Optimal window of caloric restriction onset limits its beneficial impact on T‐cell senescence in primates
Open accessAbstract
Summary: We have recently shown in non‐human primates that caloric restriction (CR) initiated during adulthood can delay T‐cell aging and preserve naïve CD8 and CD4 T cells into advanced age. An important question is whether CR can be initiated at any time in life, and whether age at the time of onset would modulate the beneficial effects of CR. In the current study, we evaluated the impact of CR started before puberty or during advanced age on T‐cell senescence and compared it to the effects of CR started in early adulthood. Our data demonstrate that the beneficial effects of adult‐onset CR on T‐cell aging were lost by both early and late CR onset. In fact, some of our results suggest that inappropriate initiation of CR may be harmful to the maintenance of T‐cell function. This suggests that there may be an optimal window during adulthood where CR can delay immune senescence and improve correlates of immunity in primates.
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Caloric restriction slows the buildup of senescent T cells in rodents and non-human primates.
“CR has been reported to have multiple beneficial effects on the immune system of both rodents and non-human primates that include a delay in the accumulation of senescent T cells (112) and a stimulation of thymopoiesis (113).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [112]
In non-human primates, caloric restriction helps when begun in adulthood but not when begun before puberty or in old age.
“beneficial effects were observed when it commenced in adults but were not evident when initiated in prepubertal or aged non-human primates (112).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [112]
Caloric restriction stimulates thymopoiesis in rodents and non-human primates.
“CR has been reported to have multiple beneficial effects on the immune system of both rodents and non-human primates that include a delay in the accumulation of senescent T cells (112) and a stimulation of thymopoiesis (113).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [112]
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- Authors
- Messaoudi, I., Fischer, M., Warner, J., Park, B., Mattison, J., Ingram, D. K., Totonchy, T., Mori, M., & Nikolich‐Žugich, J.
- Affiliations
- Oregon Health & Science University (US)
- Oregon National Primate Research Center (US)
- University of Arizona (US)
- Louisiana State University (US)
- Corresponding author
- Nikolich‐Žugich, Janko
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-11-24
- Volume
- 7
- Issue
- 6
- Pages
- 908-919
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC2659568
- OpenAlex
- W1993040858
- Cited by
- 57
- References
- 70
- Citations by year
- 2026: 2 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2013: 6 · 2012: 8
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (RR0163)
- U.S. Public Health Service
- Oregon National Primate Research Center
- National Institute on Aging (Z01AG000371, AG 21384, U01AG021384)
- National Institute of Allergy and Infectious Diseases (T32AI007472)
- National Center for Research Resources (RR-0163, P51RR000163, K01RR000163)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- caloric restriction, T cell senescence, immunosenescence, CD8+ T cells, CD4+ T cells, naive T cells, onset time, non-human primates, aging, puberty
- MeSH terms
- Age Factors, Aging, Animals, Cells, Cultured, Female, Macaca mulatta, Male, Primates, Immunophenotyping, T-Lymphocyte Subsets, Cellular Senescence, Caloric Restriction
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