Dietary deprivation extends lifespan in Caenorhabditis elegans

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

Frye, R. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3000 · Cited by 1,409 · see citing works

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214 · see citing works

Influence of TOR kinase on lifespan in C. elegans

Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057 · see citing works

Overview of caloric restriction and ageing

Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 1,054 · see citing works

Signals from the reproductive system regulate the lifespan of C. elegans

Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,015 · see citing works

The genetics of caloric restriction in Caenorhabditis elegans

Lakowski, B., & Hekimi, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13091 · Cited by 967 · see citing works

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 913 · see citing works

Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span

Klass, M. R. (1977) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(77)90043-4 · Cited by 793 · see citing works

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.

Ishii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D., & Suzuki, K. (1998) · Nature · doi:10.1038/29331 · Cited by 687 · cited 1× · see citing works

Toward a unified theory of caloric restriction and longevity regulation

Sinclair, D. A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.019 · Cited by 561 · see citing works

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen

Hansen, M., Hsu, A., Dillin, A. G., & Kenyon, C. J. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010017 · Cited by 533 · see citing works

Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans

Huang, C., Xiong, C., & Kornfeld, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400848101 · Cited by 532 · see citing works

Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans

Arantes-Oliveira, N., Apfeld, J., Dillin, A. G., & Kenyon, C. J. (2002) · Science · doi:10.1126/science.1065768 · Cited by 530 · see citing works

Interacting genes in nematode dauer larva formation

Riddle, D. L., Swanson, M. M., & Albert, P. S. (1981) · Nature · doi:10.1038/290668a0 · Cited by 518 · see citing works

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

Kaeberlein, M., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020296 · Cited by 441 · see citing works

Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans

Wilson, M. A., Shukitt‐Hale, B., Kalt, W., Ingram, D. K., Joseph, J. A., & Wolkow, C. A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00192.x · Cited by 374 · see citing works

Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans

Avery, L., & Horvitz, H. R. (1990) · Journal of Experimental Zoology · doi:10.1002/jez.1402530305 · Cited by 361 · see citing works

Dietary Restriction in Long-Lived Dwarf Flies

Clancy, D. J., Gems, D., Hafen, E., Leevers, S. J., & Partridge, L. (2002) · Science · doi:10.1126/science.1069366 · Cited by 289 · see citing works

Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age

Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., & Cider, N. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90107-q · Cited by 279 · see citing works

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

Senoo-Matsuda, N., Yasuda, K., Tsuda, M., Ohkubo, T., Yoshimura, S., Nakazawa, H., Hartman, P. S., & Ishii, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104718200 · Cited by 271 · see citing works

A Delayed Wave of Death from Reproduction in Drosophila

Sgrò, C. M., & Partridge, L. (1999) · Science · doi:10.1126/science.286.5449.2521 · Cited by 268 · see citing works

Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster

Magwere, T., Chapman, T., & Partridge, L. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.1.b3 · Cited by 264 · see citing works

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO

Wang, Y., & Tissenbaum, H. A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.005 · Cited by 263 · see citing works

Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans

Houthoofd, K. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00161-x · Cited by 245 · see citing works

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans

Houthoofd, K., Braeckman, B. P., Lenaerts, I., Brys, K., Vreese, A. D., Eygen, S. V., & Vanfleteren, J. R. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00173-0 · Cited by 211 · see citing works

Sensory control of dauer larva formation in Caenorhabditis elegans

Albert, P. S., Brown, S. J., & Riddle, D. L. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980305 · Cited by 202 · see citing works

Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster

Tu, M., & Tatar, M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00064.x · Cited by 190 · see citing works

Behavioral Deficits During Early Stages of Aging in Caenorhabditis elegans Result From Locomotory Deficits Possibly Linked to Muscle Frailty

Glenn, C. F., Chow, D. K., David, L., Cooke, C. A., Gami, M. S., Iser, W. B., Hanselman, K. B., Goldberg, I., & Wolkow, C. A. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.12.1251 · Cited by 189 · see citing works

The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions

Spence, A. M. (1990) · Cell · doi:10.1016/0092-8674(90)90346-g · Cited by 177 · see citing works

Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.

Johnson, T. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3777 · Cited by 175 · see citing works

Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster

Good, T. P., & Tatar, M. (2001) · Journal of Insect Physiology · doi:10.1016/s0022-1910(01)00138-x · Cited by 172 · see citing works

Dietary restriction in C. elegans: From rate-of-living effects to nutrient sensing pathways

Walker, G. A., Houthoofd, K., Vanfleteren, J. R., & Gems, D. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.014 · Cited by 167 · see citing works

Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span

Yanase, S., Yasuda, K., & Ishii, N. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00093-3 · Cited by 163 · see citing works

Effects of Intermittent Feeding Upon Growth and Life Span in Rats

Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., & Cider, N. L. (2009) · Gerontology · doi:10.1159/000212538 · Cited by 158 · see citing works

Calorie restriction and SIR2 genes—Towards a mechanism

Guarente, L. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.013 · Cited by 157 · see citing works

daf-16 Protects the Nematode Caenorhabditis elegans During Food Deprivation

Henderson, S. T., Bonafè, M., & Johnson, T. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.5.444 · Cited by 154 · see citing works

Intersex, a temperature-sensitive mutant of the nematode Caenorhabditis elegans

Nelson, G. A., Lew, K. K., & Ward, S. (1978) · Developmental Biology · doi:10.1016/0012-1606(78)90247-6 · Cited by 150 · see citing works

Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan

Chow, D. K., Glenn, C. F., JOHNSTON, J., Goldberg, I., & Wolkow, C. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.12.004 · Cited by 142 · see citing works

The effects of reproduction on longevity and fertility in male Drosophila melanogaster

Prowse, N., & Partridge, L. (1997) · Journal of Insect Physiology · doi:10.1016/s0022-1910(97)00014-0 · Cited by 129 · see citing works

Modelling the disposable soma theory of ageing

Drenos, F., & Kirkwood, T. B. L. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.026 · Cited by 89 · see citing works

The diet restriction paradigm: a brief review of the effects of every-other-day feeding

Anson, R. M., Jones, B., & de Cabo, R. (2005) · AGE · doi:10.1007/s11357-005-3286-2 · Cited by 78 · see citing works

Dietary Restriction in the Nematode Caenorhabditis elegans

Houthoofd, K., Johnson, T. E., & Vanfleteren, J. R. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.9.1125 · Cited by 72 · see citing works

Effects of Caloric Intake and Dietary Composition on the Development of Proteinuria, Age-Associated Renal Disease and Longevity in the Male Rat

Everitt, A. V., Porter, B. D., & Wyndham, J. R. (2009) · Gerontology · doi:10.1159/000212530 · Cited by 47 · see citing works

Inside Insulin Signaling, Communication Is Key to Long Life

Antebi, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.23.pe25 · Cited by 7 · see citing works

Telomerase activity in human germline and embryonic tissues and cells

Wright, W. E., Piatyszek, M. A., Rainey, W. E., Byrd, W., & Shay, J. W. (1996) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1996)18:2

Fasting: molecular mechanisms and clinical applications

Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425 · see citing works

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

Cabreiro, F., Au, C., Leung, K.-Y., Vergara-Irigaray, N., Cochemé, H. M., Noori, T., Weinkove, D., Schuster, E., Greene, N. D. E., & Gems, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.035 · Cited by 967 · see citing works

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S.-J., & Kenyon, C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 918 · see citing works

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801 · see citing works

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766 · see citing works

Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1 and SKN-1

Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671 · see citing works

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 600 · see citing works

Replicative and chronological aging in Saccharomyces cerevisiae

Longo, V. D., Shadel, G. S., Kaeberlein, M., & Kennedy, B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.002 · Cited by 595 · see citing works

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 574 · see citing works

Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster

Skorupa, D., Dervisefendic, A., Zwiener, J., & Pletcher, S. D. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00400.x · Cited by 439 · see citing works

Sirtuin signaling in cellular senescence and aging

Lee, S.-H., Lee, J.-H., Lee, H., & Min, K. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.290 · Cited by 438 · see citing works

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.007 · Cited by 435 · see citing works

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

Bishop, N. A., & Guarente, L. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2188 · Cited by 421 · see citing works

Caloric restriction, SIRT1 and longevity

Cantó, C., & Auwerx, J. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.03.008 · Cited by 395 · see citing works

Dietary restriction and lifespan: lessons from invertebrate models

Kapahi, P., Kaeberlein, M., & Hansen, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.005 · Cited by 340 · see citing works

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

Li, Y., Xu, W., McBurney, M. W., & Longo, V. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.004 · Cited by 331 · see citing works

Optimization of Dietary Restriction Protocols in Drosophila

Bass, T. M., Grandison, R. C., Wong, R., Martinez, P., Partridge, L., & Piper, M. D. W. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.10.1071 · Cited by 325 · see citing works

Nano-CeO 2 Exhibits Adverse Effects at Environmental Relevant Concentrations

Zhang, H., He, X. B., Zhang, Z., Zhang, P., Li, Y., Ma, Y., Kuang, Y., Zhao, Y., & Chai, Z. (2011) · Environmental Science & Technology · doi:10.1021/es103309n · Cited by 300 · see citing works

Dietary factors, hormesis and health

Mattson, M. P. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.08.004 · Cited by 293 · see citing works

Sirtuins: guardians of mammalian healthspan

Giblin, W., Skinner, M. E., & Lombard, D. B. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.04.007 · Cited by 280 · see citing works

Lifespan and healthspan extension by resveratrol

Bhullar, K. S., & Hubbard, B. P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.012 · Cited by 273 · see citing works

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Honjoh, S., Yamamoto, T., Uno, M., & Nishida, E. (2008) · Nature · doi:10.1038/nature07583 · Cited by 271 · see citing works

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf‐1 ‐dependent mechanism in Caenorhabditis elegans

Steinkraus, K. A., Smith, E. D., Davis, C., Carr, D. T., Pendergrass, W. R., Sutphin, G. L., Kennedy, B. K., & Kaeberlein, M. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00385.x · Cited by 265 · see citing works

The H3K27 demethylase UTX‐1 regulates <i>C. elegans</i> lifespan in a germline‐independent, insulin‐dependent manner

Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256 · see citing works

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

Chen, D., Thomas, E. L., & Kapahi, P. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000486 · Cited by 250 · see citing works

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

Mehta, R., Steinkraus, K. A., Sutphin, G. L., Ramos, F. J., Shamieh, L. S., Huh, A., Davis, C., Chandler-Brown, D. B., & Kaeberlein, M. R. (2009) · Science · doi:10.1126/science.1173507 · Cited by 243 · see citing works

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.006 · Cited by 230 · see citing works

Diet and Aging

Piper, M. D. W., & Bartke, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.012 · Cited by 219 · see citing works

The role of declining adaptive homeostasis in ageing

Pomatto, L. C. D., & Davies, K. J. A. (2017) · The Journal of Physiology · doi:10.1113/jp275072 · Cited by 223 · see citing works

Biology of Ageing and Role of Dietary Antioxidants

Peng, C., Wang, X., Chen, J., Jiao, R., Wang, L., Li, Y. M., Zuo, Y., Liu, Y., Lei, L., Ma, K. Y., et al. (2014) · BioMed Research International · doi:10.1155/2014/831841 · Cited by 226 · see citing works

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster : not required, but its activity modulates the response

Giannakou, M. E., Goss, M. W., & Partridge, L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00362.x · Cited by 217 · see citing works

Lifespan-regulating genes in C. elegans

Uno, M., & Nishida, E. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.10 · Cited by 192 · see citing works

Genetics of Aging in Caenorhabditis elegans

Antebi, A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030129 · Cited by 188 · see citing works

Longevity and stress in Caenorhabditis elegans

Zhou, K. I., Pincus, Z., & Slack, F. J. (2011) · Aging · doi:10.18632/aging.100367 · Cited by 189 · see citing works

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180 · see citing works

Converging Pathways in Lifespan Regulation

Narasimhan, S. D., Yen, K., & Tissenbaum, H. A. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.013 · Cited by 165 · see citing works

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

Sheaffer, K. L., Updike, D. L., & Mango, S. E. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.097 · Cited by 165 · see citing works

Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

Hwangbo, D., Lee, H., Abozaid, L. S., & Min, K. (2020) · Nutrients · doi:10.3390/nu12041194 · Cited by 164 · see citing works

The controversial world of sirtuins

Dang, W. (2012) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2012.08.003 · Cited by 153 · see citing works

Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction

Kannan, K., & Fridell, Y.-W. C. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00288 · Cited by 153 · see citing works

Apoptosis Maintains Oocyte Quality in Aging Caenorhabditis elegans Females

Andux, S., & Ellis, R. E. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000295 · Cited by 151 · see citing works

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity

Testa, G., Biasi, F., Poli, G., & Chiarpotto, E. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660699 · Cited by 148 · see citing works

Starvation Responses Throughout theCaenorhabditis elegansLife Cycle

Baugh, L. R., & Hu, P. J. (2020) · Genetics · doi:10.1534/genetics.120.303565 · Cited by 141 · see citing works

AMP‐activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction–induced Longevity

Greer, E. L., Banko, M. R., & Brunet, A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04019.x · Cited by 146 · see citing works

Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?

Piper, M. D. W., & Partridge, L. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030057 · Cited by 146 · see citing works

Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors

Margina, D. M., Ungurianu, A., Purdel, C. N., Tsoukalas, D., Sarandi, E., Thanasoula, M., Tekos, F., Mesnage, R., Kouretas, D., & Tsatsakis, A. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17114135 · Cited by 139 · see citing works

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

Smith, E. D., Kaeberlein, T. L., Lydum, B. T., Sager, J. E., Welton, K. L., Kennedy, B. K., & Kaeberlein, M. R. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-49 · Cited by 133 · see citing works

Blueberry extract prolongs lifespan of Drosophila melanogaster

Peng, C., Zuo, Y., Kwan, K. M., Liang, Y., Ma, K. Y., Chan, H. Y. E., Huang, Y., Yu, H., & Chen, Z. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.12.001 · Cited by 131 · see citing works

A pharmacological network for lifespan extension in C aenorhabditis elegans

Ye, X., Linton, J. M., Schork, N. J., Buck, L. B., & Petrascheck, M. (2013) · Aging Cell · doi:10.1111/acel.12163 · Cited by 128 · see citing works

Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans

Chen, D., Li, P. W.-L., Goldstein, B. A., Cai, W., Thomas, E. L., Chen, F., Hubbard, A., Melov, S., & Kapahi, P. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.018 · Cited by 128 · see citing works

A Method for High-Throughput Quantitative Analysis of Yeast Chronological Life Span

Murakami, C. J., Burtner, C. R., Kennedy, B. K., & Kaeberlein, M. R. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.2.113 · Cited by 127 · see citing works

Longevity–fertility trade‐offs in the tephritid fruit fly,Anastrepha ludens, across dietary‐restriction gradients

Carey, J. R., Harshman, L. G., Liedo, P., Müller, H., Wang, J., & Zhang, Z. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00389.x · Cited by 121 · see citing works

Caenorhabditis elegans Genomic Response to Soil Bacteria Predicts Environment-Specific Genetic Effects on Life History Traits

Coolon, J. D., Jones, K. L., TODD, T. C., Carr, B. C., & Herman, M. A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000503 · Cited by 120 · see citing works

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

Uno, M., Honjoh, S., Matsuda, M., Hoshikawa, H., Kishimoto, S., Yamamoto, T., Ebisuya, M., Yamamoto, T., Matsumoto, K., & Nishida, E. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.12.018 · Cited by 118 · see citing works

Apple Polyphenols Extend the Mean Lifespan of Drosophila melanogaster

Peng, C., Chan, H. Y. E., Huang, Y., Yu, H., & Chen, Z. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1046267 · Cited by 114 · see citing works

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling

Zhang, M., Poplawski, M. M., Yen, K., Cheng, H., Bloss, E. B., Zhu, X., Patel, H., & Mobbs, C. V. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000245 · Cited by 113 · see citing works

Autophagy in C. elegans.

Meléndez, A., & Levine, B. (2009) · WormBook · doi:10.1895/wormbook.1.147.1 · Cited by 112 · see citing works

Sir2 and calorie restriction in yeast: A skeptical perspective

Kaeberlein, M. R., & Powers, R. W. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.04.001 · Cited by 108 · see citing works

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

Minois, N., Carmona‐Gutiérrez, D., Bauer, M. A., Rockenfeller, P., Eisenberg, T., Brandhorst, S., Sigrist, S. J., Kroemer, G., & Madeo, F. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.139 · Cited by 108 · see citing works

Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans

Hsu, A., Feng, Z., Hsieh, M.-Y., & Xu, X. Z. S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.007 · Cited by 102 · see citing works

Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1

Ludewig, A. H., Izrayelit, Y., Park, D., Malik, R. U., Zimmermann, A., Mahanti, P., Fox, B. W., Bethke, A., Doering, F., Riddle, D. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214467110 · Cited by 98 · see citing works

TOR and ageing: a complex pathway for a complex process

McCormick, M. A., Tsai, S., & Kennedy, B. K. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0198 · Cited by 96 · see citing works

Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size

Reinke, S. N., Hu, X., Sykes, B. D., & Lemire, B. D. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.03.013 · Cited by 96 · see citing works

Dietary Restriction of Caenorhabditis elegans by Axenic Culture Reflects Nutritional Requirement for Constituents Provided by Metabolically Active Microbes

Lenaerts, I., Walker, G. A., Hoorebeke, L. V., Gems, D., & Vanfleteren, J. R. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.3.242 · Cited by 94 · see citing works

Current nutritional and pharmacological anti-aging interventions

Ros, M., & Carrascosa, J. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 95 · see citing works

Forkhead transcription factors and ageing

Partridge, L., & Brüning, J. C. (2008) · Oncogene · doi:10.1038/onc.2008.28 · Cited by 95 · see citing works

Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease

Geltinger, F., Schartel, L., Wiederstein, M., Tevini, J., Aigner, E. S., Felder, T. K., & Rinnerthaler, M. (2020) · Molecules · doi:10.3390/molecules25215053 · Cited by 94 · see citing works

Dietary restriction involves NAD +‐dependent mechanisms and a shift toward oxidative metabolism

Moroz, N., Carmona, J. J., Anderson, E. N., Hart, A. C., Sinclair, D. A., & Blackwell, T. K. (2014) · Aging Cell · doi:10.1111/acel.12273 · Cited by 90 · see citing works

Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology

Scharf, A., Pohl, F., Egan, B. M., Kocsisova, Z., & Kornfeld, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.718522 · Cited by 87 · see citing works

Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans

Suo, S., Culotti, J. G., & Tol, H. H. M. V. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.194 · Cited by 88 · see citing works

Mitochondria and Organismal Longevity

Hwang, A. B., Jeong, D., & Lee, S. (2012) · Current Genomics · doi:10.2174/138920212803251427 · Cited by 86 · see citing works

Dietary activators of Sirt1

Allard, J. S., Perez, E., Zou, S., & de Cabo, R. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.018 · Cited by 86 · see citing works

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

Mair, W. B., Panowski, S. H., Shaw, R. J., & Dillin, A. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004535 · Cited by 85 · see citing works

Toxicity ranking of heavy metals with screening method using adult Caenorhabditis elegans and propidium iodide replicates toxicity ranking in rat

Hunt, P. R., Olejnik, N., & Sprando, R. L. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.06.051 · Cited by 85 · see citing works

Linking sirtuins, IGF-I signaling, and starvation

Longo, V. D. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.005 · Cited by 84 · see citing works

Deletion of microRNA-80 Activates Dietary Restriction to Extend C. elegans Healthspan and Lifespan

Vora, M., Shah, M. B., Ostafi, S., Onken, B., Xue, J., Ni, J. Z., Gu, S. G., & Driscoll, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003737 · Cited by 82 · see citing works

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

Ravichandran, M., Priebe, S., Grigolon, G., Rozanov, L. F., Groth, M., Laube, B., Guthke, R., Platzer, M., Zarse, K., & Ristow, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.004 · Cited by 79 · see citing works

Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans

Thondamal, M., Witting, M. A., Schmitt‐Kopplin, P., & Aguilaniu, H. (2014) · Nature Communications · doi:10.1038/ncomms5879 · Cited by 81 · see citing works

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

Denzel, M. S., Lapierre, L. R., & Mack, H. I. D. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.001 · Cited by 81 · see citing works

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

Benjamin, D. I., Both, P., Benjamin, J. S., Nutter, C. W., Tan, J. H., Kang, J., Machado, L. A., Klein, J. D. D., de Morree, A., Kim, S., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.012 · Cited by 79 · see citing works

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

Leiser, S. F., & Kaeberlein, M. R. (2010) · Biological Chemistry · doi:10.1515/bc.2010.123 · Cited by 77 · see citing works

Assessing Health Span in Caenorhabditis elegans: Lessons From Short-Lived Mutants

Rollins, J. A., Howard, A. C., Dobbins, S., Washburn, E. H., & Rogers, A. N. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw248 · Cited by 75 · see citing works

MicroRNAs Mediate Dietary-Restriction-Induced Longevity through PHA-4/FOXA and SKN-1/Nrf Transcription Factors

Smith-Vikos, T., de Lencastre, A., Inukai, S., Shlomchik, M., Holtrup, B., & Slack, F. J. (2014) · Current Biology · doi:10.1016/j.cub.2014.08.013 · Cited by 75 · see citing works

Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans

Sutphin, G. L., Bishop, E., Yanos, M. E., Moller, R. M., & Kaeberlein, M. R. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-9 · Cited by 75 · see citing works

Some highlights of research on aging with invertebrates, 2010

Partridge, L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00649.x · Cited by 74 · see citing works

The role of the TOR pathway in mediating the link between nutrition and longevity

Lushchak, O., Strilbytska, O., Piskovatska, V., Storey, K. B., Koliada, A., & Vaiserman, A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.03.005 · Cited by 73 · see citing works

Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes

Sutphin, G. L., & Kaeberlein, M. R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.019 · Cited by 71 · see citing works

Stress by poor food quality and exposure to humic substances: Daphnia magna responds with oxidative stress, lifespan extension, but reduced offspring numbers

Steinberg, C. E. W., Ouerghemmi, N., Herrmann, S., Bouchnak, R., Timofeyev, M. A., & Menzel, R. (2010) · Hydrobiologia · doi:10.1007/s10750-010-0334-4 · Cited by 69 · see citing works

Black tea theaflavins extend the lifespan of fruit flies

Peng, C., Chan, H. Y. E., Li, Y. M., Huang, Y., & Chen, Z. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.004 · Cited by 69 · see citing works

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki, E., Markaki, M., & Tavernarakis, N. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.05.001 · Cited by 69 · see citing works

Physiological Control of Germline Development

Hubbard, E. J. A., Korta, D. Z., & Dalfó, D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4015-4_5 · Cited by 65 · see citing works

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

Bennett, C. F., Kwon, J. J., Chen, C., Russell, J., Acosta, K., Burnaevskiy, N., Crane, M. M., Bitto, A., Wende, H. V., Simko, M., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006695 · Cited by 65 · see citing works

Invertebrate models of age-related muscle degeneration

Augustin, H., & Partridge, L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.011 · Cited by 66 · see citing works

A gene-expression-based neural code for food abundance that modulates lifespan

Entchev, E. V., Patel, D. S., Zhan, M., Steele, A. J., Lu, H., & Ch'ng, Q.-L. (2015) · eLife · doi:10.7554/elife.06259 · Cited by 66 · see citing works

Caenorhabditis elegans 2007: The premier model for the study of aging

JOHNSON, T. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.09.008 · Cited by 65 · see citing works

Effects of juvenile and adult diet on ageing and reproductive effort of male and female black field crickets, Teleogryllus commodus

Zajitschek, F., Hunt, J., Jennions, M. D., Hall, M. D., & Brooks, R. C. (2008) · Functional Ecology · doi:10.1111/j.1365-2435.2008.01520.x · Cited by 65 · see citing works

Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation

Hadad, N., Unnikrishnan, A., Jackson, J. A., Masser, D. R., Otalora, L., Stanford, D. R., Richardson, A. G., & Freeman, W. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.009 · Cited by 65 · see citing works

Elevated CO 2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans

Sharabi, K., Hurwitz, A., Simon, A. J., Beitel, G. J., Morimoto, R. I., Rechavi, G., Sznajder, J. I., & Gruenbaum, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900309106 · Cited by 64 · see citing works

Life‐span extension by dietary restriction is mediated by NLP‐7 signaling and coelomocyte endocytosis in C. elegans

Park, S., Link, C. D., & Johnson, T. E. (2009) · The FASEB Journal · doi:10.1096/fj.09-142984 · Cited by 65 · see citing works

Lifespan extension in Caenorhabditis elegans by complete removal of food

Kaeberlein, T. L., Smith, E. D., Tsuchiya, M., Welton, K. L., Thomas, J. H., Fields, S., Kennedy, B. K., & Kaeberlein, M. R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00238.x · Cited by 336 · see citing works

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

Smith, E. D., Kaeberlein, T. L., Lydum, B. T., Sager, J. E., Welton, K. L., Kennedy, B. K., & Kaeberlein, M. R. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-49 · Cited by 133 · see citing works

Dietary Restriction-Induced Longevity in Caenorhabditis elegans: Mediated by Stress Defense, NAD\(^+\)-Dependent Mechanisms and a Respiratory Shift

Karagodsky, N. (2014) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell

Kaeberlein, T. L., Smith, E. D., Tsuchiya, M., Welton, K. L., Thomas, J. H., Fields, S., Kennedy, B. K., & Kaeberlein, M. R. (2006)

Dietary Restriction in the Nematode Caenorhabditis elegans

Houthoofd, K., Johnson, T. E., & Vanfleteren, J. R. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.9.1125 · Cited by 72 · see citing works