Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals

Goronzy, Jörg J.; Fulbright, James W.; Crowson, Cynthia S.; Poland, Gregory A.; O'Fallon, William M.; Weyand, Cornelia M.

doi:10.1128/jvi.75.24.12182-12187.2001

Cited by 402Influenza Virus Research StudiesImmune responses and vaccinationsT-cell and B-cell Immunology

Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals

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Goronzy, Jörg J., Fulbright, James W., Crowson, Cynthia S., Poland, Gregory A., O'Fallon, William M., Weyand, Cornelia M.·2001·Journal of Virology

DOI 10.1128/jvi.75.24.12182-12187.2001PMC PMC116115

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Abstract

Elderly individuals are at high risk for morbidity and mortality when infected with influenza virus. Vaccinations with inactivated virus are less effective in the elderly due to the declining competency of the aging immune system. We have explored whether immunological parameters predict poor anti-influenza virus vaccine responses and can be used as biological markers of immunosenescence. One hundred fifty-three residents of community-based retirement facilities aged 65 to 98 years received a trivalent influenza vaccine. Vaccine-induced antibody responses were determined by comparing hemagglutination inhibition titers before and 28 days after immunization. The composition of the T-cell compartment was analyzed by flow cytometry and the sizes of three T-cell subsets, CD4+CD45RO+cells, CD4+CD28 null cells, and CD8+CD28 null cells, were determined. Only 17% of the vaccine recipients were able to generate an increase in titers of antibody to all three vaccine components, and 46% of the immunized individuals failed to respond to any of the three hemagglutinins. The likelihood of successful vaccination declined with age and was independently correlated with the expansion of a particular T-cell subset, CD8+CD28 null T cells. The sizes of the CD4+CD45RO+memory T-cell and CD4+CD28 null T-cell subsets had no effect on the ability to mount anti-influenza virus antibody responses. Frequencies of CD8+CD28 null T cells are useful biological markers of compromised immunocompetence, identifying individuals at risk for insufficient antibody responses.

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Frequencies of CD8+ TEMRA cells, many reactive to CMV, inversely predict antibody response to trivalent influenza vaccination.
“frequencies of CD8+ TEMRA cells, many of them reactive to CMV, inversely predicted the antibody response to trivalent influenza vaccination (TIV)”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Goronzy et al., 2001

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Authors: Goronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M.
Affiliations: Departments of Medicine1 and
Mayo Clinic (US)
Biostatistics,2 Mayo Clinic, Rochester, Minnesota
ORCID: Crowson, Cynthia S.
Poland, Gregory A.
Weyand, Cornelia M.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2001-12-15
Volume: 75
Issue: 24
Pages: 12182-12187
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.75.24.12182-12187.2001
PMC: PMC116115
OpenAlex: W2089244708
Cited by: 402
References: 52
Citations by year: 2026: 3 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 19 · 2020: 14 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 15 · 2015: 16 · 2014: 15 · 2013: 27 · 2012: 29
FWCI: 7.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Mayo Foundation for Medical Education and Research
National Institutes of Health
National Institute on Aging (R01AG015043, R01AG15043)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: influenza vaccination, immunosenescence, vaccine response prediction, older adults, CD8+CD28- T cells, T cell subsets, hemagglutination inhibition antibodies, trivalent influenza vaccine, immunological markers, immunocompetence
MeSH terms: Age Factors, Aged, Aged, 80 and over, Aging, Antibodies, Viral, Female, Humans, Influenza Vaccines, Male, Vaccination, CD4 Antigens, T-Lymphocyte Subsets, Leukocyte Common Antigens, CD28 Antigens

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Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals

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