Miller, Richard A.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 3,766

The aging immune system: primer and prospectus

Miller, R. A. (1996) · Science

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 1,165

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 896

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 826

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., et al. (2014) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 445

Extending the Lifespan of Long-Lived Mice

Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S. (2001) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 422

Using DNA methylation profiling to evaluate biological age and longevity interventions

Petkovich, D. A., Podolskiy, D. I., Lobanov, A. V., Lee, S.-G., Miller, R. A., & Gladyshev, V. N. (2017) · Cell Metabolism

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 398

Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., et al. (2016) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 362

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., et al. (2008) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 349

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 293

Multiplex stress resistance in cells from long-lived dwarf mice

Murakami, S., Salmon, A., & Miller, R. A. (2003) · The FASEB Journal

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 207

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., Khaitovich, P., Clish, C. B., Miller, R. A., & Gladyshev, V. N. (2019) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 167

Distinct longevity mechanisms across and within species and their association with aging

Tyshkovskiy, A., Ma, S., Shindyapina, A. V., Tikhonov, S., Lee, S.-G., Bozaykut, P., Castro, J. P., Seluanov, A., Schork, N. J., Gorbunova, V., et al. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 162

Pursuing the Longevity Dividend: Scientific Goals for an Aging World

OLSHANSKY, S. J., PERRY, D., MILLER, R. A., & BUTLER, R. N. (2007) · Annals of the New York Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 122

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Ma, S., Upneja, A., Galecki, A., Tsai, Y.-M., Burant, C. F., Raskind, S., Zhang, Q., Zhang, Z. D., Seluanov, A., Gorbunova, V., et al. (2016) · eLife

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 89

‘Accelerated aging’: a primrose path to insight?

Miller, R. A. (2004) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 87

Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice

Drake, J. C., Peelor, F. F., Biela, L. M., Watkins, M. K., Miller, R. A., Hamilton, K. L., & Miller, B. F. (2013) · The Journals of Gerontology Series A

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 87

Measures of Healthspan as Indices of Aging in Mice—A Recommendation

Richardson, A., Fischer, K. E., Speakman, J. R., de Cabo, R., Mitchell, S. J., Peterson, C. A., Rabinovitch, P., Chiao, Y. A., Taffet, G., Miller, R. A., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 81

Science fact and the SENS agenda: What can we reasonably expect from ageing research?

Warner, H., Anderson, J., Austad, S., Bergamini, E., Bredesen, D., Butler, R., Carnes, B. A., Clark, B. F. C., Cristofalo, V., Faulkner, J., et al. (2005) · The EMBO Reports

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 74

mTOR regulates the expression of DNA damage response enzymes in long‐lived Snell dwarf, GHRKO, and PAPPA‐KO mice

Dominick, G., Bowman, J., Li, X., Miller, R. A., & Garcia, G. G. (2017) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 62

Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle

Zhao, Y., Zheng, Z., Zhang, Z., Xu, Y., Hillpot, E., Lin, Y. S., Zakusilo, F. T., Lu, J. Y., Ablaeva, J., Biashad, S. A., et al. (2023) · Nature Communications

Proteoglycans and glycosaminoglycans researchSubterranean biodiversity and taxonomy

Cited by 34

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

Zhao, Y., Zheng, Z., Zhang, Z., Hillpot, E., Lin, Y. S., Zakusilo, F. T., Lu, J. Y., Ablaeva, J., Miller, R. A., Nevo, E., et al. (2023) · Nature Communications

Proteoglycans and glycosaminoglycans researchSubterranean biodiversity and taxonomy

Cited by 34

Differential effects of ageing on cytokine and chemokine responses during type-1 (Mycobacterial) and type-2 (Schistosomal) pulmonary granulomatous inflammation in mice

Chiu, B. C., Shang, X., Frait, K. A., Hu, J. S., Komuniecki, E., Miller, R. A., & Chensue, S. W. (2002) · Mechanisms of Ageing and Development

Tuberculosis Research and EpidemiologyParasites and Host Interactions

Cited by 19