Pekny, Milos

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 2,513

Astrocyte activation and reactive gliosis

Pekny, M., & Nilsson, M. (2005) · Glia

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 1,611

Astrocyte reactivity and reactive astrogliosis: costs and benefits

Pekny, M., & Pekna, M. (2014) · Physiological Reviews

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 934

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

Hol, E. M., & Pekny, M. (2015) · Current Opinion in Cell Biology

Skin and Cellular Biology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 917

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis

Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell

Neonatal Respiratory Health ResearchInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 864

Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury

Wilhelmsson, U., Bushong, E. A., Price, D. L., Smarr, B. L., Phung, V., Terada, M., Ellisman, M. H., & Pekny, M. (2006) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 643

Glial cells in (patho)physiology

Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., et al. (2012) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 561

Protective Role of Reactive Astrocytes in Brain Ischemia

Li, L., Lundkvist, A., Andersson, D., Wilhelmsson, U., Nagai, N., Pardo, A. C., Nodin, C., Ståhlberg, A., Aprico, K., Larsson, K., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism

Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

Cited by 505

Absence of Glial Fibrillary Acidic Protein and Vimentin Prevents Hypertrophy of Astrocytic Processes and Improves Post-Traumatic Regeneration

Wilhelmsson, U., Li, L., Pekna, M., Berthold, C.-H., Blom, S., Eliasson, C., Renner, O., Bushong, E., Ellisman, M., Morgan, T. E., et al. (2004) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 455

Astrocyte intermediate filaments in CNS pathologies and regeneration

Pekny, M., & Pekna, M. (2004) · The Journal of Pathology

Skin and Cellular Biology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 420

Abnormal Reaction to Central Nervous System Injury in Mice Lacking Glial Fibrillary Acidic Protein and Vimentin

Pekny, M., Johansson, C. B., Eliasson, C., Stakeberg, J., Wallén, Å., Perlmann, T., Lendahl, U., Betsholtz, C., Berthold, C.-H., & Frisén, J. (1999) · The Journal of Cell Biology

Spinal Cord Injury ResearchSkin and Cellular Biology Research

Cited by 405

Intermediate Filament Protein Partnership in Astrocytes

Eliasson, C., Sahlgren, C., Berthold, C.-H., Stakeberg, J., Celis, J. E., Betsholtz, C., Eriksson, J. E., & Pekny, M. (1999) · Journal of Biological Chemistry

Skin and Cellular Biology ResearchConnexins and lens biology

Cited by 357

Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally.

Pekny, M., Levéen, P., Pekna, M., Eliasson, C., Berthold, C. H., Westermark, B., & Betsholtz, C. (1995) · The EMBO Journal

Skin and Cellular Biology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 336

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 324

Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin

Kinouchi, R., Takeda, M., Yang, L., Wilhelmsson, U., Lundkvist, A., Pekny, M., & Chen, D. F. (2003) · Nature Neuroscience

Retinal Development and DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 229

Intermediate filaments and stress

Pekny, M., & Lane, E. B. (2007) · Experimental Cell Research

Skin and Cellular Biology ResearchCellular Mechanics and Interactions

Cited by 174

Reactive glial cells: increased stiffness correlates with increased intermediate filament expression

Lu, Y., Iandiev, I., Hollborn, M., Körber, N., Ulbricht, E., Hirrlinger, P. G., Pannicke, T., Wei, E., Bringmann, A., Wolburg, H., et al. (2011) · The FASEB Journal

Cellular Mechanics and InteractionsSkin and Cellular Biology Research

Cited by 172

Attenuated Glial Reactions and Photoreceptor Degeneration after Retinal Detachment in Mice Deficient in Glial Fibrillary Acidic Protein and Vimentin

Nakazawa, T., Takeda, M., Lewis, G. P., Cho, K.-S., Jiao, J., Wilhelmsson, U., Fisher, S. K., Pekny, M., Chen, D. F., & Miller, J. W. (2007) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersRetinal and Macular Surgery

Cited by 168

Re-establishing the regenerative potential of central nervous system axons in postnatal mice

Cho, K.-S., Yang, L., Lu, B., Feng Ma, H., Huang, X., Pekny, M., & Chen, D. F. (2005) · Journal of Cell Science

Nerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Cited by 164

Increased Insulin Secretion and Glucose Tolerance in Mice Lacking Islet Amyloid Polypeptide (Amylin)

Gebre-Medhin, S., Mulder, H., Pekny, M., Westermark, G., Törnell, J., Westermark, P., Sundler, F., Ahrén, B., & Betsholtz, C. (1998) · Biochemical and Biophysical Research Communications

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 157

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

Kamphuis, W., Kooijman, L., Orre, M., Stassen, O., Pekny, M., & Hol, E. M. (2015) · Glia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 155

Astrocytes Negatively Regulate Neurogenesis Through the Jagged1‐Mediated Notch Pathway

Wilhelmsson, U., Faiz, M., de Pablo, Y., Sjöqvist, M., Andersson, D., Widestrand, Å., Potokar, M., Stenovec, M., Smith, P. L. P., Shinjyo, N., et al. (2012) · STEM CELLS

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 145

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 126

IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments

Vardjan, N., Gabrijel, M., Potokar, M., Švajger, U., Kreft, M., Jeras, M., de Pablo, Y., Faiz, M., Pekny, M., & Zorec, R. (2012) · Journal of Neuroinflammation

Cellular transport and secretionNeuroinflammation and Neurodegeneration Mechanisms

Cited by 117