The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
Glial cells in (patho)physiology
Open accessAbstract
Neuroglial cells define brain homeostasis and mount defense against pathological insults. Astroglia regulate neurogenesis and development of brain circuits. In the adult brain, astrocytes enter into intimate dynamic relationship with neurons, especially at synaptic sites where they functionally form the tripartite synapse. At these sites, astrocytes regulate ion and neurotransmitter homeostasis, metabolically support neurons and monitor synaptic activity; one of the readouts of the latter manifests in astrocytic intracellular Ca(2+) signals. This form of astrocytic excitability can lead to release of chemical transmitters via Ca(2+) -dependent exocytosis. Once in the extracellular space, gliotransmitters can modulate synaptic plasticity and cause changes in behavior. Besides these physiological tasks, astrocytes are fundamental for progression and outcome of neurological diseases. In Alzheimer's disease, for example, astrocytes may contribute to the etiology of this disorder. Highly lethal glial-derived tumors use signaling trickery to coerce normal brain cells to assist tumor invasiveness. This review not only sheds new light on the brain operation in health and disease, but also points to many unknowns.
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“This inflammation not only occurs in response to Aβ deposition, but is also capable of generating, via feedback mechanisms, more Aβ while weakening the mechanisms responsible for its elimination (Parpura et al., 2012).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Parpura et al., 2012
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“It has been reported that in the later stages of AD, there is destruction of axons, dendrites, and synapses, in which microglia has a relevant role (Parpura et al., 2012).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Parpura et al., 2012
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Items 201–223 of 223
Ni, Y., & Parpura, V. (2009) · Glia · doi:10.1002/glia.20849 · Cited by 69
Self-citationMalarkey, E. B., & Parpura, V. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.210435 · Cited by 69
Self-citationKirischuk, S., Иванович, М. В., Kulik, A., et al. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00205-9 · Cited by 66
Regulated exocytosis in astrocytic signal integration
Parpura, V., Baker, B. J., Jeras, M., & Zorec, R. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.007 · Cited by 64
Self-citationDynamic monitoring of cytosolic glucose in single astrocytes
Prebil, M., Vardjan, N., Jensen, J., Zorec, R., & Kreft, M. (2011) · Glia · doi:10.1002/glia.21161 · Cited by 61
Self-citationAstrocytic exocytosis vesicles and glutamate: A high‐resolution immunofluorescence study
Anlauf, E., & Derouiche, A. (2004) · Glia · doi:10.1002/glia.20094 · Cited by 59
Kinin receptors are expressed in human astrocytic tumour cells
Raidoo, D. M., Sawant, S., Mahabeer, R., & Bhoola, K. D. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00097-1 · Cited by 57
Regulation of exocytotic protein expression and Ca2+‐dependent peptide secretion in astrocytes
Paco, S., Margelí, M. A., Olkkonen, V. M., Imai, A., Blasi, J., Fischer‐Colbrie, R., & Aguado, F. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06116.x · Cited by 54
Schousboe, A., Sickmann, H. M., Bak, L. K., Schousboe, I., Jajo, F. S., Faek, S. A. A., & Waagepetersen, H. S. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22746 · Cited by 53
Self-citationSchousboe, A., Sickmann, H. M., Walls, A. B., Bak, L. K., & Waagepetersen, H. S. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9171-5 · Cited by 49
Self-citationExpression and Functional Analysis of Glutamate Receptors in Glial Cells
Condorelli, D. F., Conti, F., Gallo, V., Kirchhoff, F., Seifert, G., Steinhäuser, C., Verkhratsky, A., & Yuan, X. Q. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4685-6_5 · Cited by 44
Self-citationWaagepetersen, H. S., Westergaard, N., & Schousboe, A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00146-1 · Cited by 38
Self-citationDevelopmental expression of hexokinase 1 in the rat
Griffin, L. D., Gelb, B. D., Adams, V., & McCabe, E. R. B. (1992) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(92)90508-w · Cited by 32
Molecular Engineering of a Secreted, Highly Homogeneous, and Neurotoxic Aβ Dimer
Müller‐Schiffmann, A., Andreyeva, A., Horn, A. H. C., Gottmann, K., Korth, C., & Sticht, H. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn200011h · Cited by 26
Immunophilin deficiency augments Ca2+-dependent glutamate release from mouse cortical astrocytes
Reyes, R. C., Perry, G. M., Lesort, M. J., & Parpura, V. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.11.005 · Cited by 24
Self-citationEnergy and Amino Acid Neurotransmitter Metabolism in Astrocytes
Waagepetersen, H. S., Sonnewald, U., & Schousboe, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-79492-1_7 · Cited by 17
Self-citationHabbas, S., Ango, F., Daniel, H., & Galante, M. (2011) · Glia · doi:10.1002/glia.21224 · Cited by 17
Response to Quinlan and Nilsson: Astroglia sitting at the controls?
Pekny, M., Pekna, M., Wilhelmsson, U., & Chen, D. F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.01.012 · Cited by 15
Self-citationRojas, H., Ramos, M., Benaím, G., Caputo, C. A., & DiPolo, R. (2008) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.rp009208 · Cited by 12
GFAP and Astrocyte Intermediate Filaments
Pekny, M., & Wilhelmsson, U. (2006) · Springer eBooks · doi:10.1007/0-387-30395-2_14 · Cited by 10
Self-citationGlucose transporter proteins in brain: Delivery of glucose to neurons and glia
Vannucci, S. J., Maher, F., & Simpson, I. A. (1997) · Glia · doi:10.1002/(sici)1098-1136(199709)21:1
Flagged first, then by citations
Research works printed but not linked: 13
- Chao T. I., 2002, Tripartite Synapses: Synaptic Transmission with Glia, 3
- Dermietzel R., 2012, Astrocytes: Wiring the Brain, 179
- Golgi C., 1873, Suella struttura della sostanza grigia del cervello (comunicazione preventiva), Gazzetta Medica Italiana, Lombardia, 33, 244
- Golgi C., 1903, Opera Omnia
- Kölliker A., 1889, Handbuch der Gewebelehre des Menschen
- Lenhossek M. V., 1891, Zur Kenntnis der Neuroglia des menschlichen Ruckenmarkes, Verh. Anat. Ges., 5, 193
- 10.1242/jeb.02208 · DOI
- 10.1007/978-0-387-30381-9_14 · DOI
- Ramón y Cajal S., 1911, Histologie du Système Nerveux de L’homme et des Vertébrés
- Ramón y Cajal S., 1913, Sobre un nuevo proceder de impregnacion de la neuroglia y sus resultados en los centros nerviosos del hombre y animales, Trab. Lab. Invest. Biol. Univ. Madrid, 11, 219
- Reyes R. C., 2009, Modulation of Ca2+‐dependent glutamate release in rat cortical astrocytes by the Na+/Ca2+ exchanger, J. Neurochem., 108, 116
- Virchow R., 1858, Die Cellularpathologie in Ihrer Begründung auf Physiologische and Pathologische Gewebelehre. Zwanzig Vorlesungen Gehalten Während der Monate Februar, März und April 1858 im Pathologischen Institut zu Berlin
- Vogt C., 1937, Sitz und Wesen der Krankheiten im Lichte der topistischen Hirnforschung und des Variierens der Tiere. Erster Teil: Befunde der topistischen Hirnforschung als Beitrag zur Lehre vom Krankheitssitz, J. Psychol. Neurol., 47, 238
Cited by
Sorted by citations
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Self-citationThe role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375
“Astrocytes are implicated in various CNS disorders, e.g., Alzheimer's disease (Parpura et al., 2012) and demyelinating disorders such as neuromyelitis optica and MS (Nair et al., 2008; Kipp et al., 2011a) .”
BackgroundInfluentialStratification of astrocytes in healthy and diseased brain
Verkhratsky, A., Zorec, R., & Parpura, V. (2017) · Brain Pathology · doi:10.1111/bpa.12537 · Cited by 236
Self-citation
Metadata
- Authors
- Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., Pekny, M., Pekna, M., Zorec, R., & Verkhratsky, A.
- Affiliations
- Ikerbasque (ES)
- University of Bonn (DE)
- University of Alabama (US)
- Université de Bordeaux (FR)
- University of Copenhagen (DK)
- Tufts University (US)
- Albert Einstein College of Medicine (US)
- Leipzig University (DE)
- University of Gothenburg (SE)
- University of Ljubljana (SI)
- Corresponding author
- Parpura, Vladimir
- Verkhratsky, Alexei
- ORCID
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2012-02-02
- Volume
- 121
- Issue
- 1
- Pages
- 4-27
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- PMC
- PMC3304021
- OpenAlex
- W1549972124
- Cited by
- 561
- References
- 223
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 22 · 2023: 33 · 2022: 29 · 2021: 36 · 2020: 22 · 2019: 26 · 2018: 38 · 2017: 37 · 2016: 48 · 2015: 67 · 2014: 76 · 2013: 59 · 2012: 29
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- National Science Foundation (0943343)
- Judith Jane Mason and Harold Stannett Williams Memorial Foundation
- Alzheimer's Research Trust (ART/PG2004A/1)
- Deutsche Forschungsgemeinschaft (GRK 1097)
- Grantová Agentura České Republiky (GACR 305/08/1381)
- Javna Agencija za Raziskovalno Dejavnost RS (P3-310)
- International Society for Neurochemistry
- Medical Research Council
- National Institute on Drug Abuse (R01DA025967, DA025967)
- National Institute of Neurological Disorders and Stroke (NS-037585, R01NS037585, R37NS037585)
- Division of Chemical, Bioengineering, Environmental, and Transport Systems
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- astrocytes, glial cells, tripartite synapse, astrocyte calcium signaling, gliotransmitters, synaptic plasticity, neurogenesis, brain homeostasis, Alzheimer's disease, glioma, tumor invasion, astrocyte-neuron interaction, neurotransmitter homeostasis
- MeSH terms
- Alzheimer Disease, Animals, Humans, Synaptic Transmission, Neuroglia, Neurons
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