P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release

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P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

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Pseudoapoptosis Induced by Brief Activation of ATP-gated P2X7 Receptors

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Inhibition of Chlamydial Infectious Activity due to P2X7R-Dependent Phospholipase D Activation

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P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

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Prostaglandin E2, an Immunoactivator

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Regulation of P2X7 nucleotide receptor function in human monocytes by extracellular ions and receptor density

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The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

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Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells

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Purine Release, Metabolism, and Signaling in the Inflammatory Response

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P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

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Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

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Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

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Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis

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Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors

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The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain

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Autocrine Regulation of Macrophage Activation via Exocytosis of ATP and Activation of P2Y11 Receptor

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The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

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P2X7 Receptor as a Therapeutic Target

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Signaling through Purinergic Receptors for ATP Induces Human Cutaneous Innate and Adaptive Th17 Responses: Implications in the Pathogenesis of Psoriasis

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Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

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Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

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Ion homeostasis and ion channels in NLRP3 inflammasome activation and regulation

Hafner‐Bratkovič, I., & Pelegrı́n, P. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.010 · Cited by 94 · see citing works

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

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Modulation of innate and adaptive immunity by P2X ion channels

Virgilio, F. D., Sarti, A. C., & Grassi, F. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.026 · Cited by 89 · see citing works

Ectonucleotidases in Acute and Chronic Inflammation

Giuliani, A. L., Sarti, A. C., & Virgilio, F. D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.619458 · Cited by 78 · see citing works

Gain and Loss of Function of P2X7 Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain

Ursu, D., Ebert, P. J., Langron, E., Ruble, C., Munsie, L. M., Zou, W., Fijal, B. A., Qian, Y., McNearney, T. A., Mogg, A. J., et al. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-37 · Cited by 77 · see citing works

Emerging role of P2X7 receptors in CNS health and disease

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P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Barberà-Cremades, M., Gómez, A. I., Baroja‐Mazo, A., Martínez-Alarcón, L., Martínez, C. M., de Torre‐Minguela, C., & Pelegrı́n, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00862 · Cited by 71 · see citing works

Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death

Toki, Y., Takenouchi, T., Harada, H., Tanuma, S., Kitani, H., Kojima, S., & Tsukimoto, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.011 · Cited by 70 · see citing works

Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor

Conley, J. M., Radhakrishnan, S., Valentino, S. A., & Tantama, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187481 · Cited by 69 · see citing works

Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

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Leukotriene B4 Modulates P2X7 Receptor–Mediated Leishmania amazonensis Elimination in Murine Macrophages

Chaves, M. M., Marques-da-Silva, C., Monteiro, A. P. T., Canetti, C. D. A., & Coutinho‐Silva, R. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301058 · Cited by 67 · see citing works

The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells

Sathanoori, R., Swärd, K., Olde, B., & Erlinge, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125111 · Cited by 66 · see citing works

Sinomenine ameliorates collagen-induced arthritis in mice by targeting GBP5 and regulating the P2X7 receptor to suppress NLRP3-related signaling pathways

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Understanding the role of P2X7 in affective disorders—are glial cells the major players?

Stokes, L., Spencer, S. J., & Jenkins, T. A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00258 · Cited by 58 · see citing works

Risk of Fever After Pediatric Trivalent Inactivated Influenza Vaccine and 13-Valent Pneumococcal Conjugate Vaccine

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Involvement of P2X7 receptor signaling on regulating the differentiation of Th17 cells and type II collagen-induced arthritis in mice

Fan, Z., Zhang, Y., Yi-hong, G., Huang, N., Ma, H., Huang, H., & Yu, H. (2016) · Scientific Reports · doi:10.1038/srep35804 · Cited by 56 · see citing works

Targeting strategies for chemotherapy-induced peripheral neuropathy: does gut microbiota play a role?

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P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases

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cis -Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophages

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ATP and adenosine: Role in the immunopathogenesis of rheumatoid arthritis

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1-Aryl-1 H - and 2-aryl-2 H -1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo

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Genetic variation in P2RX7 and pain tolerance

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CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

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Novel biologics targeting the P2X7 ion channel.

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P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages

Bockstiegel, J., Engelhardt, J., & Weindl, G. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01356-1 · Cited by 45 · see citing works

The Role of Nucleotides and Purinergic Signaling in Apoptotic Cell Clearance – Implications for Chronic Inflammatory Diseases

Chen, J., Zhao, Y., & Liu, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00656 · Cited by 43 · see citing works

Inflammasome Activation Induced by a Snake Venom Lys49-Phospholipase A2 Homologue

Boeno, C. N., Paloschi, M. V., Lopes, J. A., Pires, W. L., Setúbal, S. D. S., Evangelista, J. R., Soares, A. M., & Zuliani, J. P. (2019) · Toxins · doi:10.3390/toxins12010022 · Cited by 42 · see citing works

The P2X7 Receptor in Osteoarthritis

Li, Z., Huang, Z., & Bai, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628330 · Cited by 42 · see citing works

P2X7 Receptor Function in Bone-Related Cancer

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The current status and perspectives regarding the clinical implication of intracellular calcium in breast cancer

Tajbakhsh, A., Pasdar, A., Rezaee, M., Fazeli, M., Soleimanpour, S., Hassanian, S. M., FarshchiyanYazdi, Z., Rad, T. Y., Ferns, G. A., & Avan, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26277 · Cited by 40 · see citing works

P2X7 receptor in cardiovascular disease: The heart side

Martinez, C. G. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13079 · Cited by 40 · see citing works

Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death

Schachter, J., Guijarro, A., Angosto-Bazarra, D., Pinilla, M., Hurtado‐Navarro, L., Meunier, É., Pérez‐Oliva, A. B., Schwarzbaum, P. J., & Pelegrı́n, P. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115233 · Cited by 39 · see citing works

P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

Garré, J. M., Silva, H. M., Lafaille, J. J., & Yang, G. (2020) · Nature Communications · doi:10.1038/s41467-020-15590-5 · Cited by 39 · see citing works

Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates

Baroja‐Mazo, A., & Pelegrı́n, P. (2012) · Journal of Osteoporosis · doi:10.1155/2012/408242 · Cited by 38 · see citing works

Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells

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OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion

Shimada, H., Nakamura, Y., Nakanishi, T., & Tamai, I. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.10.009 · Cited by 36 · see citing works

Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury

Nadal-Nicolás, F. M., Galindo‐Romero, C., Valiente‐Soriano, F. J., Barberà-Cremades, M., de Torre‐Minguela, C., Salinas‐Navarro, M., Pelegrı́n, P., & Agudo‐Barriuso, M. (2016) · Scientific Reports · doi:10.1038/srep38499 · Cited by 35 · see citing works

The role of microglia and P2X7 receptors in gliomas

Kan, L. K., Williams, D. J., Drummond, K. J., O'Brien, T. J., & Monif, M. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.04.010 · Cited by 35 · see citing works

Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation

Calzaferri, F., Narros‐Fernández, P., de Pascual, R., de Diego, A. M. G., Nicke, A., Egea, J., de Diego, A. M. G., & Rı́os, C. D. L. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02145 · Cited by 35 · see citing works

The contribution of ion channels to shaping macrophage behaviour

Selezneva, A. I., Gibb, A. J., & Willis, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.970234 · Cited by 32 · see citing works

P2X7 receptor deletion suppresses γ-radiation-induced hyposalivation

Gilman, K. E., Camden, J. M., Klein, R. R., Zhang, Q., Weisman, G. A., & Limesand, K. H. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00192.2018 · Cited by 32 · see citing works

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

Baroja‐Mazo, A., Compan, V., Martín‐Sánchez, F., Tapia‐Abellán, A., Couillin, I., & Pelegrı́n, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-42298-4 · Cited by 30 · see citing works

Crosstalk between purinergic receptors and lipid mediators in leishmaniasis

Chaves, M. M., Canetti, C. D. A., & Coutinho‐Silva, R. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1781-1 · Cited by 28 · see citing works

Modulating ion channel function with antibodies and nanobodies

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Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system

Lucas‐Ruiz, F., Agudo‐Barriuso, M., Galindo‐Romero, C., Albaladejo‐García, V., & Vidal‐Sanz, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.310670 · Cited by 26 · see citing works

Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice ,

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P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption

Jiang, Z., Wu, W. H., Hu, H.-B., Li, Z., Zhong, M., & Zhang, L. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i36.5265 · Cited by 25 · see citing works

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function

Aprile-Garcia, F., Metzger, M. W., Páez-Pereda, M., Stadler, H., Acuña, M., Liberman, A. C., Senin, S. A., Gerez, J., Hoijman, E., Refojo, D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151862 · Cited by 25 · see citing works

Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation

Fliegert, R., Heeren, J., Koch‐Nolte, F., Nikolaev, V. O., Lohr, C., Meier, C., & Guse, A. H. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180419 · Cited by 25 · see citing works

Purinergic receptors and the inflammatory response mediated by lipids

Alarcón‐Vila, C., Pizzuto, M., & Pelegrı́n, P. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.02.004 · Cited by 25 · see citing works

Differences in PGE2 Production between Primary Human Monocytes and Differentiated Macrophages: Role of IL-1β and TRIF/IRF3

Endo, Y., Blinova, K., Romantseva, T., Golding, H., & Zaitseva, M. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098517 · Cited by 25 · see citing works

The P2X7 Receptor Is Overexpressed in the Lesional Skin of Subjects Affected by Hidradenitis Suppurativa: A Preliminary Study

Manfredini, M., Giuliani, A. L., Ruina, G., Gafà, R., Bosi, C., Zoppas, E., Virgilio, F. D., & Bettoli, V. (2019) · Dermatology · doi:10.1159/000502026 · Cited by 25 · see citing works

Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer

Mohammed, A., Janakiram, N. B., Madka, V., Pathuri, G., Li, Q., Ritchie, R. L., Biddick, L., Kutche, H., Zhang, Y., Singh, A. K., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22085 · Cited by 24 · see citing works

Dynamics of action of a Lys-49 and an Asp-49 PLA2s on inflammasome NLRP3 activation in murine macrophages

Boeno, C. N., Paloschi, M. V., Lopes, J. A., Souza Silva, M. D., Evangelista, J. R., dos Reis, V. P., da S. Setúbal, S., Soares, A. M., & Zuliani, J. P. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109194 · Cited by 24 · see citing works

Selective Impairment of P2Y Signaling by Prostaglandin E2 in Macrophages: Implications for Ca2+-Dependent Responses

Través, P. G., Pimentel-Santillana, M., Carrasquero, L. M. G., Pérez‐Sen, R., Delicado, E. G., Luque, A., Izquierdo, M., Martín‐Sanz, P., Miras‐Portugal, M. T., & Boscá, L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203029 · Cited by 24 · see citing works

Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1

Kamo, S., Nakanishi, T., Aotani, R., Nakamura, Y., Gose, T., & Tamai, I. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.04.046 · Cited by 23 · see citing works

ATP-Activated P2X7R Promote the Attack of Acute Gouty Arthritis in Rats Through Activating NLRP3 Inflammasome and Inflammatory Cytokine Production

Dai, X., Fang, X., Xia, Y., Li, M., Li, X., Wang, Y., Tao, J., & Li, X.-P. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s351660 · Cited by 22 · see citing works

P2X7 receptor activation impairs antitumour activity of natural killer cells

Baroja‐Mazo, A., Peñín‐Franch, A., Lucas‐Ruiz, F., de Torre‐Minguela, C., Alarcón‐Vila, C., Hernández‐Caselles, T., & Pelegrı́n, P. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15951 · Cited by 22 · see citing works

R270C polymorphism leads to loss of function of the canine P2X7 receptor

Spildrejorde, M., Bartlett, R., Stokes, L., Jalilian, I., Peranec, M., Sluyter, V., Curtis, B. L., Skarratt, K. K., Skora, A. S., Bakhsh, T., et al. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00195.2013 · Cited by 22 · see citing works

P2X7 receptor in skin biology and diseases

Geraghty, N. J., Watson, D., Adhikary, S. R., & Sluyter, R. (2016) · World Journal of Dermatology · doi:10.5314/wjd.v5.i2.72 · Cited by 21 · see citing works

Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs

Xu, X., Pocock, G. M., Sharma, A., Peery, S. L., Fites, J. S., Felley, L. E., Żarnowski, R., Stewart, D., Berthier, E., Klein, B. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.061 · Cited by 21 · see citing works

Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins

Stojilković, S. S., Leiva‐Salcedo, E., Rokic, M. B., & Coddou, C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5549 · Cited by 21 · see citing works

Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2in the Auditory System

Mittal, R., Chan, B., Grati, M., Mittal, J., Patel, K., Debs, L. H., Patel, A. P., Yan, D. L. S., Chapagain, P. P., & Liu, X. Z. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25274 · Cited by 21 · see citing works

Isolation of functional mature peritoneal macrophages from healthy humans

Ruiz‐Alcaraz, A. J., Martínez‐Banaclocha, H., Marín‐Sánchez, P., Carmona‐Martínez, V., Iniesta‐Albadalejo, M. A., Tristán‐Manzano, M., Tapia‐Abellán, A., García–Peñarrubia, P., Machado‐Linde, F., Pelegrı́n, P., et al. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12305 · Cited by 20 · see citing works

The Potential Antipyretic Mechanism of Ellagic Acid with Brain Metabolomics Using Rats with Yeast-Induced Fever

Xie, F., Xu, L., Zhu, H., Chen, Y., Li, Y., Nong, L., Zeng, Y., & Cen, S. (2022) · Molecules · doi:10.3390/molecules27082465 · Cited by 19 · see citing works

The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression

Zou, Y.-T., Li, J., Chai, J.-Y., Hu, Y., Zhang, W., & Zhang, Q. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149513 · Cited by 18 · see citing works

P2X7 receptors in body temperature, locomotor activity, and brain mRNA and lncRNA responses to sleep deprivation

Davis, C. J., Taishi, P., Honn, K. A., Koberstein, J. N., & Krueger, J. M. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00167.2016 · Cited by 18 · see citing works

Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection

Meyer, L., Leymarie, O., Chevalier, C., Esnault, E., Moroldo, M., da Costa, B. R., Georgeault, S., Roingeard, P., Delmas, B., Quéré, P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176355 · Cited by 18 · see citing works

P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats

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Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

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Liaisons dangereuses: P2X7 and the inflammasome

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