Cited by 307Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in MedicineDietary Effects on Health

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Dietary deprivation extends lifespan in Caenorhabditis elegans

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Lee, Garrick D., Wilson, Mark A., Zhu, Min, Wolkow, Catherine A., De Cabo, Rafael, Ingram, Donald K., Zou, Sige·2006·Aging Cell

DOI 10.1111/j.1474-9726.2006.00241.xPMC PMC2546582

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Abstract

Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends lifespan in a variety of species; however, its underlying mechanisms remain unclear. We have found in Caenorhabditis elegans that dietary deprivation (DD) during adulthood, defined as removal of their food source Escherichia coli after the completion of larval development, increased lifespan and enhanced thermotolerance and resistance to oxidative stress. DD-induced longevity was independent of one C. elegans SIRTUIN, sir-2.1, which is required for the effects of DR, and was independent of the daf-2/insulin-like signaling pathway that independently regulates longevity and larval diapause in C. elegans. DD did not significantly alter lifespan of fem-1(hc17); eat-2(ad465) worms, a genetic model of DR. These findings suggest that DD and DR share some downstream effectors. In addition, DD was detrimental for longevity when imposed on reproductively active young adults, suggesting that DD may only be beneficial in the absence of competing metabolic demands, such as fertility. Adult-onset DD offers a new paradigm for investigating dietary regulation of longevity in C. elegans. This study presents the first evidence that long-term DD, instead of being detrimental, can extend lifespan of a multicellular adult organism.

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Authors: Lee, G. D., Wilson, M. A., Zhu, M., Wolkow, C. A., De Cabo, R., Ingram, D. K., & Zou, S.
Affiliations: National Institutes of Health (US)
National Institute on Aging (US)
Pennington Biomedical Research Center (US)
Corresponding author: Zou, Sige
ORCID: Lee, Garrick D.
Ingram, Donald K.
Venue: Aging Cell
Publisher: Wiley
Published: 2006-10-20
Volume: 5
Issue: 6
Pages: 515-524
ISSN: 1474-9718 (ISSN-L)
1474-9726
DOI: 10.1111/j.1474-9726.2006.00241.x
PMC: PMC2546582
OpenAlex: W2061756062
Cited by: 307
References: 55
Citations by year: 2026: 10 · 2025: 18 · 2024: 11 · 2023: 13 · 2022: 10 · 2021: 21 · 2020: 14 · 2019: 11 · 2018: 14 · 2017: 15 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 13
FWCI: 7.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Aging Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Ellison Medical Foundation
National Institutes of Health (NIH0011061953)
National Institute on Aging (Z01AG000320)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: food deprivation, dietary restriction, lifespan extension, Caenorhabditis elegans, heat tolerance, oxidative stress resistance, sir-2.1, sirtuins, insulin-like signaling, daf-2, EAT-2, fertility
MeSH terms: Aging, Animals, Energy Metabolism, Food Deprivation, Immunity, Innate, Insulin-Like Growth Factor I, Longevity, Motor Activity, Reproduction, Signal Transduction, Cyclins, Caenorhabditis elegans, Oxidative Stress, Heat Stress Disorders, Models, Animal, Caenorhabditis elegans Proteins, Caloric Restriction, Sirtuins

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Dietary deprivation extends lifespan in Caenorhabditis elegans

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