Ferulic acid, a natural protector against carbon tetrachloride-induced toxicity
Abstract
The present work is aimed at evaluating the protective effect of ferulic acid (FA), a naturally occurring phenolic compound on CCl4 induced toxicity. The activities of liver markers (alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyl transferase), lipid peroxidative index (thiobarbituric acid-reactive substances, hydroperoxides, nitric oxide, protein carbonyl content), the antioxidant status (superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione) were used as biomarkers to monitor the protective role of FA. The liver marker enzymes in plasma and lipid peroxidative index in liver and kidney were increased in CCl4-treated groups, which were decreased significantly on treatment with FA. The antioxidants, which were depleted in CCl4-treated groups, were improved significantly by FA treatment. Administration of FA to normal rats did not produce any harmful effects. Thus our results show that FA is an effective antioxidant without any side-effects and may be a great gain in the current search for natural therapy.
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Caffeic and ferulic acids are beneficial in the kidney as they prevent oxidative stress.
“The disturbed kidney parameters may have been induced by the reduction of phenolic acids in our study, since caffeic and ferulic acids are beneficial in the kidney as they prevent oxidative stress (Srinivasan et al., 2005;U Rehman and Sultana, 2011).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Srinivasan et al., 2005
The disturbed kidney parameters may have been induced by the reduction of phenolic acids in this study.
“The disturbed kidney parameters may have been induced by the reduction of phenolic acids in our study, since caffeic and ferulic acids are beneficial in the kidney as they prevent oxidative stress (Srinivasan et al., 2005;U Rehman and Sultana, 2011).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Srinivasan et al., 2005
The disturbed kidney functional parameters may have been induced by the reduced levels of phenolic acids in the GM maize feed used in the study, since caffeic and ferulic acids are beneficial to the kidney as they prevent oxidative stress.
“Therefore, the disturbed kidney functional parameters may have been induced by the reduced levels of phenolic acids in the GM maize feed used in our study, since caffeic and ferulic acids are beneficial to the kidney as they prevent oxidative stress [38,39].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [38]
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“The disturbed kidney parameters may have been induced by the reduction of phenolic acids in our study, since caffeic and ferulic acids are beneficial in the kidney as they prevent oxidative stress (Srinivasan et al., 2005; U Rehman and Sultana, 2011).”
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- Authors
- Srinivasan, M., Rukkumani, R., Ram Sudheer, A., & Menon, V. P.
- Affiliations
- Annamalai University (IN)
- Corresponding author
- Menon, Venugopal P.
- Venue
- Fundamental & Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2005-04-21
- Volume
- 19
- Issue
- 4
- Pages
- 491-496
- ISSN
- 0767-3981 (ISSN-L)
- 1472-8206
- OpenAlex
- W2118088886
- Cited by
- 120
- References
- 46
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 11
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fundamental and Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- ferulic acid, carbon tetrachloride poisoning, hepatoprotection, antioxidant activity, lipid peroxidation, liver enzymes, oxidative stress, natural phenolic compounds, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, nitric oxide, protein carbonyls, hydroperoxides, nephrotoxicity
- MeSH terms
- Animals, Antioxidants, Carbon Tetrachloride, Coumaric Acids, Female, Glutathione, Liver, Nitric Oxide, Lipid Peroxidation, Rats, Wistar, Rats
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