Regulates NFATc2 Transactivation through Phosphorylation within the N-terminal Regulatory Domain
Ortega‐Pérez, I., Cano, E., Were, F., Villar, M., Vázquez, J., & Redondo, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501898200 · Cited by 82 · see citing works
CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer
Parenty, G., Appelbe, S., & Milligan, G. (2008) · Biochemical Journal · doi:10.1042/bj20071689 · Cited by 74 · see citing works
NF-κB and c-Jun-dependent regulation of macrophage inflammatory protein-2 gene expression in response to lipopolysaccharide in RAW 264.7 cells
Kim, D., Han, J. H., & Kwon, H. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.07.001 · Cited by 72 · see citing works
Modulation of monocyte signaling and pore formation in response to agonists of the nucleotide receptor P2X7
Aga, M., Johnson, C. J., Hart, A. P., Guadarrama, A. G., Suresh, M., Svaren, J. P., Bertics, P. J., & Darien, B. J. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.222 · Cited by 72 · see citing works
Macrophage Inflammatory Protein-2 and KC Induce Chemokine Production by Mouse Astrocytes
Luo, Y., Fischer, F. R., Hancock, W. W., & Dorf, M. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.4015 · Cited by 67 · see citing works
Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
Potucek, Y., Crain, J. M., & Watters, J. J. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.04.005 · Cited by 61 · see citing works
Transcription Cooperation by NFAT·C/EBP Composite Enhancer Complex
Yang, T. T. C., & Chow, C.-W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211560200 · Cited by 57 · see citing works
Accumulation of microglial cells expressing ELR motif-positive CXC chemokines and their receptor CXCR2 in monkey hippocampus after ischemia-reperfusion
Popivanova, B. K., Koike, K., Tonchev, A. B., Ishida, Y., Kondo, T., Ogawa, S., Mukaida, N., Inoue, M., & Yamashima, T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02343-6 · Cited by 51 · see citing works
MafA transcription factor is phosphorylated by p38 MAP kinase
Sii-Felice, K., Pouponnot, C., Gillet, S., Lecoin, L., Girault, J., Eychène, A., & Felder‐Schmittbuhl, M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.086 · Cited by 48 · see citing works
Chemokine MIP-2/CXCL2, acting on CXCR2, induces motor neuron death in primary cultures
De Paola, M., Buanne, P., Biordi, L., Bertini, R., Ghezzi, P., & Mennini, T. (2007) · NeuroImmunoModulation · doi:10.1159/000123834 · Cited by 47 · cited 1× · see citing works
“…reports indicate that CXCR2 is involved in Alzheimer’s disease (Bakshi et al. 2009), ischemia (Popivanova et al. 2003), traumatic injury (Valles et al. 2006), multiple sclerosis (Kerstetter et al. 2009), neuronal death (De Paola et al. 2007) and opioid receptor function (Parenty et al. 2008).”
Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells
Ramnath, R. D., Sun, J. T., Adhikari, S., Liang, Z., & Bhatia, M. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00360.2007 · Cited by 34 · see citing works
Identification of PSF, the polypyrimidine tract-binding protein-associated splicing factor, as a developmentally regulated neuronal protein
Chanas-Sacré, G., Mazy‐Servais, C., Wattiez, R., Pirard, S., Rogister, B., Patton, J. G., Belachew, S. M., Malgrange, B., Moonen, G., & Leprince, P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990701)57:1 · Cited by 33 · see citing works
Identification of protein kinase C isoforms involved in interferon-gamma-induced expression of inducible nitric oxide synthase in murine BV2 microglia
Kang, J., Yang, M.-S., Jou, I., & Joe, E.-H. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01515-4 · Cited by 27 · see citing works
Structural optimization of a CXCR2-directed antagonist that indirectly inhibits γ-secretase and reduces Aβ
Bakshi, P., Jin, C., Broutin, P., Berhane, B. T., Reed, J. M., & MULLAN, M. J. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.051 · Cited by 22 · see citing works
Analysis of the mechanism regulating the stability of rat macrophage inflammatory protein‐2 mRNA in RBL‐2H3 cells
Numahata, K., Komagata, T., Hirasawa, N., Someya, K., Xiao, Y., & Ohuchi, K. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10710 · Cited by 14 · see citing works
Microglial ecto-Ca2+-ATPase activity in a rat model of focal homologous blood clot embolic cerebral ischemia: an enzyme histochemical study
Igarashi, H., Yokofujita, J., Murakami, K., Okada, A., & Kuroda, M. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00028-5 · Cited by 7 · see citing works

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Ó 2010 The Authors Journal Compilation Ó 2010 International Society for Neurochemistry, J. Neurochem. (2010) 114, 810-819 P2X7 mediated CXCL2 release | 817 14714159, 2010, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06809.x by Mount Vernon Nazarene University, Wiley Online Library on [17/08/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
Ó 2010 The Authors Journal Compilation Ó 2010 International Society for Neurochemistry, J. Neurochem. (2010) 114, 810-819 P2X7 mediated CXCL2 release | 819 14714159, 2010, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06809.x by Mount Vernon Nazarene University, Wiley Online Library on [17/08/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI

Sorted by citations

Physiology of Microglia
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
Gong, T., Liu, L., Jiang, W., & Zhou, R. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0215-7 · Cited by 1,672 · see citing works
The P2X7 Receptor in Infection and Inflammation
Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267 · see citing works
“…and mouse mast cells (Panenka et al., 2001; Kurashima et al., 2012), IL-8 in rat C6 glioma cells (Wei et al., 2008), CC-chemokine ligand 3 (CCL3) in mouse microglial MG-5 cells (Kataoka et al., 2009), and CXCL2 in mouse microglia and mast cells (Shiratori et al., 2010; Kurashima et al., 2012).”
The biphasic function of microglia in ischemic stroke
Ma, Y., Wang, J., Wang, Y., & Yang, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 724 · see citing works
“Culture supernatants derived from Th1 cells promoted microglia to up-regulate M1 phenotype related genes such as MCP-1 and CCL-2 expression, indicating that Th1 could affect microglia polarization in a paracrine manner.”
Influential
The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases
Nakahira, K., Hisata, S., & Choi, A. M. K. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6407 · Cited by 363 · see citing works
Neuroinflammation after intracerebral hemorrhage
Mracsko, E. Z., & Veltkamp, R. C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00388 · Cited by 343 · see citing works
“Beyond the neurotoxic cytokines, chemokines such as CXCL2 produced by microglia (Shiratori et al., 2010) have chemotactic activity on neutrophils and thus exacerbate the inflammatory reaction (Tessier et al., 1997).”
Background
Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors
Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works
Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage
Zhu, H., Wang, Z., Yu, J., Yang, X., He, F., Liu, Z., Che, F., Chen, X., Ren, H., Hong, M., et al. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.03.003 · Cited by 319 · see citing works
Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage
Zhang, Z., Zhang, Z., Lu, H., Yang, Q., Wu, H., & Wang, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9785-6 · Cited by 276 · see citing works
Neuronal and microglial mechanisms of neuropathic pain
Zhuo, M., Wu, G., & Wu, L. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-31 · Cited by 256 · see citing works
“Activation of P2X4 in microglia facilitates BDNF release [74], while activation of P2X7 in microglia induces IL1b release and CXCL2 production [75,76].”
Background
The mechanisms of microgliosis and pain following peripheral nerve injury
Calvo, M., & Bennett, D. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.018 · Cited by 224 · see citing works
“ATP binding to different receptors in microglia stimulates cytokine release: P2X7 receptors activation leads to secretion of TNFα (Hide et al., 2000), CXCL2 (Shiratori et al., 2010), and IL-1β (Clark et al., 2010a); and an unidentified P2Y receptor stimulates IL-6 secretion (Shigemoto-Mogami et al., 2001).”
Background
The microglial ATP‐gated ion channel P2X7 as a CNS drug target
Bhattacharya, A., & Biber, K. (2016) · Glia · doi:10.1002/glia.23001 · Cited by 221 · see citing works
“…causes IL-1b (and IL-18) release (Bhattacharya et al., 2013; Monif et al., 2010) although reports of TNF-a, IL-6, CCL2, CCL3 and CXCL2 release in microglia have also been reported in response to P2X7 activation (Kataoka et al., 2009; Mingam et al., 2008; Shieh et al., 2014; Shiratori et al., 2010).”
Background
Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ ‐47965567
Bhattacharya, A., Wang, Q., Ao, H., Shoblock, J. R., Lord, B., Aluisio, L. E., Fraser, I. C., Nepomuceno, D. H., Neff, R. A., Welty, N., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12314 · Cited by 200 · see citing works
“In addition to IL-1β, P2X7 dependent release of glutamate (Ando and Sperlagh, 2013), cathepsins (Clark et al., 2010) and chemokines (Shiratori et al., 2010) have been reported, and all of these mediators can serve as ‘gliotransmitters’ aiding in the neuroimmune cross-talk and modulating synaptic…”
Background
Microglial Phenotype and Adaptation
Eggen, B. J. L., Raj, D. D. A., Hanisch, U., & Boddeke, H. W. G. M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9490-4 · Cited by 176 · see citing works
P2X7‐dependent, but differentially regulated release of IL‐6, CCL2, and TNF‐α in cultured mouse microglia
Shieh, C., Heinrich, A., Serchov, T., van Calker, D., & Biber, K. (2014) · Glia · doi:10.1002/glia.22628 · Cited by 179 · see citing works
“P2X7 stimulation leads to IL-1b, CCL3, TNF-a, and CXCL2 release in immortalized microglia-like cells or rat microglia (Ferrari et al., 1997; Hide et al., 2000; Kataoka et al., 2009; Shiratori et al., 2010; Suzuki et al., 2004).”
Background
The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review
Zeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., & Ge, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047550 · Cited by 175 · see citing works
P2X7 in Cancer: From Molecular Mechanisms to Therapeutics
Lara, R., Adinolfi, E., Harwood, C. A., Philpott, M. P., Barden, J. A., Virgilio, F. D., & McNulty, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00793 · Cited by 165 · see citing works
“P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways.”
Chronic Pain States: Pharmacological Strategies to Restore Diminished Inhibitory Spinal Pain Control
Zeilhofer, H. U., Benke, D., & Yévenes, G. E. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134636 · Cited by 161 · see citing works
The P2X7 Receptor: Central Hub of Brain Diseases
Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works
“Additionally, the P2X7 receptor may also stimulate the release of TNF, IL-6, CCL2, CCL3, and CXCL2 (Suzuki et al., 2004; Kataoka et al., 2009; Shiratori et al., 2010; Shieh et al., 2014).”
Background
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release
Barberà‐Cremades, M., Baroja‐Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., & Pelegrín, P. (2012) · The FASEB Journal · doi:10.1096/fj.12-205765 · Cited by 142 · see citing works
Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles
Hu, X., Liou, A. K. F., Leak, R. K., Xu, M., An, C., Suenaga, J., Shi, Y., Gao, Y., Zheng, P., & Chen, J. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.06.002 · Cited by 131 · see citing works
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
Akhtar‐Schäfer, I., Wang, L., Krohne, T. U., Xu, H., & Langmann, T. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708259 · Cited by 127 · see citing works
“…cells or elevated glucose levels increase the extracellular ATP concentration, which activates the P2X7 receptor (P2X7R) on MPs and induces a chemokine release through PKC/MAP kinase pathway activation (Fig 2; Potucek et al, 2006; Costa et al, 2009; Shiratori et al, 2010; He et al, 2017).”
Background
Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-κB and MAPK pathways
Liang, H., Chen, A., Lai, X., Liu, J., Wu, J., Kang, Y., Wang, X., & Shao, L. (2018) · Particle and Fibre Toxicology · doi:10.1186/s12989-018-0274-0 · Cited by 118 · see citing works
Microglial Regulation of Neuropathic Pain
Tsuda, M., Masuda, T., Tozaki‐Saitoh, H., & Inoue, K. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12r14cp · Cited by 114 · see citing works
Self-citation
Calcineurin and glial signaling: neuroinflammation and beyond
Furman, J. L., & Norris, C. M. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0158-7 · Cited by 109 · see citing works
“While this review has focused primarily on the role of CN in astrocytes, other work showing similar roles of CN in microglia [56-58,74] underscores the necessity to characterize the signaling properties of CN in other glial subtypes.”
Microglia and intractable chronic pain
Tsuda, M., Beggs, S., Salter, M. W., & Inoue, K. (2013) · Glia · doi:10.1002/glia.22379 · Cited by 113 · see citing works
“Furthermore, it has been shown that microglial P2X7R stimulation can induce synthesis and release of chemokines including CCL3 and CXCL2 (Kataoka et al., 2009; Shiratori et al., 2010).”
BackgroundSelf-citation
Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release
Zimmermann, H. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9483-2 · Cited by 105 · see citing works
Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats
Okubo, M., Yamanaka, H., Kobayashi, K., Dai, Y., Kanda, H., Yagi, H., & Noguchi, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153375 · Cited by 105 · see citing works
“Phosphorylation of p38 mitogen activated protein kinase (p-p38 MAPK), one of the indicators for activated-state, occurred in microglia following application of ATP in vitro [5].”
BackgroundInfluential
Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain
Sawicki, C. M., McKim, D. B., Wohleb, E. S., Jarrett, B. L., Reader, B. F., Norden, D. M., Godbout, J. P., & Sheridan, J. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.004 · Cited by 101 · see citing works
“Others have reported that activated microglia release CXCL2 in models of P2X7 receptor stimulation (Shiratori et al., 2010) and LPS injection (Thomas et al.”
Background
P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?
Young, C., & Górecki, D. C. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00248 · Cited by 95 · see citing works
P2X7 Receptor Orchestrates Multiple Signalling Pathways Triggering Inflammation, Autophagy and Metabolic/Trophic Responses
Orioli, E., Marchi, E. D., Giuliani, A. L., & Adinolfi, E. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170303161659 · Cited by 95 · see citing works
Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury
Furman, J. L., Sompol, P. M., Kraner, S. D., Pleiss, M. M., Putman, E. J., Dunkerson, J., Abdul, H. M., Roberts, K. N., Scheff, S. W., & Norris, C. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1930-15.2016 · Cited by 94 · see citing works
“…CN/NFAT pathway is an important regulator of the activated phenotypes of both astrocytes (Norris et al., 2005; Fernandez et al., 2007; Sama et al., 2008; Serrano-Pérez et al., 2011; Furman et al., 2012) and microglia (Kataoka et al., 2009; Nagamoto-Combs and Combs, 2010; Shiratori et al., 2010).”
Background
The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells
Tsai, S. H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Obata‐Ninomiya, K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.015 · Cited by 93 · see citing works
The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies
Zalpoor, H., Akbari, A., Samei, A., Forghaniesfidvajani, R., Kamali, M., Afzalnia, A., Manshouri, S., Heidari, F., Pornour, M., Khoshmirsafa, M., et al. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00311-1 · Cited by 91 · see citing works
“Further, activation of the P2X7 receptor by ATP stimulates the activation of both MAPKs (p38, ERK, and JNK) and nuclear factor of activated T cells (NFAT) [45].”
Background
Purinergic Signaling During Immune Cell Trafficking
Ferrari, D., McNamee, E. N., Idzko, M., Gambari, R., & Eltzschig, H. K. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.004 · Cited by 88 · see citing works
“It has been shown that extracellular ATP induces activation of the transcription factor nuclear factor of activated T cells (NFAT) in mouse microglial cells and recent data indicate a role of NFAT in P2X7-induced CCL3 and CXCL2 secretion in microglia [50,85] (Figure 2B and Table 1).”
Background
Neuron–microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration
Tsuda, M., & Inoue, K. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.042 · Cited by 86 · see citing works
“Furthermore, it has been shown that microglial P2X7R stimulation ca induce synthesis and release of the chemokines CCL3 and CXCL2 (Kataoka et al., 2009; Shiratori et al., 2010).”
BackgroundSelf-citation
P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation
Weisman, G. A., Camden, J. M., Peterson, T. S., Ajit, D., Woods, L. T., & Erb, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8263-z · Cited by 85 · see citing works
Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors
Inoue, K., & Tsuda, M. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114309 · Cited by 78 · see citing works
Self-citation
Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures
Kumamaru, H., Saiwai, H., Kobayakawa, K., Kubota, K., van Rooijen, N., Inoue, K., Iwamoto, Y., & Okada, S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-116 · Cited by 74 · see citing works
“, Department of Medical Physiology, University Medical Center Groningen, University of Groningen) was cultured in DMEM with 5% FBS, 2 mM L-glutamine, and 1% penicillin–streptomycin, as described previously [34,35].”
MethodSelf-citation
P2 receptors, microglial cytokines and chemokines, and neuropathic pain
Tsuda, M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23816 · Cited by 71 · see citing works
“Furthermore, it was demonstrated that microglial P2X7R stimulation can induce synthesis and the release of chemokines, including CCL3 and CXCL2 (Kataoka et al., 2009; Shiratori et al., 2010).”
BackgroundSelf-citation
Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432
Lord, B., Aluisio, L. E., Shoblock, J. R., Neff, R. A., Varlinskaya, E. I., Ceusters, M., Lovenberg, T. W., Carruthers, N. I., Bonaventure, P., Letavic, M. A., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.218487 · Cited by 73 · see citing works
“…to IL-1b, P2X7-dependent release of glutamate (Andó and Sperlágh, 2013; Ficker et al., 2014), cathepsins (Clark et al., 2010), and chemokines (Shiratori et al., 2010) have been reported, and all of these mediators can serve as “gliotransmitters” aiding in the neuroimmune cross-talk and…”
Background
Emerging role of P2X7 receptors in CNS health and disease
Tewari, M., & Seth, P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.10.001 · Cited by 74 · see citing works
Attenuation of microglial activation in a mouse model of Alzheimer’s disease via NFAT inhibition
Rojanathammanee, L., Floden, A. M., Manocha, G. D., & Combs, C. K. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0255-2 · Cited by 71 · see citing works
“It is clear that microglia express NFAT isoforms [65,68-72] with particularly high levels of NFATc2 [70,71].”
Background
A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., Bansal, R., & Broersen, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210497 · Cited by 73 · see citing works
“While increased NF-AT expression was also associated with astrocyte activation in an inflammatory brain damage mouse model, the cytoplasmic NF-AT3 transcripts were found to be upregulated [249] and nuclear translocation of NF-ATs is induced by ATP that activates of purinergic type 2 (P2)X7 receptor which stimulates th…”
Background
Role of P2X7 Receptors in Immune Responses During Neurodegeneration
Oliveira-Giacomelli, Á., Petiz, L. L., Andrejew, R., Turrini, N., Silva, J. B., Sack, U., & Ulrich, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.662935 · Cited by 68 · see citing works
P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders
Chrovian, C. C., Rech, J. C., Bhattacharya, A., & Letavic, M. A. (2014) · Progress in medicinal chemistry · doi:10.1016/b978-0-444-63380-4.00002-0 · Cited by 67 · see citing works
The role and pharmacological properties of the P2X7 receptor in neuropathic pain
Zhang, W., Zhu, J., & Liu, Z.-X. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.11.006 · Cited by 67 · see citing works
LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2
Yu, Y., Zhang, Y., Zhang, Y., Lai, Y., Chen, W., Xiao, Z., Zhang, W., Jin, M., & Yu, B. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.016 · Cited by 64 · see citing works
RETRACTED: ATP ion channel P2X purinergic receptors in inflammation response
Liu, J., Liu, S.-C., Hu, S.-Q., Lu, J., Wu, C., Hu, D.-X., & Zhang, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114205 · Cited by 62 · see citing works
Retracted
Extracellular ATP‐stimulated macrophages produce macrophage inflammatory protein‐2 which is important for neutrophil migration
Kawamura, H., Kawamura, T., Kanda, Y., Kobayashi, T., & Abo, T. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03601.x · Cited by 60 · see citing works
Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability
Weiss, S., Melom, J. E., Ormerod, K. G., Zhang, Y. V., & Littleton, J. T. (2019) · eLife · doi:10.7554/elife.44186 · Cited by 56 · see citing works
“…activation, immune-like responses and cytokine production (Furman and Norris, 2014), with the pathway being intimately involved in neuroinflammation (Furman and Norris, 2014; Kataoka et al., 2009; Nagamoto-Combs and Combs, 2010; Rojanathammanee et al., 2013; Shiratori et al., 2010).”
Background
Electroacupuncture may alleviate neuropathic pain via suppressing P2X7R expression
Wu, Q., Yue, J., Lin, L., Yu, X., Zhou, Y. H., Ying, X., Chen, X., Tu, W., Lou, X., Yang, G., et al. (2021) · Molecular Pain · doi:10.1177/1744806921997654 · Cited by 54 · see citing works
Astroglial and Microglial Purinergic P2X7 Receptor as a Major Contributor to Neuroinflammation during the Course of Multiple Sclerosis
Sidoryk‐Wȩgrzynowicz, M., & Strużyńska, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168404 · Cited by 51 · see citing works
“Calcineurin-dependent nuclear factor of activated T cells (NFAT) and protein kinase C (PKC)/MAP kinase (MAPK) are downstream pathways of P2X7R activation that are implicated in this chemokine release [84].”
Background
P2X7 receptor in inflammation and pain
Hu, S.-Q., Hu, J., Zou, F.-L., Liu, J., Luo, H., Hu, D.-X., Wu, L., & Zhang, W. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.006 · Cited by 50 · see citing works
APOEgenotype-dependent modulation of astrocyte chemokine CCL3 production
Cudaback, E., Yang, Y. J., Montine, T. J., & Keene, C. D. (2014) · Glia · doi:10.1002/glia.22732 · Cited by 46 · see citing works
“Nuclear factor of acti- vated T cells (NFAT) is a transcription factor known to regulate the induction of CCL3, CCL4, and CXCL2, including in primary astrocytes (Ahamed et al., 2004; Kim et al., 2011; Shiratori et al., 2010).”
Background
ATP Induces Protein Arginine Deiminase 2-Dependent Citrullination in Mast Cells through the P2X7 Purinergic Receptor
Arandjelovic, S., McKenney, K. R., Leming, S. S., & Mowen, K. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201098 · Cited by 47 · see citing works
“Because mast cells can produce chemokines and P2X7-dependent chemokine expression has been demonstrated in microglial cells, chemokines could be PAD2 targets after P2X7 stimulation (33, 62, 63).”
BackgroundMethod
Brain injury and repair after intracerebral hemorrhage: The role of microglia and brain-infiltrating macrophages
Dasari, R., Bonsack, F., & Sukumari‐Ramesh, S. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104923 · Cited by 43 · see citing works
Biofilm-Infected Intracerebroventricular Shunts Elicit Inflammation within the Central Nervous System
Snowden, J. N., Beaver, M., Smeltzer, M. S., & Kielian, T. (2012) · Infection and Immunity · doi:10.1128/iai.00645-12 · Cited by 46 · see citing works
“CXCL2 has chemotactic properties similar to those of CXCL1, recruiting neutrophils to sites of infection or injury (5, 20, 35).”
Background
P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia
Liu, P.-W., Yue, M.-X., Zhou, R., Niu, J., Huang, D., Xu, T., Luo, P., Liu, X., & Zeng, J. (2017) · Journal of Pain Research · doi:10.2147/jpr.s137131 · Cited by 45 · see citing works
Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease
Gallart‐Palau, X., Serra, A., Lee, B. S. T., Guo, X., & Sze, S. K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0946-y · Cited by 45 · see citing works
P2X receptors in neuroglia
Verkhratsky, A., Pankratov, Y. V., Lalo, U., & Nedergaard, M. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.12 · Cited by 44 · see citing works
The Role of ATP Receptors in Pain Signaling
Inoue, K. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03516-6 · Cited by 42 · see citing works
“Activation of microglial P2X7Rs also induces the production and release of chemokines including CCL3 and CXCL2 [132, 133].”
BackgroundSelf-citation
Mitochondrial DAMPs: Key mediators in neuroinflammation and neurodegenerative disease pathogenesis
Yu, H., Ren, K., Jin, Y., Zhang, L., Liu, H., Huang, Z., Zhang, Z., Chen, X., Yang, Y., & Wei, Z. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110217 · Cited by 44 · see citing works
Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death
Lecca, D., Ceruti, S., Fumagalli, M., & Abbracchio, M. P. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9310-y · Cited by 42 · see citing works
Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function
Pleiss, M. M., Sompol, P. M., Kraner, S. D., Abdul, H. M., Furman, J. L., Guttmann, R. P., Wilcock, D. M., Nelson, P. T., & Norris, C. M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.05.007 · Cited by 42 · see citing works
Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis
Lemche, E., Killick, R., Mitchell, J., Caton, P., Choudhary, P., & Howard, J. K. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106485 · Cited by 42 · see citing works
P2X7 Receptor Function in Bone-Related Cancer
Adinolfi, E., Amoroso, F., & Giuliani, A. L. (2012) · Journal of Osteoporosis · doi:10.1155/2012/637863 · Cited by 41 · see citing works
“NFAT is one of themain pathways activated through Ca2+ and calcineurin following P2X7 stimulation [29, 85–88].”
Background
Neuroinflammation in CNS diseases: Molecular mechanisms and the therapeutic potential of plant derived bioactive molecules
Welcome, M. O. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100176 · Cited by 41 · see citing works
Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation
Giblin, M. J., Smith, T. E., Winkler, G. A., Pendergrass, H. A., Kim, M. J., Capozzi, M. E., Yang, R., McCollum, G. W., & Penn, J. S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166238 · Cited by 40 · see citing works
Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases
Zheng, H., Liu, Q., Zhou, S., Luo, H., & Zhang, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1345625 · Cited by 40 · see citing works
Purinergic Modulation of Spinal Neuroglial Maladaptive Plasticity Following Peripheral Nerve Injury
Cirillo, G., Colangelo, A. M., Berbenni, M., Ippolito, V. M., Luca, C. D., Verdesca, F., Savarese, L., Alberghina, L., Maggio, N., & Papa, M. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8943-y · Cited by 39 · see citing works
“cytokines [33], and (v) induce activation of matrix metalloproteinases [34] and mechanisms of cell death via caspase activation [35].”
Background
Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor
Swanson, D. M., Savall, B. M., Coe, K. J., Schoetens, F., Koudriakova, T. B., Skaptason, J., Wall, J. L., Rech, J. C., Deng, X., Angelis, M. D., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00989 · Cited by 38 · see citing works
Cerebrovascular inflammation: A critical trigger for neurovascular injury?
Naveed, M., Zhou, Q., & Han, F. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.011 · Cited by 36 · see citing works
“of P2X7 activation is release of the pro-inflammatory cytokines IL-18, IL-1β, IL-6, TNF-α, and chemokines (Shiratori et al., 2010; W et al., 2001), cathepsins (Clark et al.”
Intracerebral Hemorrhage: The Effects of Aging on Brain Injury
Watson, N. J., Bonsack, F., & Sukumari‐Ramesh, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.859067 · Cited by 37 · see citing works
Role of Purinergic Receptors in CNS Function and Neuroprotection
Tozaki‐Saitoh, H., Tsuda, M., & Inoue, K. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385526-8.00015-1 · Cited by 37 · see citing works
“Several chemokines are also known to be released from microglia, as release of CCL3 and CXCL2 is induced by extracellular ATP via the P2X7 receptor (Kataoka et al., 2009; Shiratori et al., 2010).”
BackgroundSelf-citation
Circulating P2X7 Receptor Signaling Components as Diagnostic Biomarkers for Temporal Lobe Epilepsy
Conte, G., Menéndez‐Méndez, A., Bauer, S., Naggar, H. E., Alves, M., Nicke, A., Delanty, N., Rosenow, F., Henshall, D. C., & Engel, T. (2021) · Cells · doi:10.3390/cells10092444 · Cited by 36 · see citing works
NFATc2 mediates epigenetic modification of dendritic cell cytokine and chemokine responses to dectin-1 stimulation
Yu, H.-B., Yurieva, M., Balachander, A., Foo, I., Leong, X., Zelante, T., Zolezzi, F., Poidinger, M., & Ricciardi‐Castagnoli, P. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1369 · Cited by 34 · see citing works
“Of these, CXCL2 has previously been shown to be regulated by NFAT in microglia (45), and Cxcl8 expression was reported to depend on NFAT in adenocarcinoma cells (46).”
Background
NFATc2 Modulates Microglial Activation in the AβPP/PS1 Mouse Model of Alzheimer’s Disease
Manocha, G. D., Ghatak, A., Puig, K. L., Kraner, S. D., Norris, C. M., & Combs, C. K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-151203 · Cited by 34 · see citing works
Ca2+ store depletion and endoplasmic reticulum stress are involved in P2X7 receptor‐mediated neurotoxicity in differentiated NG108‐15 cells
Chao, C., Huang, C., Lu, D., Wong, K., Chen, Y., Cheng, T., & Leung, Y. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24010 · Cited by 34 · see citing works
“…can be seen in the online version of this article, available at http://wileyonlinelibrary.com/journal/jcb] 1384 P2X7R-MEDIATED NEUROTOXICITY INVOLVES ER STRESS JOURNAL OF CELLULAR BIOCHEMISTRY types [Amstrup and Novak, 2003; Pfeiffer et al., 2004; Stefano et al., 2007; Shiratori et al., 2010].”
Background
Actions of Thyroid Hormone Analogues on Chemokines
Davis, P. J., Glinsky, G. V., Lin, H., & Mousa, S. A. (2016) · Journal of Immunology Research · doi:10.1155/2016/3147671 · Cited by 36 · see citing works
“ATP activates signal transducing mitogen-activated protein kinase (MAPK) in these cells that down-stream results in CXCL2 gene expression [34].”
P2 receptor networks regulate signaling duration over a wide dynamic range of ATP concentrations
Grol, M. W., Pereverzev, A., Sims, S. M., & Dixon, S. J. (2013) · Journal of Cell Science · doi:10.1242/jcs.122705 · Cited by 33 · see citing works
“The role of the Ca2+regulated NFAT transcription factors in P2 receptor signaling has also been examined previously (Ferrari et al., 1999; Abbott et al., 2000; Kataoka et al., 2009; Shiratori et al., 2010).”
Background
Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis
Karpurapu, M., Lee, Y. G., Qian, Z., Wen, J., Ballinger, M. N., Rusu, L., Chung, S., Deng, J., Qian, F., Reader, B. F., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24320 · Cited by 33 · see citing works
Immunomodulatory role of mitochondrial DAMPs: a missing link in pathology?
Garg, M., Johri, S., & Chakraborty, K. (2022) · FEBS Journal · doi:10.1111/febs.16563 · Cited by 32 · see citing works
“…mtDNA, certain viruses such as HPV induce mtDNA stress leading to the activation of the cGAS – STING – IRF3 axis Neuronal cell lines, microglia [141,142,144] Age-related macular degeneration (AMD) ATP P2X7 receptor-induced apoptosis Murine models [143] mtDNA TLR-9-mediated inﬂammation In murine…”
Inhibition of microglial activation contributes to propofol‐induced protection against post‐cardiac arrest brain injury in rats
Wang, W., Lu, R., Feng, D., Liang, L., Liu, B., & Zhang, H. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13179 · Cited by 30 · see citing works
“Extracellular ATP activates P2X7R in microglial membrane and in turn leads to microglial activation (Shiratori et al. 2010; Eyo et al. 2013).”
Background
ATP induces PAD4 in renal proximal tubule cells via P2X7 receptor activation to exacerbate ischemic AKI
Rabadi, M. M., Kim, M., Li, H., Han, S. J., Choi, Y., D’Agati, V. D., & Lee, H. T. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00364.2017 · Cited by 30 · see citing works
“In contrast, p38 MAPK or ERK MAPK does not appear to play a role as neither SB203680 (a p38 MAPK inhibitor) nor PD98059 (an ERK MAPK inhibitor) attenuated ATP-mediated PAD4 induction in HK-2 cells (N 3–4).”
Background
Differential Cellular Expression of Galectin-1 and Galectin-3 After Intracerebral Hemorrhage
Bonsack, F., & Sukumari‐Ramesh, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00157 · Cited by 30 · see citing works
“Furthermore, inflammatory response after ICH also regulates the brain recruitment of blood-derived monocytes/macrophages that are known to regulate ICH-induced brain injury and thereby functional recovery (Tessier et al., 1997; Shiratori et al., 2010; Starossom et al., 2012).”
Background
The hallmark and crosstalk of immune cells after intracerebral hemorrhage: Immunotherapy perspectives
Zhang, W., Wu, Q., Hao, S., & Chen, S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1117999 · Cited by 29 · see citing works
“In addition, it has also been spotted that CCL20, CXCL2, and CXCL10 can accelerate the migration of peripheral immune cells (Shiratori et al., 2010; Guedj et al., 2014; Chong et al., 2015).”
Background
Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells.
Lenertz, L. Y., Baughman, C. J., Waldschmidt, N. V., Thaler, R., & van Wijnen, A. J. (2015) · Gene · doi:10.1016/j.gene.2015.06.031 · Cited by 28 · see citing works
“…and paracrine functions involve the calcium-dependent transcription factor nuclear factor of activated T cells (NFAT), which is known to be induced by extracellular nucleotides, at least in microglia, human MSCs and osteoblasts (Shiratori et al., 2010; Glaser et al., 2013; Grol et al., 2013).”
Background
Targeting inflammatory components in neuropathic pain: The analgesic effect of thymulin related peptide
Safieh‐Garabedian, B., Nomikos, M., & Saadé, N. E. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.041 · Cited by 27 · see citing works
Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway
Gąssowska-Dobrowolska, M., Olech-Kochańczyk, G., Culmsee, C., & Adamczyk, A. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s468609 · Cited by 27 · see citing works
“167 It has been reported that cardiolipin externalisation and relocation to the surface of dysregulated mitochondria also mediates the activation of NLRP3 to initiate a caspase-1-dependent neuroinflammatory response and release bioactive IL-18 and IL-1β.”
Background
Simulation of P2X‐mediated calcium signalling in microglia
Chun, B. J., Stewart, B. D., Vaughan, D. D., Bachstetter, A. D., & Kekenes-Huskey, P. M. (2018) · The Journal of Physiology · doi:10.1113/jp277377 · Cited by 24 · see citing works
The Role of Microglial Purinergic Receptors in Pain Signaling
Tozaki‐Saitoh, H., Takeda, H., & Inoue, K. (2022) · Molecules · doi:10.3390/molecules27061919 · Cited by 24 · see citing works
Self-citation
The Role of the NFAT Signaling Pathway in Retinal Neovascularization
Bretz, C. A., Savage, S. R., Capozzi, M. E., & Penn, J. S. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12183 · Cited by 22 · see citing works
NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel
Liu, M., Zhang, S., Luo, Y., Yang, Y., Zhang, X., Li, B., Meng, Y., Chen, Y.-J., Guo, R., Xiong, Y.-C., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01992-1 · Cited by 22 · see citing works
P2Y12 receptors in primary microglia activate nuclear factor of activated T‐cell signaling to induce C–C chemokine 3 expression
Tozaki‐Saitoh, H., Miyata, H., Yamashita, T., Matsushita, K., Tsuda, M., & Inoue, K. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13968 · Cited by 21 · see citing works
“(2017) 141, 100--110 (Kataoka et al. 2009; Shiratori et al. 2010; Kim et al. 2011).”
BackgroundSelf-citation
A Possible Causal Involvement of Neuroinflammatory, Purinergic P2X7 Receptors in Psychiatric Disorders
Tang, Y., Illes, P., Zhang, Y., Yin, H.-Y., & Rubini, P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302152400 · Cited by 20 · see citing works
“, chemokine [C-X-C motif] ligand 2; CXCL2) and monocyte chemoattractant protein 1 (MCP-1) in astrocytes and microglia [32, 35, 36].”
Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy
Zhang, H.-L., Sandai, D. A., Zhang, Z.-W., Song, Z., Babu, D., Tabana, Y., Dahham, S. S., Adam, M. A. A., Wang, Y., Wang, W. J., et al. (2023) · World Journal of Clinical Oncology · doi:10.5306/wjco.v14.i12.549 · Cited by 20 · see citing works
The azetidine derivative, KHG26792 protects against ATP-induced activation of NFAT and MAPK pathways through P2X7 receptor in microglia
Kim, E.-A. L., Cho, C. H., Kim, J., Hahn, H., Choi, S. Y., Yang, S.-J., & Cho, S. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.10.013 · Cited by 20 · see citing works
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition
Hu, Y., Tao, X., Han, X., Xu, L., Yin, L., Qi, Y., Zhao, Y., Xu, Y., Wang, C., & Peng, J. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.09.014 · Cited by 20 · see citing works

Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT
Kataoka, A., Tozaki‐Saitoh, H., Koga, Y., Tsuda, M., & Inoue, K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05744.x · Cited by 121 · see citing works
Self-citation
P2X7‐dependent, but differentially regulated release of IL‐6, CCL2, and TNF‐α in cultured mouse microglia
Shieh, C., Heinrich, A., Serchov, T., van Calker, D., & Biber, K. (2014) · Glia · doi:10.1002/glia.22628 · Cited by 179 · see citing works
The role of microglial P2X7: modulation of cell death and cytokine release
He, Y., Taylor, N., Fourgeaud, L., & Bhattacharya, A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0904-8 · Cited by 194 · see citing works
Rapid Morphologic and Molecular Activation of Microglial Cells by Stimulation of the P2X7 Receptor Correlates with Neuron LossPreprint
Campagno, K. E., Lu, W., Jassim, A. H., Albalawi, F., Cenaj, A., Tso, H., Clark, S. P., Sripinun, P., Gómez, N. M., & Mitchell, C. H. (2021) · Research Square · doi:10.21203/rs.3.rs-424697/v1 · Cited by 1 · see citing works
Mechanisms underlying extracellular ATP‐evoked interleukin‐6 release in mouse microglial cell line, MG‐5
Shigemoto‐Mogami, Y., Koizumi, S., Tsuda, M., Ohsawa, K., Kohsaka, S., & Inoue, K. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00514.x · Cited by 173 · see citing works
Self-citation

Authors: Shiratori, M., Tozaki‐Saitoh, H., Yoshitake, M., Tsuda, M., & Inoue, K.
Affiliations: Kyushu University (JP)
Corresponding author: Inoue, Kazuhide
ORCID: Tozaki‐Saitoh, Hidetoshi
Tsuda, Makoto
Inoue, Kazuhide
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2010-07-06
Volume: 114
Issue: 3
Pages: 810-819
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2010.06809.x
OpenAlex: W1575476617
Cited by: 153
References: 77
Citations by year: 2026: 3 · 2025: 9 · 2024: 8 · 2023: 11 · 2022: 11 · 2021: 9 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 11 · 2014: 13 · 2013: 6 · 2012: 14
FWCI: 5.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords: P2X7 receptor, microglia, CXCL2, chemokine secretion, ATP, NFAT, MAPK signaling, protein kinase C, p38 MAPK, ERK, JNK, Brilliant Blue G, neuroinflammation, neurodegeneration
MeSH terms: Adenosine Triphosphate, Animals, Cell Line, Protein Kinase C, Up-Regulation, Microglia, Receptors, Purinergic P2, MAP Kinase Signaling System, NFATC Transcription Factors, Mice, Rats, Chemokine CXCL2, Receptors, Purinergic P2X7, Purinergic P2 Receptor Agonists

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P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

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