The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Dietary deprivation extends lifespan in Caenorhabditis elegans
Open accessAbstract
Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends lifespan in a variety of species; however, its underlying mechanisms remain unclear. We have found in Caenorhabditis elegans that dietary deprivation (DD) during adulthood, defined as removal of their food source Escherichia coli after the completion of larval development, increased lifespan and enhanced thermotolerance and resistance to oxidative stress. DD-induced longevity was independent of one C. elegans SIRTUIN, sir-2.1, which is required for the effects of DR, and was independent of the daf-2/insulin-like signaling pathway that independently regulates longevity and larval diapause in C. elegans. DD did not significantly alter lifespan of fem-1(hc17); eat-2(ad465) worms, a genetic model of DR. These findings suggest that DD and DR share some downstream effectors. In addition, DD was detrimental for longevity when imposed on reproductively active young adults, suggesting that DD may only be beneficial in the absence of competing metabolic demands, such as fertility. Adult-onset DD offers a new paradigm for investigating dietary regulation of longevity in C. elegans. This study presents the first evidence that long-term DD, instead of being detrimental, can extend lifespan of a multicellular adult organism.
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“CR has been shown to extend both medium and maximum lifespan and delay the onset of age-related diseases in a variety of species, including yeast (Kaeberlein et al., 2007), C. elegans (Lee et al., 2006), rodents (Masoro, 2009) and Rhesus monkeys (Colman et al., 2014).”
From Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases (2017) · cites this paper as Lee et al., 2006
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Metadata
- Authors
- Lee, G. D., Wilson, M. A., Zhu, M., Wolkow, C. A., De Cabo, R., Ingram, D. K., & Zou, S.
- Affiliations
- National Institutes of Health (US)
- National Institute on Aging (US)
- Pennington Biomedical Research Center (US)
- Corresponding author
- Zou, Sige
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2006-10-20
- Volume
- 5
- Issue
- 6
- Pages
- 515-524
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC2546582
- OpenAlex
- W2061756062
- Cited by
- 307
- References
- 55
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 11 · 2023: 13 · 2022: 10 · 2021: 21 · 2020: 14 · 2019: 11 · 2018: 14 · 2017: 15 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 13
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health (NIH0011061953)
- National Institute on Aging (Z01AG000320)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- food deprivation, dietary restriction, lifespan extension, Caenorhabditis elegans, heat tolerance, oxidative stress resistance, sir-2.1, sirtuins, insulin-like signaling, daf-2, EAT-2, fertility
- MeSH terms
- Aging, Animals, Energy Metabolism, Food Deprivation, Immunity, Innate, Insulin-Like Growth Factor I, Longevity, Motor Activity, Reproduction, Signal Transduction, Cyclins, Caenorhabditis elegans, Oxidative Stress, Heat Stress Disorders, Models, Animal, Caenorhabditis elegans Proteins, Caloric Restriction, Sirtuins
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