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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
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The National Institute on Aging's Interventions Testing Program was established to evaluate agents that are purported to increase lifespan and delay the appearance of age‐related disease in genetically heterogeneous mice. Up to five compounds are added to the study each year and each compound is tested at three test sites (The Jackson Laboratory, University of Michigan, and University of Texas Health Science Center at San Antonio). Mice in the first cohort were exposed to one of four agents: aspirin, nitroflurbiprofen, 4‐OH‐α‐phenyl‐N‐tert‐butyl nitrone, or nordihydroguaiaretic acid (NDGA). Sample size was sufficient to detect a 10% difference in lifespan in either sex, with 80% power, using data from two of the three sites. Pooling data from all three sites, a log‐rank test showed that both NDGA ( p = 0.0006) and aspirin ( p = 0.01) led to increased lifespan of male mice. Comparison of the proportion of live mice at the age of 90% mortality was used as a surrogate for measurement of maximum lifespan; neither NDGA ( p = 0.12) nor aspirin ( p = 0.16) had a significant effect in this test. Measures of blood levels of NDGA or aspirin and its salicylic acid metabolite suggest that the observed lack of effects of NDGA or aspirin on lifespan in females could be related to gender differences in drug disposition or metabolism. Further studies are warranted to find whether NDGA or aspirin, over a range of doses, might prove to postpone death and various age‐related outcomes reproducibly in mice.
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“Moreover, long-term treatment with the NSAID aspirin prolonged lifespan in genetically heterogeneous wt mice56.”
From Chronic inflammation induces telomere dysfunction and accelerates ageing in mice (2014) · cites this paper as [56]
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“Moreover, the long-term administration of anti-inflammatory agents such as aspirin may increase longevity in mice and healthy aging in humans (Rothwell et al., 2011; Strong et al., 2008).”
From The Hallmarks of Aging (2013) · cites this paper as Strong et al., 2008
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“aspirin has been confirmed to extend the lifespan of Drosophila melanogaster and mice in a sex-dependent manner.478,479”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [479]
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“The National Institute on Aging Interventions Testing Program (ITP) evaluates agents that may delay ageing and increase lifespan in genetically heterogeneous mice15–17.”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [17]
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“Female mice given 2500 ppm had lower blood levels of NDGA compared with males, suggesting that the sex effect might reflect sex‐specific differences in drug metabolism or excretion (Strong et al., 2008).”
From Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer (2016) · cites this paper as Strong et al., 2008
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“the failure of NDGA, at 2500 ppm, to increase longevity in female mice (Strong et al., 2008) seems not to be due merely to lower blood concentrations of this agent in females, because we fail to see increased female lifespan even at a concentration, 5000 ppm, that produces blood levels similar to those seen in males at 2500 ppm (Harrison et al., 2014).”
From Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer (2016) · cites this paper as Strong et al., 2008
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“In the earlier study, 9% of male control mice were alive at the joint 90th percentile age, compared with 13% of NDGA‐treated males (P = 0.12).”
From Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer (2016) · cites this paper as Strong et al., 2008
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“Aspirin improves lifespan in mice”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [273]
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“and oxylipin synthesis inhibitors extend male mouse life span (Strong et al., 2008).”
From Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis (2021) · cites this paper as Strong et al., 2008
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“we tested the effects of NDGA on survival of male and female UM‐HET3 mice at a dose of 2500 ppm and reported that median lifespan was increased in males by 12%, with no benefit in female mice (Strong et al., 2008).”
From Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer (2016) · cites this paper as Strong et al., 2008
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“First, the failure of NDGA, at 2500 ppm, to increase longevity in female mice (Strong et al., 2008) seems not to be due merely to lower blood concentrations of this agent in females”
From Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer (2016) · cites this paper as Strong et al., 2008
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Cites
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J., & Vane, J. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11693 · Cited by 1,659
Role of oxygen free radicals in carcinogenesis and brain ischemia
Floyd, R. A. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.9.2189775 · Cited by 877
Self-citationFlurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826
Self-citationIn Search of Methuselah: Estimating the Upper Limits to Human Longevity
Olshansky, S. J., Carnes, B. A., & Cassel, C. (1990) · Science · doi:10.1126/science.2237414 · Cited by 645
Fungal laccase: properties and activity on lignin
Leonowicz, A., Cho, N.-S., Luterek, J., Jarosz‐Wilkołazka, A., Wojtaś-Wasilewska, M., Matuszewska, A., Hofrichter, M., Wesenberg, D., & Rogalski, J. (2001) · Journal of Basic Microbiology · doi:10.1002/1521-4028(200107)41:3/4 · Cited by 578
Handbook of the Biology of Aging
(1986) · Journal of Gerontology · doi:10.1093/geronj/41.1.120 · Cited by 563
Lim, S. S., Gaziano, T. A., Gakidou, E. E., Reddy, K. S., Farzadfar, F., Lozano, R., & Rodgers, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61699-7 · Cited by 373
The mouse as a model for human biology: a resource guide for complex trait analysis
Peters, L. L., Robledo, R. F., Bult, C. J., Churchill, G. A., Paigen, B. J., & Svenson, K. L. (2006) · Nature Reviews Genetics · doi:10.1038/nrg2025 · Cited by 293
Aspirin Dose and Duration of Use and Risk of Colorectal Cancer in Men
Chan, A. T., Giovannucci, E. L., Meyerhardt, J. A., Schernhammer, E. S., Wu, K., & Fuchs, C. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.035 · Cited by 241
Research works printed but not linked: 2
- 10.1096/fasebj.14.10.1464 · DOI
- Schneider EL, 1998, Brockelhurst's Textbook of Geriatric Medicine, 193
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Hasty, P., Livi, C. B., Dodds, S. G., Jones, D., Strong, R., Javors, M. A., Fischer, K. E., Sloane, L. B., Murthy, K., Hubbard, G. B., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0299 · Cited by 69
Self-citationNF-κB signaling as a driver of ageing
Osorio, F. G., Soria‐Valles, C., Santiago‐Fernández, O., Freije, J. M. P., & López-Otı́n, C. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.04.003 · Cited by 67
Strong, R., Miller, R. A., Cheng, C. J., Nelson, J. F., Gelfond, J., Allani, S. K., Diaz, V., Dorigatti, A. O., Dorigatti, J., Fernandez, E., et al. (2022) · Aging Cell · doi:10.1111/acel.13724 · Cited by 76
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Saraswat, K., & Rizvi, S. I. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1349750 · Cited by 66
Aliper, A. M., Belikov, A. V., Garazha, A., Jellen, L. C., Artemov, A. V., Suntsova, M., Ivanova, A., Venkova, L. S., Borisov, N. M., Buzdin, A. A., et al. (2016) · Aging · doi:10.18632/aging.101047 · Cited by 67
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Floyd, R. A., Towner, R. A., He, T., Hensley, K., & Maples, K. R. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.014 · Cited by 65
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Danilov, A., Shaposhnikov, M., Shevchenko, O., Zemskaya, N., Zhavoronkov, A., & Moskalev, A. (2015) · Oncotarget · doi:10.18632/oncotarget.5118 · Cited by 64
Bennett, C. F., & Kaeberlein, M. R. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.02.002 · Cited by 61
Ayyadevara, S., Balasubramaniam, M., Kakraba, S., Alla, R., Mehta, J. L., & Reis, R. J. S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6978 · Cited by 59
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Snyder, J. M., Ward, J. M., & Treuting, P. M. (2015) · Veterinary Pathology · doi:10.1177/0300985815610391 · Cited by 61
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Garratt, M., Lagerborg, K. A., Tsai, Y., Galecki, A., Jain, M., & Miller, R. A. (2018) · Aging Cell · doi:10.1111/acel.12786 · Cited by 63
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Piskovatska, V., Strilbytska, O. M., Koliada, A. K., Vaiserman, A. M., & Lushchak, O. V. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_13 · Cited by 62
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Madreiter‐Sokolowski, C. T., Sokolowski, A., Waldeck‐Weiermair, M., Malli, R., & Graier, W. F. (2018) · Genes · doi:10.3390/genes9030165 · Cited by 61
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Furrer, R., & Handschin, C. (2025) · Physiological Reviews · doi:10.1152/physrev.00045.2024 · Cited by 68
Galow, A.-M., & Peleg, S. (2022) · Cells · doi:10.3390/cells11030468 · Cited by 60
Harrison, D. E., Strong, R., Reifsnyder, P., Rosenthal, N., Korstanje, R., Fernandez, E., Flurkey, K., Ginsburg, B. C., Murrell, M. D., Javors, M. A., et al. (2023) · GeroScience · doi:10.1007/s11357-023-01011-0 · Cited by 56
Self-citationAntiaging Strategies and Remedies: A Landscape of Research Progress and Promise
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00532 · Cited by 62
Melin, A. D., Hogan, J. D., Campos, F. A., Wikberg, E. C., King‐Bailey, G., Webb, S. E., Kalbitzer, U., Asensio, N., Murillo‐Chacon, E., Hernández, S. C., et al. (2020) · Biotropica · doi:10.1111/btp.12867 · Cited by 60
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Katsube, M., Ishimoto, T., Fukushima, Y., Kagami, A., Shuto, T., & Kato, Y. (2024) · GeroScience · doi:10.1007/s11357-024-01111-5 · Cited by 56
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Lim, S. H. Y., Hansen, M., & Kumsta, C. (2024) · Cells · doi:10.3390/cells13161364 · Cited by 62
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Pils, V., Terlecki‐Ζaniewicz, L., Schosserer, M., Grillari, J., & Lämmermann, I. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111527 · Cited by 56
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Liu, Y., Fang, M., Tu, X., Mo, X., Zhang, L., Yang, B., Wang, F., Kim, Y., Huang, C., Chen, L., et al. (2024) · Nutrients · doi:10.3390/nu16193305 · Cited by 62
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Tsai, Y.-C., Cheng, L., Liu, Y.-W., Jeng, O.-J., & Lee, Y. K. (2020) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2020-026 · Cited by 58
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Folch, J., Busquets, O., Ettcheto, M., Sánchez‐López, E., Pallàs, M., Beas‐Zárate, C., Marin, M., Casadesús, G., Olloquequi, J., Auladell, C., et al. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170707155345 · Cited by 53
Garratt, M., Leander, D. C., Pifer, K., Bower, B., Herrera, J. J., Day, S. M., Fiehn, O., Brooks, S. V., & Miller, R. A. (2019) · Aging Cell · doi:10.1111/acel.12920 · Cited by 51
Self-citationRiera, C. E., & Dillin, A. G. (2015) · Nature Medicine · doi:10.1038/nm.4005 · Cited by 48
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Austad, S. N. (2016) · Advances in Geroscience · doi:10.1007/978-3-319-23246-1_1 · Cited by 43
Parkhitko, A. A., Favorova, O. O., Khabibullin, D., Anisimov, V. N., & Henske, E. P. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914020023 · Cited by 44
Pun, F. W., Leung, G. H. D., Leung, H.-W., Rice, J., Schmauck‐Medina, T., Lautrup, S., Long, X., Liu, B. H. M., Wong, C. W., Ozerov, I. V., et al. (2023) · Aging Cell · doi:10.1111/acel.14017 · Cited by 44
Feng, M., Kim, J., Field, K. P., Reid, C., Chatzistamou, I., & Shim, M. (2019) · FASEB BioAdvances · doi:10.1096/fba.2019-00041 · Cited by 44
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Mangan, D. F. (2021) · Aging · doi:10.18632/aging.203612 · Cited by 43
Hernández‐Damián, J., Andérica‐Romero, A. C., & Pedraza‐Chaverrí, J. (2014) · Archiv der Pharmazie · doi:10.1002/ardp.201400159 · Cited by 41
miRNAs and aging: A genetic perspective
Garg, D., & Cohen, S. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.04.001 · Cited by 39
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Tezil, T., Chamoli, M., Ng, C.-P., Simon, R. P., Butler, V. J., Jung, M., Andersen, J., Kao, A. W., & Verdin, E. (2019) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-019-0037-7 · Cited by 40
Repurposing drugs to fight aging: The difficult path from bench to bedside
Vaiserman, A. M., Koliada, A. K., Lushchak, O. V., & Castillo, M. J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21773 · Cited by 42
Espinoza, S. E., Woods, R. L., Ekram, A. R. M. S., Ernst, M. E., Polekhina, G., Wolfe, R., Shah, R. C., Ward, S. A., Storey, E., Nelson, M. R., et al. (2022) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab340 · Cited by 39
Infante‐Garcia, C., Ramos‐Rodríguez, J. J., Hierro‐Bujalance, C., Ortegon, E., Pickett, E. K., Jackson, R. J., Pacho, F. H., Spires‐Jones, T. L., & García-Alloza, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0825-7 · Cited by 42
In search of antiaging modalities: Evaluation of mTOR‐ and ROS/DNA damage‐signaling by cytometry
Darżynkiewicz, Z., Zhao, H., Halicka, H. D., Li, J., Lee, Y., Hsieh, T., & WU, J. M. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22452 · Cited by 39
Effects of NSAIDs on the risk factors of colorectal cancer: a mini review
Hamoya, T., Fujii, G., Miyamoto, S., Takahashi, M., Totsuka, Y., Wakabayashi, K., Toshima, J., & Mutoh, M. (2016) · Genes and Environment · doi:10.1186/s41021-016-0033-0 · Cited by 38
Bulterijs, S. (2011) · Rejuvenation Research · doi:10.1089/rej.2011.1153 · Cited by 37
Kritchevsky, S. B., & Cummings, S. R. (2025) · JAMA · doi:10.1001/jama.2025.11289 · Cited by 40
Hurvitz, N., Elkhateeb, N., Sigawi, T., Rinsky‐Halivni, L., & Ilan, Y. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1044038 · Cited by 38
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Lorusso, J. S., Sviderskiy, O., & Labunskyy, V. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7163 · Cited by 39
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Castillo-Quan, J. I., Kinghorn, K. J., & Bjedov, I. (2015) · Advances in genetics · doi:10.1016/bs.adgen.2015.06.002 · Cited by 37
Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules
Heiß, C., Spyridopoulos, I., & Haendeler, J. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.015 · Cited by 36
Siddique, Y. H., Ara, G., Jyoti, S., & Afzal, M. (2011) · Journal of Dietary Supplements · doi:10.3109/19390211.2011.630716 · Cited by 34
Wang, X., Lü, J., Khaidakov, M., Mitra, S., Ding, Z., Raina, S., Goyal, T., & Mehta, J. L. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.013 · Cited by 33
Pickering, A. M., Lehr, M., Gendron, C. M., Pletcher, S. D., & Miller, R. A. (2017) · Aging Cell · doi:10.1111/acel.12596 · Cited by 33
Self-citationHerrera, J. J., Louzon, S., Pifer, K., Leander, D. C., Merrihew, G. E., Park, J. H., Szczesniak, K., Whitson, J. D., Wilkinson, J. E., Fiehn, O., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137474 · Cited by 31
Self-citationShamalnasab, M., Gravel, S., St‐Pierre, J., Breton, L., Jäger, S., & Aguilaniu, H. (2018) · Aging Cell · doi:10.1111/acel.12830 · Cited by 32
Lagger, C., Ursu, E., Equey, A., Avelar, R. A., Pisco, A. O., Tăcutu, R., & de Magalhães, J. P. (2023) · Nature Aging · doi:10.1038/s43587-023-00514-x · Cited by 36
Universal transcriptomic hallmarks of mammalian ageing and mortality
Tyshkovskiy, A., Kholdina, D., Davitadze, M., Molière, A., Moldakozhayev, A., Tongu, Y., Kasahara, T., Glubokov, D., Eames, A., Kats, L., et al. (2026) · Nature · doi:10.1038/s41586-026-10542-3 · Cited by 39
Self-citationA sex skew in life-history research: the problem of missing males
Archer, C. R., Paniw, M., Vega‐Trejo, R., & Sepil, I. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.1117 · Cited by 28
Gnabre, J., Bates, R. B., & Huang, R. C. C. (2015) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2014.11.024 · Cited by 31
Huang, X., Mu, X.-H., Wan, Q.-L., He, X.-M., Wu, G.-S., & Luo, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184027 · Cited by 30
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Mishra, S. K., Balendra, V., Esposto, J., Obaid, A. A., Maccioni, R. B., Jha, N. K., Perry, G. L., Moustafa, M., Al-Shehri, M., Singh, M. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102515 · Cited by 34
Garratt, M. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-190067 · Cited by 30
Darcy, J., Fang, Y., McFadden, S., Lynes, M. D., Leiria, L. O., Dreyfuss, J. M., Bussburg, V., Tolstikov, V., Greenwood, B. P., Narain, N. R., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00221-0 · Cited by 29
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McElroy, G. S., Chakrabarty, R. P., D’Alessandro, K. B., Hu, Y., Vasan, K., Tan, J., Stoolman, J. S., Weinberg, S. E., Steinert, E. M., Reyfman, P. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-09074-3 · Cited by 27
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Metadata
- Authors
- Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R., & Harrison, D. E.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- University of Michigan (US)
- Jackson Laboratory (US)
- Oklahoma Medical Research Foundation (US)
- University of Florida (US)
- National Institutes of Health (US)
- University of Minnesota (US)
- Corresponding author
- Strong, Randy
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-09-17
- Volume
- 7
- Issue
- 5
- Pages
- 641-650
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC2695675
- OpenAlex
- W1965507724
- Cited by
- 349
- References
- 54
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 35 · 2023: 16 · 2022: 21 · 2021: 27 · 2020: 21 · 2019: 23 · 2018: 21 · 2017: 24 · 2016: 24 · 2015: 24 · 2014: 14 · 2013: 14 · 2012: 20
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute on Aging (AG 022308, AG13319, P30AG025707, AG022307, AG022303, AG025707, P30AG013319, U01AG022307, P30AG028740, U01AG022308, U01AG022303)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- nordihydroguaiaretic acid, aspirin, lifespan extension, maximum lifespan, genetically heterogeneous mice, age-related diseases, drug metabolism, anti-aging interventions
- MeSH terms
- Animals, Aspirin, Cyclic N-Oxides, Female, Flurbiprofen, Longevity, Male, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Masoprocol, Random Allocation, Sex Characteristics, Survival Analysis, Free Radical Scavengers, Lipoxygenase Inhibitors, Cyclooxygenase Inhibitors, Genetic Heterogeneity, Mice
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